LOCUS       NM_153607               7778 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens CREB3 regulatory factor (CREBRF), transcript variant
            1, mRNA.
ACCESSION   NM_153607
VERSION     NM_153607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7778)
  AUTHORS   Amitrano,F., Krishnan,M., Murphy,R., Okesene-Gafa,K.A.M., Ji,M.,
            Thompson,J.M.D., Taylor,R.S., Merriman,T.R., Rush,E., McCowan,M.,
            McCowan,L.M.E. and McKinlay,C.J.D.
  TITLE     The impact of CREBRF rs373863828 Pacific-variant on infant body
            composition
  JOURNAL   Sci Rep 14 (1), 8825 (2024)
   PUBMED   38627436
  REMARK    GeneRIF: The impact of CREBRF rs373863828 Pacific-variant on infant
            body composition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7778)
  AUTHORS   Wu,Z.H., Li,F.F., Ruan,L.L., Feng,Q., Zhang,S., Li,Z.H., Otoo,A.,
            Tang,J., Fu,L.J., Liu,T.H. and Ding,Y.B.
  TITLE     miR-181d-5p, which is upregulated in fetal growth restriction
            placentas, inhibits trophoblast fusion via CREBRF
  JOURNAL   J Assist Reprod Genet 40 (11), 2725-2737 (2023)
   PUBMED   37610607
  REMARK    GeneRIF: miR-181d-5p, which is upregulated in fetal growth
            restriction placentas, inhibits trophoblast fusion via CREBRF.
            Erratum:[J Assist Reprod Genet. 2024 Jan;41(1):231. doi:
            10.1007/s10815-023-02970-1.. PMID: 37856054]
REFERENCE   3  (bases 1 to 7778)
  AUTHORS   Zhang,J.Z., Heinsberg,L.W., Krishnan,M., Hawley,N.L., Major,T.J.,
            Carlson,J.C., Harre Hindmarsh,J., Watson,H., Qasim,M., Stamp,L.K.,
            Dalbeth,N., Murphy,R., Sun,G., Cheng,H., Naseri,T., Reupena,M.S.,
            Kershaw,E.E., Deka,R., McGarvey,S.T., Minster,R.L., Merriman,T.R.
            and Weeks,D.E.
  TITLE     Multivariate analysis of a missense variant in CREBRF reveals
            associations with measures of adiposity in people of Polynesian
            ancestries
  JOURNAL   Genet Epidemiol 47 (1), 105-118 (2023)
   PUBMED   36352773
  REMARK    GeneRIF: Multivariate analysis of a missense variant in CREBRF
            reveals associations with measures of adiposity in people of
            Polynesian ancestries.
REFERENCE   4  (bases 1 to 7778)
  AUTHORS   Hawley,N.L., Duckham,R.L., Carlson,J.C., Naseri,T., Reupena,M.S.,
            Lameko,V., Pomer,A., Wetzel,A., Selu,M., Lupematisila,V., Unasa,F.,
            Vesi,L., Fatu,T., Unasa,S., Faasalele-Savusa,K., Rivara,A.C.,
            Russell,E., Delany,J.P., Viali,S., Kershaw,E.E., Minster,R.L.,
            Weeks,D.E. and McGarvey,S.T.
  TITLE     The protective effect of rs373863828 on type 2 diabetes does not
            operate through a body composition pathway in adult Samoans
  JOURNAL   Obesity (Silver Spring) 30 (12), 2468-2476 (2022)
   PUBMED   36284436
  REMARK    GeneRIF: The protective effect of rs373863828 on type 2 diabetes
            does not operate through a body composition pathway in adult
            Samoans.
REFERENCE   5  (bases 1 to 7778)
  AUTHORS   Fu,H., Hawley,N.L., Carlson,J.C., Russell,E.M., Pomer,A., Cheng,H.,
            Naseri,T., Reupena,M.S., Deka,R., Choy,C.C., McGarvey,S.T.,
            Minster,R.L. and Weeks,D.E.
