LOCUS       NM_003805               1189 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens CASP2 and RIPK1 domain containing adaptor with death
            domain (CRADD), transcript variant 1, mRNA.
ACCESSION   NM_003805
VERSION     NM_003805.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1189)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1189)
  AUTHORS   Koprulu,M., Shabbir,R.M.K., Zaman,Q., Nalbant,G., Malik,S. and
            Tolun,A.
  TITLE     CRADD and USP44 mutations in intellectual disability, mild
            lissencephaly, brain atrophy, developmental delay, strabismus,
            behavioural problems and skeletal anomalies
  JOURNAL   Eur J Med Genet 64 (4), 104181 (2021)
   PUBMED   33647455
  REMARK    GeneRIF: CRADD and USP44 mutations in intellectual disability, mild
            lissencephaly, brain atrophy, developmental delay, strabismus,
            behavioural problems and skeletal anomalies.
REFERENCE   3  (bases 1 to 1189)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1189)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1189)
  AUTHORS   Choi,S.G., Olivet,J., Cassonnet,P., Vidalain,P.O., Luck,K.,
            Lambourne,L., Spirohn,K., Lemmens,I., Dos Santos,M., Demeret,C.,
            Jones,L., Rangarajan,S., Bian,W., Coutant,E.P., Janin,Y.L., van der
            Werf,S., Trepte,P., Wanker,E.E., De Las Rivas,J., Tavernier,J.,
            Twizere,J.C., Hao,T., Hill,D.E., Vidal,M., Calderwood,M.A. and
            Jacob,Y.
  TITLE     Maximizing binary interactome mapping with a minimal number of
            assays
  JOURNAL   Nat Commun 10 (1), 3907 (2019)
   PUBMED   31467278
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1189)
  AUTHORS   Villunger,A., Huang,D.C., Holler,N., Tschopp,J. and Strasser,A.
  TITLE     Fas ligand-induced c-Jun kinase activation in lymphoid cells
            requires extensive receptor aggregation but is independent of DAXX,
            and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD
  JOURNAL   J Immunol 165 (3), 1337-1343 (2000)
   PUBMED   10903735
REFERENCE   7  (bases 1 to 1189)
  AUTHORS   Shearwin-Whyatt,L.M., Harvey,N.L. and Kumar,S.
  TITLE     Subcellular localization and CARD-dependent oligomerization of the
            death adaptor RAIDD
  JOURNAL   Cell Death Differ 7 (2), 155-165 (2000)
   PUBMED   10713730
REFERENCE   8  (bases 1 to 1189)
  AUTHORS   Chou,J.J., Matsuo,H., Duan,H. and Wagner,G.
  TITLE     Solution structure of the RAIDD CARD and model for CARD/CARD
            interaction in caspase-2 and caspase-9 recruitment
  JOURNAL   Cell 94 (2), 171-180 (1998)
   PUBMED   9695946
REFERENCE   9  (bases 1 to 1189)
  AUTHORS   Ahmad,M., Srinivasula,S.M., Wang,L., Talanian,R.V., Litwack,G.,
            Fernandes-Alnemri,T. and Alnemri,E.S.
  TITLE     CRADD, a novel human apoptotic adaptor molecule for caspase-2, and
            FasL/tumor necrosis factor receptor-interacting protein RIP
  JOURNAL   Cancer Res 57 (4), 615-619 (1997)
   PUBMED   9044836
REFERENCE   10 (bases 1 to 1189)
  AUTHORS   Duan,H. and Dixit,V.M.
  TITLE     RAIDD is a new 'death' adaptor molecule
  JOURNAL   Nature 385 (6611), 86-89 (1997)
   PUBMED   8985253
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY113325.1, BC017042.1 and
            AA150833.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003805.4.
