LOCUS       XM_011510650            9976 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cAMP responsive element binding protein 1
            (CREB1), transcript variant X7, mRNA.
ACCESSION   XM_011510650
VERSION     XM_011510650.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011510650.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..9976
                     /gene="CREB1"
                     /gene_synonym="CREB; CREB-1"
                     /note="cAMP responsive element binding protein 1; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 mRNAs, 31 ESTs, 1135 long SRA reads, 19 Proteins,
                     and 98% coverage of the annotated genomic feature by
                     RNAseq alignments, including 7 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:1385"
                     /db_xref="HGNC:HGNC:2345"
                     /db_xref="MIM:123810"
     CDS             141..1046
                     /gene="CREB1"
                     /gene_synonym="CREB; CREB-1"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 1
                     isoform X5"
                     /protein_id="XP_011508952.1"
                     /db_xref="GeneID:1385"
                     /db_xref="HGNC:HGNC:2345"
                     /db_xref="MIM:123810"
                     /translation="MPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQ
                     TVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLS
                     SDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDG
                     VQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAP
                     TSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVA
                     VLENQNKTLIEELKALKDLYCHKSD"
ORIGIN      
        1 atacatcata cagtaacaca cttatgtgca ccattggtgc tgagctgctg gttatcccac
       61 tctgccatgt gtgctgtttc tctttgcttt tgccactact ccactctgtg cttgaaattc
      121 tgtgactctt ccctgtatct atgccagcag ctcatgcaac atcatctgct cccaccgtaa
      181 ctctagtaca gctgcccaat gggcagacag ttcaagtcca tggagtcatt caggcggccc
      241 agccatcagt tattcagtct ccacaagtcc aaacagttca gtcttcctgt aaggacttaa
      301 aaagactttt ctccggaaca cagatttcaa ctattgcaga aagtgaagat tcacaggagt
      361 cagtggatag tgtaactgat tcccaaaagc gaagggaaat tctttcaagg aggccttcct
      421 acaggaaaat tttgaatgac ttatcttctg atgcaccagg agtgccaagg attgaagaag
      481 agaagtctga agaggagact tcagcacctg ccatcaccac tgtaacggtg ccaactccaa
      541 tttaccaaac tagcagtgga cagtatattg ccattaccca gggaggagca atacagctgg
      601 ctaacaatgg taccgatggg gtacagggcc tgcaaacatt aaccatgacc aatgcagcag
      661 ccactcagcc gggtactacc attctacagt atgcacagac cactgatgga cagcagatct
      721 tagtgcccag caaccaagtt gttgttcaag ctgcctctgg agacgtacaa acataccaga
      781 ttcgcacagc acccactagc actattgccc ctggagttgt tatggcatcc tccccagcac
      841 ttcctacaca gcctgctgaa gaagcagcac gaaagagaga ggtccgtcta atgaagaaca
