LOCUS       NM_001310               3770 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cAMP responsive element binding protein like 2
            (CREBL2), mRNA.
ACCESSION   NM_001310
VERSION     NM_001310.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Hong,T., Xiong,X., Chen,Y., Wang,Q., Fu,X., Meng,Q., Lu,Y. and
            Li,X.
  TITLE     Parathyroid hormone receptor-1 signaling aggravates hepatic
            fibrosis through upregulating cAMP response element-binding
            protein-like 2
  JOURNAL   Hepatology 78 (6), 1763-1776 (2023)
   PUBMED   36939197
  REMARK    GeneRIF: Parathyroid hormone receptor-1 signaling aggravates
            hepatic fibrosis through upregulating cAMP response element-binding
            protein-like 2.
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Al-Shehhi,H., Konn,Z.J., Schwab,C.J., Erhorn,A., Barber,K.E.,
            Wright,S.L., Gabriel,A.S., Harrison,C.J. and Moorman,A.V.
  TITLE     Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute
            lymphoblastic leukemia
  JOURNAL   Genes Chromosomes Cancer 52 (2), 202-213 (2013)
   PUBMED   23077088
  REMARK    GeneRIF: Data indicate that LRP6, BCL2L14, DUSP16, CREBL2, and
            CDKN1B were involed in centromeric (12p11.21-12p13.2) deletion in
            ETV6-RUNX1 B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
REFERENCE   5  (bases 1 to 3770)
  AUTHORS   Yang,W., Tang,H., Zhang,Y., Tang,X., Zhang,J., Sun,L., Yang,J.,
            Cui,Y., Zhang,L., Hirankarn,N., Cheng,H., Pan,H.F., Gao,J.,
            Lee,T.L., Sheng,Y., Lau,C.S., Li,Y., Chan,T.M., Yin,X., Ying,D.,
            Lu,Q., Leung,A.M., Zuo,X., Chen,X., Tong,K.L., Zhou,F., Diao,Q.,
            Tse,N.K., Xie,H., Mok,C.C., Hao,F., Wong,S.N., Shi,B., Lee,K.W.,
            Hui,Y., Ho,M.H., Liang,B., Lee,P.P., Cui,H., Guo,Q., Chung,B.H.,
            Pu,X., Liu,Q., Zhang,X., Zhang,C., Chong,C.Y., Fang,H., Wong,R.W.,
            Sun,Y., Mok,M.Y., Li,X.P., Avihingsanon,Y., Zhai,Z.,
            Rianthavorn,P., Deekajorndej,T., Suphapeetiporn,K., Gao,F.,
            Shotelersuk,V., Kang,X., Ying,S.K., Zhang,L., Wong,W.H., Zhu,D.,
            Fung,S.K., Zeng,F., Lai,W.M., Wong,C.M., Ng,I.O.,
            Garcia-Barcelo,M.M., Cherny,S.S., Shen,N., Tam,P.K., Sham,P.C.,
            Ye,D.Q., Yang,S., Zhang,X. and Lau,Y.L.
  TITLE     Meta-analysis followed by replication identifies loci in or near
            CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic
            lupus erythematosus in Asians
  JOURNAL   Am J Hum Genet 92 (1), 41-51 (2013)
   PUBMED   23273568
REFERENCE   6  (bases 1 to 3770)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3770)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   8  (bases 1 to 3770)
  AUTHORS   Hoornaert,I., Marynen,P. and Baens,M.
  TITLE     CREBL2, a novel transcript from the chromosome 12 region flanked by
            ETV6 and CDKN1B
  JOURNAL   Genomics 51 (1), 154-157 (1998)
   PUBMED   9693048
REFERENCE   9  (bases 1 to 3770)
  AUTHORS   Andreasson,P., Johansson,B., Arheden,K., Billstrom,R., Mitelman,F.
            and Hoglund,M.
  TITLE     Deletions of CDKN1B and ETV6 in acute myeloid leukemia and
            myelodysplastic syndromes without cytogenetic evidence of 12p
            abnormalities
  JOURNAL   Genes Chromosomes Cancer 19 (2), 77-83 (1997)
   PUBMED   9171997
REFERENCE   10 (bases 1 to 3770)
  AUTHORS   Wlodarska,I., Baens,M., Peeters,P., Aerssens,J., Mecucci,C.,
            Brock,P., Marynen,P. and Van den Berghe,H.
  TITLE     Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21)
            childhood acute lymphoblastic leukemia case
  JOURNAL   Cancer Res 56 (11), 2655-2661 (1996)
   PUBMED   8653712
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY795169.2, BC106052.1,
            AC008115.4 and AI375846.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001310.3.
