LOCUS       NM_001255978            1749 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cAMP responsive element binding protein 3 like 4
            (CREB3L4), transcript variant 2, mRNA.
ACCESSION   NM_001255978
VERSION     NM_001255978.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Ito,T., Saito,A., Kamikawa,Y., Nakazawa,N. and Imaizumi,K.
  TITLE     AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in
            Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer
  JOURNAL   Mol Cancer Res 22 (4), 373-385 (2024)
   PUBMED   38236913
  REMARK    GeneRIF: AIbZIP/CREB3L4 Promotes Cell Proliferation via the
            SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative
            Breast Cancer.
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Li,C., Feng,S. and Chen,L.
  TITLE     MSC-AS1 knockdown inhibits cell growth and temozolomide resistance
            by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt
            pathway
  JOURNAL   Mol Cell Biochem 476 (2), 699-713 (2021)
   PUBMED   33106913
  REMARK    GeneRIF: MSC-AS1 knockdown inhibits cell growth and temozolomide
            resistance by regulating miR-373-3p/CPEB4 axis in glioma through
            PI3K/Akt pathway.
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Pu,Q., Lu,L., Dong,K., Geng,W.W., Lv,Y.R. and Gao,H.D.
  TITLE     The Novel Transcription Factor CREB3L4 Contributes to the
            Progression of Human Breast Carcinoma
  JOURNAL   J Mammary Gland Biol Neoplasia 25 (1), 37-50 (2020)
   PUBMED   32026099
  REMARK    GeneRIF: The Novel Transcription Factor CREB3L4 Contributes to the
            Progression of Human Breast Carcinoma.
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Jing,X., Liang,H., Hao,C., Yang,X. and Cui,X.
  TITLE     Overexpression of MUC1 predicts poor prognosis in patients with
            breast cancer
  JOURNAL   Oncol Rep 41 (2), 801-810 (2019)
   PUBMED   30483806
  REMARK    GeneRIF: Study demonstrated that MCU1 is frequently overexpressed
            in breast cancer and abnormally high expression of MUC1 indicates
            poor prognosis. Subsequent data mining across multiple large
            databases demonstrated a positive association between MUC1 mRNA
            expression CREB3L4 in breast cancer tissues. Results indicated that
            MUC1 transcript expression may regulate tumor invasion and
            metastasis associated with CREB3L4 transcription.
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Ben Aicha,S., Lessard,J., Pelletier,M., Fournier,A., Calvo,E. and
            Labrie,C.
  TITLE     Transcriptional profiling of genes that are regulated by the
            endoplasmic reticulum-bound transcription factor AIbZIP/CREB3L4 in
            prostate cells
  JOURNAL   Physiol Genomics 31 (2), 295-305 (2007)
   PUBMED   17712038
  REMARK    GeneRIF: In LNCaP cell lines that conditionally express the
            processed form of AIbZIP, downstream targets of AIbZIP include
            genes for protein processing, transcriptional regulation, small
            molecule transport, signal transduction, metabolism & cell
            homeostasis.
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Stirling,J. and O'hare,P.
  TITLE     CREB4, a transmembrane bZip transcription factor and potential new
            substrate for regulation and cleavage by S1P
  JOURNAL   Mol Biol Cell 17 (1), 413-426 (2006)
   PUBMED   16236796
  REMARK    GeneRIF: S1P cleavage of CREB4 may be suppressed by a determinant
            in the C-terminal region
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Stelzer,G. and Don,J.
  TITLE     Atce1: a novel mouse cyclic adenosine
            3',5'-monophosphate-responsive element-binding protein-like gene
            exclusively expressed in postmeiotic spermatids
  JOURNAL   Endocrinology 143 (5), 1578-1588 (2002)
   PUBMED   11956138
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Qi,H., Fillion,C., Labrie,Y., Grenier,J., Fournier,A., Berger,L.,
            El-Alfy,M. and Labrie,C.
  TITLE     AIbZIP, a novel bZIP gene located on chromosome 1q21.3 that is
            highly expressed in prostate tumors and of which the expression is
            up-regulated by androgens in LNCaP human prostate cancer cells
  JOURNAL   Cancer Res 62 (3), 721-733 (2002)
   PUBMED   11830526
  REMARK    GeneRIF: AIbZIP, a novel bZIP gene located on chromosome 1q21.3
            that is highly expressed in prostate tumors and of which the
            expression is up-regulated by androgens in LNCaP human prostate
            cancer cells.
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Cao,G., Ni,X., Jiang,M., Ma,Y., Cheng,H., Guo,L., Ji,C., Gu,S.,
            Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human cAMP
            response element-binding (CREB) gene (CREB4)
  JOURNAL   J Hum Genet 47 (7), 373-376 (2002)
   PUBMED   12111373
  REMARK    GeneRIF: identified a novel human CREB gene (CREB4) that was 1592
            bp long and encoded a protein of 395 amino acid residues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB012316.1 and AY049977.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001255978.1.
