LOCUS       NM_194071               7441 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cAMP responsive element binding protein 3 like 2
            (CREB3L2), transcript variant 1, mRNA.
ACCESSION   NM_194071 XM_291242
VERSION     NM_194071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7441)
  AUTHORS   Hu,L., Chen,X., Narwade,N., Lim,M.G.L., Chen,Z., Tennakoon,C.,
            Guan,P., Chan,U.I., Zhao,Z., Deng,M., Xu,X., Sung,W.K. and
            Cheung,E.
  TITLE     Single-cell analysis reveals androgen receptor regulates the
            ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate
            cancer progression
  JOURNAL   Oncogene 40 (47), 6479-6493 (2021)
   PUBMED   34611310
  REMARK    GeneRIF: Single-cell analysis reveals androgen receptor regulates
            the ER-to-Golgi trafficking pathway with CREB3L2 to drive prostate
            cancer progression.
REFERENCE   2  (bases 1 to 7441)
  AUTHORS   Oh-Hashi,K., Yamamoto,A., Murase,R. and Hirata,Y.
  TITLE     Comparative Analysis of CREB3 and CREB3L2 Protein Expression in
            HEK293 Cells
  JOURNAL   Int J Mol Sci 22 (5), 2767 (2021)
   PUBMED   33803345
  REMARK    GeneRIF: Comparative Analysis of CREB3 and CREB3L2 Protein
            Expression in HEK293 Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7441)
  AUTHORS   Huang,W., Ji,R., Ge,S., Zhou,D., Liu,Z., Sun,Y., Huang,W. and Lu,C.
  TITLE     MicroRNA-92b-3p promotes the progression of liver fibrosis by
            targeting CREB3L2 through the JAK/STAT signaling pathway
  JOURNAL   Pathol Res Pract 219, 153367 (2021)
   PUBMED   33618248
  REMARK    GeneRIF: MicroRNA-92b-3p promotes the progression of liver fibrosis
            by targeting CREB3L2 through the JAK/STAT signaling pathway.
REFERENCE   4  (bases 1 to 7441)
  AUTHORS   Matsuhisa,K., Saito,A., Cai,L., Kaneko,M., Okamoto,T., Sakaue,F.,
            Asada,R., Urano,F., Yanagida,K., Okochi,M., Kudo,Y., Matsumoto,M.,
            Nakayama,K.I. and Imaizumi,K.
  TITLE     Production of BBF2H7-derived small peptide fragments via
            endoplasmic reticulum stress-dependent regulated intramembrane
            proteolysis
  JOURNAL   FASEB J 34 (1), 865-880 (2020)
   PUBMED   31914686
  REMARK    GeneRIF: found BBF2H7-derived small peptide fragments located
            between the site-1 protease and site-1 protease cleavage sites in
            cells exposed to ER stress
REFERENCE   5  (bases 1 to 7441)
  AUTHORS   Pellegrin,S., Haydn-Smith,K.L., Hampton-O'Neil,L.A., Hawley,B.R.,
            Heesom,K.J., Fermo,E., Bianchi,P. and Toye,A.M.
  TITLE     Transduction with BBF2H7/CREB3L2 upregulates SEC23A protein in
            erythroblasts and partially corrects the hypo-glycosylation
            phenotype associated with CDAII
  JOURNAL   Br J Haematol 184 (5), 876-881 (2019)
   PUBMED   29536501
  REMARK    GeneRIF: Transduction with BBF2H7/CREB3L2 upregulates SEC23A
            protein in erythroblasts and partially corrects the
            hypo-glycosylation phenotype associated with CDAII.
REFERENCE   6  (bases 1 to 7441)
  AUTHORS   Lui,W.O., Zeng,L., Rehrmann,V., Deshpande,S., Tretiakova,M.,
            Kaplan,E.L., Leibiger,I., Leibiger,B., Enberg,U., Hoog,A.,
            Larsson,C. and Kroll,T.G.
