LOCUS       NM_182899               8188 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens cAMP responsive element binding protein 5 (CREB5),
            transcript variant 3, mRNA.
ACCESSION   NM_182899
VERSION     NM_182899.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8188)
  AUTHORS   Yamada,C., Okada,K., Odaira,K., Tokoro,M., Iwamoto,E., Sanada,M.,
            Noura,M., Okamoto,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     RGS1 and CREB5 are direct and common transcriptional targets of
            ZNF384-fusion proteins
  JOURNAL   Cancer Med 13 (14), e7471 (2024)
   PUBMED   39015025
  REMARK    GeneRIF: RGS1 and CREB5 are direct and common transcriptional
            targets of ZNF384-fusion proteins.
REFERENCE   2  (bases 1 to 8188)
  AUTHORS   Li,Z., Dai,F., Zhu,R., Zhang,Y., Chen,J., Chen,L., Liu,H. and
            Cheng,Y.
  TITLE     Dysregulation of CREB5 Impairs Decidualization and Maternal-Fetal
            Interactions by Inhibiting Autophagy in Recurrent Spontaneous
            Abortion
  JOURNAL   Reprod Sci 31 (7), 1983-2000 (2024)
   PUBMED   38424407
  REMARK    GeneRIF: Dysregulation of CREB5 Impairs Decidualization and
            Maternal-Fetal Interactions by Inhibiting Autophagy in Recurrent
            Spontaneous Abortion.
REFERENCE   3  (bases 1 to 8188)
  AUTHORS   Wu,Z., Wang,X., Wu,H., Du,S., Wang,Z., Xie,S., Zhang,R., Chen,G.
            and Chen,H.
  TITLE     Identification of CREB5 as a prognostic and immunotherapeutic
            biomarker in glioma through multi-omics pan-cancer analysis
  JOURNAL   Comput Biol Med 173, 108307 (2024)
   PUBMED   38547657
  REMARK    GeneRIF: Identification of CREB5 as a prognostic and
            immunotherapeutic biomarker in glioma through multi-omics
            pan-cancer analysis.
REFERENCE   4  (bases 1 to 8188)
  AUTHORS   Zhou,R., Zhao,L., Wang,Q., Cheng,Y., Song,M. and Huang,C.
  TITLE     Plasma microRNA-320c as a Potential Biomarker for the Severity of
            Knee Osteoarthritis and Regulates cAMP Responsive Element Binding
            Protein 5 (CREB5) in Chondrocytes
  JOURNAL   Dis Markers 2024, 9936295 (2024)
   PUBMED   38549717
  REMARK    GeneRIF: Plasma microRNA-320c as a Potential Biomarker for the
            Severity of Knee Osteoarthritis and Regulates cAMP Responsive
            Element Binding Protein 5 (CREB5) in Chondrocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8188)
  AUTHORS   Gong,D.A., Zhou,P., Chang,W.Y., Yang,J.Y., Zhang,Y.L., Huang,A.L.,
            Tang,N. and Wang,K.
  TITLE     SPOP promotes CREB5 ubiquitination to inhibit MET signaling in
            liver cancer
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119642 (2024)
   PUBMED   37996058
  REMARK    GeneRIF: SPOP promotes CREB5 ubiquitination to inhibit MET
            signaling in liver cancer.
REFERENCE   6  (bases 1 to 8188)
  AUTHORS   Qi,L. and Ding,Y.
  TITLE     Involvement of the CREB5 regulatory network in colorectal cancer
            metastasis
  JOURNAL   Yi Chuan 36 (7), 679-684 (2014)
   PUBMED   25076032
  REMARK    GeneRIF: CREB5 accelerate the metastasis of colorectal cancer by
            regulating these five key genes.
REFERENCE   7  (bases 1 to 8188)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 8188)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   9  (bases 1 to 8188)
  AUTHORS   Zu,Y.L., Maekawa,T., Nomura,N., Nakata,T. and Ishii,S.
  TITLE     Regulation of trans-activating capacity of CRE-BPa by phorbol ester
            tumor promoter TPA
  JOURNAL   Oncogene 8 (10), 2749-2758 (1993)
   PUBMED   8378084
REFERENCE   10 (bases 1 to 8188)
  AUTHORS   Nomura,N., Zu,Y.L., Maekawa,T., Tabata,S., Akiyama,T. and Ishii,S.
