LOCUS       XM_047443436           10065 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cAMP responsive element binding protein 1
            (CREB1), transcript variant X3, mRNA.
ACCESSION   XM_047443436
VERSION     XM_047443436.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..10065
                     /gene="CREB1"
                     /gene_synonym="CREB; CREB-1"
                     /note="cAMP responsive element binding protein 1; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 4 mRNAs, 26 ESTs, 954 long SRA reads, 6 Proteins, and
                     98% coverage of the annotated genomic feature by RNAseq
                     alignments, including 11 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:1385"
                     /db_xref="HGNC:HGNC:2345"
                     /db_xref="MIM:123810"
     CDS             66..1034
                     /gene="CREB1"
                     /gene_synonym="CREB; CREB-1"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 1
                     isoform X3"
                     /protein_id="XP_047299392.1"
                     /db_xref="GeneID:1385"
                     /db_xref="HGNC:HGNC:2345"
                     /db_xref="MIM:123810"
                     /translation="MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAA
                     HATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVD
                     SVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPI
                     YQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQ
                     ILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRL
                     MKNSSIRSEAFIGSHWAKMKVSAGLHSFLEVLGKQLESVVERRKNM"
ORIGIN      
        1 agtcggcggc ggctgctgct gcctgtggcc cgggcggctg ggagaagcgg agtgttggta
       61 actaaatgac catggaatct ggagccgaga accagcagag tggagatgca gctgtaacag
      121 aagctgaaaa ccaacaaatg acagttcaag cccagccaca gattgccaca ttagcccagg
      181 tatctatgcc agcagctcat gcaacatcat ctgctcccac cgtaactcta gtacagctgc
      241 ccaatgggca gacagttcaa gtccatggag tcattcaggc ggcccagcca tcagttattc
      301 agtctccaca agtccaaaca gttcagattt caactattgc agaaagtgaa gattcacagg
      361 agtcagtgga tagtgtaact gattcccaaa agcgaaggga aattctttca aggaggcctt
      421 cctacaggaa aattttgaat gacttatctt ctgatgcacc aggagtgcca aggattgaag
      481 aagagaagtc tgaagaggag acttcagcac ctgccatcac cactgtaacg gtgccaactc
      541 caatttacca aactagcagt ggacagtata ttgccattac ccagggagga gcaatacagc
      601 tggctaacaa tggtaccgat ggggtacagg gcctgcaaac attaaccatg accaatgcag
      661 cagccactca gccgggtact accattctac agtatgcaca gaccactgat ggacagcaga
      721 tcttagtgcc cagcaaccaa gttgttgttc aagctgcctc tggagacgta caaacatacc
      781 agattcgcac agcacccact agcactattg cccctggagt tgttatggca tcctccccag
      841 cacttcctac acagcctgct gaagaagcag cacgaaagag agaggtccgt ctaatgaaga
      901 acagttctat aagatcagag gccttcattg gatctcactg ggctaaaatg aaggtgtcag
