LOCUS       NM_001039618            7140 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CREB/ATF bZIP transcription factor (CREBZF),
            transcript variant 1, mRNA.
ACCESSION   NM_001039618
VERSION     NM_001039618.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7140)
  AUTHORS   Liu,Y., Su,W., Liu,Z., Hu,Z., Shen,J., Zheng,Z., Ding,D., Huang,W.,
            Li,W., Cai,G., Wei,S., Li,N., Fang,X., Li,H., Qin,J., Zhang,H.,
            Xiao,Y., Bi,Y., Cui,A., Zhang,C. and Li,Y.
  TITLE     Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate
            Insulin Resistance and Type 2 Diabetes
  JOURNAL   Adv Sci (Weinh) 11 (13), e2306685 (2024)
   PUBMED   38286660
  REMARK    GeneRIF: Macrophage CREBZF Orchestrates Inflammatory Response to
            Potentiate Insulin Resistance and Type 2 Diabetes.
REFERENCE   2  (bases 1 to 7140)
  AUTHORS   Sharma,A.E., Dermawan,J.K., Sherrod,A.E., Chopra,S., Maki,R.G. and
            Antonescu,C.R.
  TITLE     When molecular outsmarts morphology: Malignant ossifying
            fibromyxoid tumors masquerading as osteosarcomas, including a novel
            CREBZF::PHF1 fusion
  JOURNAL   Genes Chromosomes Cancer 63 (1), e23206 (2024)
   PUBMED   37819540
  REMARK    GeneRIF: When molecular outsmarts morphology: Malignant ossifying
            fibromyxoid tumors masquerading as osteosarcomas, including a novel
            CREBZF::PHF1 fusion.
REFERENCE   3  (bases 1 to 7140)
  AUTHORS   Ma,F., Liu,Y., Hu,Z., Xue,Y., Liu,Z., Cai,G., Su,W., Zheng,Z.,
            Fang,X., Yan,X., Ding,D., Sun,X., Jiang,Y., Wei,S., Li,W., Zhao,J.,
            Zhang,H., Li,H., Xiao,D., Zhang,C., Ying,H., Qin,J., Gao,X.,
            Dai,X., Fu,W., Xu,Y., Li,Y. and Cui,A.
  TITLE     Intrahepatic osteopontin signaling by CREBZF defines a checkpoint
            for steatosis-to-NASH progression
  JOURNAL   Hepatology 78 (5), 1492-1505 (2023)
   PUBMED   36680394
  REMARK    GeneRIF: Intrahepatic osteopontin signaling by CREBZF defines a
            checkpoint for steatosis-to-NASH progression.
REFERENCE   4  (bases 1 to 7140)
  AUTHORS   Truong,X.T., Lee,Y.S., Nguyen,T.T.P., Kim,H.J., Kim,S.H., Moon,C.,
            Kim,D.K., Choi,H.S. and Jeon,T.I.
  TITLE     SMILE Downregulation during Melanogenesis Induces MITF
            Transcription in B16F10 Cells
  JOURNAL   Int J Mol Sci 23 (23), 15094 (2022)
   PUBMED   36499416
  REMARK    GeneRIF: SMILE Downregulation during Melanogenesis Induces MITF
            Transcription in B16F10 Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7140)
  AUTHORS   Fang,J., Jiang,G., Mao,W., Huang,L., Huang,C., Wang,S., Xue,H.,
            Ke,J. and Ni,Q.
  TITLE     Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast
            cancer progression by modulating miR-423-5p/CREBZF axis
  JOURNAL   Bioengineered 13 (2), 3707-3723 (2022)
   PUBMED   35094653
  REMARK    GeneRIF: Up-regulation of long noncoding RNA MBNL1-AS1 suppresses
            breast cancer progression by modulating miR-423-5p/CREBZF axis.
REFERENCE   6  (bases 1 to 7140)
  AUTHORS   Hogan,M.R., Cockram,G.P. and Lu,R.
  TITLE     Cooperative interaction of Zhangfei and ATF4 in transactivation of
            the cyclic AMP response element
  JOURNAL   FEBS Lett 580 (1), 58-62 (2006)
   PUBMED   16343488
  REMARK    GeneRIF: ZF binds ATF4/CREB2 and enhances its response to MEK1
            activation.
REFERENCE   7  (bases 1 to 7140)
  AUTHORS   Akhova,O., Bainbridge,M. and Misra,V.
