LOCUS       NM_004380              10790 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens CREB binding protein (CREBBP), transcript variant 1,
            mRNA.
ACCESSION   NM_004380
VERSION     NM_004380.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10790)
  AUTHORS   Sardar,S., McNair,C.M., Ravindranath,L., Chand,S.N., Yuan,W.,
            Bogdan,D., Welti,J., Sharp,A., Ryan,N.K., Knudsen,L.A.,
            Schiewer,M.J., DeArment,E.G., Janas,T., Su,X.A., Butler,L.M., de
            Bono,J.S., Frese,K., Brooks,N., Pegg,N., Knudsen,K.E. and
            Shafi,A.A.
  TITLE     AR coactivators, CBP/p300, are critical mediators of DNA repair in
            prostate cancer
  JOURNAL   Oncogene 43 (43), 3197-3213 (2024)
   PUBMED   39266679
  REMARK    GeneRIF: AR coactivators, CBP/p300, are critical mediators of DNA
            repair in prostate cancer.
REFERENCE   2  (bases 1 to 10790)
  AUTHORS   Yuan,X., Hao,X., Chan,H.L., Zhao,N., Pedroza,D.A., Liu,F., Le,K.,
            Smith,A.J., Calderon,S.J., Lieu,N., Soth,M.J., Jones,P., Zhang,X.H.
            and Rosen,J.M.
  TITLE     CREB-binding protein/P300 bromodomain inhibition reduces neutrophil
            accumulation and activates antitumor immunity in triple-negative
            breast cancer
  JOURNAL   JCI Insight 9 (20), e182621 (2024)
   PUBMED   39287984
  REMARK    GeneRIF: CREB-binding protein/P300 bromodomain inhibition reduces
            neutrophil accumulation and activates antitumor immunity in
            triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10790)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   4  (bases 1 to 10790)
  AUTHORS   Ebrahimi,A., Waha,A., Schittenhelm,J., Gohla,G., Schuhmann,M.U. and
            Pietsch,T.
  TITLE     BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS
            expands the spectrum of methylation class CNS tumor with
            BCOR/BCOR(L1)-fusion
  JOURNAL   Acta Neuropathol Commun 12 (1), 60 (2024)
   PUBMED   38637838
  REMARK    GeneRIF: BCOR::CREBBP fusion in malignant neuroepithelial tumor of
            CNS expands the spectrum of methylation class CNS tumor with
            BCOR/BCOR(L1)-fusion.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10790)
  AUTHORS   Chen,Y., Wu,J., Zhai,L., Zhang,T., Yin,H., Gao,H., Zhao,F.,
            Wang,Z., Yang,X., Jin,M., Huang,B., Ding,X., Li,R., Yang,J., He,Y.,
            Wang,Q., Wang,W., Kloeber,J.A., Li,Y., Hao,B., Zhang,Y., Wang,J.,
            Tan,M., Li,K., Wang,P., Lou,Z. and Yuan,J.
  TITLE     Metabolic regulation of homologous recombination repair by MRE11
            lactylation
  JOURNAL   Cell 187 (2), 294-311 (2024)
   PUBMED   38128537
REFERENCE   6  (bases 1 to 10790)
  AUTHORS   Petrij,F., Giles,R.H., Dauwerse,H.G., Saris,J.J., Hennekam,R.C.,
            Masuno,M., Tommerup,N., van Ommen,G.J., Goodman,R.H., Peters,D.J.
            et al.
  TITLE     Rubinstein-Taybi syndrome caused by mutations in the
            transcriptional co-activator CBP
  JOURNAL   Nature 376 (6538), 348-351 (1995)
   PUBMED   7630403
REFERENCE   7  (bases 1 to 10790)
  AUTHORS   Chen,X.N. and Korenberg,J.R.
  TITLE     Localization of human CREBBP (CREB binding protein) to 16p13.3 by
            fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 71 (1), 56-57 (1995)
   PUBMED   7606928
REFERENCE   8  (bases 1 to 10790)
  AUTHORS   Stevens,C.A.
  TITLE     Rubinstein-Taybi Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301699
REFERENCE   9  (bases 1 to 10790)
  AUTHORS   Lacombe,D., Saura,R., Taine,L. and Battin,J.