      961 caggactgca ttccttcctg gaggttctag ggaagcagct cgagagtgtc gtagaaagaa
     1021 gaaagaatat gtgaaatgtt tagaaaacag agtggcagtg cttgaaaatc aaaacaagac
     1081 attgattgag gagctaaaag cacttaagga cctttactgc cacaaatcag attaatttgg
     1141 gatttaaatt ttcacctgtt aaggtggaaa atggactggc ttggccacaa cctgaaagac
     1201 aaaataaaca ttttattttc taaacatttc tttttttcta tgcgcaaaac tgcctgaaag
     1261 caactacaga atttcattca tttgtgcttt tgcattaaac tgtgaatgtt ccaacacctg
     1321 cctccacttc tcccctcaag aaattttcaa cgccaggaat catgaagaga cttctgcttt
     1381 tcaaccccca ccctcctcaa gaagtaataa tttgtttact tgtaaattga tgggagaaat
     1441 gaggaaaaga aaatcttttt aaaaatgatt tcaaggtttg tgctgagctc cttgattgcc
     1501 ttagggacag aattacccca gcctcttgag ctgaagtaat gtgtgggccg catgcataaa
     1561 gtaagtaagg tgcaatgaag aagtgttgat tgccaaattg acatgttgtc acattctcat
     1621 tgtgaattat gtaaagttgt taagagacat accctctaaa aaagaacttt agcatggtat
     1681 tgaaggaatt agaaatgaat ttggagtgct ttttatgtat gttgtcttct tcaatactga
     1741 aaatttgtcc ttggttctta aaagcattct gtactaatac agctcttcca tagggcagtt
     1801 gttgcttctt aattcagttc tgtatgtgtt caacattttt gaatacatta aaagaagtaa
     1861 ccaactgaac gacaaagcat ggtatttgaa ttttaaatta aagcaaagta aataaaagta
     1921 caaagcatat tttagttagt actaaattct tagtaaaatg ctgatcagta aaccaatccc
     1981 ttgagttata taacaagatt tttaaataaa tgttattgtc ctcaccttca aaaatattta
     2041 tattgtcact catttacgta aaaagatatt tctaatttac tgttgcccat tgcacttaca
     2101 taccaccacc aagaaagcct tcaagatgtc aaataaagca aagtgatata tatttgttta
     2161 tgaaatgtta catgtagaaa aatactgatt ttaaatattt tccatattaa caatttaaca
     2221 gagaatctct agtgaatttt ttaaatgaaa gaagttgtaa ggatataaaa agtacagtgt
     2281 tagatgtgca caaggaaagt tattttcaga catatttgaa tgactgctgt actgcaatat
     2341 ttggattgtc attcttacaa aacatttttt tgttctcttg taaaaagagt agttattagt
     2401 tctgctttag ctttccaata tgctgtatag cctttgtcat tttataattt taattcctga
     2461 ttaaaacagt ctgtatttgt gtatatcata cattgttttc aataccactt ttaattgtta
     2521 ctcattttat tcactaagct cgataaatct aacagttact cttaaaaaaa aaaaaaaaag
     2581 actaaggtgg attttaaaaa ttggaaactg acataatgtt aggttataat ttctcatttg
     2641 gagccgggcg cagtggctca cgcctgtaat cccagcactt tgggaggcca aggtgggtgg
     2701 atcacctgtg gtcaagagtt caagaccagc ctggccatca tggtgaaacc ccatctctac
     2761 taaaaataca aaaattagcc aggcgtggtg gctggcgcct gtaatcccag ctactcagga
     2821 ggttgaggca gcagaattgc ttgaacccag gaggcagagg gttgcagtga gccgagatag
     2881 caccattgca ctccagcctg ggcgactcca tctcaaaaaa taaaaataaa aaaaatgtct
     2941 catttgggaa ggaaattcct tttaaaaaag agttgagaca cttagaaaac taatgtttta
     3001 tatttagtca agagttattt aagaaagtca agcttgttta acaacaaaat atgaagattt
     3061 aagtgttaat tgctggatcc attttaaaat aagattttaa ttaacatttg taaatggtat
     3121 attttcgttt gtaacaaacc attgtctttt ttcaaggatg aacagagttt atgaaggagc
     3181 atcattctaa gaattaagtg atgtagtctt tatgtttgga cagttcacca gattctcaag