  TITLE     The neuronal host cell factor-binding protein Zhangfei inhibits
            herpes simplex virus replication
  JOURNAL   J Virol 79 (23), 14708-14718 (2005)
   PUBMED   16282471
  REMARK    GeneRIF: ZF suppresses the ability of VP16 to activate herpes
            simplex virus IE gene expression
REFERENCE   8  (bases 1 to 7140)
  AUTHORS   Misra,V., Rapin,N., Akhova,O., Bainbridge,M. and Korchinski,P.
  TITLE     Zhangfei is a potent and specific inhibitor of the host cell
            factor-binding transcription factor Luman
  JOURNAL   J Biol Chem 280 (15), 15257-15266 (2005)
   PUBMED   15705566
  REMARK    GeneRIF: ZF suppresses the ability of Luman/CREB3 to activate gene
            expression
REFERENCE   9  (bases 1 to 7140)
  AUTHORS   Mahajan,S.S., Little,M.M., Vazquez,R. and Wilson,A.C.
  TITLE     Interaction of HCF-1 with a cellular nuclear export factor
  JOURNAL   J Biol Chem 277 (46), 44292-44299 (2002)
   PUBMED   12235138
REFERENCE   10 (bases 1 to 7140)
  AUTHORS   Lu,R. and Misra,V.
  TITLE     Zhangfei: a second cellular protein interacts with herpes simplex
            virus accessory factor HCF in a manner similar to Luman and VP16
  JOURNAL   Nucleic Acids Res 28 (12), 2446-2454 (2000)
   PUBMED   10871379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000642.5.
            
            On Jan 28, 2020 this sequence version replaced NM_001039618.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC060807.1, AK313471.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527447.2/ ENSP00000433459.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7140              AP000642.5         36709-43848         c
FEATURES             Location/Qualifiers
     source          1..7140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..7140
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="CREB/ATF bZIP transcription factor"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
     exon            1..7140
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1319
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="Zhangfei; HCF-binding transcription factor
                     Zhangfei; SHP-interacting leucine zipper protein; host
                     cell factor-binding transcription factor Zhangfei; small
                     heterodimer partner-interacting leucine zipper"
                     /codon_start=1
                     /product="CREB/ATF bZIP transcription factor"
                     /protein_id="NP_001034707.1"
                     /db_xref="CCDS:CCDS41697.1"
                     /db_xref="GeneID:58487"
                     /db_xref="HGNC:HGNC:24905"
                     /db_xref="MIM:606444"
                     /translation="MRHSLTKLLAASGSNSPTRSESPEPAATCSLPSDLTRAAAGEEE
                     TAAAGSPGRKQQFGDEGELEAGRGSRGGVAVRAPSPEEMEEEAIASLPGEETEDMDFL
                     SGLELADLLDPRQPDWHLDPGLSSPGPLSSSGGGSDSGGLWRGDDDDEAAAAEMQRFS
                     DLLQRLLNGIGGCSSSSDSGSAEKRRRKSPGGGGGGGSGNDNNQAATKSPRKAAAAAA
                     RLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLANETG
                     LARLLSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQKQDLLEEDDSAGGVCLHVDKD
                     KVSVEFCSACARKASSSLKM"
     regulatory      4038..4043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="hexamer: ATTAAA"