  TITLE     Isolation and characterization of a novel member of the gene family
            encoding the cAMP response element-binding protein CRE-BP1
  JOURNAL   J Biol Chem 268 (6), 4259-4266 (1993)
   PUBMED   8440710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L05913.1, AC006367.3,
            AB451409.1, AC005013.3 and BQ130001.1.
            
            On Aug 14, 2020 this sequence version replaced NM_182899.4.
            
            Summary: The product of this gene belongs to the CRE (cAMP response
            element)-binding protein family. Members of this family contain
            zinc-finger and bZIP DNA-binding domains. The encoded protein
            specifically binds to CRE as a homodimer or a heterodimer with
            c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks two 5' exons and uses an
            alternate 5' terminal exon which results in the use of a downstream
            in-frame start codon, compared to variant 1. It encodes isoform
            gamma which has a shorter N-terminus compared to isoform alpha.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L05913.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                L05913.1           1-14
            15-15               AC006367.3         1691-1691
            16-121              L05913.1           16-121
            122-1570            AB451409.1         76-1524
            1571-7667           AC005013.3         38561-44657
            7668-8188           BQ130001.1         23-543              c
FEATURES             Location/Qualifiers
     source          1..8188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.1-p14.3"
     gene            1..8188
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /note="cAMP responsive element binding protein 5"
                     /db_xref="GeneID:9586"
                     /db_xref="HGNC:HGNC:16844"
                     /db_xref="MIM:618262"
     exon            1..121
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            122..215
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1573
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /note="isoform gamma is encoded by transcript variant 3;
                     cAMP response element-binding protein CRE-BPa; cyclic
                     AMP-responsive element-binding protein 5; cAMP-response
                     element-binding protein A"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 5
                     isoform gamma"
                     /protein_id="NP_878902.2"
                     /db_xref="CCDS:CCDS43562.1"
                     /db_xref="GeneID:9586"
                     /db_xref="HGNC:HGNC:16844"
                     /db_xref="MIM:618262"
                     /translation="MIHRHKHEMTLKFPSIKTDNMLSDQTPTPTRFLKNCEEVGLFSE
                     LDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSARLPNHDTNVVIQQAM
                     PSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPGTLPNPTMPGSSA
                     VLMPMERQMSVNSSIMGMQGPNLSNPCASPQVQPMHSEAKMRLKAALTHHPAAMSNGN
                     MNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQ
                     NHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRR
                     RVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEVSMLK
                     NEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSS
                     SVSEVVGSSTLSQLTTHRTDLNPIL"
     exon            216..337
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            338..510
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            511..637
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            638..748