     3241 aaggctttca aacaactata aagtttgatg tttgtcctgc tgagctaatg gggaaagtta
     3301 tagcataaaa attgtgtaac cgcatagata tgtcattttt aaaaactggt ttaacagaaa
     3361 tcaagcaaag tcacaaatat gttcacaagt tggaattatt tattgagtca aaatgtcgaa
     3421 tcgaacattt tgaatgaagt aagtgttata aatgaaaaat tgcctgatgt ttagcagttt
     3481 gtattctcta aagctttttt tcaaaagttc aggctttcta cttactggga agttggtggt
     3541 cctcttagtc cctgataaat caaggcaatc acattcatgt gagctggatg aatttataag
     3601 ttataaagac cttatccttc ataccttgag gatgattgca ctggttttga agtcagttgc
     3661 ttaatgatga ggtgagaaat gtatcctgtt gctaaatctg tcttagaccc ttggtgaaac
     3721 ttgaagattt cagtttataa agataaaatc aagcatcttt tgtgcagttt tcttttttta
     3781 atgcaagaat ggtggggagg tttgtttgta agcatgaaac tttgagaatc tttattaaga
     3841 aaatgacata atttttaaaa accttgtagc caagaacata tgtggccaca ttaccagtaa
     3901 taaatgtttt tctctttata ttggccaaaa gggaataaaa atgtcatcat aggaatttgt
     3961 acatatgcta ctgatttgcc tagaaaatag caagtttgat attgctcact ttgcaaatat
     4021 agggccatgt ggcactttta tctataggac agattaataa aaatgaagtg gggaggggtt
     4081 tatttttgat atattactct tatgagtttt caagctttga taatgtttaa ctgaaaagtg
     4141 gcttagaaag ggctagatcc aatgtgttca ttattaaata attgctatca gatacaattt
     4201 taagttcatt ctttttcaaa ctcaagtacc atattggcaa ccataatatt gtcataggtg
     4261 ctctcttcat ttagatattc ttgggggggg tggcatttgt ataatatatg tgtacatata
     4321 tatatatata tatatatata catacagtat ataatctaaa gctctgagag ctcttaagtc
     4381 aggaatgctg agtattatag tatattgagg tcagatgaaa ttttacattt ttgtgtgttc
     4441 tgttgcattc cttctggtag tttctatgac tgcattactc cagcactcat gattgatttt
     4501 atcttctaat tttcttccaa gtattttatt ttttattagt tttctttggc ttgatacttt
     4561 taaatatgtt actagtcact tgaaagcctc tcccccaaaa gtatttggtt tgtatgcttt
     4621 gtctgtggca gctataacag tggtaagaac attttgaaga tagcttttta aaggaaccac
     4681 tgattttttc aaaaatcatc ctgggggagg aattttggca tttcatttga gcagggattt
     4741 tgtcagaaaa tgtgttttga tggtaggtca gcagcagtgc tagtctctga aagcacaata
     4801 ccagtcaggc agcctatccc atcagatgtc atctggctga agtttatctc tgtctctcag
     4861 gataaatccc tgtaggacaa atccctacta tcatttctac cttttggggt gacatgtgga
     4921 atcatacaaa ggcttaggaa gaaatacgtt tgtttaaacc aggatgcttt acttacttga
     4981 agtgacttca atctagattt cttttaatat ttaacaaatt tttaattcta tgatcagcca
     5041 cagtcagcta ttaccataaa ttggtctctg tttattttga agatcacggc tgcttcattt
     5101 tgcaggatta agtagggcta atgtatctta aagttaagat cttgaattaa agtgagtttt
     5161 agaaatagtg ttacatacct tttcagttgt tttcaagagg ctttattttt gttgcctttg
     5221 tagccctgaa agctgttggt atattttttc cctcatggac ccaatagaaa agttgtatat
     5281 ttatttggat tatatttaca ttctgtcctt tgtaaatgtt tggtgtaact tgcacttttt
     5341 taaatgaccc agtttgggta ttagcaactt aagaaattcc ctcatcaagt aattctcaac
     5401 tttttagtct ttctcctctc ttcaaatcat gtgacttttt aaatggaagt ttttcattga
     5461 ttaaaatatt ttagcaccta aaagctagcc ttaaaaacag ctgtaaaaga aaaacatcag
