LOCUS       NM_014478               2774 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CGRP receptor component (CRCP), transcript variant 1,
            mRNA.
ACCESSION   NM_014478
VERSION     NM_014478.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2774)
  AUTHORS   Nelson-Maney,N.P., Balint,L., Beeson,A.L., Serafin,D.S.,
            Kistner,B.M., Douglas,E.S., Siddiqui,A.H., Tauro,A.M. and
            Caron,K.M.
  TITLE     Meningeal lymphatic CGRP signaling governs pain via cerebrospinal
            fluid efflux and neuroinflammation in migraine models
  JOURNAL   J Clin Invest 134 (15), e175616 (2024)
   PUBMED   38743922
  REMARK    GeneRIF: Meningeal lymphatic CGRP signaling governs pain via
            cerebrospinal fluid efflux and neuroinflammation in migraine
            models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2774)
  AUTHORS   Hou,H., Li,Y., Wang,M., Liu,A., Yu,Z., Chen,K., Zhao,D. and Xu,Y.
  TITLE     Structural insights into RNA polymerase III-mediated transcription
            termination through trapping poly-deoxythymidine
  JOURNAL   Nat Commun 12 (1), 6135 (2021)
   PUBMED   34675218
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2774)
  AUTHORS   Ramsay,E.P., Abascal-Palacios,G., Daiss,J.L., King,H., Gouge,J.,
            Pilsl,M., Beuron,F., Morris,E., Gunkel,P., Engel,C. and Vannini,A.
  TITLE     Structure of human RNA polymerase III
  JOURNAL   Nat Commun 11 (1), 6409 (2020)
   PUBMED   33335104
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2774)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2774)
  AUTHORS   Tringali,G. and Navarra,P.
  TITLE     Anti-CGRP and anti-CGRP receptor monoclonal antibodies as
            antimigraine agents. Potential differences in safety profile
            postulated on a pathophysiological basis
  JOURNAL   Peptides 116, 16-21 (2019)
   PUBMED   31018157
  REMARK    GeneRIF: both anti-CGRP and anti-CGRP receptor monoclonal
            antibodies (mABs) completed clinical development, and the first
            representatives of these 2 classes are available on the market.
            MABs are approved for prevention of migraine attacks in chronic or
            episodic migraine, involving long-term treatments.
            Review article
REFERENCE   6  (bases 1 to 2774)
  AUTHORS   Moreno,M.J., Terron,J.A., Stanimirovic,D.B., Doods,H. and Hamel,E.
  TITLE     Characterization of calcitonin gene-related peptide (CGRP)
            receptors and their receptor-activity-modifying proteins (RAMPs) in
            human brain microvascular and astroglial cells in culture
  JOURNAL   Neuropharmacology 42 (2), 270-280 (2002)
   PUBMED   11804624
REFERENCE   7  (bases 1 to 2774)
  AUTHORS   Prado,M.A., Evans-Bain,B., Oliver,K.R. and Dickerson,I.M.
  TITLE     The role of the CGRP-receptor component protein (RCP) in
            adrenomedullin receptor signal transduction
  JOURNAL   Peptides 22 (11), 1773-1781 (2001)
   PUBMED   11754963
REFERENCE   8  (bases 1 to 2774)
  AUTHORS   Evans,B.N., Rosenblatt,M.I., Mnayer,L.O., Oliver,K.R. and
            Dickerson,I.M.
  TITLE     CGRP-RCP, a novel protein required for signal transduction at
            calcitonin gene-related peptide and adrenomedullin receptors
  JOURNAL   J Biol Chem 275 (40), 31438-31443 (2000)
   PUBMED   10903324
REFERENCE   9  (bases 1 to 2774)
  AUTHORS   Balkan,W., Oates,E.L., Howard,G.A. and Roos,B.A.