  TITLE     CREB3L2-PPARgamma fusion mutation identifies a thyroid signaling
            pathway regulated by intramembrane proteolysis
  JOURNAL   Cancer Res 68 (17), 7156-7164 (2008)
   PUBMED   18757431
  REMARK    GeneRIF: findings identify a novel CREB3L2-PPARgamma gene fusion
            mutation in thyroid carcinoma and reveal a thyroid signaling
            pathway that is regulated by intramembrane proteolysis and
            disrupted in cancer
REFERENCE   7  (bases 1 to 7441)
  AUTHORS   Guillou,L., Benhattar,J., Gengler,C., Gallagher,G.,
            Ranchere-Vince,D., Collin,F., Terrier,P., Terrier-Lacombe,M.J.,
            Leroux,A., Marques,B., Aubain Somerhausen Nde,S., Keslair,F.,
            Pedeutour,F. and Coindre,J.M.
  TITLE     Translocation-positive low-grade fibromyxoid sarcoma:
            clinicopathologic and molecular analysis of a series expanding the
            morphologic spectrum and suggesting potential relationship to
            sclerosing epithelioid fibrosarcoma: a study from the French
            Sarcoma Group
  JOURNAL   Am J Surg Pathol 31 (9), 1387-1402 (2007)
   PUBMED   17721195
  REMARK    GeneRIF: Presence of FUS/CREB3L2 and FUS/CREB3L1 in low-grade
            fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma
            suggests these neoplasms may be related.
REFERENCE   8  (bases 1 to 7441)
  AUTHORS   Kondo,S., Saito,A., Hino,S., Murakami,T., Ogata,M., Kanemoto,S.,
            Nara,S., Yamashita,A., Yoshinaga,K., Hara,H. and Imaizumi,K.
  TITLE     BBF2H7, a novel transmembrane bZIP transcription factor, is a new
            type of endoplasmic reticulum stress transducer
  JOURNAL   Mol Cell Biol 27 (5), 1716-1729 (2007)
   PUBMED   17178827
  REMARK    GeneRIF: BBF2H7, a novel transmembrane bZIP transcription factor,
            is a new type of endoplasmic reticulumm stress transducer.
REFERENCE   9  (bases 1 to 7441)
  AUTHORS   Panagopoulos,I., Moller,E., Dahlen,A., Isaksson,M., Mandahl,N.,
            Vlamis-Gardikas,A. and Mertens,F.
  TITLE     Characterization of the native CREB3L2 transcription factor and the
            FUS/CREB3L2 chimera
  JOURNAL   Genes Chromosomes Cancer 46 (2), 181-191 (2007)
   PUBMED   17117415
  REMARK    GeneRIF: CREB3L2 is not only structurally, but also functionally
            very similar to CREB3L1.
REFERENCE   10 (bases 1 to 7441)
  AUTHORS   Storlazzi,C.T., Mertens,F., Nascimento,A., Isaksson,M., Wejde,J.,
            Brosjo,O., Mandahl,N. and Panagopoulos,I.
  TITLE     Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma
  JOURNAL   Hum Mol Genet 12 (18), 2349-2358 (2003)
   PUBMED   12915480
  REMARK    GeneRIF: BBF2H7 was fused with FUS in a low grade myxoid
            liposarcoma.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ711676.1, AK131517.1, BX649143.1, AC022173.7 and CR749563.1.
            
            On Nov 23, 2018 this sequence version replaced NM_194071.3.