  TITLE     Confirmation of assignment of a locus for Rubinstein-Taybi syndrome
            gene to 16p13.3
  JOURNAL   Am J Med Genet 44 (1), 126-128 (1992)
   PUBMED   1519642
REFERENCE   10 (bases 1 to 10790)
  AUTHORS   Benbrook,D.M. and Jones,N.C.
  TITLE     Heterodimer formation between CREB and JUN proteins
  JOURNAL   Oncogene 5 (3), 295-302 (1990)
   PUBMED   2138276
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U85962.3, AB210043.1 and
            AC006111.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 19, 2019 this sequence version replaced NM_004380.2.
            
            Summary: This gene is ubiquitously expressed and is involved in the
            transcriptional coactivation of many different transcription
            factors. First isolated as a nuclear protein that binds to
            cAMP-response element binding protein (CREB), this gene is now
            known to play critical roles in embryonic development, growth
            control, and homeostasis by coupling chromatin remodeling to
            transcription factor recognition. The protein encoded by this gene
            has intrinsic histone acetyltransferase activity and also acts as a
            scaffold to stabilize additional protein interactions with the
            transcription complex. This protein acetylates both histone and
            non-histone proteins. This protein shares regions of very high
            sequence similarity with protein p300 in its bromodomain,
            cysteine-histidine-rich regions, and histone acetyltransferase
            domain. Mutations in this gene cause Rubinstein-Taybi syndrome
            (RTS). Chromosomal translocations involving this gene have been
            associated with acute myeloid leukemia. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85962.3, SRR14038196.3158172.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262367.10/ ENSP00000262367.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-593               U85962.3           19-611
            594-2013            AB210043.1         1-1420
            2014-8126           U85962.3           2035-8147
            8127-10790          AC006111.4         182796-185459       c
FEATURES             Location/Qualifiers
     source          1..10790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..10790
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /note="CREB binding protein"
                     /db_xref="GeneID:1387"
                     /db_xref="HGNC:HGNC:2348"
                     /db_xref="MIM:600140"
     exon            1..882
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             798..8126
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /EC_number="2.3.1.48"
                     /note="isoform a is encoded by transcript variant 1;
                     histone lysine acetyltransferase CREBBP; protein-lysine
                     acetyltransferase CREBBP; protein lactyltransferas CREBBP"
                     /codon_start=1
                     /product="CREB-binding protein isoform a"
                     /protein_id="NP_004371.2"
                     /db_xref="CCDS:CCDS10509.1"
                     /db_xref="GeneID:1387"
                     /db_xref="HGNC:HGNC:2348"
                     /db_xref="MIM:600140"
                     /translation="MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDEL
                     IPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQ
                     AQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVG
                     LATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGR
                     GRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPF
                     GQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGI
