LOCUS       NM_201253               4958 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens crumbs cell polarity complex component 1 (CRB1),
            transcript variant 1, mRNA.
ACCESSION   NM_201253
VERSION     NM_201253.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4958)
  AUTHORS   Daher,A., Banjak,M., Noureldine,J., Nehme,J. and El Shamieh,S.
  TITLE     Genotype-phenotype associations in CRB1 bi-allelic patients: a
            novel mutation, a systematic review and meta-analysis
  JOURNAL   BMC Ophthalmol 24 (1), 167 (2024)
   PUBMED   38622537
  REMARK    GeneRIF: Genotype-phenotype associations in CRB1 bi-allelic
            patients: a novel mutation, a systematic review and meta-analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4958)
  AUTHORS   Stehle,I.F., Imventarza,J.A., Woerz,F., Hoffmann,F., Boldt,K.,
            Beyer,T., Quinn,P.M. and Ueffing,M.
  TITLE     Human CRB1 and CRB2 form homo- and heteromeric protein complexes in
            the retina
  JOURNAL   Life Sci Alliance 7 (6), e202302440 (2024)
   PUBMED   38570189
  REMARK    GeneRIF: Human CRB1 and CRB2 form homo- and heteromeric protein
            complexes in the retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4958)
  AUTHORS   den Hollander,A.I., Heckenlively,J.R., van den Born,L.I., de
            Kok,Y.J., van der Velde-Visser,S.D., Kellner,U., Jurklies,B., van
            Schooneveld,M.J., Blankenagel,A., Rohrschneider,K., Wissinger,B.,
            Cruysberg,J.R., Deutman,A.F., Brunner,H.G., Apfelstedt-Sylla,E.,
            Hoyng,C.B. and Cremers,F.P.
  TITLE     Leber congenital amaurosis and retinitis pigmentosa with Coats-like
            exudative vasculopathy are associated with mutations in the crumbs
            homologue 1 (CRB1) gene
  JOURNAL   Am J Hum Genet 69 (1), 198-203 (2001)
   PUBMED   11389483
  REMARK    Erratum:[Am J Hum Genet 2001 Nov;69(5):1160]
REFERENCE   4  (bases 1 to 4958)
  AUTHORS   den Hollander,A.I., ten Brink,J.B., de Kok,Y.J., van Soest,S., van
            den Born,L.I., van Driel,M.A., van de Pol,D.J., Payne,A.M.,
            Bhattacharya,S.S., Kellner,U., Hoyng,C.B., Westerveld,A.,
            Brunner,H.G., Bleeker-Wagemakers,E.M., Deutman,A.F.,
            Heckenlively,J.R., Cremers,F.P. and Bergen,A.A.
  TITLE     Mutations in a human homologue of Drosophila crumbs cause retinitis
            pigmentosa (RP12)
  JOURNAL   Nat Genet 23 (2), 217-221 (1999)
   PUBMED   10508521
REFERENCE   5  (bases 1 to 4958)
  AUTHORS   den Hollander,A.I., van Driel,M.A., de Kok,Y.J., van de Pol,D.J.,
            Hoyng,C.B., Brunner,H.G., Deutman,A.F. and Cremers,F.P.
  TITLE     Isolation and mapping of novel candidate genes for retinal
            disorders using suppression subtractive hybridization
  JOURNAL   Genomics 58 (3), 240-249 (1999)
   PUBMED   10373321
REFERENCE   6  (bases 1 to 4958)
  AUTHORS   van Soest,S., te Nijenhuis,S., van den Born,L.I.,
            Bleeker-Wagemakers,E.M., Sharp,E., Sandkuijl,L.A., Westerveld,A.
            and Bergen,A.A.
  TITLE     Fine mapping of the autosomal recessive retinitis pigmentosa locus
            (RP12) on chromosome 1q; exclusion of the phosducin gene (PDC)
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 81-85 (1996)
   PUBMED   8646891
REFERENCE   7  (bases 1 to 4958)
  AUTHORS   van Soest,S., van den Born,L.I., Gal,A., Farrar,G.J.,
            Bleeker-Wagemakers,L.M., Westerveld,A., Humphries,P.,
            Sandkuijl,L.A. and Bergen,A.A.
  TITLE     Assignment of a gene for autosomal recessive retinitis pigmentosa
            (RP12) to chromosome 1q31-q32.1 in an inbred and genetically
            heterogeneous disease population
  JOURNAL   Genomics 22 (3), 499-504 (1994)
   PUBMED   8001962
REFERENCE   8  (bases 1 to 4958)
  AUTHORS   Kumaran,N., Pennesi,M.E., Yang,P., Trzupek,K.M., Schlechter,C.,
            Moore,A.T., Weleber,R.G. and Michaelides,M.