  TITLE     The missense variant, rs373863828, in CREBRF plays a role in
            longitudinal changes in body mass index in Samoans
  JOURNAL   Obes Res Clin Pract 16 (3), 220-227 (2022)
   PUBMED   35606300
  REMARK    GeneRIF: The missense variant, rs373863828, in CREBRF plays a role
            in longitudinal changes in body mass index in Samoans.
REFERENCE   6  (bases 1 to 7778)
  AUTHORS   Xue,H., Zhang,J., Guo,X., Wang,J., Li,J., Gao,X., Guo,X., Li,T.,
            Xu,S., Zhang,P., Liu,Q. and Li,G.
  TITLE     CREBRF is a potent tumor suppressor of glioblastoma by blocking
            hypoxia-induced autophagy via the CREB3/ATG5 pathway
  JOURNAL   Int J Oncol 49 (2), 519-528 (2016)
   PUBMED   27278737
  REMARK    GeneRIF: Findings provide new insight into the molecular mechanisms
            underlying hypoxia-induced glioblastoma cell autophagy and indicate
            that the hypoxia/CREBRF/CREB3/ATG5 pathway plays a central role in
            malignant glioma progression.
REFERENCE   7  (bases 1 to 7778)
  AUTHORS   Martyn,A.C., Choleris,E., Gillis,D.J., Armstrong,J.N., Amor,T.R.,
            McCluggage,A.R., Turner,P.V., Liang,G., Cai,K. and Lu,R.
  TITLE     Luman/CREB3 recruitment factor regulates glucocorticoid receptor
            activity and is essential for prolactin-mediated maternal instinct
  JOURNAL   Mol Cell Biol 32 (24), 5140-5150 (2012)
   PUBMED   23071095
REFERENCE   8  (bases 1 to 7778)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 7778)
  AUTHORS   Audas,T.E., Li,Y., Liang,G. and Lu,R.
  TITLE     A novel protein, Luman/CREB3 recruitment factor, inhibits Luman
            activation of the unfolded protein response
  JOURNAL   Mol Cell Biol 28 (12), 3952-3966 (2008)
   PUBMED   18391022
REFERENCE   10 (bases 1 to 7778)
  AUTHORS   Liang,G., Audas,T.E., Li,Y., Cockram,G.P., Dean,J.D., Martyn,A.C.,
            Kokame,K. and Lu,R.
  TITLE     Luman/CREB3 induces transcription of the endoplasmic reticulum (ER)
            stress response protein Herp through an ER stress response element
  JOURNAL   Mol Cell Biol 26 (21), 7999-8010 (2006)
   PUBMED   16940180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX647768.1, AY139008.1 and AC008378.6.
            
            On Nov 23, 2018 this sequence version replaced NM_153607.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.32056.1,
                                           SRR1660803.167214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296953.6/ ENSP00000296953.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BX647768.1         2-16
            16-2000             AY139008.1         1-1985
            2001-2001           AC008378.6         73113-73113         c
            2002-5461           AY139008.1         1987-5446
            5462-7778           AC008378.6         56909-59225         c
FEATURES             Location/Qualifiers
     source          1..7778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..7778
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /note="CREB3 regulatory factor"
                     /db_xref="GeneID:153222"