                     VPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVL
                     NHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPA
                     SGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQ
                     PAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGS
                     NSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDR
                     RMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQ
                     PALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMG
                     PRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQ
                     FPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPT
                     PPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQS
                     TPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRV
                     PTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGAS
                     QVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPE
                     ELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQ
                     YQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKY
                     EFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTI
                     SKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRK
                     ENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSR
                     FVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDS
                     IHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIP
                     KPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEES
                     IKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSM
                     PNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFL
                     TLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDY
                     DLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQ
                     CRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPF
                     CLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTP
                     QTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEA
                     ARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSM
                     PPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTL
                     KSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPG
                     MHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYR
                     EMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQ
                     RMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIG
                     SPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPS
                     PRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSS
                     ELSLVGDTTGDTLEKFVEGL"
     exon            883..1595
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1772
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2013
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2127
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2370
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2473
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2620
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2738
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2910
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2911..2955
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3080
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3260
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3677
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3857
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4047
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4166
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4406
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4495
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4496..4576
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..4633
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4634..4711
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4712..4779
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4780..4930
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4931..5077
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5191
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5357
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5358..5525
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5526..5687
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5688..5969
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5970..10790
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9003..9008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /note="hexamer: AATAAA"
     polyA_site      9028
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /note="major polyA site"
     regulatory      9172..9177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /note="hexamer: TATAAA"
     polyA_site      9193
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
     regulatory      10759..10764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
                     /note="hexamer: AATAAA"
     polyA_site      10790
                     /gene="CREBBP"
                     /gene_synonym="CBP; KAT3A; MKHK1; RSTS; RSTS1"
ORIGIN      
        1 aattgaggaa tcaacagccg ccatcttgtc gcggacccga ccggggcttc gagcgcgatc
       61 tactcggccc cgccggtccc gggccccaca accgcccgcg caccccgctc cgcccggccg
      121 gcccgctccg cccggccctc ggcgcccgcc ccggcggccc cgctcgcctc tcggctcggc
      181 ctcccggagc ccggcggcgg cggcggcggc agcggcggcg gcggcggcgg aacggggggt
      241 gggggggccg cggcggcggc ggcgaccccg ctcggcgcat tgtttttcct cacggcggcg
      301 gcggcggcgg gccgcgggcc gggagcggag cccggagccc cctcgtcgtc gggccgcgag
      361 cgaattcatt aagtggggcg cgggggggga gcgaggcggc ggcggcggcg gcaccatgtt
      421 ctcggggact gcctgagccg cccggccggg cgccgtcgct gccagccggg cccggggggg
      481 cggccgggcc gccggggcgc ccccaccgcg gagtgtcgcg ctcgggaggc gggcagggga
      541 tgagggggcc gcggccggcg gcggcggcgg cggccggggg cgggcggtga gcgctgcggg
      601 gcgctgttgc tgtggctgag atttggccgc cgcctccccc acccggcctg cgccctccct
      661 ctccctcggc gcccgcccgc ccgctcgcgg cccgcgctcg ctcctctccc tcgcagccgg
      721 cagggccccc gacccccgtc cgggccctcg ccggcccggc cgcccgtgcc cggggctgtt
      781 ttcgcgagca ggtgaaaatg gctgagaact tgctggacgg accgcccaac cccaaaagag
      841 ccaaactcag ctcgcccggt ttctcggcga atgacagcac agattttgga tcattgtttg
      901 acttggaaaa tgatcttcct gatgagctga tacccaatgg aggagaatta ggccttttaa
      961 acagtgggaa ccttgttcca gatgctgctt ccaaacataa acaactgtcg gagcttctac
     1021 gaggaggcag cggctctagt atcaacccag gaataggaaa tgtgagcgcc agcagccccg
     1081 tgcagcaggg cctgggtggc caggctcaag ggcagccgaa cagtgctaac atggccagcc
     1141 tcagtgccat gggcaagagc cctctgagcc agggagattc ttcagccccc agcctgccta
     1201 aacaggcagc cagcacctct gggcccaccc ccgctgcctc ccaagcactg aatccgcaag
     1261 cacaaaagca agtggggctg gcgactagca gccctgccac gtcacagact ggacctggta
     1321 tctgcatgaa tgctaacttt aaccagaccc acccaggcct cctcaatagt aactctggcc
     1381 atagcttaat taatcaggct tcacaagggc aggcgcaagt catgaatgga tctcttgggg
     1441 ctgctggcag aggaagggga gctggaatgc cgtaccctac tccagccatg cagggcgcct
     1501 cgagcagcgt gctggctgag accctaacgc aggtttcccc gcaaatgact ggtcacgcgg
     1561 gactgaacac cgcacaggca ggaggcatgg ccaagatggg aataactggg aacacaagtc
     1621 catttggaca gccctttagt caagctggag ggcagccaat gggagccact ggagtgaacc
     1681 cccagttagc cagcaaacag agcatggtca acagtttgcc caccttccct acagatatca
     1741 agaatacttc agtcaccaac gtgccaaata tgtctcagat gcaaacatca gtgggaattg