  TITLE     Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   30285347
REFERENCE   9  (bases 1 to 4958)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
REFERENCE   10 (bases 1 to 4958)
  AUTHORS   Weleber,R.G., Francis,P.J., Trzupek,K.M. and Beattie,C.
  TITLE     Leber Congenital Amaurosis - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513325.13, AL136322.24 and
            AL139136.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_201253.2.
            
            Summary: This gene encodes a protein which is similar to the
            Drosophila crumbs protein and localizes to the inner segment of
            mammalian photoreceptors. In Drosophila crumbs localizes to the
            stalk of the fly photoreceptor and may be a component of the
            molecular scaffold that controls proper development of polarity in
            the eye. Mutations in this gene are associated with a severe form
            of retinitis pigmentosa, RP12, and with Leber congenital amaurosis.
            Alternate splicing results in multiple transcript variants, some
            protein coding and some non-protein coding.[provided by RefSeq, Apr
            2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY043325.1, MT470365.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367400.8/ ENSP00000356370.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AL513325.13        60835-61065
            232-813             AL513325.13        121005-121586
            814-1009            AL513325.13        136864-137059
            1010-1149           AL513325.13        139923-140062
            1150-1332           AL513325.13        149414-149596
            1333-2289           AL136322.24        2694-3650
            2290-2837           AL136322.24        9148-9695
            2838-3003           AL136322.24        11143-11308
            3004-3910           AL136322.24        16400-17306
            3911-4039           AL136322.24        20241-20369
            4040-4166           AL136322.24        23860-23986
            4167-4958           AL139136.17        5404-6195
FEATURES             Location/Qualifiers
     source          1..4958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.3"
     gene            1..4958
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /note="crumbs cell polarity complex component 1"
                     /db_xref="GeneID:23418"
                     /db_xref="HGNC:HGNC:2343"
                     /db_xref="MIM:604210"
     exon            1..231
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..4382
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; crumbs family member 1, photoreceptor
                     morphogenesis associated; protein crumbs homolog 1; crumbs
                     1, cell polarity complex component"
                     /codon_start=1
                     /product="protein crumbs homolog 1 isoform 1 precursor"
                     /protein_id="NP_957705.1"
                     /db_xref="CCDS:CCDS1390.1"
                     /db_xref="GeneID:23418"
                     /db_xref="HGNC:HGNC:2343"
                     /db_xref="MIM:604210"
                     /translation="MALKNINYLLIFYLSFSLLIYIKNSFCNKNNTRCLSNSCQNNST
                     CKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGY
                     SGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNG
                     AVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSG
                     VNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGL
                     CVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGA
                     QCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGI
                     HCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQC
                     LNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWVKSGSVTTKGSVC
                     NIALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGE
                     WHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNSFLGGLPVGMTSNG
                     VALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCVRKDWCESQPCQ
