LOCUS       NM_032607               2588 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cAMP responsive element binding protein 3 like 3
            (CREB3L3), transcript variant 1, mRNA.
ACCESSION   NM_032607
VERSION     NM_032607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2588)
  AUTHORS   Kim,H., Song,Z., Zhang,R., Davies,B.S.J. and Zhang,K.
  TITLE     A hepatokine derived from the ER protein CREBH promotes
            triglyceride metabolism by stimulating lipoprotein lipase activity
  JOURNAL   Sci Signal 16 (768), eadd6702 (2023)
   PUBMED   36649378
  REMARK    GeneRIF: A hepatokine derived from the ER protein CREBH promotes
            triglyceride metabolism by stimulating lipoprotein lipase activity.
REFERENCE   2  (bases 1 to 2588)
  AUTHORS   Shimizu-Albergine,M., Basu,D., Kanter,J.E., Kramer,F., Kothari,V.,
            Barnhart,S., Thornock,C., Mullick,A.E., Clouet-Foraison,N.,
            Vaisar,T., Heinecke,J.W., Hegele,R.A., Goldberg,I.J. and
            Bornfeldt,K.E.
  TITLE     CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes
            by decreasing circulating remnant lipoproteins
  JOURNAL   J Clin Invest 131 (22) (2021)
   PUBMED   34491909
  REMARK    GeneRIF: CREBH normalizes dyslipidemia and halts atherosclerosis in
            diabetes by decreasing circulating remnant lipoproteins.
REFERENCE   3  (bases 1 to 2588)
  AUTHORS   Dron,J.S., Dilliott,A.A., Lawson,A., McIntyre,A.D., Davis,B.D.,
            Wang,J., Cao,H., Movsesyan,I., Malloy,M.J., Pullinger,C.R.,
            Kane,J.P. and Hegele,R.A.
  TITLE     Loss-of-Function CREB3L3 Variants in Patients With Severe
            Hypertriglyceridemia
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (8), 1935-1941 (2020)
   PUBMED   32580631
  REMARK    GeneRIF: Loss-of-Function CREB3L3 Variants in Patients With Severe
            Hypertriglyceridemia.
REFERENCE   4  (bases 1 to 2588)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2588)
  AUTHORS   Nakagawa,Y. and Shimano,H.
  TITLE     CREBH Regulates Systemic Glucose and Lipid Metabolism
  JOURNAL   Int J Mol Sci 19 (5), 1396 (2018)
   PUBMED   29738435
  REMARK    GeneRIF: CREBH has a crucial role in glucose and lipid metabolism
            in the liver and small intestine.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2588)
  AUTHORS   Bailey,D., Barreca,C. and O'Hare,P.
  TITLE     Trafficking of the bZIP transmembrane transcription factor CREB-H
            into alternate pathways of ERAD and stress-regulated intramembrane
            proteolysis
  JOURNAL   Traffic 8 (12), 1796-1814 (2007)
   PUBMED   17875199
  REMARK    GeneRIF: analysis of CREB-H trafficking into alternate pathways of
            ERAD and stress-regulated intramembrane proteolysis
REFERENCE   7  (bases 1 to 2588)
  AUTHORS   Zhang,K., Shen,X., Wu,J., Sakaki,K., Saunders,T., Rutkowski,D.T.,
            Back,S.H. and Kaufman,R.J.
  TITLE     Endoplasmic reticulum stress activates cleavage of CREBH to induce
            a systemic inflammatory response
  JOURNAL   Cell 124 (3), 587-599 (2006)
   PUBMED   16469704
REFERENCE   8  (bases 1 to 2588)
  AUTHORS   Stirling,J. and O'hare,P.
  TITLE     CREB4, a transmembrane bZip transcription factor and potential new
            substrate for regulation and cleavage by S1P
  JOURNAL   Mol Biol Cell 17 (1), 413-426 (2006)
   PUBMED   16236796
REFERENCE   9  (bases 1 to 2588)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
REFERENCE   10 (bases 1 to 2588)
  AUTHORS   Omori,Y., Imai,J., Watanabe,M., Komatsu,T., Suzuki,Y., Kataoka,K.,
            Watanabe,S., Tanigami,A. and Sugano,S.