      901 gggaagcagc tcgagagtgt cgtagaaaga agaaagaata tgtgaaatgt ttagaaaaca
      961 gagtggcagt gcttgaaaat caaaacaaga cattgattga ggagctaaaa gcacttaagg
     1021 acctttactg ccacaaatca gattaatttg ggatttaaat tttcacctgt taaggtggaa
     1081 aatggactgg cttggccaca acctgaaaga caaaataaac attttatttt ctaaacattt
     1141 ctttttttct atgcgcaaaa ctgcctgaaa gcaactacag aatttcattc atttgtgctt
     1201 ttgcattaaa ctgtgaatgt tccaacacct gcctccactt ctcccctcaa gaaattttca
     1261 acgccaggaa tcatgaagag acttctgctt ttcaaccccc accctcctca agaagtaata
     1321 atttgtttac ttgtaaattg atgggagaaa tgaggaaaag aaaatctttt taaaaatgat
     1381 ttcaaggttt gtgctgagct ccttgattgc cttagggaca gaattacccc agcctcttga
     1441 gctgaagtaa tgtgtgggcc gcatgcataa agtaagtaag gtgcaatgaa gaagtgttga
     1501 ttgccaaatt gacatgttgt cacattctca ttgtgaatta tgtaaagttg ttaagagaca
     1561 taccctctaa aaaagaactt tagcatggta ttgaaggaat tagaaatgaa tttggagtgc
     1621 tttttatgta tgttgtcttc ttcaatactg aaaatttgtc cttggttctt aaaagcattc
     1681 tgtactaata cagctcttcc atagggcagt tgttgcttct taattcagtt ctgtatgtgt
     1741 tcaacatttt tgaatacatt aaaagaagta accaactgaa cgacaaagca tggtatttga
     1801 attttaaatt aaagcaaagt aaataaaagt acaaagcata ttttagttag tactaaattc
     1861 ttagtaaaat gctgatcagt aaaccaatcc cttgagttat ataacaagat ttttaaataa
     1921 atgttattgt cctcaccttc aaaaatattt atattgtcac tcatttacgt aaaaagatat
     1981 ttctaattta ctgttgccca ttgcacttac ataccaccac caagaaagcc ttcaagatgt
     2041 caaataaagc aaagtgatat atatttgttt atgaaatgtt acatgtagaa aaatactgat
     2101 tttaaatatt ttccatatta acaatttaac agagaatctc tagtgaattt tttaaatgaa
     2161 agaagttgta aggatataaa aagtacagtg ttagatgtgc acaaggaaag ttattttcag
     2221 acatatttga atgactgctg tactgcaata tttggattgt cattcttaca aaacattttt
     2281 ttgttctctt gtaaaaagag tagttattag ttctgcttta gctttccaat atgctgtata
     2341 gcctttgtca ttttataatt ttaattcctg attaaaacag tctgtatttg tgtatatcat
     2401 acattgtttt caataccact tttaattgtt actcatttta ttcactaagc tcgataaatc
     2461 taacagttac tcttaaaaaa aaaaaaaaaa gactaaggtg gattttaaaa attggaaact
     2521 gacataatgt taggttataa tttctcattt ggagccgggc gcagtggctc acgcctgtaa
     2581 tcccagcact ttgggaggcc aaggtgggtg gatcacctgt ggtcaagagt tcaagaccag
     2641 cctggccatc atggtgaaac cccatctcta ctaaaaatac aaaaattagc caggcgtggt
     2701 ggctggcgcc tgtaatccca gctactcagg aggttgaggc agcagaattg cttgaaccca
     2761 ggaggcagag ggttgcagtg agccgagata gcaccattgc actccagcct gggcgactcc
     2821 atctcaaaaa ataaaaataa aaaaaatgtc tcatttggga aggaaattcc ttttaaaaaa
     2881 gagttgagac acttagaaaa ctaatgtttt atatttagtc aagagttatt taagaaagtc
     2941 aagcttgttt aacaacaaaa tatgaagatt taagtgttaa ttgctggatc cattttaaaa
     3001 taagatttta attaacattt gtaaatggta tattttcgtt tgtaacaaac cattgtcttt
     3061 tttcaaggat gaacagagtt tatgaaggag catcattcta agaattaagt gatgtagtct
     3121 ttatgtttgg acagttcacc agattctcaa gaaggctttc aaacaactat aaagtttgat