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1072
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1300
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1409
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..8188
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8165..8170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /note="hexamer: AATAAA"
     polyA_site      8188
                     /gene="CREB5"
                     /gene_synonym="CRE-BPA; CREB-5; CREBPA"
                     /note="major polyA site"
ORIGIN      
        1 gatctgatga atccaaggag tggagcaaga ggcagatttt ggacacggtt atgagaatga
       61 cagaaactgc ctaaagcatt tatgctctgg cattcgtccc tgtttctgga ggtccagtaa
      121 gcgcttccca acagaggacc atctgatgat tcataggcac aaacatgaaa tgactttgaa
      181 gtttccttca ataaaaacag acaatatgtt atcagatcaa actccgaccc caacgagatt
      241 cctgaagaac tgcgaggagg tgggcctctt cagcgagctg gactgctccc tggagcacga
      301 gttcaggaag gctcaggaag aggagagcag caagcggaat atctcgatgc ataatgcagt
      361 tggtggggcc atgacggggc ccggaactca ccagcttagc agcgctcggc tgcccaacca
      421 tgacaccaac gttgtgattc agcaagccat gccgtcgcct cagtccagct ctgtcatcac
      481 tcaggcacct tccaccaacc gccagatcgg gcctgtccca ggctctctat cttctctgct
      541 acatctccac aacagacaga gacagcccat gccagcctcc atgcctggga ccctgcccaa
      601 ccctacaatg ccaggatctt ccgccgtctt gatgccaatg gagcgacaaa tgtcagtgaa
      661 ctccagcatc atggggatgc aaggtccaaa tctcagcaac ccctgtgctt ctccccaggt
      721 ccagccaatg cattcagaag ccaaaatgag gttgaaggct gcattgactc accaccctgc
      781 tgccatgtca aatgggaaca tgaacaccat gggacacatg atggagatga tgggctcccg
      841 gcaggaccag acgccacacc atcacatgca ctcgcacccg catcagcacc agacactgcc
      901 accccatcac ccttacccac accagcacca gcacccagca caccatcctc accctcaacc
      961 ccatcaccag cagaaccatc cacatcacca ctcccattcc caccttcatg cacacccagc
     1021 acatcaccag acctcgccac atccgcccct gcacaccggc aaccaagcac aggtttcacc
     1081 agcaacacaa cagatgcagc caacccagac aatacagcca ccccagccca caggggggcg
     1141 ccggcgaagg gtggtagacg aggatccgga cgagaggcgg cggaaatttc tggaacggaa
     1201 ccgggcagct gccacccgct gcagacagaa gaggaaggtc tgggtgatgt cattggaaaa
     1261 gaaagcagaa gaactcaccc agacaaacat gcagcttcag aatgaagtgt ctatgttgaa
     1321 aaatgaggtg gcccagctga aacagttgtt gttaacacat aaagactgcc caataacagc
     1381 catgcagaaa gaatcacaag gatatctaag tccagagagt agccctcctg ctagtcctgt
     1441 cccagcttgc tcccagcaac aagtcatcca gcataatacc atcactactt cctcatcggt
     1501 cagcgaggtg gtaggaagct ccaccctcag ccagctcacc actcacagaa cagacctgaa
     1561 tccgattctt taaaatgcac catcagacct ggcctccaag aagagctgta gcgtaccatg
     1621 cgtcctttct tttaagggca tttttagaat taactcagac ctggaagact cctcagttct
     1681 tcaaagactg gctttcattt ttatagttat tatggaaatg ttgtctttta tacttagtta
     1741 tataagaaaa aagggagtta tgcaattaat atctatcagc ttgggaaacg ctttggtgct
     1801 tttctccagt tttctggtac cagttacttg tttataaact gaaccttttc tgtatatagc
     1861 catggtttca ttcttatcag tccaaccctt tgcctgaaac attgaatctt gttaaaccac
     1921 agcttttagc taaaatgagg tatacctaga tgtcaagtaa gacagatcca aggtaactgg
     1981 gtaggaaatc ttttgacatc ttaactcatg ttgagtttgt gctgtggtgt caccagaatt
     2041 ccagataaac acacagcctt tcccatacct ttttttttct tactataaaa tattataaga
     2101 tccattgatg tccaaataat accaccaagc atctcttcac ctctcctcct cttggtccac
     2161 ttgctaatgc ccagttttct tctccatttc cactttttct taggctccct atttactatt
     2221 cattttgact tccttctgtt ttattttttt ccctttagca ttgcatgtga ataagaaaat
     2281 aatgtttaaa gaaaaaaaaa aaaaagcaaa cctccaaaac gtggacctaa ccattgcttc
     2341 acttacactt cacccacagc tggagttcat tcaactcttg cttttcacaa aatagtaacc