     1801 tacccacaca agcaattgca acaggcccca ctgcagatcc tgaaaaacgc aaactgatac
     1861 agcagcagct ggttctactg cttcatgctc ataagtgtca gagacgagag caagcaaacg
     1921 gagaggttcg ggcctgctcg ctcccgcatt gtcgaaccat gaaaaacgtt ttgaatcaca
     1981 tgacgcattg tcaggctggg aaagcctgcc aagttgccca ttgtgcatct tcacgacaaa
     2041 tcatctctca ttggaagaac tgcacacgac atgactgtcc tgtttgcctc cctttgaaaa
     2101 atgccagtga caagcgaaac caacaaacca tcctggggtc tccagctagt ggaattcaaa
     2161 acacaattgg ttctgttggc acagggcaac agaatgccac ttctttaagt aacccaaatc
     2221 ccatagaccc cagctccatg cagcgagcct atgctgctct cggactcccc tacatgaacc
     2281 agccccagac gcagctgcag cctcaggttc ctggccagca accagcacag cctcaaaccc
     2341 accagcagat gaggactctc aaccccctgg gaaataatcc aatgaacatt ccagcaggag
     2401 gaataacaac agatcagcag cccccaaact tgatttcaga atcagctctt ccgacttccc
     2461 tgggggccac aaacccactg atgaacgatg gctccaactc tggtaacatt ggaaccctca
     2521 gcactatacc aacagcagct cctccttcta gcaccggtgt aaggaaaggc tggcacgaac
     2581 atgtcactca ggacctgcgg agccatctag tgcataaact cgtccaagcc atcttcccaa
     2641 cacctgatcc cgcagctcta aaggatcgcc gcatggaaaa cctggtagcc tatgctaaga
     2701 aagtggaagg ggacatgtac gagtctgcca acagcaggga tgaatattat cacttattag
     2761 cagagaaaat ctacaagata caaaaagaac tagaagaaaa acggaggtcg cgtttacata
     2821 aacaaggcat cttggggaac cagccagcct taccagcccc gggggctcag ccccctgtga
     2881 ttccacaggc acaacctgtg agacctccaa atggacccct gtccctgcca gtgaatcgca
     2941 tgcaagtttc tcaagggatg aattcattta accccatgtc cttggggaac gtccagttgc
     3001 cacaagcacc catgggacct cgtgcagcct ccccaatgaa ccactctgtc cagatgaaca
     3061 gcatgggctc agtgccaggg atggccattt ctccttcccg aatgcctcag cctccgaaca
     3121 tgatgggtgc acacaccaac aacatgatgg cccaggcgcc cgctcagagc cagtttctgc
     3181 cacagaacca gttcccgtca tccagcgggg cgatgagtgt gggcatgggg cagccgccag
     3241 cccaaacagg cgtgtcacag ggacaggtgc ctggtgctgc tcttcctaac cctctcaaca
     3301 tgctggggcc tcaggccagc cagctacctt gccctccagt gacacagtca ccactgcacc
     3361 caacaccgcc tcctgcttcc acggctgctg gcatgccatc tctccagcac acgacaccac
     3421 ctgggatgac tcctccccag ccagcagctc ccactcagcc atcaactcct gtgtcgtctt
     3481 ccgggcagac tcccaccccg actcctggct cagtgcccag tgctacccaa acccagagca
     3541 cccctacagt ccaggcagca gcccaggccc aggtgacccc gcagcctcaa accccagttc
     3601 agcccccgtc tgtggctacc cctcagtcat cgcagcaaca gccgacgcct gtgcacgccc
     3661 agcctcctgg cacaccgctt tcccaggcag cagccagcat tgataacaga gtccctaccc
     3721 cctcctcggt ggccagcgca gaaaccaatt cccagcagcc aggacctgac gtacctgtgc
     3781 tggaaatgaa gacggagacc caagcagagg acactgagcc cgatcctggt gaatccaaag
     3841 gggagcccag gtctgagatg atggaggagg atttgcaagg agcttcccaa gttaaagaag
     3901 aaacagacat agcagagcag aaatcagaac caatggaagt ggatgaaaag aaacctgaag
     3961 tgaaagtaga agttaaagag gaagaagaga gtagcagtaa cggcacagcc tctcagtcaa
     4021 catctccttc gcagccgcgc aaaaaaatct ttaaaccaga ggagttacgc caggccctca
     4081 tgccaaccct agaagcactg tatcgacagg acccagagtc attacctttc cggcagcctg
     4141 tagatcccca gctcctcgga attccagact attttgacat cgtaaagaat cccatggacc
     4201 tctccaccat caagcggaag ctggacacag ggcaatacca agagccctgg cagtacgtgg
     4261 acgacgtctg gctcatgttc aacaatgcct ggctctataa tcgcaagaca tcccgagtct
     4321 ataagttttg cagtaagctt gcagaggtct ttgagcagga aattgaccct gtcatgcagt
     4381 cccttggata ttgctgtgga cgcaagtatg agttttcccc acagactttg tgctgctatg
     4441 ggaagcagct gtgtaccatt cctcgcgatg ctgcctacta cagctatcag aataggtatc
     4501 atttctgtga gaagtgtttc acagagatcc agggcgagaa tgtgaccctg ggtgacgacc
     4561 cttcacagcc ccagacgaca atttcaaagg atcagtttga aaagaagaaa aatgatacct
     4621 tagaccccga acctttcgtt gattgcaagg agtgtggccg gaagatgcat cagatttgcg
     4681 ttctgcacta tgacatcatt tggccttcag gttttgtgtg cgacaactgc ttgaagaaaa
     4741 ctggcagacc tcgaaaagaa aacaaattca gtgctaagag gctgcagacc acaagactgg