            
            Summary: This gene encodes a member of the oasis bZIP transcription
            factor family. Members of this family can dimerize but form
            homodimers only. The encoded protein is a transcriptional
            activator. Translocations between this gene on chromosome 7 and the
            gene fused in sarcoma on chromosome 16 can be found in some tumors.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.121180.1, BC110813.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330387.11/ ENSP00000329140.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               BQ711676.1         15-306
            293-1493            AK131517.1         274-1474
            1494-2664           BX649143.1         1101-2271
            2665-4913           AC022173.7         90542-92790
            4914-7441           CR749563.1         4609-7136
FEATURES             Location/Qualifiers
     source          1..7441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..7441
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /note="cAMP responsive element binding protein 3 like 2"
                     /db_xref="GeneID:64764"
                     /db_xref="HGNC:HGNC:23720"
                     /db_xref="MIM:608834"
     exon            1..483
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1944
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TCAG_1951439; basic transcription factor 2; cyclic
                     AMP-responsive element-binding protein 3-like protein 2;
                     B-ZIB transcription factor; FUS/BBF2H7 protein; BBF2 human
                     homolog on chromosome 7; cAMP-responsive element-binding
                     protein 3-like protein 2"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 2 isoform 1"
                     /protein_id="NP_919047.2"
                     /db_xref="CCDS:CCDS34760.1"
                     /db_xref="GeneID:64764"
                     /db_xref="HGNC:HGNC:23720"
                     /db_xref="MIM:608834"
                     /translation="MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFS
                     QNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSD
                     SFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPL
                     EMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSL
                     SPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIA
                     EGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENL
                     ELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFG
                     SFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGEL
                     GGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLK
                     VVELDRRVNTTF"
     exon            484..700
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            701..876
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            877..964
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1149
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1296
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1355
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1424
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1524
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1651
