LOCUS       NM_052854               2673 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens cAMP responsive element binding protein 3 like 1
            (CREB3L1), transcript variant 1, mRNA.
ACCESSION   NM_052854
VERSION     NM_052854.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Greenwood,M., Gillard,B.T., Murphy,D. and Greenwood,M.P.
  TITLE     Dimerization of hub protein DYNLL1 and bZIP transcription factor
            CREB3L1 enhances transcriptional activation of CREB3L1 target genes
            like arginine vasopressin
  JOURNAL   Peptides 179, 171269 (2024)
   PUBMED   38960286
  REMARK    GeneRIF: Dimerization of hub protein DYNLL1 and bZIP transcription
            factor CREB3L1 enhances transcriptional activation of CREB3L1
            target genes like arginine vasopressin.
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Cong,S., Fu,Y., Zhao,X., Guo,Q., Liang,T., Wu,D., Wang,J. and
            Zhang,G.
  TITLE     KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the
            Progression of Ovarian Cancer
  JOURNAL   J Immunol Res 2024, 4817924 (2024)
   PUBMED   38380081
  REMARK    GeneRIF: KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit
            the Progression of Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Pan,Z., Xu,T., Bao,L., Hu,X., Jin,T., Chen,J., Chen,J., Qian,Y.,
            Lu,X., Li,L., Zheng,G., Zhang,Y., Zou,X., Song,F., Zheng,C.,
            Jiang,L., Wang,J., Tan,Z., Huang,P. and Ge,M.
  TITLE     CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid
            carcinoma by remodeling the tumor microenvironment
  JOURNAL   Mol Cancer 21 (1), 190 (2022)
   PUBMED   36192735
  REMARK    GeneRIF: CREB3L1 promotes tumor growth and metastasis of anaplastic
            thyroid carcinoma by remodeling the tumor microenvironment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   De Marchi,F., Okuda,M., Morishita,S., Imai,M., Baba,T., Horino,M.,
            Mori,Y., Furuya,C., Ogata,S., Yang,Y., Ando,J., Ando,M., Araki,M.
            and Komatsu,N.
  TITLE     Clinical and biological relevance of CREB3L1 in Philadelphia
            chromosome-negative myeloproliferative neoplasms
  JOURNAL   Leuk Res 119, 106883 (2022)
   PUBMED   35689957
  REMARK    GeneRIF: Clinical and biological relevance of CREB3L1 in
            Philadelphia chromosome-negative myeloproliferative neoplasms.
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Mellor,P., Kendall,S., Smith,S., Saxena,A. and Anderson,D.H.
  TITLE     Reduced CREB3L1 expression in triple negative and luminal a breast
            cancer cells contributes to enhanced cell migration,
            anchorage-independent growth and metastasis
  JOURNAL   PLoS One 17 (7), e0271090 (2022)
   PUBMED   35802566
  REMARK    GeneRIF: Reduced CREB3L1 expression in triple negative and luminal
            a breast cancer cells contributes to enhanced cell migration,
            anchorage-independent growth and metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 2673)
  AUTHORS   Guillou,L., Benhattar,J., Gengler,C., Gallagher,G.,
            Ranchere-Vince,D., Collin,F., Terrier,P., Terrier-Lacombe,M.J.,
            Leroux,A., Marques,B., Aubain Somerhausen Nde,S., Keslair,F.,
            Pedeutour,F. and Coindre,J.M.
  TITLE     Translocation-positive low-grade fibromyxoid sarcoma:
            clinicopathologic and molecular analysis of a series expanding the
            morphologic spectrum and suggesting potential relationship to
            sclerosing epithelioid fibrosarcoma: a study from the French
            Sarcoma Group
  JOURNAL   Am J Surg Pathol 31 (9), 1387-1402 (2007)
   PUBMED   17721195
  REMARK    GeneRIF: Presence of FUS/CREB3L2 and FUS/CREB3L1 in low-grade
            fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma
            suggests these neoplasms may be related.
REFERENCE   8  (bases 1 to 2673)
  AUTHORS   Stirling,J. and O'hare,P.
  TITLE     CREB4, a transmembrane bZip transcription factor and potential new
            substrate for regulation and cleavage by S1P
  JOURNAL   Mol Biol Cell 17 (1), 413-426 (2006)
   PUBMED   16236796
REFERENCE   9  (bases 1 to 2673)
  AUTHORS   Newman,J.R. and Keating,A.E.