     3181 gtttgtcctg ctgagctaat ggggaaagtt atagcataaa aattgtgtaa ccgcatagat
     3241 atgtcatttt taaaaactgg tttaacagaa atcaagcaaa gtcacaaata tgttcacaag
     3301 ttggaattat ttattgagtc aaaatgtcga atcgaacatt ttgaatgaag taagtgttat
     3361 aaatgaaaaa ttgcctgatg tttagcagtt tgtattctct aaagcttttt ttcaaaagtt
     3421 caggctttct acttactggg aagttggtgg tcctcttagt ccctgataaa tcaaggcaat
     3481 cacattcatg tgagctggat gaatttataa gttataaaga ccttatcctt cataccttga
     3541 ggatgattgc actggttttg aagtcagttg cttaatgatg aggtgagaaa tgtatcctgt
     3601 tgctaaatct gtcttagacc cttggtgaaa cttgaagatt tcagtttata aagataaaat
     3661 caagcatctt ttgtgcagtt ttcttttttt aatgcaagaa tggtggggag gtttgtttgt
     3721 aagcatgaaa ctttgagaat ctttattaag aaaatgacat aatttttaaa aaccttgtag
     3781 ccaagaacat atgtggccac attaccagta ataaatgttt ttctctttat attggccaaa
     3841 agggaataaa aatgtcatca taggaatttg tacatatgct actgatttgc ctagaaaata
     3901 gcaagtttga tattgctcac tttgcaaata tagggccatg tggcactttt atctatagga
     3961 cagattaata aaaatgaagt ggggaggggt ttatttttga tatattactc ttatgagttt
     4021 tcaagctttg ataatgttta actgaaaagt ggcttagaaa gggctagatc caatgtgttc
     4081 attattaaat aattgctatc agatacaatt ttaagttcat tctttttcaa actcaagtac
     4141 catattggca accataatat tgtcataggt gctctcttca tttagatatt cttggggggg
     4201 gtggcatttg tataatatat gtgtacatat atatatatat atatatatat acatacagta
     4261 tataatctaa agctctgaga gctcttaagt caggaatgct gagtattata gtatattgag
     4321 gtcagatgaa attttacatt tttgtgtgtt ctgttgcatt ccttctggta gtttctatga
     4381 ctgcattact ccagcactca tgattgattt tatcttctaa ttttcttcca agtattttat
     4441 tttttattag ttttctttgg cttgatactt ttaaatatgt tactagtcac ttgaaagcct
     4501 ctcccccaaa agtatttggt ttgtatgctt tgtctgtggc agctataaca gtggtaagaa
     4561 cattttgaag atagcttttt aaaggaacca ctgatttttt caaaaatcat cctgggggag
     4621 gaattttggc atttcatttg agcagggatt ttgtcagaaa atgtgttttg atggtaggtc
     4681 agcagcagtg ctagtctctg aaagcacaat accagtcagg cagcctatcc catcagatgt
     4741 catctggctg aagtttatct ctgtctctca ggataaatcc ctgtaggaca aatccctact
     4801 atcatttcta ccttttgggg tgacatgtgg aatcatacaa aggcttagga agaaatacgt
     4861 ttgtttaaac caggatgctt tacttacttg aagtgacttc aatctagatt tcttttaata
     4921 tttaacaaat ttttaattct atgatcagcc acagtcagct attaccataa attggtctct
     4981 gtttattttg aagatcacgg ctgcttcatt ttgcaggatt aagtagggct aatgtatctt
     5041 aaagttaaga tcttgaatta aagtgagttt tagaaatagt gttacatacc ttttcagttg
     5101 ttttcaagag gctttatttt tgttgccttt gtagccctga aagctgttgg tatatttttt
     5161 ccctcatgga cccaatagaa aagttgtata tttatttgga ttatatttac attctgtcct
     5221 ttgtaaatgt ttggtgtaac ttgcactttt ttaaatgacc cagtttgggt attagcaact
     5281 taagaaattc cctcatcaag taattctcaa ctttttagtc tttctcctct cttcaaatca
     5341 tgtgactttt taaatggaag tttttcattg attaaaatat tttagcacct aaaagctagc
     5401 cttaaaaaca gctgtaaaag aaaaacatca ggaaattaga tatgactagc ccagttaatt