     5521 gaaattagat atgactagcc cagttaatta aaagacgggc tcaaaccttg ttttattctt
     5581 tttcatcttg gatgaagatt gaagggaaaa taactcaagt gcataatatt tattttcaat
     5641 ttttaatgag actttatcct catcacaaca ttaatactgt acatagtatg ccaaaatatc
     5701 cattaatttg tctagaatag tacaagactt tttaaagcaa ttgtcctcac agagaccaca
     5761 tgtaatatac tgaaatatgt tcatttttaa tggctttgtt aacatcaaag aaatgctgcc
     5821 taaatttgat ttcagatgag gaaggagaaa gtaaagtgtg catagtaagg ctgtaggtga
     5881 agagttgtga gataaatagt tcactcagtt gtacaaagca caactagaac tttttgttgg
     5941 gaggcttaca tacatcttga atattcttaa tgtaataatg ttgactatta agttggctac
     6001 acagtcactg tatgtactag gaactggttt ccttgacatt ctagaatcaa tggctaggag
     6061 aggcattaat ctttgagggg ctgaacatat catgaagctg agtcagtatg gaaaattttc
     6121 aaataaacag ggtgctgaag ttccatctgt ctcatctgct tatgataagt tcttattgat
     6181 tagtgaatgt agcttaagcc tttgtatgtg tcctcagggg gcagaccgac tttaagaggg
     6241 accagataac gtttgaatgg agggattata tttcaggtgt tttagcttga aatttatttt
     6301 ttaaaaaaag aaaaatttaa aaaatatata aataaaatag aacaaagccg gtgatgcaag
     6361 ttgatattat aaacaggcag ttttagcaca gaaagaaaat actgacctgt ctgcattctg
     6421 gtacggtggg tgcaggtccc agctgggtat gacatgatac atttttaatt attctcacca
     6481 gcaagtaaaa ggaaaatgaa caatcttttg gaattgtctt tgaaaaggat caaagagtag
     6541 gaaattcaca tttgacctaa cattacttgc ctatagaagt atggcatttc caagcttttg
     6601 tctgaggagc atctcagaga agtgagagta aatctgagtt agcttaaaaa ttggtaggga
     6661 ggaagaaaat ctctgcaaat aatgatttta tgtttgttgg ccaagtgaaa tgatctatca
     6721 ttgtgtttgg gaggttttat tttcttatgt ttttaaaatt ggtaaatgct ttatagatgt
     6781 atttttatcc aagtgccact ccaatttgtg tatgtaataa aattatttat attaaaagtg
     6841 ggaaataatt gtcaacattt tttttgagta tagatttatt aggggtggca aagaagagtg
     6901 ctagttagca gttttccatg taaagttgtc cttgactgat ttgtccacat gtcagttgta
     6961 actcccccac tccctgcaaa aggaattatt tctaacccag atgtatcact tgaaactttt
     7021 tagaagcaaa ataatcaggg aagttcctag aaaggtgttt ggctttttgg tttttgaggg
     7081 ttggggtaaa gaagacttcc cccacaactg tcagcacaaa acagggtatt gatttttaac
     7141 tctgatgttt ctattggagt tgaatactaa ataaataact ataatgaggg aaatacattt
     7201 ctaataaaat tccctacatt ctagaaacat ccctgtttta atttttttat ctaaatcttt
     7261 ttgtgcttta tgtgtaaaga aaaaaatgta ctgagttaca atgcatttta ttaacactat
     7321 gtacataata gctgctttgt gttcagaata gtagcagttg ctttgtatat taaagtgatc
     7381 cttgtgaatt tgtgaaatat tgtcataaag tgctttttct tactgtaatc tttgtggtat
     7441 caactgtcat aatgctcttt ttacacaaac atttatgtgc agtcacataa acatgctttt
     7501 aaaaactctg taagtctctt ttttggggat gggatctcta tattttgttg ggtttttttt
     7561 gctagtagtg tgaagccatg ttttattgga cttaaagtta caatatatta caagcttgtg
     7621 ttggaaggca gcaaaactaa ttcagacaac aacatgtctt cagttactgg atccctaatt
     7681 ttcaggacaa aacctgtttt tcaataagat tgaacagtgc ctatttgtgg atttggagat
     7741 gttactgtca agatgactaa tggagacata cgaccagctg tgtctgatgt cataaaacac