            
            Summary: This gene encodes a CREB (cAMP responsive element binding)
            protein with a transmembrane domain which localizes it to the ER
            membrane. The encoded protein is a transcriptional activator which
            contains a dimerization domain, and this protein may function in a
            number of processing pathways including protein processing.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY049977.1, BC038962.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368607.8/ ENSP00000357596.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB012316.1         64-64
            2-1749              AY049977.1         1-1748
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1749
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /note="cAMP responsive element binding protein 3 like 4"
                     /db_xref="GeneID:148327"
                     /db_xref="HGNC:HGNC:18854"
                     /db_xref="MIM:607138"
     exon            1..263
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            264..441
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1455
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /note="isoform 1 is encoded by transcript variant 2;
                     cyclic AMP-responsive element-binding protein 3-like
                     protein 4; cAMP responsive element binding protein 1;
                     CREB-4; tisp40; attaching to CRE-like 1; cAMP-responsive
                     element-binding protein 4; androgen-induced basic leucine
                     zipper protein; cyclic AMP-responsive element-binding
                     protein 4; transcript induced in spermiogenesis protein
                     40; cAMP-responsive element-binding protein 3-like protein
                     4; Androgen-Induced bZIP"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 4 isoform 1"
                     /protein_id="NP_001242907.1"
                     /db_xref="CCDS:CCDS1056.1"
                     /db_xref="GeneID:148327"
                     /db_xref="HGNC:HGNC:18854"
                     /db_xref="MIM:607138"
                     /translation="MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQE
                     QGLQGWKSGGDRGCGLQESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPP
                     APRATSSPMLYEVVYEAGALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPF
                     DAHAHILPRAGTVAPVPCTTLLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVL
                     KKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQKKVQELERHNISLVAQ
                     LRQLQTLIAQTSNKAAQTSTCVLILLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTS
                     RNILTHKDVTENLETQVVESRLREPPGAKDANGSTRTLLEKMGGKPRPSGRIRSVLHA
                     DEM"
     exon            442..688
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            689..810
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            811..903
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1010
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1079
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1164
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1261
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1749
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1730..1735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /note="hexamer: AATAAA"
     polyA_site      1749
                     /gene="CREB3L4"
                     /gene_synonym="AIBZIP; ATCE1; CREB3; CREB4; hJAL; JAL"
                     /note="major polyA site"
ORIGIN      
        1 gcctttgttt acaaccctgc catgatctcc ctcttgcaaa agcgagggct acagaacagg
       61 cattcaggag tcctgtgctc cagtcacagc cttttctgtt cttcagctag gagacaccaa
      121 accctcagga agatttacta tagctaagag aaaactgcag cagaaagggc gcggctacct
      181 acttcttaaa ttccgtttgt ggaccctcag actcttagtc ccctactccc agatacagcg
      241 gccctaccgt ggctcctggc aagaagcatg gatctcggaa tccctgacct gctggacgcg
      301 tggctggagc ccccagagga tatcttctcg acaggatccg tcctggagct gggactccac
      361 tgcccccctc cagaggttcc ggtaactagg ctacaggaac agggactgca aggctggaag
      421 tccggtgggg accgtggctg tggccttcaa gagagtgagc ctgaagattt cttgaagctt
      481 ttcattgatc ccaatgaggt gtactgctca gaagcatctc ctggcagtga cagtggcatc
      541 tctgaggacc cctgccatcc agacagtccc cctgccccca gggcaaccag ttctcctatg
      601 ctctatgagg ttgtctatga ggcaggggcc ctggagagga tgcaggggga aactgggcca
      661 aatgtaggcc ttatctccat ccagctagat cagtggagcc cagcatttat ggtgcctgat
      721 tcctgcatgg tcagtgagct gccctttgat gctcatgccc acatcctgcc cagagcaggc
      781 accgtagccc cagtgccctg tacaaccctg ctgccctgtc aaaccctgtt cctgaccgat
      841 gaggagaagc gtctgctggg gcaggaaggg gtttccctgc cctctcacct gcccctcacc
      901 aaggcagagg agagggtcct caagaaggtc aggaggaaaa tccgtaacaa gcagtcagct
      961 caggacagtc ggcggcggaa gaaggagtac attgatgggc tggagagcag ggtggcagcc
     1021 tgttctgcac agaaccaaga attacagaaa aaagtccagg agctggagag gcacaacatc
     1081 tccttggtag ctcagctccg ccagctgcag acgctaattg ctcaaacttc caacaaagct
     1141 gcccagacca gcacttgtgt tttgattctt cttttttccc tggctctcat catcctgccc
     1201 agcttcagtc cattccagag tcgaccagaa gctgggtctg aggattacca gcctcacgga
     1261 gtgacttcca gaaatatcct gacccacaag gacgtaacag aaaatctgga gacccaagtg
     1321 gtagagtcca gactgaggga gccacctgga gccaaggatg caaatggctc aacaaggaca
     1381 ctgcttgaga agatgggagg gaagccaaga cccagtgggc gcatccggtc cgtgctgcat
     1441 gcagatgaga tgtgagctgg aacagacctt cctggcccac ttcctgatca caaggaatcc
     1501 tgggcttcct tatggctttg cttcccactg ggattcctac ttaggtgtct gccctcaggg
     1561 gtccaaatca cttcaggaca ccccaagaga tgtcctttag tctctgcctg aggcctagtc
     1621 tgcatttgtt tgcatatatg agagggtacc tcaaatactt ctgttatgta tctgtgattt
     1681 tatttcttct ttgggtatag ggttgagggg aaataagttt tgagtgagaa ataaacgttt
     1741 tagctgaaa
//