     2401 aggagatgtt taatgtgcct gatttaatgt ttttaataat cacagcaaat gaaaggtggt
     2461 ttagttataa gtgaagcatg gttgaatacc agctggggag acactaggga agggagcttt
     2521 gtaagccttg attgcgaaag tccaaatttt gatgtggggc tataacatga cacccttgga
     2581 ttgcgactgg ttttatacgg cctgcctata acgttgaaaa tccatgtact acataataat
     2641 tcagaagggc tctattcact acacagatta cattgttcaa tcatcagctg ctaatagcct
     2701 aagatttatt tttttttttt tcttaagcct atggaaccgg ctttgctgtt ctggggggtg
     2761 aaaatagact aactactgga gaaacaaaga gagaaagaaa acccagtgtt tccatagggg
     2821 cacttttagc cttcccacaa cagttaagca ctctttgact gctgaaggaa ccccatggat
     2881 gaggtgcagg ctacttcact cttttttttt cttttttgag acagagtctc acctattgcc
     2941 cagactgaag tgcagtggtg cgatcatgga tcactgcagc agcatcctcc gagttcaagc
     3001 tatccttcca cctccgcctc ctgagtagct gggaccacag gttcacataa ccatgcctgg
     3061 ctaatttatt tttactttta ttttaaaata aaagatgagg tctgtcttat gttgcccagg
     3121 ctggtctcaa actatcctac ttcttcctcc caaagtgttg ggattatagg tgtgagccac
     3181 tgcacccagc ctacttcact cttctgaatt attctgattt attttcaaca acttttgtga
     3241 acttgcccgt gatacaaagc agatagtccc tgaaccacag tcgtgcctcc ttgaaacaag
     3301 ccattctact gtgctaatgt tttaatatca catctcacaa ataacagggg tgaatgtttc
     3361 tctctagcaa tctaggcagg tgctggtgtt tcatctccat ttgaatgctt gacctcttaa
     3421 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttcatggg ttttaaaaga acagtatttt
     3481 acaaaaggtg tagcttttat aagagtgcag aaaagggaag gatgtgtttt tttctctcac
     3541 tatagtataa gaatctattt tggagaaaaa aagaaaatat gagggtctcg aagcatgatt
     3601 tttatataac tagtttcagt tttatctaat aacttacttt ttaaatcaat atttatcaac
     3661 aatctttcct tgtatgcagt gctttcaaaa gatggttttg agtgtccagt gaaacttatg
     3721 acttggatat atggttgaag aatcaaaaca aaagcaaaaa aaaaaagcaa aaaaagaaaa
     3781 gagaaaaaaa gaaaaaatgc aaatggaata attttctatt atattttaga caaacatatc
     3841 attttcgagt attttaaata ctgaattcat agttgttgtt ttttaaattc caacagtaac
     3901 agctgaatgg tttaatctga ctggcttcct aagaaatgtt taagactcag ctttaaaaag
     3961 aagttaacat tcatatctct gttttgaaat caaaaatcat atttcaaaat tctttcctag
     4021 gaccatctat gtgtctcccc tcccctccac aaaaaggaga aagagtgcat taaaatgttt
     4081 agttgggttt tttaattttt aatttttatg ttatgttttg ctttgtttta agtaaacaaa
     4141 aatttttctt tctttactgc atgcatagca cttaataaaa tggattttta aaaaatccac
     4201 tagtaatatc agaatgtcca gggagtgact gtcactacaa tgatggttta gtttacttct
     4261 gttccacctt ttgattgaaa tatttagttg ttaggctgaa agcctcggca gttaagaact
     4321 tgcctgagtt ttcttcgttc agcaacttga cagtttgact gatgtgcatt atatatagct
     4381 caattatgtc tgttttttat gctaagtagg aaaaccaacc acacacatta gcaaaccggc
     4441 ctcaacatat aattagaata aactgtcttc ttgttctact cagggccttt aggtgtgttc
     4501 attcacggta tggaaataca gtaaatgaaa gattccaact agttgtcagt gcttcttgaa
     4561 attccaaaca gaaagataca ttggtcaaat ccaacacttg gcttatcaat attaagtctt
     4621 ttacctaaag gcccagccgt caccagacaa cagaataatc aatctgcctg aaaatccctc
     4681 ctccttgtcc tacacttttt gcctgtttgg gagaatatct ttgtactcca ttctcctccc
     4741 tcagccagtt actgggtcac ccatccatgt gttcatgaat caatcatcac ggcctgcaga
     4801 gcacctgtcc taaggaggga aaatcctgtc acactgcctc tccccattcg tgtgtggttt
     4861 tcttgatcgg tgagatctgt ctctgaagtc actgccagcc tccctgggaa cgtctatagt
     4921 gcctcccctg ccttatgtga tgggagttaa caactcagat aagtacacct gagagcattt
     4981 ctatcaggta aactgtcact taaatggagg tgtccacatc ttaattgttt ctccttgaca
     5041 catttctcaa tccacgaagc caggagaggt agagtgaaaa tcccagccat ggatgaatgt
     5101 actaatttga aagccaagtg ttaagtcgga tgttttcccg ttacactact actcagccct
     5161 ctcctgcggc cacatcaacg gatgcaagtc acagtcttaa cacagcctgt gggagacaag
     5221 cagtttgtgt gctcacagta tatattatag taattagggt gacttagagc aaatactctt