  TITLE     Testes exhibit elevated expression of calcitonin gene-related
            peptide receptor component protein
  JOURNAL   Endocrinology 140 (3), 1459-1469 (1999)
   PUBMED   10067875
REFERENCE   10 (bases 1 to 2774)
  AUTHORS   Luebke,A.E., Dahl,G.P., Roos,B.A. and Dickerson,I.M.
  TITLE     Identification of a protein that confers calcitonin gene-related
            peptide responsiveness to oocytes by using a cystic fibrosis
            transmembrane conductance regulator assay
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3455-3460 (1996)
   PUBMED   8622957
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI600330.1, BC105808.1,
            U51134.1, AC068533.7 and BC052570.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014478.4.
            
            Summary: This gene encodes a membrane protein that functions as
            part of a receptor complex for a small neuropeptide that increases
            intracellular cAMP levels. Alternate transcriptional splice
            variants, encoding different isoforms, have been characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.927212.1,
                                           SRR1803616.115188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395326.8/ ENSP00000378736.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BI600330.1         49-60
            13-703              BC105808.1         5-695
            704-1103            U51134.1           649-1048
            1104-2424           AC068533.7         4272-5592           c
            2425-2774           BC052570.1         2790-3139
FEATURES             Location/Qualifiers
     source          1..2774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.21"
     gene            1..2774
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /note="CGRP receptor component"
                     /db_xref="GeneID:27297"
                     /db_xref="HGNC:HGNC:17888"
                     /db_xref="MIM:606121"
     exon            1..124
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..563
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /note="isoform a is encoded by transcript variant 1;
                     calcitonin gene-related peptide-receptor component
                     protein; DNA-directed RNA polymerase III subunit RPC9; RNA
                     polymerase III subunit C9; CGRP-receptor component
                     protein"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase III subunit RPC9
                     isoform a"
                     /protein_id="NP_055293.1"
                     /db_xref="CCDS:CCDS5532.1"
                     /db_xref="GeneID:27297"
                     /db_xref="HGNC:HGNC:17888"
                     /db_xref="MIM:606121"
                     /translation="MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNT
                     ITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVE
                     ESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA"
     exon            125..161
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /inference="alignment:Splign:2.1.0"
     exon            162..260
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /inference="alignment:Splign:2.1.0"
     exon            261..355
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /inference="alignment:Splign:2.1.0"
     exon            356..413
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /inference="alignment:Splign:2.1.0"
     exon            414..2774
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /note="hexamer: AATAAA"
     polyA_site      2774
                     /gene="CRCP"