  TITLE     CREB-H: a novel mammalian transcription factor belonging to the
            CREB/ATF family and functioning via the box-B element with a
            liver-specific expression
  JOURNAL   Nucleic Acids Res 29 (10), 2154-2162 (2001)
   PUBMED   11353085
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313099.1, AB050902.1 and
            AB073612.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032607.2.
            
            Summary: This gene encodes a member of the basic-leucine zipper
            family and the AMP-dependent transcription factor family. The
            encoded protein is localized to the endoplasmic reticulum and acts
            as a transcription factor activated by cyclic AMP stimulation. The
            encoded protein binds the cyclic AMP response element (CRE) and the
            box-B element and has been linked to acute inflammatory response,
            hepatocellular carcinoma, triglyceride metabolism, and hepcidin
            expression. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB050902.1, SRR1660803.50103.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000078445.7/ ENSP00000078445.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK313099.1         3-3
            2-31                AB050902.1         1-30
            32-32               AB073612.1         23-23
            33-2585             AB050902.1         32-2584
            2586-2588           AB073612.1         2574-2576
FEATURES             Location/Qualifiers
     source          1..2588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2588
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /note="cAMP responsive element binding protein 3 like 3"
                     /db_xref="GeneID:84699"
                     /db_xref="HGNC:HGNC:18855"
                     /db_xref="MIM:611998"
     exon            1..144
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1503
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /note="isoform a is encoded by transcript variant 1;
                     CREB/ATF family transcription factor; cyclic
                     AMP-responsive element-binding protein 3-like protein 3;
                     cAMP-responsive element-binding protein, hepatic-specific"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 3 isoform a"
                     /protein_id="NP_115996.1"
                     /db_xref="CCDS:CCDS12121.1"
                     /db_xref="GeneID:84699"
                     /db_xref="HGNC:HGNC:18855"
                     /db_xref="MIM:611998"
                     /translation="MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGE
                     GWGHVKDQQVLPNPDSDDFLSSILGSGDSLPSSPLWSPEGSDSGISEDLPSDPQDTPP
                     RSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGR
                     ICAEKPADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTED
                     EKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMS
                     ACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAVLLLSFALI
                     ILPSISPFGPNKTESPGDFAPVRVFSRTLHNDAASRVAADAVPGSEAPGPRPEADTTR
                     EESPGSPGADWGFQDTANLTNSTEELDNATLVLRNATEGLGQVALLDWVAPGPSTGSG
                     RAGLEAAGDEL"
     exon            145..273
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            274..574
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..693
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..831
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..938
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1007
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1092
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1189