            
            Summary: cAMP response element (CRE)-binding protein-like-2
            (CREBL2) was identified in a search to find genes in a commonly
            deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B
            genes, frequently associated with hematopoietic malignancies, as
            well as breast, non-small-cell lung and ovarian cancers. CREBL2
            shares a 41% identity with CRE-binding protein (CREB) over a
            48-base long region which encodes the bZip domain of CREB. The bZip
            domain consists of about 30 amino acids rich in basic residues
            involved in DNA binding, followed by a leucine zipper motif
            involved in protein dimerization. This suggests that CREBL2 encodes
            a protein with DNA binding capabilities. The occurance of CREBL2
            deletion in malignancy suggests that CREBL2 may act as a tumor
            suppressor gene. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106052.1, AF039081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228865.3/ ENSP00000228865.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY795169.2         44-59
            17-2599             BC106052.1         1-2583
            2600-2600           AC008115.4         73907-73907
            2601-3330           BC106052.1         2585-3314
            3331-3331           AC008115.4         74638-74638
            3332-3497           BC106052.1         3316-3481
            3498-3498           AC008115.4         74805-74805
            3499-3770           AI375846.1         11-282              c
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..3770
                     /gene="CREBL2"
                     /note="cAMP responsive element binding protein like 2"
                     /db_xref="GeneID:1389"
                     /db_xref="HGNC:HGNC:2350"
                     /db_xref="MIM:603476"
     exon            1..312
                     /gene="CREBL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..660
                     /gene="CREBL2"
                     /note="MHBs-binding protein 1"
                     /codon_start=1
                     /product="cAMP-responsive element-binding protein-like 2"
                     /protein_id="NP_001301.1"
                     /db_xref="CCDS:CCDS8651.1"
                     /db_xref="GeneID:1389"
                     /db_xref="HGNC:HGNC:2350"
                     /db_xref="MIM:603476"
                     /translation="MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARK
                     KLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQ
                     NSSRHTKAGKTDANSNSW"
     exon            313..510
                     /gene="CREBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            511..655
                     /gene="CREBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            656..3770
                     /gene="CREBL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBL2"
                     /note="hexamer: AATAAA"
     polyA_site      2980
                     /gene="CREBL2"
                     /note="major polyA site"
     regulatory      3748..3753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBL2"
                     /note="hexamer: ATTAAA"
     polyA_site      3770
                     /gene="CREBL2"
                     /note="major polyA site"
ORIGIN      
        1 ggtctcggcg gctctccaga gcgtctgtaa acacccagag actgtcatgg agggggagga
       61 ggaggcggcg gcggcgaagg gaggcgtttg gggccgcctc cagggtccgc tctgccattc
      121 ctgaactggt ccctcgtccc cgtgactctg gcatcaggga agcgaactgt taggcgagag
      181 gaggaggcag ccagaaccat atccccttct tcctcggggc gggggccggg ccaggccggc
      241 tgagccgggg gagggctccg ggagggagtg cctggccagg ccggcctgtc tgccgcgatg
      301 gatgacagta aggtggttgg aggcaaagta aagaagcccg gtaaacgtgg tcggaagcca
      361 gccaaaattg acttgaaagc aaaacttgag aggagccggc agagtgcaag agaatgccga
      421 gcccgaaaaa agctgagata tcagtatttg gaagagttgg tatccagtcg agaaagagct
      481 atatgtgccc tcagagagga actggaaatg tacaagcagt ggtgcatggc aatggaccaa