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1868
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..7441
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7416..7421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /note="hexamer: AATAAA"
     polyA_site      7441
                     /gene="CREB3L2"
                     /gene_synonym="BBF2H7"
                     /note="major polyA site"
ORIGIN      
        1 agagccgagg agccctgggg tccctcaaag tttgtgtctg gagccgtagc ggcaagtggg
       61 cttgcggcta agggattttc ctgggatgag agcgggtctt ctgccttcat tttggatgca
      121 catcccgctt tagccccggc agcctttggt ccggctcgtg tccctgggga ttctcggatc
      181 tccgaggaca ccggacggga gcgcttggcc atcctctctc cggcagagga gcagacgttt
      241 gctttccaag tgcaaaacta cagacacgcg cgcgcacaca cgcaagcaca cgcggagaga
      301 gaggaacctt gccggtccga ggcagctctg cgcgtcccct cctgcgctta gcatcctcgg
      361 cccagcgcgg cccgcaccgc catggaggtg ctggagagcg gggagcaggg cgtgctgcag
      421 tgggaccgca agctgagcga gctgtcagag cccggggacg gcgaggccct catgtaccac
      481 acgcacttct cagaacttct ggatgagttt tcccagaacg tcttgggtca gctcctgaat
      541 gatcctttcc tctcagagaa gagtgtgtca atggaggtgg aaccttcccc gacgtccccg
      601 gcgcctctca tccaggctga gcacagctac tccctgtgcg aggagcctcg ggcccagtcg
      661 cccttcaccc acattaccac cagtgacagc ttcaatgacg atgaggtgga aagtgagaaa
      721 tggtacctgt ctacagactt cccttcaaca tccatcaaga cagagccagt tacagacgaa
      781 ccacccccag gactcgttcc gtctgtcact ctgaccatca cagccatctc caccccgttg
      841 gaaaaggagg aacctcctct ggaaatgaac actggggttg attcctcgtg ccagaccatt
      901 attcctaaaa ttaagctgga gcctcatgaa gtggatcagt ttctaaactt ctctcctaaa
      961 gaagccccag tggaccacct gcatttgccg cccacccctc cgagcagtca cggcagtgac
     1021 tcagagggca gcctgagtcc caacccacgc ctgcacccct tcagcctgcc tcagacccac
     1081 agcccctcca gagctgcacc ccgggccccc tccgccctct ccagctcccc tctcctcacg
     1141 gctcctcata aactgcaggg atcaggccct ctggtcctga cagaggagga gaagaggacc
     1201 ctgatcgctg agggctatcc catccccacc aaattgcccc tgtcaaaatc agaggagaag
     1261 gccctgaaga aaattcggag gaagatcaag aataagattt ctgctcagga aagtaggaga
     1321 aagaagaaag aatacatgga cagcctggag aaaaaagtgg agtcttgttc aactgagaac
     1381 ttggagcttc ggaagaaggt agaggttcta gagaacacta ataggactct ccttcagcaa
     1441 ctccagaagc ttcagacttt ggtgatgggc aaggtttctc gaacctgcaa gttagctggc
     1501 acgcagactg gcacctgcct catggttgtg gtgctgtgct ttgccgttgc attcggcagc
     1561 ttctttcaag gctacgggcc ctatccttct gccaccaaga tggctctgcc cagccagcat
     1621 tccctgcagg agccctacac agcctccgtg gtgagatcca gaaacctgct gatctacgag
     1681 gaacattctc ccccagagga gtcatccagc ccgggctcgg ctggggagct ggggggctgg
     1741 gatagaggtt cctccctgct cagggtgtca gggctggagt ccaggccgga tgtggatctt
     1801 ccccatttca ttatctcgaa tgagaccagc ctggagaagt cagtgctttt ggagctgcag
     1861 cagcacctgg tcagcgccaa actggagggg aatgaaacac taaaagttgt agaactcgac
     1921 agaagagtga acaccacttt ctaaagaggc tgcctgcacc ccctcccttt cccttaactc
     1981 tacttttaca tccccaaacc acctttgtca tcagcttttc ctctttgcca ctggatcttc
     2041 atggagacat gggcaagcat tagtggcttc agattggaga ccagcctggg acttccctgc
     2101 agtgagagag catctccccc tggtccatgc ccctcctgtg cagaagggag cctgcatccc
     2161 tcccttcctt tctcttactg ccataggaaa ttattttagg ggttggaggt gggacaagca
