LOCUS       NM_003851               1969 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens cellular repressor of E1A stimulated genes 1 (CREG1),
            mRNA.
ACCESSION   NM_003851
VERSION     NM_003851.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Song,H., Tian,X., He,L., Liu,D., Li,J., Mei,Z., Zhou,T., Liu,C.,
            He,J., Jia,X., Yang,Z., Yan,C. and Han,Y.
  TITLE     CREG1 deficiency impaired myoblast differentiation and skeletal
            muscle regeneration
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (2), 587-602 (2024)
   PUBMED   38272853
  REMARK    GeneRIF: CREG1 deficiency impaired myoblast differentiation and
            skeletal muscle regeneration.
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Song,H., Li,J., Peng,C., Liu,D., Mei,Z., Yang,Z., Tian,X.,
            Zhang,X., Jing,Q., Yan,C. and Han,Y.
  TITLE     The role of CREG1 in megakaryocyte maturation and
            thrombocytopoiesis
  JOURNAL   Int J Biol Sci 19 (11), 3614-3627 (2023)
   PUBMED   37496998
  REMARK    GeneRIF: The role of CREG1 in megakaryocyte maturation and
            thrombocytopoiesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Liu,Y., Tian,X., Liu,S., Liu,D., Li,Y., Liu,M., Zhang,X., Yan,C.
            and Han,Y.
  TITLE     DNA hypermethylation: A novel mechanism of CREG gene suppression
            and atherosclerogenic endothelial dysfunction
  JOURNAL   Redox Biol 32, 101444 (2020)
   PUBMED   32067910
  REMARK    GeneRIF: DNA hypermethylation: A novel mechanism of CREG gene
            suppression and atherosclerogenic endothelial dysfunction.
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Tian,X., Yan,C. and Han,Y.
  TITLE     Cellular Repressor of E1A-stimulated Genes, A New Potential
            Therapeutic Target for Atherosclerosis
  JOURNAL   Curr Drug Targets 18 (15), 1800-1804 (2017)
   PUBMED   27784214
  REMARK    GeneRIF: Studies demonstrated that CREG may modulate homeostasis of
            vascular wall cells and inhibit inflammation of vascular tissue
            cells and macrophages. Mechanistically, CREG behaves like a typical
            soluble lysosomal protein that regulates the formation and
            maturation of lysosomes by modulating the small GTPase protein
            Rab7, to mediate autophagy in vascular vascular tissue cells.
            [review]
            Review article
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Clark,D.J., Mei,Y., Sun,S., Zhang,H., Yang,A.J. and Mao,L.
  TITLE     Glycoproteomic Approach Identifies KRAS as a Positive Regulator of
            CREG1 in Non-small Cell Lung Cancer Cells
  JOURNAL   Theranostics 6 (1), 65-77 (2016)
   PUBMED   26722374
  REMARK    GeneRIF: These results indicate that CREG1 is a down-stream
            effector of KRAS in a sub-type of non-small cell lung cancer cells
            and a novel candidate biomarker or therapeutic target for KRAS
            mutant non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Di Bacco,A. and Gill,G.
  TITLE     The secreted glycoprotein CREG inhibits cell growth dependent on
            the mannose-6-phosphate/insulin-like growth factor II receptor
  JOURNAL   Oncogene 22 (35), 5436-5445 (2003)
   PUBMED   12934103
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Jiang,L.Q., Wen,S.J., Wang,H.Y. and Chen,L.Y.
  TITLE     Screening the proteins that interact with calpain in a human heart
            cDNA library using a yeast two-hybrid system
  JOURNAL   Hypertens Res 25 (4), 647-652 (2002)
   PUBMED   12358155
REFERENCE   9  (bases 1 to 1969)
  AUTHORS   Veal,E., Groisman,R., Eisenstein,M. and Gill,G.
  TITLE     The secreted glycoprotein CREG enhances differentiation of NTERA-2
            human embryonal carcinoma cells
  JOURNAL   Oncogene 19 (17), 2120-2128 (2000)
   PUBMED   10815803
REFERENCE   10 (bases 1 to 1969)
  AUTHORS   Veal,E., Eisenstein,M., Tseng,Z.H. and Gill,G.
  TITLE     A cellular repressor of E1A-stimulated genes that inhibits
            activation by E2F
  JOURNAL   Mol Cell Biol 18 (9), 5032-5041 (1998)
   PUBMED   9710587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF084523.1 and BC006786.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003851.2.
