LOCUS       NM_006368               1496 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cAMP responsive element binding protein 3 (CREB3),
            mRNA.
ACCESSION   NM_006368
VERSION     NM_006368.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Lee,G.E., Bang,G., Byun,J., Lee,C.J., Chen,W., Jeung,D., An,H.J.,
            Kang,H.C., Lee,J.Y., Lee,H.S., Hong,Y.S., Kim,D.J., Keniry,M.,
            Kim,J.Y., Choi,J.S., Fanto,M., Cho,S.J., Kim,K.D. and Cho,Y.Y.
  TITLE     Dysregulated CREB3 cleavage at the nuclear membrane induces
            karyoptosis-mediated cell death
  JOURNAL   Exp Mol Med 56 (3), 686-699 (2024)
   PUBMED   38480902
  REMARK    GeneRIF: Dysregulated CREB3 cleavage at the nuclear membrane
            induces karyoptosis-mediated cell death.
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Zhan,S., Qiu,M., Wei,X., Wei,J., Qin,L., Jiang,B., Wen,Q., Chen,P.,
            Lin,Q., Wei,X., Zhou,Z., Jiang,Y., Liang,X., Li,R., Liu,Y. and
            Yu,H.
  TITLE     Potentially functional genetic variants in ferroptosis-related
            CREB3 and GALNT14 genes predict survival of hepatitis B
            virus-related hepatocellular carcinoma
  JOURNAL   Cancer Med 13 (1), e6848 (2024)
   PUBMED   38151984
  REMARK    GeneRIF: Potentially functional genetic variants in
            ferroptosis-related CREB3 and GALNT14 genes predict survival of
            hepatitis B virus-related hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Yadavalli,T., Sharma,P., Wu,D., Kapoor,D. and Shukla,D.
  TITLE     CREB3 Plays an Important Role in HPSE-Facilitated HSV-1 Release in
            Human Corneal Epithelial Cells
  JOURNAL   Viruses 14 (6), 1171 (2022)
   PUBMED   35746643
  REMARK    GeneRIF: CREB3 Plays an Important Role in HPSE-Facilitated HSV-1
            Release in Human Corneal Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Oh-Hashi,K., Yamamoto,A., Murase,R. and Hirata,Y.
  TITLE     Comparative Analysis of CREB3 and CREB3L2 Protein Expression in
            HEK293 Cells
  JOURNAL   Int J Mol Sci 22 (5), 2767 (2021)
   PUBMED   33803345
  REMARK    GeneRIF: Comparative Analysis of CREB3 and CREB3L2 Protein
            Expression in HEK293 Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Lu,R. and Misra,V.
  TITLE     Zhangfei: a second cellular protein interacts with herpes simplex
            virus accessory factor HCF in a manner similar to Luman and VP16
  JOURNAL   Nucleic Acids Res 28 (12), 2446-2454 (2000)
   PUBMED   10871379
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Mahajan,S.S. and Wilson,A.C.
  TITLE     Mutations in host cell factor 1 separate its role in cell
            proliferation from recruitment of VP16 and LZIP
  JOURNAL   Mol Cell Biol 20 (3), 919-928 (2000)
   PUBMED   10629049
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Lu,R. and Misra,V.
  TITLE     Potential role for luman, the cellular homologue of herpes simplex
            virus VP16 (alpha gene trans-inducing factor), in herpesvirus
            latency
  JOURNAL   J Virol 74 (2), 934-943 (2000)
   PUBMED   10623756
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Freiman,R.N. and Herr,W.
  TITLE     Viral mimicry: common mode of association with HCF by VP16 and the
            cellular protein LZIP
  JOURNAL   Genes Dev 11 (23), 3122-3127 (1997)
   PUBMED   9389645
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Lu,R., Yang,P., O'Hare,P. and Misra,V.
  TITLE     Luman, a new member of the CREB/ATF family, binds to herpes simplex
            virus VP16-associated host cellular factor
  JOURNAL   Mol Cell Biol 17 (9), 5117-5126 (1997)
   PUBMED   9271389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG701230.1 and AF211848.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006368.4.
            
            Summary: This gene encodes a transcription factor that is a member
            of the leucine zipper family of DNA binding proteins. This protein
            binds to the cAMP-response element and regulates cell
            proliferation. The protein interacts with host cell factor C1,
            which also associates with the herpes simplex virus (HSV) protein
            VP16 that induces transcription of HSV immediate-early genes. This
            protein and VP16 both bind to the same site on host cell factor C1.
