LOCUS       NM_019060                718 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cysteine rich C-terminal 1 (CRCT1), mRNA.
ACCESSION   NM_019060
VERSION     NM_019060.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 718)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 718)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 718)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 718)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 718)
  AUTHORS   Wu,N., Song,Y., Pang,L. and Chen,Z.
  TITLE     CRCT1 regulated by microRNA-520 g inhibits proliferation and
            induces apoptosis in esophageal squamous cell cancer
  JOURNAL   Tumour Biol 37 (6), 8271-8279 (2016)
   PUBMED   26718216
  REMARK    GeneRIF: CRCT1 functions as a tumor suppressor gene in ESCC and is
            regulated by miR-520 g, providing potential therapeutic targets for
            the treatment of ESCC
REFERENCE   6  (bases 1 to 718)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 718)
  AUTHORS   Torgerson,D.G., Ampleford,E.J., Chiu,G.Y., Gauderman,W.J.,
            Gignoux,C.R., Graves,P.E., Himes,B.E., Levin,A.M., Mathias,R.A.,
            Hancock,D.B., Baurley,J.W., Eng,C., Stern,D.A., Celedon,J.C.,
            Rafaels,N., Capurso,D., Conti,D.V., Roth,L.A., Soto-Quiros,M.,
            Togias,A., Li,X., Myers,R.A., Romieu,I., Van Den Berg,D.J., Hu,D.,
            Hansel,N.N., Hernandez,R.D., Israel,E., Salam,M.T., Galanter,J.,
            Avila,P.C., Avila,L., Rodriquez-Santana,J.R., Chapela,R.,
            Rodriguez-Cintron,W., Diette,G.B., Adkinson,N.F., Abel,R.A.,
            Ross,K.D., Shi,M., Faruque,M.U., Dunston,G.M., Watson,H.R.,
            Mantese,V.J., Ezurum,S.C., Liang,L., Ruczinski,I., Ford,J.G.,
            Huntsman,S., Chung,K.F., Vora,H., Li,X., Calhoun,W.J., Castro,M.,
            Sienra-Monge,J.J., del Rio-Navarro,B., Deichmann,K.A.,
            Heinzmann,A., Wenzel,S.E., Busse,W.W., Gern,J.E., Lemanske,R.F.
            Jr., Beaty,T.H., Bleecker,E.R., Raby,B.A., Meyers,D.A.,
            London,S.J., Gilliland,F.D., Burchard,E.G., Martinez,F.D.,
            Weiss,S.T., Williams,L.K., Barnes,K.C., Ober,C. and Nicolae,D.L.
  CONSRTM   Mexico City Childhood Asthma Study (MCAAS); Children's Health Study
            (CHS) and HARBORS study; Genetics of Asthma in Latino Americans
            (GALA) Study, Study of Genes-Environment and Admixture in Latino
            Americans (GALA2) and Study of African Americans, Asthma, Genes &
            Environments (SAGE); Childhood Asthma Research and Education (CARE)
            Network; Childhood Asthma Management Program (CAMP); Study of
            Asthma Phenotypes and Pharmacogenomic Interactions by
            Race-Ethnicity (SAPPHIRE); Genetic Research on Asthma in African
            Diaspora (GRAAD) Study
  TITLE     Meta-analysis of genome-wide association studies of asthma in
            ethnically diverse North American populations
  JOURNAL   Nat Genet 43 (9), 887-892 (2011)
   PUBMED   21804549
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 718)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 718)
  AUTHORS   Marenholz,I., Zirra,M., Fischer,D.F., Backendorf,C., Ziegler,A. and
            Mischke,D.
  TITLE     Identification of human epidermal differentiation complex
            (EDC)-encoded genes by subtractive hybridization of entire YACs to
            a gridded keratinocyte cDNA library
  JOURNAL   Genome Res 11 (3), 341-355 (2001)
   PUBMED   11230159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135842.15 and AJ243662.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019060.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279834.11336.1, AJ243662.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368790.4/ ENSP00000357779.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL135842.15        150609-150628
            21-212              AJ243662.1         1-192
            213-213             AL135842.15        151630-151630
            214-296             AJ243662.1         194-276
            297-297             AL135842.15        151714-151714
            298-661             AJ243662.1         278-641
            662-662             AL135842.15        152079-152079
            663-715             AJ243662.1         643-695
            716-718             AL135842.15        152133-152135
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..718
                     /gene="CRCT1"
                     /gene_synonym="C1orf42; NICE-1; NICE1"
                     /note="cysteine rich C-terminal 1"
                     /db_xref="GeneID:54544"
                     /db_xref="HGNC:HGNC:29875"
                     /db_xref="MIM:617426"
     exon            1..71
                     /gene="CRCT1"
                     /gene_synonym="C1orf42; NICE-1; NICE1"
                     /inference="alignment:Splign:2.1.0"
     exon            72..718
                     /gene="CRCT1"
                     /gene_synonym="C1orf42; NICE-1; NICE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..393
                     /gene="CRCT1"
                     /gene_synonym="C1orf42; NICE-1; NICE1"
                     /note="protein NICE-1"
                     /codon_start=1
                     /product="cysteine-rich C-terminal protein 1"
                     /protein_id="NP_061933.1"
                     /db_xref="CCDS:CCDS1012.1"
                     /db_xref="GeneID:54544"
                     /db_xref="HGNC:HGNC:29875"
                     /db_xref="MIM:617426"
                     /translation="MSSQQSAVSAKGFSKGSSQGPAPCPAPAPTPAPASSSSCCGSGR
                     GCCGDSGCCGSSSTSCCCFPRRRRRQRSSGCCCCGGGSQRSQRSNNRSSGCCSGC"
     regulatory      695..700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRCT1"
                     /gene_synonym="C1orf42; NICE-1; NICE1"
                     /note="hexamer: AATAAA"
     polyA_site      718
                     /gene="CRCT1"
                     /gene_synonym="C1orf42; NICE-1; NICE1"
                     /note="major polyA site"
ORIGIN      
        1 aatccactgc ctagcaggtg gcccattcca gttggagaac gtagtgagtc tttcagtgga
       61 gccagggtct ggtttgtcgt gaggagctcc gcgatgtcct ctcaacagag cgccgtttcc
      121 gccaaaggct tttccaaggg gtcgtcccag ggccccgctc cgtgtcccgc cccggcgccc
      181 accccggcgc ccgcctcctc ctcctcctgc tgcggctccg gcaggggctg ctgcggcgac
      241 tcaggctgct gcggctccag ctccaccagt tgctgctgct tcccaaggag acgccgccga
      301 cagcggagta gtggttgctg ctgctgcggg ggcggcagcc agaggtccca gcgctccaac
      361 aaccggagct caggatgctg ctccggctgc tgagaggccc gcaaccccca gcgctgcgct
      421 agagaaaccc gcccagccca gagcgggccc gccccgctgc ggctcccacg cggggctggg
      481 cctcggagtt tgccccgtaa agcgaattgc actttgatgt tcagaaaccc actttgttct
      541 cagccacgca aaactccctg accccgatgt gatttttctc cccggggatt cgagagccat
      601 gcgtgggaca ctggacccta ctgtctacac gggcttgcac acagcaggtg ctcagcaaat
      661 gtctattgat ttgattgtct tttgaagatg tcataataaa gcttctacct cctgagaa
//