                     SRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDESYGDTISLS
                     MFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSPKLVVKFVLNDGNVHLISL
                     KIKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQETELNGGFFKGCIQDVR
                     LNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGGVCHSRWDDFSCSCP
                     ALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVFNGQSGQILFRSNGNITRE
                     LTNITFGFRTRDANVIILHAEKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVN
                     DGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDIYVGDRAID
                     NIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQLNVCNSN
                     PCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHCTCEP
                     GYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNE
                     KTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQ
                     CLCDVAFAGERCEVDLADDLISDIFTTIGSVTVALLLILLLAIVASVVTSNKRATQGT
                     YSPSRQEKEGSRVEMWNLMPPPAMERLI"
     exon            232..813
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1009
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1149
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1332
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2289
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2837
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3003
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3910
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            3911..4039
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4166
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4958
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4941..4946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /note="hexamer: AATAAA"
     polyA_site      4958
                     /gene="CRB1"
                     /gene_synonym="CRB1-A; CRB1-B; CRB1-C; LCA8; RP12"
                     /note="major polyA site"
ORIGIN      
        1 agtccctgta ttttctgtga aggagctgta agtagggtgg gacagagatg gcacctgggg
       61 gttctgaggc acccgctcct ctctgagaca gacagggatc aggagccgga ctgggaccag
      121 accaccagca acacaccaga ggatgttctc taaataagac catggcactt aagaacatta
      181 actaccttct catcttctac ctcagtttct cactgcttat ctacataaaa aattcctttt
      241 gcaataaaaa caacaccagg tgcctctcaa attcttgcca aaacaattct acatgcaaag
      301 atttttcaaa agacaatgat tgttcttgtt cagacacagc caataatttg gacaaagact
      361 gtgacaacat gaaagaccct tgcttctcca atccctgtca aggaagtgcc acttgtgtga
      421 acaccccagg agaaaggagc tttctgtgca aatgtcctcc tgggtacagt gggacaatct
      481 gtgaaactac cattggttcc tgtggcaaga actcctgcca acatggaggt atttgccatc
      541 aggaccctat ttatcctgtc tgcatctgcc ctgctggata tgctggaaga ttctgtgaga
      601 tagatcacga tgagtgtgct tccagccctt gccaaaatgg ggccgtgtgc caggatggaa
      661 ttgatggtta ctcctgcttc tgtgtcccag gatatcaagg cagacactgc gacttggaag
      721 tggatgaatg tgcttcagat ccctgcaaga acgaggctac atgcctcaat gaaataggaa
      781 gatatacttg tatctgtccc cacaattatt ctggtgtaaa ctgtgaattg gaaattgacg
      841 aatgttggtc ccagccttgt ttaaatggtg caacttgtca ggatgctctg ggggcctatt
      901 tctgcgactg tgcccctgga ttcctggggg atcactgtga actcaacact gatgagtgtg
      961 ccagtcaacc ttgtctccat ggagggctgt gtgtggatgg agaaaacaga tatagctgta
     1021 actgcacggg tagtggattc acagggacac actgtgagac cttgatgcct ctttgttggt
     1081 caaaaccttg tcacaataat gctacatgtg aggacagtgt tgacaattac acttgtcact
     1141 gctggcctgg atacacaggt gcccagtgtg agatcgacct caatgaatgc aatagtaacc
     1201 cctgccagtc caatggggaa tgtgtggagc tgtcctcaga gaaacaatat ggacgcatca
     1261 ctggactgcc ttcttctttc agctaccatg aagcctcagg ttatgtctgt atctgtcagc
     1321 ctggattcac aggaatccac tgcgaagaag acgtcaatga atgttcttca aacccttgcc
     1381 aaaatggtgg tacttgtgag aacttgcctg ggaattatac ttgccattgc ccatttgata
     1441 acctttctag aactttttat ggaggaaggg actgttctga tattctcctg ggctgtaccc
     1501 atcagcaatg tctaaataat ggaacatgca tccctcactt ccaagatggc cagcatggat
     1561 tcagctgcct atgtccatct ggctacaccg ggtccctgtg tgaaatcgca accacacttt
     1621 catttgaggg cgatggcttc ctgtgggtca aaagtggctc agtgacaacc aagggctcag