     polyA_site      4064
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="major polyA site"
     regulatory      5396..5401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="hexamer: ATTACA"
     polyA_site      5415
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="major polyA site"
     regulatory      6296..6301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="hexamer: AATACA"
     polyA_site      6316
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
     regulatory      6432..6437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="hexamer: AATATA"
     polyA_site      6452
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
     regulatory      7110..7115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
                     /note="hexamer: AATAAA"
     polyA_site      7140
                     /gene="CREBZF"
                     /gene_synonym="SMILE; ZF"
ORIGIN      
        1 gacttccggc tacgccgttg tctgggtggc gcggtcgagt catcgcaggg cctcaccgct
       61 tcgttctccc gtccctcccc gcgccttggc gcggggggtc gactagccaa gtgaggcggg
      121 aggcgactcg gacctttccc tgcatttcgt ttcggccagt gccgggggct acccgccctg
      181 gggcctggga tccttggggc ccgtgaggcc cactcttagc ggccggggcc taccgcggcc
      241 cgccgctggc cctcatgagg catagcctga ccaagctgct ggcagcctcg ggcagcaact
      301 ccccaacccg cagtgagagc ccggagccgg ctgcaacttg ttcgctgccc tctgacctga
      361 cccgggctgc agcgggggag gaggagacgg cggcggccgg atctcccggc cgcaagcagc
      421 agtttggcga cgaaggagag ttggaagccg ggagggggag ccgcggcggc gtggccgtgc
      481 gcgcgccctc ccccgaggag atggaggagg aggcgatcgc cagcctcccg ggggaagaga
      541 cggaggatat ggactttctg tctgggctgg aactggcgga tctcctggac cccaggcaac
      601 cggactggca cctggacccc gggcttagct cgccggggcc tctctcctcg tctggcggag
      661 gctcggatag cggcggcctg tggagagggg acgatgacga tgaggccgcg gctgctgaaa
      721 tgcagcgctt ctctgacctg ctgcaaaggc tgttaaacgg tatcggaggc tgcagcagca
      781 gcagtgacag tggcagcgcc gaaaagaggc ggagaaagtc cccaggagga ggcggcggtg
      841 gcggcagcgg taacgacaac aaccaggcgg cgacaaagag tccccggaag gcggcggcgg
      901 ccgctgcccg ccttaatcga ctgaagaaga aggagtacgt gatggggctg gagagtcgag
      961 tccggggtct ggcagccgag aaccaggagc tgcgggccga gaatcgggag ctgggcaaac
     1021 gcgtacaggc actgcaggag gagagtcgct acctacgggc agtcttagcc aacgagactg
     1081 gactggctcg cttgctgagc cggctgagcg gcgtgggact gcggctgacc acctcgctct
     1141 tcagagactc gcccgccggt gaccacgact acgctctgcc ggtgggaaag cagaagcagg
     1201 acctgctgga agaggacgac tcggcgggag gagtctgtct ccatgtggac aaggataagg
     1261 tgtcggtgga gttctgctcg gcgtgcgccc ggaaggcgtc gtcttctctt aaaatgtagg
     1321 gtcaagtaat ctgctcttta tccgcgttta cccctttcaa ctcccttaca ccatgtcaaa
     1381 cttaccttag tgggacatct tcaccggaca catttcagag gagagaaaaa aagtaatatt
     1441 gaatcttaaa gtgtttagct aaaagcatga atgtgacaca gtaaccaact cctaatgata
     1501 acatgtgact attaaatctc tctgacagtt tcttttttag gtgatttcct tcctgccagg
     1561 ctccgttgta ggggttacag aacagtcgtt cccgcctcac aacctggtaa ggatccatct
     1621 cttcccgtaa cgctcatgct ctgctgcttt gtctacttta atgggcaaca tctcagtttg
     1681 tgtgtgtgtg attttttttt ttttttctgt tttggaaggt gggagggaaa tctaatttgg
     1741 gccctgtcca ccctggaaac agacttgtgc tggtcaagaa tgtatttaag atgcctcttc
     1801 tggttgaaat agctattaat gtgtcccctt attcagactt gcgtgtacct agctcttctg