     2221 ggcttgtttc caccaatagt gccaaaaaga tattgcctaa tgtgcacctg tgaggtgtaa
     2281 ccccccgctt tggagacgag atggctcttg ttcagtcaag accccagact ctggccacaa
     2341 aaatgccata atgcctgttg gtatttggca aagcactgac ccgtgtcctc cgttgctcgc
     2401 actggggtct ctggtgtgaa cacccccgac agcagccctc cgcccactct gccccctggg
     2461 agccctcgct ggatcgtctc gtctcctgca gcagcactgg caggcgaggg ctctcgttca
     2521 tattctcagg ccgcaagtgc aatgcctgag gggatcaggc ttttctactc caggcaaacc
     2581 tgccccatct tgtcgctttt aggacctccc acaacctggt tccccacaca tccatagttc
     2641 tgcctcccca gcttctcctc cccagttgta aatagtattt attagcttgc cgaggcttcc
     2701 tgctagcaac cacactgaag agatcgatgc ctcctttcaa gctagccaag ttttctgcga
     2761 gccttcagag ctaggagggc accctaggct ctgggatccc gtgtctttcc agacaatgtt
     2821 ttgtttcctt tcctttgttt tttcttttaa ctggaataat taccattgaa aaagaagttc
     2881 ctttgagcat gtatgtgtct gcctctagga tgagctcaga gcgagagatg acacaatgcc
     2941 tcactcaggc cccgggctcc ctggccacaa gctttttcta tcctgttttc atgacagaga
     3001 aggggaagcc ctgttctgac aacagacatt tcagacaacc ttgctggctt tccacacctg
     3061 cctggccccc tcctccctcc acacttccac tttgtcctcc tcgtccccta cctcaacaaa
     3121 gcagggtggg gtaggtgaca tttgtgtatc cacattctta cctttggtag tcaggtttgg
     3181 ctactttgca gctcgcccaa agagatacaa cctaatcccc aacctacttt tagttttttt
     3241 gttttttttt tatggttaaa agtaactttt gtagtttaaa aaaatctttc ctctttcata
     3301 taaataagaa gtggaaattg cctttttatt gtgtaatgta gaaaaccctc aagtgttttt
     3361 tccgagcttg ggaaagattt tgtgtaggaa atgtgcatag agtttgtatt ttatttttat
     3421 tagcagctga aatgcctttg gttttggctt ctctctctcc ctctctctct ctgtctctcc
     3481 ttctctctct ccccccacca cccaccccca cacacgtcat ctgcattgtt attggagcct
     3541 gtacttagag ggattaagcc cacaccctgg cttccattcc atatcaggta caggatttga
     3601 tgttattaac atttgtcgtc atacctcata agtcggtccc tgccttgtct gtctaggccc
     3661 atttggggct ccctgtgagt gattcccctc tctctgctat gctggagacg gttccagcct
     3721 ggaaagcggc caagttcatc ttctcactgt gagtggaagc tggatcgggc ccccgtagtc
     3781 ctggcagccc tgttgtctgg agggttcttg ttgtccctcc cattagccag ggcggagact
     3841 gtctgagctg tgcaggagga gggttgctag taggttctgc ttctgcttct ctctgctcca
     3901 ctgtctgcag cccagatcct gttgggcctg gctggtgtct ggtaaccatg ggcctccact
     3961 gacccatccc tctcttttaa actgtcaggt cattatcagg cataggcagc ctatagggcc
     4021 caaagaaggc aaaaagataa gatttactca agtagcattt gggcaatgag gaaggaaagg
     4081 tttcaaattt aggggcagaa gtgagagaat gagccaaccc atgtacctgc tgcaactgaa
     4141 ccagactggg ttttcaaggc tcccagacgt agagtaggaa acgtgctctt ctaaatgagg
     4201 agggagaaga taaaggaaac ttctagcccc tgtccttagt gctttgagga ttttattttc
     4261 tcccttacta cgcttgcttg acgtcactct ctctcgacct ccaaacagca ggactctttc
     4321 tctgggaaac catccttcca aaacggaatc tatgtagaca atgggacgtt aggcagagag
     4381 ctcagatggc ccttttaagg gggctccaag aaccaacatc actgctcttt tagataaacc
     4441 tctgccctcc actccttgct tgagtgggtt aaaggaacta acagttgtcc ctttaggagg
     4501 acaaaatggg gtcaagagga cacagaagag ttgtatagca ccagattggt tccaaatagt
     4561 taatggatgt gtgcacattt tctgttcagg gattaagacc agaatatcag tggatttgtt
     4621 ttccccacca agtggcctct tagactagtc attaacttat gattagctct aaagatttca
     4681 aatagtggca gacagtgtct tctgaatgta agttttgaga aatacgagtc tgtcagagcg
     4741 gccataagcc ataaagagtc aatctcttaa ttatattttt catcatgtaa acaagtttcc
     4801 catttccctt tcttagattg caccagtgaa ggagatgttt tgcaaagatt cagagaacta