  TITLE     Comprehensive identification of human bZIP interactions with
            coiled-coil arrays
  JOURNAL   Science 300 (5628), 2097-2101 (2003)
   PUBMED   12805554
REFERENCE   10 (bases 1 to 2673)
  AUTHORS   Omori,Y., Imai,J., Suzuki,Y., Watanabe,S., Tanigami,A. and
            Sugano,S.
  TITLE     OASIS is a transcriptional activator of CREB/ATF family with a
            transmembrane domain
  JOURNAL   Biochem Biophys Res Commun 293 (1), 470-477 (2002)
   PUBMED   12054625
  REMARK    GeneRIF: a transcriptional activator of CREB/ATF family with a
            transmembrane domain
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF131922.1, AK314072.1,
            BC015781.1 and AC116021.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_052854.3.
            
            Summary: The protein encoded by this gene is normally found in the
            membrane of the endoplasmic reticulum (ER). However, upon stress to
            the ER, the encoded protein is cleaved and the released cytoplasmic
            transcription factor domain translocates to the nucleus. There it
            activates the transcription of target genes by binding to box-B
            elements. [provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.975250.1, AB063321.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621158.5/ ENSP00000481956.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               CF131922.1         25-142
            119-899             AK314072.1         121-901
            900-2653            BC015781.1         553-2306
            2654-2654           AC116021.5         87901-87901
            2655-2673           BC015781.1         2308-2326
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..2673
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /note="cAMP responsive element binding protein 3 like 1"
                     /db_xref="GeneID:90993"
                     /db_xref="HGNC:HGNC:18856"
                     /db_xref="MIM:616215"
     exon            1..552
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..2010
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /note="isoform 1 is encoded by transcript variant 1; BBF-2
                     homolog; cyclic AMP-responsive element-binding protein
                     3-like protein 1; old astrocyte specifically-induced
                     substance; cAMP-responsive element-binding protein 3-like
                     protein 1; Osteogenesis imperfecta, type XVI"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 1 isoform 1"
                     /protein_id="NP_443086.1"
                     /db_xref="CCDS:CCDS53620.1"
                     /db_xref="GeneID:90993"
                     /db_xref="HGNC:HGNC:18856"
                     /db_xref="MIM:616215"
                     /translation="MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFT
                     ENMEDFSNDLFSSFFDDPVLDEKSPLLDMELDSPTPGIQAEHSYSLSGDSAPQSPLVP
                     IKMEDTTQDAEHGAWALGHKLCSIMVKQEQSPELPVDPLAAPSAMAAAAAMATTPLLG
                     LSPLSRLPIPHQAPGEMTQLPVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDG
                     SQSPRSLPPSSPVRPMARSSTAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYP
                     IPTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETFTSENNELWK
                     KVETLENANRTLLQQLQKLQTLVTNKISRPYKMAATQTGTCLMVAALCFVLVLGSLVP
                     CLPEFSSGSQTVKEDPLAADGVYTASQMPSRSLLFYDDGAGLWEDGRSTLLPMEPPDG
                     WEINPGGPAEQRPRDHLQHDHLDSTHETTKYLSEAWPKDGGNGTSPDFSHSKEWFHDR
                     DLGPNTTIKLS"
     exon            553..781
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            782..966
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1045
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1203
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1353
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1412
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1481