            
            Summary: The adenovirus E1A protein both activates and represses
            gene expression to promote cellular proliferation and inhibit
            differentiation. The protein encoded by this gene antagonizes
            transcriptional activation and cellular transformation by E1A. This
            protein shares limited sequence similarity with E1A and binds both
            the general transcription factor TBP and the tumor suppressor pRb
            in vitro. This gene may contribute to the transcriptional control
            of cell growth and differentiation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006786.1, AF084523.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370509.5/ ENSP00000359540.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1222              AF084523.1         13-1234
            1223-1969           BC006786.1         1211-1957
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..1969
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /note="cellular repressor of E1A stimulated genes 1"
                     /db_xref="GeneID:8804"
                     /db_xref="HGNC:HGNC:2351"
                     /db_xref="MIM:618055"
     exon            1..375
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..684
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /note="protein CREG1"
                     /codon_start=1
                     /product="protein CREG1 precursor"
                     /protein_id="NP_003842.1"
                     /db_xref="CCDS:CCDS1262.1"
                     /db_xref="GeneID:8804"
                     /db_xref="HGNC:HGNC:2351"
                     /db_xref="MIM:618055"
                     /translation="MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEAS
                     RLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLSLSDGPPGAGSGV
                     PYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKVN
                     ETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVT
                     VQ"
     exon            376..495
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /inference="alignment:Splign:2.1.0"
     exon            496..680
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /inference="alignment:Splign:2.1.0"
     exon            681..1969
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1946..1951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /note="hexamer: ATTAAA"
     polyA_site      1969
                     /gene="CREG1"
                     /gene_synonym="CREG"
                     /note="major polyA site"
ORIGIN      
        1 actcttcctg gagacaccgc catggccggg ctatcccgcg ggtccgcgcg cgcactgctc
       61 gccgccctgc tggcgtcgac gctgttggcg ctgctcgtgt cgcccgcgcg gggtcgcggc
      121 ggccgggacc acggggactg ggacgaggcc tcccggctgc cgccgctacc accccgcgag
      181 gacgcggcgc gcgtggcccg cttcgtgacg cacgtctccg actggggcgc tctggccacc
      241 atctccacgc tggaggcggt gcgcggccgg cccttcgccg acgtcctctc gctcagcgac
      301 gggcccccgg gcgcgggcag cggcgtgccc tatttctacc tgagcccgct gcagctctcc
      361 gtgagcaacc tgcaggagaa tccatatgct acactgacca tgactttggc acagaccaac
      421 ttctgcaaga aacatggatt tgatccacaa agtccccttt gtgttcacat aatgctgtca
      481 ggaactgtga ccaaggtgaa tgaaacagaa atggatattg caaagcattc gttattcatt
      541 cgacaccctg agatgaaaac ctggccttcc agccataatt ggttctttgc taagttgaat
      601 ataaccaata tctgggtcct ggactacttt ggtggaccaa aaatcgtgac accagaagaa
      661 tattataatg tcacagttca gtgaagcaga ctgtggtgaa tttagcaaca cttatgaagt
      721 ttcttaaagt ggctcataca cacttaaaag gcttaatgtt tctctggaaa gcgtcccaga
      781 atattagcca gttttctgtc acatgctggt ttgtttgctt gcttgtttac ttgcttgttt
      841 accaatagag ttgacctgtt attggatttc ctggaagatg tggtagctac ttttttccta
      901 ttttgaagcc attttcgtag agaaatatcc ttcactataa tcaaataagt tttgtcccat
      961 caattccaaa gatgtttcca gtggtgctct tgaagaggaa tgagtaccag ttttaaattg
     1021 cccattggca tttgaaggta gttgagtatg tgttctttat tcctagaagc cactgtgctt
     1081 ggtagagtgc atcactcacc acagctgcct cctgagctgc ctgagcctgg tgcaaaagga
     1141 ttggccccca ttatggtgct tctgaataaa tcttgccaag atagacaaac aatgatgaaa
     1201 ctcagatgga gcttcctact cacgttgatt tatgtctcac aatcctgggt attgttaatt
     1261 caacataggg tgaaactatt tctgataaag aacttttgaa aaacttttta tactctaaag
     1321 tgatactcag aacaaaagaa agtcataaaa ctcctgaatt taatttcccc acctaagtcg
     1381 aaacagtatt atcaaaacac atgtgcacac agattatttt ttggctccaa aactggattg
     1441 caaaagaaag aggagaagaa tattttgtgt gttcctggta ttcttttata agtaaagttt
     1501 acccaggcat ggaccagctt cagccaggga caaaatcccc tcccaaacca ctctccacag
     1561 ctttttaaaa atacttctac tcttaacaat tacctaaggc ttcctcaact gccccaaatc
     1621 tcttaatagc ttctagtgct gctacaatct aagtcaggtc accagaggga agagaacatg
     1681 gcattaaaag aatcacatct tcagaagaga agacactaat attattaccc atatacatga
     1741 tttcagaaga tgacataaga ttcctcttaa agaggaaatg tcaggaatca agccactgaa
     1801 tccttaaaga gaaaagttga atatgagtca ttgtgtctga aaactgcaaa gtgaacttaa
     1861 ctgagatcca gcaaacaggt tctgtttaag aaaaataatt tatactaaat ttagtaaaat
     1921 ggacttctta ttcaaagcat caataattaa aagaattatt ttaatgaaa
//