     1681 tttgtaacat agccctcagg tttcagactg ttcagccaat ggctcttcta cttttccgaa
     1741 gcaacaggga tgtgtttgtg aagctggagc tgctaagtgg ctacattcac ttatcaattc
     1801 aggtcaataa tcagtcaaag gtgcttctgt tcatttccca caacaccagc gatggagagt
     1861 ggcatttcgt ggaggtaata tttgcagagg ctgtgaccct taccttaatc gacgactcct
     1921 gtaaggagaa atgcatcgcg aaagctccta ctccacttga aagtgatcaa tcaatatgtg
     1981 cttttcagaa ctcctttttg ggtggtttac cagtgggaat gaccagcaat ggtgttgctc
     2041 tgcttaactt ctataatatg ccatccacac cttcgtttgt aggctgtctc caagacatta
     2101 aaattgattg gaatcacatt accctggaga acatctcgtc tggctcatca ttaaatgtca
     2161 aggcaggctg tgtgagaaag gattggtgtg aaagccaacc ttgtcaaagc agaggacgct
     2221 gcatcaactt gtggctgagt taccagtgtg actgccacag gccctatgaa ggccccaact
     2281 gtctgagaga gtatgtggca ggcagatttg gccaggatga ctccactggt tatgtcatct
     2341 ttactcttga tgagagctat ggagacacca tcagcctctc catgtttgtc cgaacgcttc
     2401 aaccatcagg cttacttcta gctttggaaa acagcactta tcaatatatc cgtgtctggc
     2461 tagagcgcgg cagactagca atgctgactc caaactctcc caaattagta gtaaaatttg
     2521 ttcttaatga tggaaatgtc cacttgatat ctttgaaaat caagccatat aaaattgaac
     2581 tgtatcagtc ttcacaaaac ctaggattta tttctgcttc tacgtggaaa atcgaaaagg
     2641 gagatgtcat ctacattggt ggcctacctg acaagcaaga gactgaactt aatggtggat
     2701 tcttcaaagg ctgtatccaa gatgtaagac taaacaacca aaatctggaa ttctttccaa
     2761 atccaacaaa caatgcatct ctcaatccag ttcttgtcaa tgtaacccaa ggctgtgctg
     2821 gagacaacag ctgcaagtcc aacccctgtc acaatggagg tgtttgccat tcccggtggg
     2881 atgacttctc ctgttcctgt cctgccctca caagtgggaa agcctgtgag gaggttcagt
     2941 ggtgtggatt cagcccgtgt cctcacggag cccagtgcca gccggtgctt caaggatttg
     3001 aatgtattgc aaatgctgtt tttaatggac aaagcggtca aatattattc agaagcaatg
     3061 ggaatattac cagagaactc accaatatca catttggttt cagaacaagg gatgcaaatg
     3121 taataatatt gcatgcagaa aaagagcctg aatttcttaa tattagcatt caagattcca
     3181 gattattctt tcaattgcaa agtggcaaca gcttttatat gctaagtctg acaagtttgc
     3241 agtcagtgaa tgatggcaca tggcacgaag tgaccctttc catgacagac ccactgtccc
     3301 agacctccag gtggcaaatg gaagtggaca acgaaacacc ttttgtgacc agcacaattg
     3361 ctactggaag cctcaacttt ttgaaggata atacagatat ttatgtggga gacagagcta
     3421 ttgacaatat aaagggcctg caagggtgtc taagtacaat agaaatcgga ggcatttatc
     3481 tctcttactt tgaaaatgtt catggtttca ttaataaacc tcaggaagag caatttctca
     3541 aaatctctac caattcagtg gtcactggct gtttgcagtt aaatgtctgc aactccaacc
     3601 cctgtttgca tggaggaaac tgtgaagaca tctatagctc ttatcattgc tcctgtccct
     3661 tgggatggtc agggaaacac tgtgaactca acatcgatga atgcttttca aacccctgta
     3721 tccatggcaa ctgctctgac agagttgcag cctaccactg cacatgtgag cctggataca
     3781 ctggtgtgaa ctgtgaagtg gatatagaca actgccagag tcaccagtgt gcaaatggag
     3841 ccacctgcat tagtcatact aatggctatt cttgcctctg ttttggaaat tttacaggaa
     3901 aattttgcag acagagcaga ttaccctcaa cagtctgtgg gaatgagaag acaaatctca
     3961 cttgctacaa tggaggcaac tgcacagagt tccagactga attaaaatgt atgtgccggc
     4021 caggttttac tggagaatgg tgtgaaaagg acattgatga gtgtgcctct gatccgtgtg
     4081 tcaatggagg tctgtgccag gacttactca acaaattcca gtgcctctgt gatgttgcct
     4141 ttgctggcga gcgctgcgag gtggacttgg cagatgactt gatctccgac attttcacca
     4201 ctattggctc agtgactgtc gccttgttac tgatcctctt gctggccatt gttgcttctg
     4261 ttgtcacctc caacaaaagg gcaactcagg gaacctacag ccccagccgt caggagaagg
     4321 agggctcccg agtggaaatg tggaacttga tgccaccccc tgcaatggag agactgattt
     4381 aggagcattg tgtcccttcg agatggggat ccacacactg tgaatgtgat gactgtactt
     4441 caggtatctc tgacatacct gacaatgtta atctgcaact gggattacac tggaactaca
     4501 ggaatgattc ctttgaccac cttaaaaact ttcacagtgg ttccgctcga caccattgtt
     4561 ttattatatt atatcagcca attgcaaaaa aagtctgtgc cagtaatttc agccttataa
     4621 ttagcaaaaa catcttccag agaataaagt cttctgtggc tttagtggct atcactgaaa
     4681 ctctttcctc ttttcaacct gggaacaaat tttagttttc attttaggtt tctgtacttt
     4741 ctgtagtttc tgtgtaaact gccatatgtt tacatggaaa ctacaggaaa aaattggcta
     4801 catttctcac ttctcctatc atgtggtcaa agttattgtt gtataccagc gatgggatgt
     4861 atacttttgt ccttcattca tggattcaga gaaagctctg ggaatgactt atggtccaaa
     4921 aaagtgaccc aatggcaaca aataaaaatt gaaatgca
//