     5461 aaaagacggg ctcaaacctt gttttattct ttttcatctt ggatgaagat tgaagggaaa
     5521 ataactcaag tgcataatat ttattttcaa tttttaatga gactttatcc tcatcacaac
     5581 attaatactg tacatagtat gccaaaatat ccattaattt gtctagaata gtacaagact
     5641 ttttaaagca attgtcctca cagagaccac atgtaatata ctgaaatatg ttcattttta
     5701 atggctttgt taacatcaaa gaaatgctgc ctaaatttga tttcagatga ggaaggagaa
     5761 agtaaagtgt gcatagtaag gctgtaggtg aagagttgtg agataaatag ttcactcagt
     5821 tgtacaaagc acaactagaa ctttttgttg ggaggcttac atacatcttg aatattctta
     5881 atgtaataat gttgactatt aagttggcta cacagtcact gtatgtacta ggaactggtt
     5941 tccttgacat tctagaatca atggctagga gaggcattaa tctttgaggg gctgaacata
     6001 tcatgaagct gagtcagtat ggaaaatttt caaataaaca gggtgctgaa gttccatctg
     6061 tctcatctgc ttatgataag ttcttattga ttagtgaatg tagcttaagc ctttgtatgt
     6121 gtcctcaggg ggcagaccga ctttaagagg gaccagataa cgtttgaatg gagggattat
     6181 atttcaggtg ttttagcttg aaatttattt tttaaaaaaa gaaaaattta aaaaatatat
     6241 aaataaaata gaacaaagcc ggtgatgcaa gttgatatta taaacaggca gttttagcac
     6301 agaaagaaaa tactgacctg tctgcattct ggtacggtgg gtgcaggtcc cagctgggta
     6361 tgacatgata catttttaat tattctcacc agcaagtaaa aggaaaatga acaatctttt
     6421 ggaattgtct ttgaaaagga tcaaagagta ggaaattcac atttgaccta acattacttg
     6481 cctatagaag tatggcattt ccaagctttt gtctgaggag catctcagag aagtgagagt
     6541 aaatctgagt tagcttaaaa attggtaggg aggaagaaaa tctctgcaaa taatgatttt
     6601 atgtttgttg gccaagtgaa atgatctatc attgtgtttg ggaggtttta ttttcttatg
     6661 tttttaaaat tggtaaatgc tttatagatg tatttttatc caagtgccac tccaatttgt
     6721 gtatgtaata aaattattta tattaaaagt gggaaataat tgtcaacatt ttttttgagt
     6781 atagatttat taggggtggc aaagaagagt gctagttagc agttttccat gtaaagttgt
     6841 ccttgactga tttgtccaca tgtcagttgt aactccccca ctccctgcaa aaggaattat
     6901 ttctaaccca gatgtatcac ttgaaacttt ttagaagcaa aataatcagg gaagttccta
     6961 gaaaggtgtt tggctttttg gtttttgagg gttggggtaa agaagacttc ccccacaact
     7021 gtcagcacaa aacagggtat tgatttttaa ctctgatgtt tctattggag ttgaatacta
     7081 aataaataac tataatgagg gaaatacatt tctaataaaa ttccctacat tctagaaaca
     7141 tccctgtttt aattttttta tctaaatctt tttgtgcttt atgtgtaaag aaaaaaatgt
     7201 actgagttac aatgcatttt attaacacta tgtacataat agctgctttg tgttcagaat
     7261 agtagcagtt gctttgtata ttaaagtgat ccttgtgaat ttgtgaaata ttgtcataaa
     7321 gtgctttttc ttactgtaat ctttgtggta tcaactgtca taatgctctt tttacacaaa
     7381 catttatgtg cagtcacata aacatgcttt taaaaactct gtaagtctct tttttgggga
     7441 tgggatctct atattttgtt gggttttttt tgctagtagt gtgaagccat gttttattgg
     7501 acttaaagtt acaatatatt acaagcttgt gttggaaggc agcaaaacta attcagacaa
     7561 caacatgtct tcagttactg gatccctaat tttcaggaca aaacctgttt ttcaataaga
     7621 ttgaacagtg cctatttgtg gatttggaga tgttactgtc aagatgacta atggagacat
     7681 acgaccagct gtgtctgatg tcataaaaca cgtgttcact gaaaggacaa taagactata