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..2588
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2569..2574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /note="hexamer: AATAAA"
     polyA_site      2588
                     /gene="CREB3L3"
                     /gene_synonym="CREB-H; CREBH; HYST1481; HYTG2"
                     /note="major polyA site"
ORIGIN      
        1 gacagagcca cagagggctg tgagcttgcc cggccccagg taacgctggc ggtgggtggg
       61 cctccagctt ggagcagaga ccccccgagg catctgcaga cagaactgga tggacccatg
      121 aatacggatt tagctgctgg aaagatggct tctgctgcct gctccatgga ccccatcgac
      181 agctttgagc tcctggatct cctgtttgac cggcaggacg gcatcctgag acacgtggag
      241 ctgggcgagg gctggggtca cgtcaaggac cagcaggtcc tgccaaaccc cgactctgac
      301 gacttcctca gctccatcct gggctctgga gactcactgc ccagctcccc actctggtcc
      361 cccgaaggca gtgatagtgg catctccgaa gacctcccct ccgaccccca ggacacccct
      421 ccacgcagcg gaccagccac ctcccccgcc ggctgccatc ctgcccagcc tggcaagggg
      481 ccctgcctct cctatcatcc tggcaactct tgctccacca caaccccagg gccagtgatc
      541 caagtacctg aagcctctgt gaccatagac ctggaaatgt ggagcccagg aggaaggatc
      601 tgtgctgaga agccggctga tccggtggac ctgtccccac gatgcaatct caccgtgaaa
      661 gacctcctcc tttcgggcag cagtggggac ctgcaacagc atcacctggg ggcctcctac
      721 ctcctgcgac ctggggctgg gcactgtcag gagctggtgc tcaccgagga tgagaagaag
      781 ctgctggcta aagaaggcat caccctgccc actcagctgc ccctcactaa gtacgaggag
      841 cgagtgctga aaaaaatccg ccggaaaatc cggaacaagc agtcggcgca agaaagcagg
      901 aagaagaaga aggaatatat cgatggcctg gagactcgga tgtcagcttg cactgctcag
      961 aatcaggagt tacagaggaa agtcttgcat ctcgagaagc aaaacctgtc cctcttggag
     1021 caactgaaga aactccaggc cattgtggtg cagtccacca gcaagtcagc ccagacaggc
     1081 acctgtgtcg cagtcctgtt gctgtccttt gccctcatca tcctcccctc catcagccct
     1141 tttggcccca acaaaaccga gagccctggg gactttgcgc ctgtacgagt gttctccaga
     1201 actttgcaca acgatgctgc ctcccgcgtg gctgctgatg ctgtgccagg ctccgaggcc
     1261 ccaggacccc gacccgaggc tgacacaacc cgagaagagt ctccaggaag ccccggggca
     1321 gactggggct tccaggacac cgcgaacctg accaattcga cggaggagct ggacaacgcc
     1381 accctggtcc tgaggaatgc aacagagggg ctgggccagg tcgccctgct ggactgggtg
     1441 gcgcctgggc cgagcactgg ctcaggacgt gcagggctgg aggcggcggg agacgagctg
     1501 tgagccccgc caggactatg ctcccaggcc cctctgccca ggggtgcctt ggggatgctg
     1561 cactgggcag ctacccacct ggggatggga cgtgaggcca agaccccagc agagatgcca
     1621 gaatggggga ggcacagctc atagccacac acccagggcc tgactgaggc ccacgcagga
     1681 accgacactc agacacaagg caaagagggc cacaggaccc gggaaataca cacagagcca
     1741 ggagcagaag caaagagcag acacacatac agcctgaaac agacctggac agacagacac
     1801 agcctgaaac agacccggac agacagacac agcctgaaac agacccagac aaacagacag
     1861 acagacacag cctgaaacag acccagacag acagacagac agcctgaaac agacccagac
     1921 acagcctgaa acagatccgg acagacagac agaaacagcc tgaaacagac ccagacagac
     1981 agacagacac agcctgaaac agacccggac agacagacag acacagcctg aaacagaccc
     2041 ggacagacag acagacacag cctgaaacag acccggacag acagacagac acagcctgaa
     2101 acagacctag acagacagac acagattgaa acagacccag acaaacagac agacacagcc
     2161 tgaaacagac ccagacacag cctgaaacag acccggacag acagacagac acagcctgaa
     2221 acagacccag acagacagac agacacagcc tgaaacagac ccagacagac agaccgacgc
     2281 agcctgaaag agacccagac agagagacag gcagacacag cctaaaacag acctggacag
     2341 acaggcagac gtagtctgaa acagacctga acagacagac agacgcacac acacaacaga
     2401 tgcgcagcaa ctccccgccc agggacccct cccggcctcc ctcgcacact gggaggagga
     2461 agccgccgag actgcaggga gcctggcccc ggagccccgg gtgcgccctg gtctttggag
     2521 cagccacggc ccacaatcac cccccttttc taagactgcc tgatccgaaa taaagtattt
     2581 tgacagaa
//