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1581
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1708
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1973
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2673
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2406..2411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /note="hexamer: AATGAA"
     polyA_site      2433
                     /gene="CREB3L1"
                     /gene_synonym="C16DELp11.2; DEL16p11.2; OASIS; OI16"
                     /note="major polyA site"
ORIGIN      
        1 agagaggaaa gtgacagaag acgtgcggag ggagacgcag agacagagga gaggccggca
       61 gccacccagt ctcgggggag cacttagctc ccccgccccg gctcccaccc tgtccggggg
      121 gctcctgaag ccctcagccc caaccccggg ctccccatgg aagccagctg tgccccagga
      181 ggagcaggag gaggtggagt cggctgaatg cccacggtgc gcccggggcc cctgagccca
      241 tcccgctcct agccgctgcc ctaaggcccc cgcgcgcccc gcgcccccca cccggggccg
      301 cgccgcctcc gtccgcccct cccccggggc ttcgccccgg acctgccccc cgcccgtttg
      361 ccagcgctca ggcaggagct ctggactggg cgcgccgccg ccctggagtg agggaagccc
      421 agtggaaggg ggtcccggga gccggctgcg atggacgccg tcttggaacc cttcccggcc
      481 gacaggctgt tccccggatc cagcttcctg gacttggggg atctgaacga gtcggacttc
      541 ctcaacaatg cgcactttcc tgagcacctg gaccacttta cggagaacat ggaggacttc
      601 tccaatgacc tgttcagcag cttctttgat gaccctgtgc tggatgagaa gagccctcta
      661 ttggacatgg aactggactc ccctacgcca ggcatccagg cggagcacag ctactccctg
      721 agcggcgact cagcgcccca gagccccctt gtgcccatca agatggagga caccacccaa
      781 gatgcagagc atggagcatg ggcgctggga cacaaactgt gctccatcat ggtgaagcag
      841 gagcagagcc cggagctgcc cgtggaccct ctggctgccc cctcggccat ggctgccgcg
      901 gccgccatgg ccaccacccc gctgctgggc ctcagcccct tgtccaggct gcccatcccc
      961 caccaggccc cgggagagat gactcagctg ccagtgatca aagcagagcc tctggaggtg
     1021 aaccagttcc tcaaagtgac accggaggac ctggtgcaga tgcctccgac gccccccagc
     1081 agccatggca gtgacagcga cggctcccag agtccccgct ctctgccccc ctccagccct
     1141 gtcaggccca tggcgcgctc ctccacggcc atctccacct ccccactcct cactgcccct
     1201 cacaaattac aggggacatc agggccactg ctcctgacag aggaggagaa gcggaccctg
     1261 attgctgagg gctaccccat ccccacaaaa ctccccctca ccaaagccga ggagaaggcc
     1321 ttgaagagag tccggaggaa aatcaagaac aagatctcag cccaggagag ccgtcgtaag
     1381 aagaaggagt atgtggagtg tctagaaaag aaggtggaga catttacatc tgagaacaat
     1441 gaactgtgga agaaggtgga gaccctggag aatgccaaca ggaccctgct ccagcagctg
     1501 cagaaactcc agactctggt caccaacaag atctccagac cttacaagat ggccgccacc
     1561 cagactggga cctgcctcat ggtggcagcc ttgtgctttg ttctggtgct gggctccctc
     1621 gtgccctgcc ttcccgagtt ctcctccggc tcccagactg tgaaggaaga ccccctggcc
     1681 gcagacggcg tctacacggc cagccagatg ccctcccgaa gcctcctatt ctacgatgac
     1741 ggggcaggct tatgggaaga tggccgcagc accctgctgc ccatggagcc cccagatggc
     1801 tgggaaatca accccggggg gccggcagag cagcggcccc gggaccacct gcagcatgat
     1861 cacctggaca gcacccacga gaccaccaag tacctgagtg aggcctggcc taaagacggt
     1921 ggaaacggca ccagccccga cttctcccac tccaaggagt ggttccacga cagggatctg
     1981 ggccccaaca ccaccatcaa actctcctag gccatgccaa gacccaggac ataggacgga
     2041 cccctggtac ccagaagagg agttcttgct cactaacccg gatccgcctc gtgcccctgc
     2101 ctcctggagc ttcccattcc aggagaaaag gctccacttc ccagcccttc cttgcccctg
     2161 acatttggac tcttcccttg ggccgaccac tctgttctca ttctccttcc caccaacatc
     2221 catccgtcct tctcagacaa accactcact gggtacccca cctcctctct catatgccca
     2281 acacgaccac tgcctccctg cccccacacc tgcacccaaa cagacacatc aacgcacccc
     2341 actcacagac accccttacc ccacccccac tgtacagaga ccaagaacag aaattgtttg
     2401 taaataatga accttatttt ttattattgc caatccccta agatattgta ttttacaaat
     2461 ctccctcttc ccttcgcccc tcccttgttt tatattttat gaagttagtg cgggctttgc
     2521 tgctccctgg cccaggaaag agggactacc tgaccctcac ctggcacccc cctgctgctg
     2581 cccaagccgc tgggcctttt taattgccaa actgctctct tcatcagctc agcacatgct
     2641 ttaagaaagc aaaaccaaaa aaaaaaaaaa aaa
//
