LOCUS       NP_006359                371 aa            linear   PRI 27-APR-2025
DEFINITION  cyclic AMP-responsive element-binding protein 3 [Homo sapiens].
ACCESSION   NP_006359
VERSION     NP_006359.3
DBSOURCE    REFSEQ: accession NM_006368.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Lee,G.E., Bang,G., Byun,J., Lee,C.J., Chen,W., Jeung,D., An,H.J.,
            Kang,H.C., Lee,J.Y., Lee,H.S., Hong,Y.S., Kim,D.J., Keniry,M.,
            Kim,J.Y., Choi,J.S., Fanto,M., Cho,S.J., Kim,K.D. and Cho,Y.Y.
  TITLE     Dysregulated CREB3 cleavage at the nuclear membrane induces
            karyoptosis-mediated cell death
  JOURNAL   Exp Mol Med 56 (3), 686-699 (2024)
   PUBMED   38480902
  REMARK    GeneRIF: Dysregulated CREB3 cleavage at the nuclear membrane
            induces karyoptosis-mediated cell death.
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Zhan,S., Qiu,M., Wei,X., Wei,J., Qin,L., Jiang,B., Wen,Q., Chen,P.,
            Lin,Q., Wei,X., Zhou,Z., Jiang,Y., Liang,X., Li,R., Liu,Y. and
            Yu,H.
  TITLE     Potentially functional genetic variants in ferroptosis-related
            CREB3 and GALNT14 genes predict survival of hepatitis B
            virus-related hepatocellular carcinoma
  JOURNAL   Cancer Med 13 (1), e6848 (2024)
   PUBMED   38151984
  REMARK    GeneRIF: Potentially functional genetic variants in
            ferroptosis-related CREB3 and GALNT14 genes predict survival of
            hepatitis B virus-related hepatocellular carcinoma.
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Yadavalli,T., Sharma,P., Wu,D., Kapoor,D. and Shukla,D.
  TITLE     CREB3 Plays an Important Role in HPSE-Facilitated HSV-1 Release in
            Human Corneal Epithelial Cells
  JOURNAL   Viruses 14 (6), 1171 (2022)
   PUBMED   35746643
  REMARK    GeneRIF: CREB3 Plays an Important Role in HPSE-Facilitated HSV-1
            Release in Human Corneal Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Oh-Hashi,K., Yamamoto,A., Murase,R. and Hirata,Y.
  TITLE     Comparative Analysis of CREB3 and CREB3L2 Protein Expression in
            HEK293 Cells
  JOURNAL   Int J Mol Sci 22 (5), 2767 (2021)
   PUBMED   33803345
  REMARK    GeneRIF: Comparative Analysis of CREB3 and CREB3L2 Protein
            Expression in HEK293 Cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Lu,R. and Misra,V.
  TITLE     Zhangfei: a second cellular protein interacts with herpes simplex
            virus accessory factor HCF in a manner similar to Luman and VP16
  JOURNAL   Nucleic Acids Res 28 (12), 2446-2454 (2000)
   PUBMED   10871379
REFERENCE   7  (residues 1 to 371)
  AUTHORS   Mahajan,S.S. and Wilson,A.C.
  TITLE     Mutations in host cell factor 1 separate its role in cell
            proliferation from recruitment of VP16 and LZIP
  JOURNAL   Mol Cell Biol 20 (3), 919-928 (2000)
   PUBMED   10629049
REFERENCE   8  (residues 1 to 371)
  AUTHORS   Lu,R. and Misra,V.
  TITLE     Potential role for luman, the cellular homologue of herpes simplex
            virus VP16 (alpha gene trans-inducing factor), in herpesvirus
            latency
  JOURNAL   J Virol 74 (2), 934-943 (2000)
   PUBMED   10623756
REFERENCE   9  (residues 1 to 371)
  AUTHORS   Freiman,R.N. and Herr,W.
  TITLE     Viral mimicry: common mode of association with HCF by VP16 and the
            cellular protein LZIP
  JOURNAL   Genes Dev 11 (23), 3122-3127 (1997)
   PUBMED   9389645
REFERENCE   10 (residues 1 to 371)
  AUTHORS   Lu,R., Yang,P., O'Hare,P. and Misra,V.
  TITLE     Luman, a new member of the CREB/ATF family, binds to herpes simplex
            virus VP16-associated host cellular factor
  JOURNAL   Mol Cell Biol 17 (9), 5117-5126 (1997)
   PUBMED   9271389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG701230.1 and AF211848.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2002 this sequence version replaced NP_006359.2.