     1861 tccccagtgt ggacatggcc ttggatgaca tcggttccaa ctgtacactg aaacctgctt
     1921 atagagagac agtttggaga cagtgaaaca ggtgaagttg aatggaagtt ccgagttgta
     1981 caaggtgcaa attggaattc cgattttagg gcaacttttc agaggttgac agttaagtat
     2041 ttggggcatg cacaaatgtg atagttattt tgctggaggt gacaggtatc tcttaaatat
     2101 caacaatgcc ttttagtttt cagtatgaga tatagaaaca gtctataatg gagtaacatt
     2161 ttaatgtctc accattagag aagttggaaa ttaacataca tatgagactc ctgcgtttta
     2221 gttaattgga gaataagaat ggctaatgtt tctttgagga ccagcagtga ttaccctatc
     2281 actgagattg aataaattgt tgaacatctt tatttttgtt gtattaaaat tttaggttaa
     2341 atttatatat gtatgattag atattgaagg ttgtgaaatg tgaatgaaaa cgtgtaaagt
     2401 gaggcttcac aaagaatctt attctctgtg tttcaaaagt atttgtccta ttttaaaata
     2461 attttttaaa ttgagtggtt ctggccactt aaatgacacg attggtacta ttttcctaag
     2521 gtgggattta ttcccttgaa tctattaacc agttgtataa attgaattat ggtgtccttc
     2581 agtgtaagag gcattaagaa attctttgtg aaacatcact gcttgataaa gtatatacgt
     2641 atttagcatc cttgtttttc tttgtgctaa agtggataca gctgttgggg cagaagagac
     2701 gggaccagct gctggccaca tttcctgctt tattttaaaa ggtagtataa gaaatgagga
     2761 aaaagaggta atatcagggc ttctgctgtt ttttattttt aacatgttca taattaaaaa
     2821 gtattttcca gcagtccaaa gatgtaagtt atcttacaca taaaatgttt tattttgtta
     2881 tttggttatg aaaatggaat ccttgttctt gcacaactgt aaatgttttg ttgctagata
     2941 atacgatttg agacctgaat tggtctttgg tttccagtgc atcacagcat attttgtaaa
     3001 atcatctact actgcacttg agcatgaatg ggtagtagcc aaactcacaa attggagtga
     3061 tgaacctgct tatacctaag ggcaggagca agcccctcac aatgcagctg catgggtttt
     3121 tagtgcctac tgaattatat atatatatac atatatatat atatatataa accaaaagta
     3181 gttggaaaga ttatttgaaa tgactaattt gtgctatctt tatgaaatat gttaaatgta
     3241 gcttttttga aacagaagcc ttgaattgaa atttaactaa tacttgaaca ttttgtatat
     3301 atttctttgt atataatttt gtgcagtacc aatgacaaaa atatggtgtc ataataaaac
     3361 caggtttgtt gatcttttag ttatgggctc aaagaattta ttcatctcta acatgatatt
     3421 ggaaaataat ggatgaaaat aggaaaaatg attgttaatg ctgactgtgg gtcttaaaag
     3481 gttctggaaa gcagtaagtt catttttcta aaaactataa cattctgttg gagtattttc
     3541 ttccttacgt caatactttt cctgcattat ttgaaattgt gggctgggga gaaacagtag
     3601 tcaaagcttt ctgaattgag atactttgaa attccaagtg tagattttta gaatgtcatt
     3661 ttataaatgg cagtttttgg aattacttga taagaacttt tgaaaatgga aggattagta
     3721 tggcctattt ttaaagctgc tttgttaggt tccttatgtt ttattaactg tcttttctca
     3781 gtttccattt catttttttt tttctagttt tggtgactta gtgattttgt cattttttac
     3841 atcaacttca tggtcttgtt tttacatggt aattgcatgt acttaggatc tatctaatag
     3901 gggctttaaa taaatttggt catatttatg tgtaagcaca ttttactgta aatgtttggg
     3961 tttctgaatt taaacagatc tgtttatttc agtatgtagt aaacaatatc ttaaagtgtc
     4021 cgattcacta cttgttaatt aaaaaagtta tgattaatgt gaaactgttg tcttactatt
     4081 tttagaaaat tgtgttctgg atgattagca catggataaa ggagatttct ggaatataaa
     4141 atggattgtt tttgaaattt ctaggtttgg ctctatttac tgtaatggtt gaaaacaatt
     4201 tagtatttgg gtgacccttt tgtttttctt ctaaatgtgc ctctggtaaa atacagaact
     4261 agactaaaga tgtagctttt taatatttgt cttttgatgg tggcaggagt tcatacatta
     4321 attgaactaa cacatcatat tttgacctac tatttctatc atattgactt actgtttctg
     4381 cacttctttg accagactta tcttaaaaag tccacttttg ttaaaatgta gtcacacctc
     4441 tgatataatc caacaagaag tgttcaaaat attttaaata tttgtgcatt ttataatcac