                     /db_xref="HGNC:HGNC:24050"
                     /db_xref="MIM:617109"
     exon            1..128
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            129..328
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2239
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     luman-recruiting factor; adult retina protein; UPF0474
                     protein C5orf41; luman/CREB3 recruitment factor; luman
                     recruitment factor"
                     /codon_start=1
                     /product="CREB3 regulatory factor isoform 1"
                     /protein_id="NP_705835.2"
                     /db_xref="CCDS:CCDS34293.1"
                     /db_xref="GeneID:153222"
                     /db_xref="HGNC:HGNC:24050"
                     /db_xref="MIM:617109"
                     /translation="MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYE
                     LDREMNYQQNPRDNFLSLEDCKDIENLESFTDVLDNEGALTSNWEQWDTYCEDLTKYT
                     KLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSL
                     FSVKQNPLPSSFPGKKITSRAAAPVCSSKTLQAEVPLSDCVQKASKPTSSTQIMVKTN
                     MYHNEKVNFHVECKDYVKKAKVKINPVQQSRPLLSQIHTDAAKENTCYCGAVAKRQEK
                     KGMEPLQGHATPALPFKETQELLLSPLPQEGPGSLAAGESSSLSASTSVSDSSQKKEE
                     HNYSLFVSDNLGEQPTKCSPEEDEEDEEDVDDEDHDEGFGSEHELSENEEEEEEEEDY
                     EDDKDDDISDTFSEPGYENDSVEDLKEVTSISSRKRGKRRYFWEYSEQLTPSQQERML
                     RPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNKV
                     ISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLFV
                     INSIKQEIVNRVQNPRDERGPNMGQKLEILIKDTLGLPVAGQTSEFVNQVLEKTAEGN
                     PTGGLVGLRIPTSKV"
     exon            329..454
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1541
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1736
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1926
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2000
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2123
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..7778
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6228..6233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /note="hexamer: AATAAA"
     polyA_site      6255
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /note="major polyA site"
     regulatory      7756..7761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
                     /note="hexamer: AATAAA"
     polyA_site      7778
                     /gene="CREBRF"
                     /gene_synonym="C5orf41; LRF"
ORIGIN      
        1 gagtcacgcg atttccggga acccgtcagg aaggacataa acaaaacaaa cccgaggcag
       61 catggagagg ggccgtggcc cctgcagcgg aaccggaccc agtccctgag ccgcccctac
      121 acccacagac agcatcgcac agaattattt taaaaaaaag cagtgatcca agcaattgaa
      181 ttggaagcac tctggggaaa cctgctgttt attgtggaaa tcatcttcga tcttggaatt
      241 gaaagtaaag ctggaaagga atttacaaac aagaaaaaaa agaagtttgg aatcggattc
      301 acaggatctg ggcttggaaa tgcctcagcc tagtgtaagc ggaatggatc cgcctttcgg
      361 ggatgccttt cgaagccaca ccttttcgga acaaactctg atgagcacag atctcttagc