     4801 gaaaccactt ggaagaccga gtgaacaaat ttttgcggcg ccagaatcac cctgaagccg
     4861 gggaggtttt tgtccgagtg gtggccagct cagacaagac ggtggaggtc aagcccggga
     4921 tgaagtcacg gtttgtggat tctggggaaa tgtctgaatc tttcccatat cgaaccaaag
     4981 ctctgtttgc ttttgaggaa attgacggcg tggatgtctg cttttttgga atgcacgtcc
     5041 aagaatacgg ctctgattgc ccccctccaa acacgaggcg tgtgtacatt tcttatctgg
     5101 atagtattca tttcttccgg ccacgttgcc tccgcacagc cgtttaccat gagatcctta
     5161 ttggatattt agagtatgtg aagaaattag ggtatgtgac agggcacatc tgggcctgtc
     5221 ctccaagtga aggagatgat tacatcttcc attgccaccc acctgatcaa aaaataccca
     5281 agccaaaacg actgcaggag tggtacaaaa agatgctgga caaggcgttt gcagagcgga
     5341 tcatccatga ctacaaggat attttcaaac aagcaactga agacaggctc accagtgcca
     5401 aggaactgcc ctattttgaa ggtgatttct ggcccaatgt gttagaagag agcattaagg
     5461 aactagaaca agaagaagag gagaggaaaa aggaagagag cactgcagcc agtgaaacca
     5521 ctgagggcag tcagggcgac agcaagaatg ccaagaagaa gaacaacaag aaaaccaaca
     5581 agaacaaaag cagcatcagc cgcgccaaca agaagaagcc cagcatgccc aacgtgtcca
     5641 atgacctgtc ccagaagctg tatgccacca tggagaagca caaggaggtc ttcttcgtga
     5701 tccacctgca cgctgggcct gtcatcaaca ccctgccccc catcgtcgac cccgaccccc
     5761 tgctcagctg tgacctcatg gatgggcgcg acgccttcct caccctcgcc agagacaagc
     5821 actgggagtt ctcctccttg cgccgctcca agtggtccac gctctgcatg ctggtggagc
     5881 tgcacaccca gggccaggac cgctttgtct acacctgcaa cgagtgcaag caccacgtgg
     5941 agacgcgctg gcactgcact gtgtgcgagg actacgacct ctgcatcaac tgctataaca
     6001 cgaagagcca tgcccataag atggtgaagt gggggctggg cctggatgac gagggcagca
     6061 gccagggcga gccacagtca aagagccccc aggagtcacg ccggctgagc atccagcgct
     6121 gcatccagtc gctggtgcac gcgtgccagt gccgcaacgc caactgctcg ctgccatcct
     6181 gccagaagat gaagcgggtg gtgcagcaca ccaagggctg caaacgcaag accaacgggg
     6241 gctgcccggt gtgcaagcag ctcatcgccc tctgctgcta ccacgccaag cactgccaag
     6301 aaaacaaatg ccccgtgccc ttctgcctca acatcaaaca caagctccgc cagcagcaga
     6361 tccagcaccg cctgcagcag gcccagctca tgcgccggcg gatggccacc atgaacaccc
     6421 gcaacgtgcc tcagcagagt ctgccttctc ctacctcagc accgcccggg acccccacac
     6481 agcagcccag cacaccccag acgccgcagc cccctgccca gccccaaccc tcacccgtga
     6541 gcatgtcacc agctggcttc cccagcgtgg cccggactca gccccccacc acggtgtcca
     6601 cagggaagcc taccagccag gtgccggccc ccccaccccc ggcccagccc cctcctgcag
     6661 cggtggaagc ggctcggcag atcgagcgtg aggcccagca gcagcagcac ctgtaccggg
     6721 tgaacatcaa caacagcatg cccccaggac gcacgggcat ggggaccccg gggagccaga
     6781 tggcccccgt gagcctgaat gtgccccgac ccaaccaggt gagcgggccc gtcatgccca
     6841 gcatgcctcc cgggcagtgg cagcaggcgc cccttcccca gcagcagccc atgccaggct
     6901 tgcccaggcc tgtgatatcc atgcaggccc aggcggccgt ggctgggccc cggatgccca
     6961 gcgtgcagcc acccaggagc atctcaccca gcgctctgca agacctgctg cggaccctga
     7021 agtcgcccag ctcccctcag cagcaacagc aggtgctgaa cattctcaaa tcaaacccgc
     7081 agctaatggc agctttcatc aaacagcgca cagccaagta cgtggccaat cagcccggca
     7141 tgcagcccca gcctggcctc cagtcccagc ccggcatgca accccagcct ggcatgcacc
     7201 agcagcccag cctgcagaac ctgaatgcca tgcaggctgg cgtgccgcgg cccggtgtgc
     7261 ctccacagca gcaggcgatg ggaggcctga acccccaggg ccaggccttg aacatcatga
     7321 acccaggaca caaccccaac atggcgagta tgaatccaca gtaccgagaa atgttacgga
     7381 ggcagctgct gcagcagcag cagcaacagc agcagcaaca acagcagcaa cagcagcagc
     7441 agcaagggag tgccggcatg gctgggggca tggcggggca cggccagttc cagcagcctc
     7501 aaggacccgg aggctaccca ccggccatgc agcagcagca gcgcatgcag cagcatctcc
     7561 ccctccaggg cagctccatg ggccagatgg cggctcagat gggacagctt ggccagatgg
     7621 ggcagccggg gctgggggca gacagcaccc ccaacatcca gcaagccctg cagcagcgga
     7681 ttctgcagca acagcagatg aagcagcaga ttgggtcccc aggccagccg aaccccatga
     7741 gcccccagca acacatgctc tcaggacagc cacaggcctc gcatctccct ggccagcaga