     7801 gtgttcactg aaaggacaat aagactatat accttctcag gtccccttgc aattctaaaa
     7861 ctctgtgatc atataaattg gaaggaaagg ggaggggata tggttaatct ttgcttaagc
     7921 tgtaagaata aaaaagttat ctcctatact attaacttct gaaataagtt ctgagacgag
     7981 acatctgaaa ataagcagct gcattatttg tatgtttctt cactgccaag atgtgttcaa
     8041 gcctgctata cctgccattg tattggaagg cttaatgaat ttcatttatt ttctgcaaca
     8101 acgattacag aatttattgc acaaaatgag acattttgag agtgatatta attacatgag
     8161 ggacaatagg catgaactag gattgttcta agcaaatcgg aatcgggtca ccctgccacg
     8221 ttcaggtgct tggaccttca ggaaaagatt gcccatcttg tcatttgacc aggcactgaa
     8281 gtgacaagac catccttgag aagtcacatc caaagataaa attctgatcc atttctagtt
     8341 ttagtgtttc gccactgaag acttaacata tgtcttttac actcaggttg caaaacacag
     8401 gcccaagaca aacttaactt ctcccccaaa tcttccttcc gctggttttt ccatctcgta
     8461 agtggtgcca ctatccatct gttaaattgt ttaggggaaa cctagaaaag cactacctta
     8521 atcagtgtta tccttcttct taactgtgcg tcctaatttc tccacatctt tcttaagtgc
     8581 agtgaccaaa ccggatgaga attctaacac gggcctgaca tcaaatggaa aggaaggata
     8641 atgtccagga gttggaatgt tatccttgtt tttaattaag atgcaattca cataaattaa
     8701 ctttttaagt gaacaattaa gtggtagtac atccacaatg gtgtacaacc accacttcta
     8761 tctagctcca aaacattctc atcactccaa aagtaaagtc ccgttactct ccattttctc
     8821 ctcccaccgc ccttgtccct ggcaaccacc aatctgcttc ctgtttcttt ggatttacat
     8881 ccgggtattt catgtgagac tcatacactg tgtattactt ctttcgtcta gctttaatgt
     8941 gttgttgagg ttgatccatt gtaacatgtt atcactactt cattcctttt tatagctaag
     9001 tatacttttt atagtaagta tgccattgta gatatatacc acaagtttat cgattcatcc
     9061 agttgagttg tttctactgt ttggctaatg ttcatagtgc tgttatgaat gttcgtgtac
     9121 aagtatttga gtccgtgttt tcaattattt ggggtatatg cctgggagtg gagttgctgg
     9181 gtcatgttga aatcgcacat ttaacttttt gaggaactgt caaactttcc ctcagcagct
     9241 gtaccgtttt accttccacc attgatgtat gagggttcca atttctccac accttcacca
     9301 acacttattt tgccatttta aaaattatag ccatcctcat gggtgtggtc tctcattgtg
     9361 gttttgattt gcatttccct gattactaat gatgtggagc atcttttgtt gtctttggcc
     9421 atctgcgtat cttctttgaa gaaatgtctg ttgaggtcct ttgttcattg aaattttgtt
     9481 gttgggttct gagttcctta tatattctgg gtactaggcc cttataatat tttcgcctat
     9541 aagtttttgc tttataatgt cctcattgtt ttcaaactta ctttatgtaa tatgtacact
     9601 tctaaaaaaa agaaacatgg aaaagggcaa actgtaagaa gttttttgtg ttatgttttt
     9661 tgtgacagtc tgtgcatata tacacaaata taatgtatgt tctctcctcc tccctctccc
     9721 tttttttaca caaaaggtag gtacaaacag tggtttataa actgctgcca ttgtacagat
     9781 acagtttaac cagtcctctt ctggggacat ttggctgttt gaaatttttt actgttacag
     9841 atatacagag gttggtaact aggtctacac aagttgtatc tccaggatac tgagaagtaa
     9901 aagttatttc tgaattatgg ttttcttcat atttggatat tgtttcctaa tgattattag
     9961 gtatctgcta agcaattttt attaacttat gttgattact atttttatgt caaactttac
    10021 agtctaggca tttttttctg gaattaaaat tagaagtggc acaga
//