      421 aaacagttcg gatccagatt tcatgtatga actggataga gagatgaact accaacagaa
      481 tcctagagac aactttcttt ctttggagga ctgcaaagac attgaaaatc tggagtcttt
      541 cacagatgtc ctggataatg agggtgcttt aacctcaaac tgggaacagt gggatacata
      601 ctgtgaagac ctaacgaaat ataccaaact aaccagctgt gacatctggg gaacaaaaga
      661 agtggattac ttgggtcttg atgacttttc tagtccttac caagatgaag aggttataag
      721 taaaactcca actttagctc aacttaatag tgaggactca cagtctgttt ctgattccct
      781 ttattacccc gattcacttt tcagtgtcaa acaaaatccc ttaccctctt cattccctgg
      841 taaaaagatc acaagcagag cagctgctcc tgtgtgttct tctaagactc tgcaggctga
      901 ggtccctttg tcagactgtg tccaaaaagc aagtaaaccc acttcaagca cacaaatcat
      961 ggtgaagacc aacatgtatc ataatgaaaa ggtgaacttt catgttgaat gtaaagacta
     1021 tgtaaaaaag gcaaaggtaa agatcaaccc agtgcaacag agccggccct tgttgagcca
     1081 gattcacaca gatgcagcaa aggagaacac ctgctactgt ggtgcagtgg caaagagaca
     1141 agagaaaaaa gggatggagc ctcttcaagg tcatgccact cccgctttgc cttttaaaga
     1201 aacccaggaa ctattactaa gtcccctgcc ccaggaaggt cctgggtcac ttgcagcagg
     1261 agagagcagc agtctttctg ccagtacatc agtctcagat tcatcccaga aaaaagaaga
     1321 gcacaattat tctctttttg tctccgacaa cttgggtgaa cagccaacta aatgcagtcc
     1381 tgaagaagat gaggaggacg aggaggatgt tgatgatgag gaccatgatg aaggattcgg
     1441 cagtgagcat gaactgtctg aaaatgagga ggaggaagaa gaggaagagg attatgaaga
     1501 tgacaaggat gatgatatta gtgatacttt ctctgaacca ggctatgaaa atgattctgt
     1561 agaagacctg aaggaggtga cttcaatatc ttcacggaag agaggtaaaa gaagatactt
     1621 ctgggagtat agtgaacaac ttacaccatc acagcaagag aggatgctga gaccatctga
     1681 gtggaaccga gatactttgc caagtaatat gtatcagaaa aatggcttac atcatggaaa
     1741 atatgcagta aagaagtcac ggagaactga tgtagaagac ctgactccaa atcctaaaaa
     1801 actcctccag ataggcaatg aacttcggaa actgaataag gtgattagtg acctgactcc
     1861 agtcagtgag cttcccttaa cagcccgacc aaggtcaagg aaggaaaaaa ataagctggc
     1921 ttccagagct tgtcggttaa agaagaaagc ccagtatgaa gctaataaag tgaaattatg
     1981 gggcctcaac acagaatatg ataatttatt gtttgtaatc aactccatca agcaagagat
     2041 tgtaaaccgg gtacagaatc caagagatga gagaggaccc aacatggggc agaagcttga
     2101 aatcctcatt aaagatactc tcggtctacc agttgctggg caaacctcag aatttgttaa
     2161 ccaagtgtta gagaagactg cagaagggaa tcccactgga ggccttgtag gattaaggat
     2221 accaacatca aaggtgtaat cagcctcatt ggaccactgg tcagaaatgt ctgcgttttg
     2281 tcacgttatc cattgtaaat tttcattctg ttttgcatgt cagttagcat tatgtaaaca
     2341 tttacaatta ggttacattg ttttaagaac taagtagcat aagtgaagca tgatccaaaa
     2401 tacttgatta ttgcattttc agagcataaa ccatgattaa aactgctact ggcatcagaa
     2461 ttgaaaatca tatgtttaag taaatgttag gtacagatta caaaaatctg ttaaagcaaa
     2521 acattttgga ggagtgaaat agtaaaatgc caagtattgt ggcagattta tgctctgaac
     2581 cacacaaaaa aattgaggaa gcattttttt aaacagtcgg tttaaattgt ttttagaatt
     2641 attgcttttt gttctaattt tccacaacca ttaatctcac ttgtatatgg cacacccagc
     2701 acttgtgcct gtgggccata ttagatgttc attgtcagag ctcaagatga tatatataaa
     2761 tatatatata tatatatata tatacacaca cacacacaaa tgtctgtgca agtaagaaaa
     2821 aaaaagcata ttctttgtgc cttgtatttt ggggaaactc taaaactggt aatattttgt