     7801 tcgccacgtc ccttagtaac caggtgcggt ctccagcccc tgtccagtct ccacggcccc
     7861 agtcccagcc tccacattcc agcccgtcac cacggataca gccccagcct tcgccacacc
     7921 acgtctcacc ccagactggt tccccccacc ccggactcgc agtcaccatg gccagctcca
     7981 tagatcaggg acacttgggg aaccccgaac agagtgcaat gctcccccag ctgaacaccc
     8041 ccagcaggag tgcgctgtcc agcgaactgt ccctggtcgg ggacaccacg ggggacacgc
     8101 tagagaagtt tgtggagggc ttgtagcatt gtgagagcat caccttttcc ctttcatgtt
     8161 cttggacctt ttgtactgaa aatccaggca tctaggttct ttttattcct agatggaact
     8221 gcgacttccg agccatggaa gggtggattg atgtttaaag aaacaataca aagaatatat
     8281 ttttttgtta aaaaccagtt gatttaaata tctggtctct ctctttggtt tttttttggc
     8341 gggggggtgg ggggggttct tttttttccg ttttgttttt gtttgggggg aggggggttt
     8401 tgtttggatt ctttttgtcg tcattgctgg tgactcatgc ctttttttaa cgggaaaaac
     8461 aagttcatta tattcatatt ttttatttgt attttcaaga ctttaaacat ttatgtttaa
     8521 aagtaagaag aaaaataata ttcagaactg attcctgaaa taatgcaagc ttataatgta
     8581 tcccgataac tttgtgatgt ttcgggaaga tttttttcta tagtgaactc tgtgggcgtc
     8641 tcccagtatt accctggatg ataggaattg actccggcgt gcacacacgt acacacccac
     8701 acacatctat ctatacataa tggctgaagc caaacttgtc ttgcagatgt agaaattgtt
     8761 gctttgtttc tctgataaaa ctggttttag acaaaaaata gggatgatca ctcttagacc
     8821 atgctaatgt tactagagaa gaagccttct tttctttctt ctatgtgaaa cttgaaatga
     8881 ggaaaagcaa ttctagtgta aatcatgcaa gcgctctaat tcctataaat acgaaactcg
     8941 agaagattca atcactgtat agaatggtaa aataccaact catttcttat atcatattgt
     9001 taaataaact gtgtgcaaca gacaaaaagg gtggtccttc ttgaattcat gtacatggta
     9061 ttaacactta gtgttcgggg ttttttgtta tgaaaatgct gttttcaaca ttgtatttgg
     9121 actatgcatg tgttttttcc ccattgtata taaagtaccg cttaaaattg atataaatta
     9181 ctgaggtttt taacatgtat tctgttcttt aagatccctg taagaatgtt taaggttttt
     9241 atttatttat atatattttt tgagtctgtt ctttgtaaga catggttctg gttgttcgct
     9301 catagcggag aggctggggc tgcggttgtg gttgtggcgg cgtgggtggt ggctgggaac
     9361 tgtggcccag gcttagcggc cgcccggagg cttttcttcc cggagactga ggtgggcgac
     9421 tgaggtgggc ggctcagcgt tggccccaca cattcgaggc tcacaggtga ttgtcgctca
     9481 cacagttagg gtcgtcagtt ggtctgaaac tgcatttggc ccactcctcc atcctccctg
     9541 tccgtcgtag ctgccacccc cagaggcggc gcttcttccc gtgttcaggc ggctcccccc
     9601 ccccgtacac gactcccaga atctgaggca gagagtgctc caggctcgcg aggtgctttc
     9661 tgacttcccc ccaaatcctg ccgctgccgc gcagcatgtc ccgtgtggcg tttgaggaaa
     9721 tgctgaggga cagacacctt ggagcaccag ctccggtccc tgttacagtg agaaaggtcc
     9781 cccacttcgg gggatacttg cacttagcca catggtcctg cctcccttgg agtccagttc
     9841 caggctccct tactgagtgg gtgagacaag ttcacaaaaa ccgtaaaact gagaggagga
     9901 ccatgggcag gggagctgaa gttcatcccc taagtctacc acccccagca cccagagaac
     9961 ccactttatc cctagtcccc caacaaaggc tggtctaggt gggggtgatg gtaattttag
    10021 aaatcacgcc ccaaatagct tccgtttggg cccttacatt cacagatagg ttttaaatag
    10081 ctgaatactt ggtttgggaa tctgaattcg aggaaccttt ctaagaagtt ggaaaggtcc
    10141 gatctagttt tagcacagag ctttgaacct tgagttataa aatgcagaat aattcaagta
    10201 aaaataagac caccatctgg cacccctgac cagcccccat tcaccccatc ccaggagggg
    10261 aagcacaggc cgggcctccg gtggagattg ctgccactgc tcggcctgct gggttcttaa
    10321 cctccagtgt cctcttcatc ttttccaccc gtagggaaac cttgagccat gtgttcaaac
    10381 aagaagtggg gctagagccc gagagcagca gctctaagcc cacactcaga aagtggcgcc
    10441 ctcctggttg tgcagccttt taatgtgggc agtggagggg cctctgtttc aggttatcct
    10501 ggaattcaaa acgttatgta ccaacctcat cctctttgga gtctgcatcc tgtgcaaccg
    10561 tcttgggcaa tccagatgtc gaaggatgtg accgagagca tggtctgtgg atgctaaccc
    10621 taagtttgtc gtaaggaaat ttctgtaaga aacctggaaa gccccaacgc tgtgtctcat
    10681 gctgtatact taagaggaga agaaaaagtc ctatatttgt gatcaaaaag aggaaacttg
    10741 aaatgtgatg gtgtttataa taaaagatgg taaaactact tggattcaaa
//