     7741 taccttctca ggtccccttg caattctaaa actctgtgat catataaatt ggaaggaaag
     7801 gggaggggat atggttaatc tttgcttaag ctgtaagaat aaaaaagtta tctcctatac
     7861 tattaacttc tgaaataagt tctgagacga gacatctgaa aataagcagc tgcattattt
     7921 gtatgtttct tcactgccaa gatgtgttca agcctgctat acctgccatt gtattggaag
     7981 gcttaatgaa tttcatttat tttctgcaac aacgattaca gaatttattg cacaaaatga
     8041 gacattttga gagtgatatt aattacatga gggacaatag gcatgaacta ggattgttct
     8101 aagcaaatcg gaatcgggtc accctgccac gttcaggtgc ttggaccttc aggaaaagat
     8161 tgcccatctt gtcatttgac caggcactga agtgacaaga ccatccttga gaagtcacat
     8221 ccaaagataa aattctgatc catttctagt tttagtgttt cgccactgaa gacttaacat
     8281 atgtctttta cactcaggtt gcaaaacaca ggcccaagac aaacttaact tctcccccaa
     8341 atcttccttc cgctggtttt tccatctcgt aagtggtgcc actatccatc tgttaaattg
     8401 tttaggggaa acctagaaaa gcactacctt aatcagtgtt atccttcttc ttaactgtgc
     8461 gtcctaattt ctccacatct ttcttaagtg cagtgaccaa accggatgag aattctaaca
     8521 cgggcctgac atcaaatgga aaggaaggat aatgtccagg agttggaatg ttatccttgt
     8581 ttttaattaa gatgcaattc acataaatta actttttaag tgaacaatta agtggtagta
     8641 catccacaat ggtgtacaac caccacttct atctagctcc aaaacattct catcactcca
     8701 aaagtaaagt cccgttactc tccattttct cctcccaccg cccttgtccc tggcaaccac
     8761 caatctgctt cctgtttctt tggatttaca tccgggtatt tcatgtgaga ctcatacact
     8821 gtgtattact tctttcgtct agctttaatg tgttgttgag gttgatccat tgtaacatgt
     8881 tatcactact tcattccttt ttatagctaa gtatactttt tatagtaagt atgccattgt
     8941 agatatatac cacaagttta tcgattcatc cagttgagtt gtttctactg tttggctaat
     9001 gttcatagtg ctgttatgaa tgttcgtgta caagtatttg agtccgtgtt ttcaattatt
     9061 tggggtatat gcctgggagt ggagttgctg ggtcatgttg aaatcgcaca tttaactttt
     9121 tgaggaactg tcaaactttc cctcagcagc tgtaccgttt taccttccac cattgatgta
     9181 tgagggttcc aatttctcca caccttcacc aacacttatt ttgccatttt aaaaattata
     9241 gccatcctca tgggtgtggt ctctcattgt ggttttgatt tgcatttccc tgattactaa
     9301 tgatgtggag catcttttgt tgtctttggc catctgcgta tcttctttga agaaatgtct
     9361 gttgaggtcc tttgttcatt gaaattttgt tgttgggttc tgagttcctt atatattctg
     9421 ggtactaggc ccttataata ttttcgccta taagtttttg ctttataatg tcctcattgt
     9481 tttcaaactt actttatgta atatgtacac ttctaaaaaa aagaaacatg gaaaagggca
     9541 aactgtaaga agttttttgt gttatgtttt ttgtgacagt ctgtgcatat atacacaaat
     9601 ataatgtatg ttctctcctc ctccctctcc ctttttttac acaaaaggta ggtacaaaca
     9661 gtggtttata aactgctgcc attgtacaga tacagtttaa ccagtcctct tctggggaca
     9721 tttggctgtt tgaaattttt tactgttaca gatatacaga ggttggtaac taggtctaca
     9781 caagttgtat ctccaggata ctgagaagta aaagttattt ctgaattatg gttttcttca
     9841 tatttggata ttgtttccta atgattatta ggtatctgct aagcaatttt tattaactta
     9901 tgttgattac tatttttatg tcaaacttta cagtctaggc atttttttct ggaattaaaa
     9961 ttagaagtgg cacaga
//