     4861 atttttcact ggataagacc tgagtaaccc agacccccca ccgtggttct tttcacagcc
     4921 ctcgactttg cacttaaaaa gggatattgt aaatgaaagg ctgcagtgcc agttttaaga
     4981 aagaatttct gtgaagtgtg aggactctgg agtctagctc acataaagag agtgttatat
     5041 aaaaatccga cagctgaact aggttgctct tttttggcag ggagtgggga tgagatttga
     5101 caccaatatg ggcaaaatta gataaccttt tggttaatat aaatgatttt gatttggagg
     5161 cctaatttgt agattgtgaa agcagctttt agtttaactt attcacagac cccttataat
     5221 taccatgttt ttttttttct tcctaaatct cttggttcag cttgtgaatc ttacgtgccc
     5281 gtaaagttgg gatgttgaat tggctcttct ttgttctggc agtgagtcaa gtgtccagca
     5341 ttttttcata agtgtttttt aaaattgttc tccagcattt tatggctcct ccctcccatg
     5401 tcctcagacc cagcaaaagc gtagaggcag aattagaggc ctctccaggc cagctcctct
     5461 gcccacatgt catacaaggt gtgaatttga gcacagtcca gaaatggaga catcccaccc
     5521 ccagttgaat aatggcccat tcatgccaac cttgccaaca cggagagggc agagatgcac
     5581 tagaagacct tcatcctccc cttcctctgc cccaagtcac tacagttggt tctattgaag
     5641 ccagtcttta agaaacctgg gttaaagaca ccagcacttc tgcttgctgg gctggctgga
     5701 cctgtgaagc catgggcagg tagtgccctc ttgagagtca ttttatttgg ccaccttcag
     5761 gtgagactat ccatagacac atgctaggat aggccccgct gggagggcag ttacaggaga
     5821 gagtaggtgg tggtgacgtg agggctgtga aggatccaga gacaagactt agatgtttcg
     5881 ttcattcact cactcattca gttactccta agacttttca gtttcataag gaagagtgtt
     5941 gcctgaggcc ctagggaata ttggggaata gaagggattg aggaaacatt aataatagtt
     6001 attcaaaaga cccaaatgct tatacttctc tctcccttct tctctctctg acacacacac
     6061 acacacacac acacacacac acacacacgt gcacattcct cccttacatg ctcatttgtg
     6121 ccttaaatgt gccttatagg taaatccagg atgactgagg aatccctcgt cactgggaga
     6181 ttttgtatat attcttttat tattagattg agttgggtgt ggggaaaaat ttttttctga
     6241 aggctcaaaa gtggtttcct aaaagtgagc cactatcaga tttgcacatc aggagaaaag
     6301 aaatagggtt acgtccatta ggaaaatccc agtttgcagg agtgcaatca catcaaaaaa
     6361 acaaccagcc aggattaaag gtattataaa tcctcatagc ggaacatttc tcagggcaaa
     6421 ggaacctggc tcatttgaag attaatgttc catgcctttg tggtcaaagg gtcagcactt
     6481 aacacaggaa aaaactaggt gttgttttgt tttgttattt tggacaacat aaaattcagg
     6541 aatgttttat ttagccttgg tttctagaag gaagggaaat aatatttctt gagcatttac
     6601 tagggtgttg cgtgctgtgc taagtaaatt ttaagtcttt cagttttata gatacggaaa
     6661 acaagggtga ctctttacca caggatgaat aaagaactaa gtaatatggg aaatgcagca
     6721 atttctggac tagctgagcc gattccttcc tgtgagcaca ctgtaagctt tcaagttctc
     6781 tgggcaggaa ttacagcacc tgtcccctgc aatggccctg ctgtgtgatg ctcatcgctt
     6841 cccttcgtgc tggagcagtc ccccaggtgt ccatctccta tctttttgtt ccaatcttct
     6901 gtgagttcca gctagcaggc tttacatctg gggaaaggaa aaccaggggt tttagctctg
     6961 ttctctgctc ccatccttcg ctcaccagct gagtgagaac atgaactttt tgcaccatgt
     7021 acccatggct tacactactt agaaaatcac cttttcagat aaaacagttt atgagttcat
     7081 agagaacacc agcactcttt gacaaaactg tgagtgaccc tttttaaaca atgctgagca
     7141 ggccctgagc tataatcaac ggtgagcttt aatgtctatg ctgacagtta ggttttgctc
     7201 tcttttgtaa caggttacgt agaccagcag tgtttaaatc taaatacgtt gtgagtctgt
     7261 tatctgtcct atcgcgtttt ttaaatgact ttttattctt tatcatagct aagtaaatac
     7321 caaaaaaaaa aaaaagcttt gtaggacact tgtacttagt ttgggaaaaa aaaataaatt
     7381 gaaattgtta tgcttttgta tttccatttc ttgcaaataa atattttttc ttaaatagta
     7441 a
//