                     /gene_synonym="C17; CGRP-RCP; CGRPRCP; POLR3I; POLR3J;
                     RCP; RCP9; RPC9"
                     /note="major polyA site"
ORIGIN      
        1 ggcgagcacc ttggcgcgcg gagctggcac cttggcgctg ttggtggcgg cggagacagc
       61 tgtgaagtgt gaggttcttt gtctgctggc agctaggggc gacgaggcgg gacgtcatgg
      121 aagtgaagga tgccaattct gcgcttctca gtaactacga ggtatttcag ttactaactg
      181 atctgaaaga gcagcgtaaa gaaagtggaa agaataaaca cagctctggg caacagaact
      241 tgaacactat cacctatgaa acgttaaaat acatatcaaa aacaccatgc aggcaccaga
      301 gtcctgaaat tgtcagagaa tttctcacag cattgaaaag ccacaagttg accaaagctg
      361 agaagctcca gctgctgaac caccggcctg tgactgctgt ggagatccag ctgatggtgg
      421 aagagagtga agagcggctc acggaggagc agattgaagc tcttctccac accgtcacca
      481 gcattctgcc tgcagagcca gaggctgagc agaagaagaa tacaaacagc aatgtggcaa
      541 tggacgaaga ggacccagca tagaagagca cagctggccc cggcgtttca tgaagtcaga
      601 aggcctggca gccatttcct ggacgttgag aggattgttt atttgatttt tatcctcatc
      661 ccagcaggcc tggctttgtg gttagttggg tacatcacaa aaataagtta aaaagaaata
      721 tttgtgcctt ggggagaaga aacatggtga aaacaggctg aggttgtcag ggcagagagc
      781 tgaaggtggg gacagtgacc gcggacccct ctgtgcttga aagatttcct ccacggcctt
      841 tgccccagtt gtggggaggt ctctgtgcac agcggggaaa atgcttgtgt cgcctttggt
      901 gggccatgtc ctaattagtt tcatctgctt ccctgggaac ttactaaggg gcccagagca
      961 ctgttggaag tctggttaga gtccccagag agttactcta agttaaaatg agccactgac
     1021 cttggctcac cttagaggaa tttcctcgag aacaacagag ataagaaaag aaccggcctg
     1081 gccaatcctt caacagctct agagcccctt ttctctgctg gcaggggctt tgtttaccag
     1141 ctcactgttt aggctaaatg ttagggacca gatcactgca gttgaaaacg ggcactccag
     1201 gcttagtgac agtggcagca gaaacagtgt tggctgcctt tctgaccacc ccactttcct
     1261 gccctgagac agcagcccag ggcaggtgct tcatattcag accaggtaag cctcatttgc
     1321 acaacagtca aattgtttgt tcctttaaaa aggacacaat tagcctggca cggtgactca
     1381 tgcttgtaat cccagcactt tgggagggca aggcaggcgg atcacctgag gtcaggagtt
     1441 tgagaccagc ctcaccaaca tggaaaaacc ccatctctac taaaaaaata caaaattaac
     1501 caggggtgat ggcacattcc tgtaatccca gctactcggg aggccgaggc aggagaatcg
     1561 cttgaacccg ggaggcagag gttgaggtga gccaagattg caccattgca ctccagcctg
     1621 ggcaacaaga gcaaaacttc atctaaaaaa cagaaaatat taagatgatt accatgtgaa
     1681 aaccttttta atattcagga tttggaaagt atagttgccc caggcatgtg gttgttgcct
     1741 taggtcctgc gaatattgct gaaaatcgga ttttccacat tcactttctt ccctgtttta
     1801 gggaagaaaa tgatcataga cattcgattt tccaaattgg cgctcttatt ttcaatgcta
     1861 attggattac ttctcttcca accctcctgc ccgtccatcc atcccagtcc ccaggcatct
     1921 taaccttacc atctgagctt cagctgaaat ctgtttatag gcaacattga aagtaccaga
     1981 ttggggccag gtgtagcggc ccacacctgt aatcccagca ctttgggagg cggaggctag
     2041 cggatcatga ggtcaggagt tcaagaccag cctggccaac atggtgaaac ccccatctct
     2101 actaaagata taaaaaacta gccgagcgtg gtgttgcatg cctgtgatcc cagctactcg
     2161 ggaggctgag gcgggggaat cgcttgaacc ggggaggcag aggttgcagt gagccagatc
     2221 gtgcattgca ctccagcctg gccgacaggg tgagactcca tctcaaaaaa gagaaagtac
     2281 cagattgtac ttttaaatct gtctagcgta ttgagaattt tagtgggagc tgttgattta
     2341 tttctcaggg catacatgtg ccaatctgtc tcattgttgt ctctctcttt tttttttttt
     2401 tttttgagac agtctcgctg tgttgcccag gagtgcagtg gcacgatctc tgctcactgc
     2461 aacctctgcc tcccagattc aagcgattct ggtgccttag cctcctgagt agctgggact
     2521 tacaggcacg taccactata ccctgctaaa atttgtattt ttagtagaga cagggttttg
     2581 ccatattggc caggctagtc gtaatgtctc tttttaacac tgaatatgtt aggtggtttt
     2641 tcttgatgga tttagggtta acctagttaa taataaattg tttccaggta attatcaagt
     2701 tttgtcattt tataaatctg aagagttaat attgtcatcg atacaaataa agtgaaatct
     2761 gactgaggct aaaa
//