     5281 cagatcctat gtagtcagtg aaacaaaatg gagagcgtat tctgatagaa ggacgtcgac
     5341 ggtgaatgtt ctggtggttg ttgcctgtta agtaaacttt agtgtgtaag ttgagtttgt
     5401 cattaaaatc ataaaccagc tgcggtaaca gacaagcctt tggctgggga gttttaagcc
     5461 tcggtaactg ctataaaact agccatccag ttaggataga atgtgtttct ttctggttaa
     5521 aaaaaggaaa aaccatctaa gaaaatatat atgtatgtat gtgtgtatac agtggaattc
     5581 aaaggaccaa agcaaaattt gaacaggaat ctattaattt agaattttat aagatattta
     5641 ttaataaatg ttatttttaa acattccatt tgaacagtat tctgtaggat ctacttgttt
     5701 ttaaagtgtt agtccataat aaactactat agttatgtgt attttcattt ttcagggttt
     5761 caaatggcta ttctccatca tttggtggaa atgtttgctt agatctctgt gcatagacat
     5821 ttcaaggatt tttattgctc tgtgagttat tttttaatca acattctgaa cagttttttt
     5881 taaacattta tttctgtgtg ttcattttta aagtaagctc tttcatttag gaagcagagt
     5941 tcagctaaag ggaatcagta actctaactg gaacagcttt cttgtagaag tgtaaaaaca
     6001 gcttcatctc tgcctctctc caccccaccc caatttccta gaaagccttg cactattcag
     6061 ctcccttagt gctttttgtc ccttcccgaa caatatgcag tagctttaag ccattcaagc
     6121 tccattatgc agtatatctg agaagggaaa ggaaacaacc catttaaatt tgaataaaac
     6181 cgtgcctatg cgaacagtag caatttagaa tctcttttct gcttttaaaa taatttatat
     6241 ttaaaaattg cactttagct ttttgatccc tttgtatttc tcttattctc tttctaacct
     6301 cttctctgtc ctcaaacttg cctttgctct cctttacaat accccccacc cctcctccaa
     6361 ggctctgagc ggcatcattt aaaatacttt acagatattt gcaccaggta catttatgtg
     6421 cgtccattgg tagcacagct gagacctgtg tctcacatca gcctaggtga agcctactac
     6481 aagaatgcca aggagaagag ccagtacact atatggttta tactctttat ccctttattc
     6541 atagcatgtt ttttaaaaat gttatattat gcaacagatg tgaggcagca gctaagctat
     6601 acttaagaat tttctctcac cttccaaacc aaagtgtcct gaataagcca ggagacttat
     6661 tcttttgtgc accctggtgc acatctgact gttgtcctag ccatagactc tctgaggcca
     6721 ctgaaagaac agtggcccta tcgatttcat tcctaggtct caaaaataca atgttgcctt
     6781 gtaacataat tagggacagc acctctattt cacaattata atctaaggta ggataagacg
     6841 acacagcagc aataaactta caagtaaaat tcaataccaa aacaaacaca aagaaattta
     6901 aaaaacaaaa aacctagctc atcatgttgt gaaaatgaaa aagtgaatgt ccattcaaaa
     6961 tattttacta tttcttgtgg agtttttcag tgatgtaatg cttgtagcca aattgcttaa
     7021 agagtgttta tatatttttt tccttataaa ttgtctattt tttaaaaaag ctatttaacc
     7081 acagctgaag tggggggtaa ggccaaattg ccaacacttg ttaaaagatt aatactctta
     7141 agtggcactc tgataccttt ccaacttgtc atcagaaagg aatcaataat taccaactgt
     7201 tgtatttaga ccaacttaca atatctagct cattagaagc caggatctag aaagctcctt
     7261 ctaagccatt taagatattc ttacattgag cttcatatta tagaacttta taggattgga
     7321 tattttacaa tagaataatt tagcctcagg actgagaatg tggaagctga ataaattagc
     7381 tttaaataca tcattaaaat cttatgcaca ataagctcat tagattctag ttttctcctt
     7441 tagaatacca atgccacaga cactacagga gataatgaaa ggtatcagtt gtgttgagtg
     7501 gagggagttt aagagaaagg acccttccca accagcagcc agtagaaaat acaacctact
     7561 cacctttttc ccttctaagt tctgctaaat cacatctgcc tcatagagaa aggaatgttg
     7621 cctttgagaa ctgtcttgga gaacagataa gcttgaaatg ttctctctag agaggacata
     7681 gggtttggga tcctctgaaa aggcccagaa aaatagctca gttcaaatac aatgttctag
     7741 gacaattgga atataaatat tgtccaaaaa tataattaaa agaaaaaagt ttagcactgt
     7801 gtaaagtaag tgttaactga ggaagtccca aaaaggtgct gtcactttaa gttctggact
     7861 tggggttctt tgtatttgta aacagcaaag catttgtgtt tgtttgtcta tttgtaaagc
     7921 aaccaccttc cttattggaa ggagaaaaaa aggggtacat acatgtaaat acttgctgca
     7981 gcatttaata tgtttaattt tgtgttaagc tttttgttgc atcgtgaaca catttattgt
     8041 taccaatgga caatgagttc attaagactg ttcaactagg tcagattttt acatctcttt
     8101 ctagcaagaa gagacaagat tttgtgcatt tgtacaaatg ttaatatcac tgcaattcca
     8161 atataataaa gcactcaaat gcaaataa
//