     2881 atgatgaaaa ccctaatgag aaaaaacaag atatatagat ggaaaaatta tggggtttaa
     2941 atgttttttt gttccaactc tttttcagat tttttgaatg tatataggac tatgttgaaa
     3001 tgtagatata tgccacagag tctgtgtatt gtataaaaaa caaaacaaaa aacaacaaaa
     3061 aaaagatggc tctagaaaac tcatatttcg gtacttgacc ggaagaagac aaatacttgc
     3121 acattattgc gattgtttta ttttttgtac caaagacaaa tgcaactgat atggcaaact
     3181 gccagtctaa gtaaagtttt gcacagctta catgatactg tatgaatgta tgaaaaaaaa
     3241 ggagaaaaaa aagaaaaaaa aaggtcaggg ttagggatct tactgaactg tgaattttat
     3301 ttctgtttgg gtccaattat ctacagaagg agcatccata catacaaata ttattttgct
     3361 gttcctctag ttcgcttcca tagtagataa gttggtggcc atttagatgt cttttatttc
     3421 tgcacttatt gtaggaaatt ttaatatatt tcattttagt aagctattga taaaatagtt
     3481 tttgactttg aaaattaaaa tgtttattta gcttattgta gtatacttcc accagacaac
     3541 aaaatagatt atttttattg tattatgtat atatatatat gtaaagaaag aaaaaagcta
     3601 aaaatatcta attctttagt tgccactttt ccgattgatg tattattgtg catgtaatat
     3661 tttcaaagat caacacaggc taaaacaaaa acaatttata gatttttata tttttgtaca
     3721 ggtattttca aactagcttc ttcaaactta acatgtgact tattcttcta tagtttctag
     3781 aattgagaaa cattaacaca tttagttttt aggtgctctt ttttgctcat ataaaacagc
     3841 ttcattagtc agtgttttaa ctgtgttcaa gctttacctc ttgatgagaa atttcttatg
     3901 tcaaggcagc attataaacc ttcccccaca gatttttcca tcctgtctct cttactgttt
     3961 tattctcaaa tcttgtgctt tgaactctga aaactggtgg cttaaaaact aaaaaaagaa
     4021 aaaaagcata tttagcaagg aaaaaaatac caaaaatttc aggcatagct gctggaaaaa
     4081 ttatctattt ctccattacc cactgtagga tttctttttt aattatactt tgactataaa
     4141 gtgtcaaagt ataatttgtt cttttctttt actttgttac cccatttgta agctatagca
     4201 tatgaagcta tatatatagc ttgtgaaggt ttgatctaga acacccagta acaaatgaac
     4261 aatgttgctt acctgcttct ttgacatctt aaaaaagaaa tccaaggagg attgtaagga
     4321 ttgtcttacc accttagctg aactgtgatg cacaagattt ttctatgtgt ttggtggaaa
     4381 tgtacctggt ttgtacattc acgctaaaca gatgataagc tcaagtctga tggtttaata
     4441 gaatgtaagt tcatcgttta aagcttttcc tttttaggtt ggagaaggca aaacacaggc
     4501 ttgcaagttg gaagtatatg aagtcttgac agagtgtgtc tggtaaattg aaaagtgttt
     4561 caaactatgg cagttttgca atcaggtgaa aatcacctca tgatattcag ctgataaggt
     4621 ttataaaatt gcccctttct agctgctctg ttaggaattc tggtttttga tacttttttc
     4681 ctgtctgcaa accagaattt gattttttgg tcttgcattt caaaaaaaaa aagactttga
     4741 atctgtttag tagattccat atctttgagt ttcagtgttt tatatgtact acttaagtta
     4801 aatagttaaa agcttttaaa tagttgagct ttttaatgtt gacactttat tttgtaccta
     4861 tttatatatg tatgtatatc ttagaaaagc actttgttaa aaaaaaattg cattttatat
     4921 gattcctgcc atttgctgct aaatctgggc tggtcagaat gctgcagcga tacttgatct
     4981 atataaaaac ctggcagtaa aatgtagagt gaaagttaaa tcctcttgct gttttaactt
     5041 tatcataaag atgacatagg caagctgtgc agctttacat tttaaccagg ggactctgtg
     5101 gcatttaaaa ccgtctagaa atggttgtac tttaatgcca gtaataatct gcttcctcta
     5161 ttgtcattaa aatatatacg tttagtgtat cacacaaacc aatcttataa gggtaatgta
     5221 aaaaccccaa caattgtaca tgttctgttt ttgaaaattg tggcatgtat ttttgggtga
     5281 agatcattag agaagagttc tctaaaggtt ttctgtgttc atacatggta tacagatagc