     4501 taaattaatc tctctctctt ctctttgaac agcttagcag tgtctgcaaa aacgaatctt
     4561 ttcctacaac ctgttaactg actggactgt tggtaacaaa gtaattgtga gaaccatgtc
     4621 ggtcaaaaat ttggcatctg ctgaaaaaaa tgaatgccat tttcaagttc ccaaattact
     4681 tctatactga tttcactttc cagaaatgga gatatgaaaa gattctctgg aatccttgaa
     4741 agacttaata gagatacatg agactaagtt aatcttggaa caaaattata ctttttttgt
     4801 ctttcatggg agtgatactc agttattgca tatctttaca aaattgtaac ctttggagaa
     4861 ttacagtatt tcatcaagaa attagagttt ttacataatc aagagcatat tctatggaat
     4921 taacatttag tggactagaa ttacataagc aggccatcag tgatcacaag gcatatgagt
     4981 ttgtatttat ttcctggaac atgagagcta atttggagta cagacagaca ccctgctgag
     5041 tagaatataa aagttaatgt aaagttctga actataaaga gtagtccttt taaatagatg
     5101 cattgatttg tatatctttg aaaaagttga ttatgattaa atgtgtgggt agttaattac
     5161 aatttagggt aacaaccagg atgtatggat tcttgaggtt ttggcttctt gagctttctc
     5221 ttgagtactt gatactgttt tctgaatatt ttgaggtttc taattaatgg tatgctagtt
     5281 tctactgttt tatataaaaa tttatctagt gttgtataag gactttagta ttgtggatga
     5341 tgggagtggc tttttgtggc atatggttgt tttaattgaa atattttttc agtttattac
     5401 aagtgtgaaa aaacactcaa aactctggat tgttttattt catttttgtt ggattatgtt
     5461 aatacattcc ttcacgtggt ttagattgag tcattttatc tcacttactt ggaaatgtgc
     5521 agctgataga agagggattg ggtaggagat tggcttttac ttcataataa atatacagtt
     5581 ggttattgta ttattcaaaa cttattaaat ccattcagtt tcttaccatt ttaagtgtat
     5641 tcagtgcctg tgaagccagg cagcagagta ttcccactgg cttaaaactt aggcgctgat
     5701 gctcctacag tacagctagt tataattcca gaaccaaagg caccaacatt atttggtgac
     5761 cttaactact actttgatag aacagactgg gtaattcact gataatgagt cattaccttt
     5821 ttaatatgtg attatctagt tcagcatttt gaatgtgtag tttaaggtct gatttagtaa
     5881 aattttaaag ctaaataatc tgatgactct tgaaagttta attggtagta tgacatttat
     5941 gtttttttcc cccagactca cagccaatac aaagttttga gactcctaaa tgttaatatt
     6001 tttgctgttt ttctgagctg tttttttatt tacttaccac ctaagctgcg gatcaaaaag
     6061 ggaattcttc cattagaaat ttgtagtgtt gtgtggccag cacagtattt ttcagatttg
     6121 aatttcagta cctctgtgta gcctcagtac tctcaacacc agtcactctt tattgtctta
     6181 aaatattcca tactttttgt tgacccaaaa ttgttgaaaa tattttgctc agttttcaca
     6241 atgaactaat tgaaaagtgt agttactgtg ttgtaaacat ttgtgtagtt ctgttaatac
     6301 actgatttga attttattta tctcaacttc ctttagcgtc tgcctccaaa ttttgtcttt
     6361 gctgtatacc cactgagatc aattccctag acccctctgg ctcttagtgt actataattt
     6421 gggctttata aaatatattg tcttaattta aatagaatgt gagccctctt tttttttttt
     6481 taagccaaat aactacacaa agtaaattat aaaagattta aatagtttgt ctacagtgac
     6541 tagactgaaa tataaaaatt gattgagggt agtttacttc aggtgttagc tacaaatgac
     6601 taaatgtcct taaataatgc agatatctgc cctctgaaca aaaattttgg caaagtaaat
     6661 ttgtagcaac agacttaaca tgatttattg cttatgttgc ccatttctgc taatggaaaa
     6721 gataatttaa aaatatgtgg cagaggacag atattagaaa tactttttgg ttacagaaac
     6781 cattgtaaac tcatcctcat ttataaatgg tattatgcta gggagtaatt ggactaggaa
     6841 tgtttaaaga taagtaagga aacaatgtgt gctcaatcgt caaagaactt agttatatca
     6901 ttgggctttg aattatctaa gttgattaca taattctata ttcttaagga gtcttaactc
     6961 ggtacttggg ttaacgccag aaattacttt taattcattg tttttttcac tgggatgagt
     7021 agaactctgc ttttagtaaa agtgacagaa tataggtaaa atggatgatt tgggatcaga
     7081 gcttttcatc ttgatatttt agcctgtaaa ataaacagct atattgtttt gccctttaaa
//