      541 ggaaaaatcc cttctgaaat aaaggcccta ctcactggag aagagcagaa caaatctcag
      601 cagaactcaa gcaggcatac caaggctggg aagacagatg ctaatagcaa ttcctggtga
      661 agattatata aagatgagtc agtgattgaa gccaatattc tgattcccat ggaagatgga
      721 tgggcaagag tgtacttctt ggctccattt actacctact gctcagtagt catctctgta
      781 aatctgcaat ttctaccaaa atgtgtgatc gtagatctca aaggatcttg ctttaacttt
      841 caacacttag aaaatctaca aacattcaga cctgtctggg ttggtattgc cacccatgac
      901 atttaacatg ttgtgatgct tgaaaacaca ggagtagaga aaatcgatga agattgtatt
      961 tttgcacctt aactccacat tgctttattg gttaatttat attctttcca tgtaattcat
     1021 gtaattgtat gtctgtgtgt gttttatgtg tcaccacctt tcatgttttt gattgcccta
     1081 caaagagaaa ccaaatgagc tgattactga ctataagttc tcagccttta tggacctaat
     1141 cttattttta tttacttgag taatgtttat tctctgcatg aaccatgatt tctcctgtga
     1201 gccattccag cataagctgt gaatatgtat taacaaatat atacatttct atttttataa
     1261 tccataagga tatgcctgtt ttaaataaca tacatattaa caatatctat caggaaaacc
     1321 ctcaagacag cttctagtta aaacctttgt tgctgtcctc tcaaactata tttataaaaa
     1381 tttgctaggg ccaaatccat acttgcagaa taattcatca aattttattt ttaagtgaaa
     1441 agtaaccttt caggcatttc agcagcatac attgacaatc tagggtatat atgtatgtat
     1501 gtttcttatt gtatgtctat atatgtatgt ggggaggaca ggagtgaatg ttcacacact
     1561 tttcttgcgt actcaactaa attggagaat gtttctgaag aaaattggat gaaattagct
     1621 gctgagattg agtttctgcc ttaaaatctg aaacaaaaaa agggacaaat tgctggtaga
     1681 tctactgact gtagccatca ccagaacact tagtttcttc ccagacatga atttcctgac
     1741 aggctctgag ccagaaacac actgtgggcg tgcatctggt tcagccctgg atatgcctcc
     1801 actgtggagg gaagcattgg aactggagtt gtgcacagca ccgcagctag tgggcctggc
     1861 tgggggtgca gaagggcagg gtagttcttt ccatttcccc ttgcagctac acttactttc
     1921 tccctgacta ccaaatggag tgacggttga agaatcaagc tcataatatg atacacccag
     1981 acagacccag aaatcttttg atttccccag cgagatactt accactctct cttctctttc
     2041 ccatggttaa aacaggagtt gtgttctctg tcgctgctaa attattcttc acttgagtga
     2101 agcaaatatt tagcttccaa ataaagtata ttttgttctg aactggcagt ttaagaggag
     2161 ataccgtagt ctagattgtc tttgaggtag aatatatgat ggaccacata gtttaagatt
     2221 acaaggtact ttccctcttc tctcaggcca tgcatttgaa taaagtgcct cccttagcct
     2281 gagctcctaa agacctcttg tacttggttg caaactcaga tctctagtct agtctagtct
     2341 agtctagtct agtcatgtgt gactgtgtac tgagatacca ctagcccagt ttgctgggtc
     2401 tctatgtttt ggaagttggg ggtttaataa tatttaatgt ctttttagga tcataaacat
     2461 aaataggttt gttgatattc aggccttcag aatttaaggg ttttaaatat agcattcaga
     2521 ttgtaattgg tatgtttttg ccatctggtc cactcaattg tatattttta ttttgcaaaa
     2581 caacccaaaa cttactttat gttgctttgt tcagtacctt ttgaattccc ccagaagagt
     2641 tgttttcaaa acaaacattc cagaatgaat gtcgctcttc aatggaacgt ctttattgtg
     2701 cttgaagtat ttcttctctg gttgtaattc taaattacag agtcatttga gctttctccc
     2761 ctcccgctag tatctttaca ggagcaggga agagcagtag aggatgtata attttgggcg
     2821 aagttaaatt acaatttatt tgaggttatt cctaaaccta tttatttggt gttttggagg
     2881 agatcacaca ctaagagaac gttgattgcc tcggctattg tgctggctgg acactttggt
     2941 cacttttgaa gcatgttaat aaatgtcact gattaaaaca gctggagcat ttccttccct
     3001 ttccagtgaa ggagcagcat agtgaaatcc tggcacccct cacctttttg tgatgacaag
     3061 atggctgaca gtcacggagt ccaggagaag gtgctgctct ccttgctttc tgagtaaaca
     3121 gagtaatgtt ttttttctta ttttcccaaa gaaagaaaag ggggaaaata tatttgtatg
     3181 tttagaccag ccaaattctg tcattatttt agtatcaacc tgctgtatat tagagcaact
     3241 gaatataata tggaataagt ttgaccaggt caagttttag gatatagttg aatttcttta
     3301 aaaagttttc tattttatct aaaatctttc cattatatct aaattagaat gatcatcctg
     3361 cgcaaattca gattactgtt tgctggctaa ttgacagtat ttctcagcat cactatgtag
     3421 cattctgttt tagcatcttt gaattatgat catttgattt ggctaattac aaaaagtaca
     3481 ggtttaaact ggacttagct tgagttaaag gcaaagaaaa tctaaaaaca taaatgttat
     3541 atttcacaag aaatcagttg catattatcc attacatatt tagttttaaa aggaggagtc
     3601 accttgaatt attttctgag tcaccttgag ttatttgatc tctcagcctg ctttctcatc
     3661 tgtaaaaaag gggggaggat aactttcaca gggtaattgg taggctaaat aggagttaca
     3721 gaaaactgtt aaatagggaa gaactacatt aaatttaaat attcacatta
//