     5341 tcataatgaa gtccagaatc ttacttttaa gtgaaggcat tgtgaattca cctcaagtaa
     5401 acccattgtt ccaaagcaat tataaacttt gactctagta ctactatgat ttaaaaaaaa
     5461 aaaaaaccaa caaaaacctt ttttcctagt ttcagataca ctggattctt tatagagttt
     5521 gtctccatat gaaagcatgc tgtccagtcg ctcttgttaa gatcttgtct gagttttgaa
     5581 ttgggtgcca cacttttcca gtcaatataa ttgcttgttc tactgtacca tgtatgattc
     5641 ttgtcctttc ctatatcctt catgacagat tatgatgtgg ctttatattg tgccttactt
     5701 gtacatttaa aactaaacgt cttcattccc ttccacttcc tacatcttta actttgacct
     5761 ttttggtaag agaatcagaa ctattacaaa agcatcatga aggatttcag atgggtatgg
     5821 tttcaaattc cctctcttta tagttatttt atatttgtat gaaagaccag ttttggatgg
     5881 tctttgaata taggggggaa agattagcag taatttcact acatcccttt tctctgactt
     5941 tcatgcattt ctcatacatc ttctttctga tgcttgactt tatttgcttc ctagcaatag
     6001 tctgcattta aagaaaggtg tgttcaattc atcagcttga aattgactat ttcatttttc
     6061 caggattttt taggagaaga gtacccattt tgttttataa aaacagatga caagtctctt
     6121 taaaagaaac agaagtacag tacttttgaa atacaatgct gttagtttgg atttcttttt
     6181 atatatatat ataatattca tacaatgatc tgatgtttgc cttcattaat aaagctgtta
     6241 gtttattcac caaaatgtca agaatggatg tgcttttctt tattccacac atttaaaaaa
     6301 atttagctgc taagatttaa tgttataaga aatgaattca agttgccttc agcaagaatt
     6361 aacaaaaact tatgttccct ttctttatat agtttcctaa aattctgttc aagtattttc
     6421 tagttaatta tgtaacagaa tgttagcatc tctccatatc ttgaaacttg aattttgaga
     6481 atgcattgaa ttatgctttc agtgttaaag taaaaggttt caattatcct tctagtgaag
     6541 tctgttgtgg aataccattt cccatggaac tgaggccatt tccacaactt tgcacagaac
     6601 tgcagtcttg ttcttccctt ggatcatgac aaataagtct cacacagtgc cgtaatactt
     6661 gtggattctt ttgtaatctt tgtaatctta ataagggcat tatgagaaga cgactccatg
     6721 tttttttaat acttcaaaca cattgggatg taacaatgaa tgtcaactgt aggaatggtg
     6781 gtttcgtttt aaggaataag catgttgggg aaagatgatg aaaatgtact actgaaagtt
     6841 atacacttcc ataggcaaat gggattatgt gttgaagcat agtcctcatg cttaataaac
     6901 tgactgaaat cgtagaaatt acacctagga actgagctag gccaaattgc catttttgtt
     6961 tagagagttt tggaggtagt agtgagggga cagagcctta aaactacttc caaacagtat
     7021 tttggaattg aagacttggt aactagtgaa gaacatcaaa gttgggtatt tcaatgtgcc
     7081 aagtttgggt gaactaggtt cggtttgcct ctttcataac aatgtaaaca caatggtgta
     7141 gttaattaaa ttctgggtgg ataggagcag gactgattac tatgtcttgc ccttcgccct
     7201 ttgttttttt cagaaccaaa taacagaaat gtgtatgtgt gtactgtatc tgcctttcca
     7261 ccacattttt atgacactgt attccactgc ctgctttttt accttctttc cctaggattt
     7321 gtcctacagc ttagtattgt ggttgacagc gatactaggg ctgacagcac agaagtcaca
     7381 agagaagagt ggaagggcaa gaattcaaag catttgttca tacaatgtgg caacctcttt
     7441 tgcatagttg cgtaggatcc tgtttgtaat gctatcataa atattctgta gttttttttt
     7501 tttctctccc aactggagct atgacacttt ttattggatt cagtcttgtc tcttgtctag
     7561 aaagaacttt atcttgttga cgcatgagct gtttaaaaat tatcctatta aatgttggtt
     7621 aatagttgtg cagtttttca tttcagatgg aaaggcaatg caaattttgc ctttgttttc
     7681 tgtcaccttc caacccctga gcacttctag tcagatacag attcatcagt gtatgcaaca
     7741 tcctttgtaa tttaaaataa aaaaagatga aaagaaaa
//