            It is thought that the interaction between this protein and host
            cell factor C1 plays a role in the establishment of latency during
            HSV infection. This protein also plays a role in leukocyte
            migration, tumor suppression, and endoplasmic reticulum
            stress-associated protein degradation. Additional transcript
            variants have been identified, but their biological validity has
            not been determined.[provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.967257.1, AF211848.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353704.3/ ENSP00000342136.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               BG701230.1         352-670
            320-1496            AF211848.1         651-1827
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1496
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /note="cAMP responsive element binding protein 3"
                     /db_xref="GeneID:10488"
                     /db_xref="HGNC:HGNC:2347"
                     /db_xref="MIM:606443"
     exon            1..236
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1223
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /note="cyclic AMP response element (CRE)-binding
                     protein/activating transcription factor 1; basic leucine
                     zipper protein; small leucine zipper protein;
                     transcription factor LZIP-alpha; leucin zipper proitein"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 3"
                     /protein_id="NP_006359.3"
                     /db_xref="CCDS:CCDS6588.1"
                     /db_xref="GeneID:10488"
                     /db_xref="HGNC:HGNC:2347"
                     /db_xref="MIM:606443"
                     /translation="MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEV
                     PSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGT
                     QMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRN
                     KRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVI
                     EISNKTSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQ
                     LELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFS
                     EPLCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG"
     exon            237..384
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     exon            385..452
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     exon            453..542
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     exon            543..649
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     exon            650..718
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     exon            719..803
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     exon            804..888
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1496
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1357
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /note="major polyA site"
     regulatory      1478..1483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
ORIGIN      
        1 gtagagggac agtggatagg tgcccgaggc ctacagctgg cctggggctc gtgtctgggc
       61 ttcggacgtt ggggcccggt ggcccaccct ttccgtagtt gtcccaaatg gagctggaat
      121 tggatgctgg tgaccaagac ctgctggcct tcctgctaga ggaaagtgga gatttgggga
      181 cggcacccga tgaggccgtg agggccccac tggactgggc gctgccgctt tctgaggtac
      241 cgagcgactg ggaagtagat gatttgctgt gctccctgct gagtccccca gcgtcgttga
      301 acattctcag ctcctccaac ccctgccttg tccaccatga ccacacctac tccctcccac
      361 gggaaactgt ctctatggat ctagagagtg agagctgtag aaaagagggg acccagatga
      421 ctccacagca tatggaggag ctggcagagc aggagattgc taggctagta ctgacagatg
      481 aggagaagag tctattggag aaggaggggc ttattctgcc tgagacactt cctctcacta
      541 agacagagga acaaattctg aaacgtgtgc ggaggaagat tcgaaataaa agatctgctc
      601 aagagagccg caggaaaaag aaggtgtatg ttgggggttt agagagcagg gtcttgaaat
      661 acacagccca gaatatggag cttcagaaca aagtacagct tctggaggaa cagaatttgt
      721 cccttctaga tcaactgagg aaactccagg ccatggtgat tgagatatca aacaaaacca
      781 gcagcagcag cacctgcatc ttggtcctac tagtctcctt ctgcctcctc cttgtacctg
      841 ctatgtactc ctctgacaca agggggagcc tgccagctga gcatggagtg ttgtcccgcc
      901 agcttcgtgc cctccccagt gaggaccctt accagctgga gctgcctgcc ctgcagtcag
      961 aagtgccgaa agacagcaca caccagtggt tggacggctc agactgtgta ctccaggccc
     1021 ctggcaacac ttcctgcctg ctgcattaca tgcctcaggc tcccagtgca gagcctcccc
     1081 tggagtggcc attccctgac ctcttctcag agcctctctg ccgaggtccc atcctccccc
     1141 tgcaggcaaa tctcacaagg aagggaggat ggcttcctac tggtagcccc tctgtcattt
     1201 tgcaggacag atactcaggc tagatatgag gatatgtggg gggtctcagc aggagcctgg
     1261 ggggctcccc atctgtgtcc aaataaaaag cggtgggcaa gggctggccg cagctcctgt
     1321 gccctgtcag gacgactgag ggctcaaaca caccacactt aatggctttc tgggtctttt
     1381 atttgtaccc atgtgtctgt cacaccatga atgtacctgg ggaaatcaac tgacctccct
     1441 gaacatttca cgcagtcagg gaacaggtga ggaaagaaat aaataagtga ttctaa
//