            
            Summary: This gene encodes a transcription factor that is a member
            of the leucine zipper family of DNA binding proteins. This protein
            binds to the cAMP-response element and regulates cell
            proliferation. The protein interacts with host cell factor C1,
            which also associates with the herpes simplex virus (HSV) protein
            VP16 that induces transcription of HSV immediate-early genes. This
            protein and VP16 both bind to the same site on host cell factor C1.
            It is thought that the interaction between this protein and host
            cell factor C1 plays a role in the establishment of latency during
            HSV infection. This protein also plays a role in leukocyte
            migration, tumor suppression, and endoplasmic reticulum
            stress-associated protein degradation. Additional transcript
            variants have been identified, but their biological validity has
            not been determined.[provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.967257.1, AF211848.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353704.3/ ENSP00000342136.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     Protein         1..371
                     /product="cyclic AMP-responsive element-binding protein 3"
                     /note="cyclic AMP response element (CRE)-binding
                     protein/activating transcription factor 1; basic leucine
                     zipper protein; small leucine zipper protein;
                     transcription factor LZIP-alpha; leucin zipper proitein"
                     /calculated_mol_wt=41248
     Region          1..92
                     /region_name="Transcription activation (acidic).
                     /evidence=ECO:0000269|PubMed:10984507"
                     /note="propagated from UniProtKB/Swiss-Prot (O43889.2)"
     Region          13..17
                     /region_name="LXXLL motif 1"
                     /note="propagated from UniProtKB/Swiss-Prot (O43889.2)"
     Region          54..58
                     /region_name="LXXLL motif 2"
                     /note="propagated from UniProtKB/Swiss-Prot (O43889.2)"
     Region          78..81
                     /region_name="HCFC1-binding-motif (HBM)"
                     /note="propagated from UniProtKB/Swiss-Prot (O43889.2)"
     Region          151..211
                     /region_name="bZIP_CREB3"
                     /note="Basic leucine zipper (bZIP) domain of Cyclic
                     AMP-responsive element-binding protein 3 (CREB3) and
                     similar proteins: a DNA-binding and dimerization domain;
                     cd14689"
                     /db_xref="CDD:269837"
     Region          152..184
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O43889.2)"
     Region          153..204
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269837"
     Site            order(156..157,159..161,163..168,170..172)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269837"
     Site            order(171,174..175,178..179,181..182,185..186,188..189,
                     192..193,195..196,199..200,202..203)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269837"
     Region          192..213
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (O43889.2)"
     Site            231..247
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O43889.2)"
     Site            263..264
                     /site_type="cleavage"
                     /note="Cleavage, by PS1.
                     /evidence=ECO:0000269|PubMed:12138176; propagated from
                     UniProtKB/Swiss-Prot (O43889.2)"
     Site            266..267
                     /site_type="cleavage"
                     /note="Cleavage, by PS1.
                     /evidence=ECO:0000269|PubMed:12138176; propagated from
                     UniProtKB/Swiss-Prot (O43889.2)"
     Site            307
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O43889.2)"
     Site            348
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O43889.2)"
     CDS             1..371
                     /gene="CREB3"
                     /gene_synonym="LUMAN; LZIP; sLZIP"
                     /coded_by="NM_006368.5:108..1223"
                     /db_xref="CCDS:CCDS6588.1"
                     /db_xref="GeneID:10488"
                     /db_xref="HGNC:HGNC:2347"
                     /db_xref="MIM:606443"
ORIGIN      
        1 meleldagdq dllafllees gdlgtapdea vrapldwalp lsevpsdwev ddllcsllsp
       61 paslnilsss npclvhhdht yslpretvsm dlesescrke gtqmtpqhme elaeqeiarl
      121 vltdeeksll ekeglilpet lpltkteeqi lkrvrrkirn krsaqesrrk kkvyvggles
      181 rvlkytaqnm elqnkvqlle eqnlslldql rklqamviei snktsssstc ilvllvsfcl
      241 llvpamyssd trgslpaehg vlsrqlralp sedpyqlelp alqsevpkds thqwldgsdc
      301 vlqapgntsc llhympqaps aepplewpfp dlfseplcrg pilplqanlt rkggwlptgs
      361 psvilqdrys g
//