            
            Summary: This gene encodes a protein containing a death domain (DD)
            motif. This protein recruits caspase 2/ICH1 to the cell death
            signal transduction complex, which includes tumor necrosis factor
            receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting
            apoptosis. A mutation in this gene was associated with cognitive
            disability. A related pseudogene is found on chromosome 3.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.72421.1,
                                           SRR5189655.88198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332896.8/ ENSP00000327647.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                HY113325.1         6-29
            25-1169             BC017042.1         1-1145
            1170-1189           AA150833.1         13-32               c
FEATURES             Location/Qualifiers
     source          1..1189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..1189
                     /gene="CRADD"
                     /gene_synonym="MRT34; RAIDD"
                     /note="CASP2 and RIPK1 domain containing adaptor with
                     death domain"
                     /db_xref="GeneID:8738"
                     /db_xref="HGNC:HGNC:2340"
                     /db_xref="MIM:603454"
     exon            1..98
                     /gene="CRADD"
                     /gene_synonym="MRT34; RAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            99..402
                     /gene="CRADD"
                     /gene_synonym="MRT34; RAIDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..704
                     /gene="CRADD"
                     /gene_synonym="MRT34; RAIDD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     caspase and RIP adaptor with death domain; RIP-associated
                     ICH1/CED3-homologous protein with death domain; death
                     adaptor molecule RAIDD; death domain containing protein
                     CRADD; CRADD/LYZ fusion"
                     /codon_start=1
                     /product="death domain-containing protein CRADD isoform 1"
                     /protein_id="NP_003796.1"
                     /db_xref="CCDS:CCDS9048.1"
                     /db_xref="GeneID:8738"
                     /db_xref="HGNC:HGNC:2340"
                     /db_xref="MIM:603454"
                     /translation="MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEI
                     NAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDR
                     LTGIPSHILNSSPSDRQINQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQV
                     VEAFIRWRQRFGKQATFQSLHNGLRAVEVDPSLLLHMLE"
     exon            403..1189
                     /gene="CRADD"
                     /gene_synonym="MRT34; RAIDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRADD"
                     /gene_synonym="MRT34; RAIDD"
                     /note="hexamer: AATAAA"
     polyA_site      1189
                     /gene="CRADD"
                     /gene_synonym="MRT34; RAIDD"
                     /note="major polyA site"
ORIGIN      
        1 gccattaaca aagatggtgc ttatggggca ggttccctaa cagtcaggat tccggttgca
       61 gtttttctcc cccgccccaa agatacgtgg ttgcagacgg agaaatggag gccagagaca
      121 aacaagtact ccgctcactt cgcctggagc tgggtgcaga ggtattggtg gagggactgg
      181 ttcttcagta cctctaccag gaaggaatct tgacggaaaa ccatattcaa gaaatcaatg
      241 ctcaaaccac aggcctccgg aaaacaatgc tcctgctgga tatcctacct tccaggggcc
      301 ctaaagcatt tgatacattc ctagattccc tacaggagtt tccctgggtc agggagaagc
      361 tgaagaaggc aagggaagag gccatgaccg acctgcctgc aggtgacaga ttgactggga
      421 tcccctcgca catcctcaac agctccccat cagaccggca gattaaccag ctggcccaga
      481 ggctgggccc tgagtgggag cccatggtgc tgtctctggg actgtcccag acggatatct
      541 accgctgtaa ggccaaccac ccccacaacg tgcagtcgca ggtggtggag gccttcatcc
      601 gttggcggca gcgcttcggg aagcaggcca ccttccagag cctgcacaac gggctgcggg
      661 ctgtggaggt ggacccctcg ctgctcctgc acatgttgga gtgatggtgc ctccagcaac
      721 cgctggggag tgtgtccctg agtcatgtgg gctgaatcct gactttcact cagagcaggt
      781 ggttttttgt gtaggtttgt tttttatttt tgatgatctt cagatggaag gagaaaacag
      841 ggtttccact agacattact tgaaaggcca gattactcag cagatctccc atgttggctc
      901 aacaattctt tgtttttaat tgcttgaaga ttgcattgtt gtaattgttc agtttttaaa
      961 tgtgtaatgg cattttaata gactagtaaa tcacagtggt tcaaaatata tatccatata
     1021 tatatatatc catatatata tctcatgtca tcacattaca ggcaggtgtc tcatatgtaa
     1081 aacatttacc tgaatgttgt ctgaggactg aactgtggac tttactattc ataatgataa
     1141 aataataaaa tgcgaattac tatatataat gtgcctcact catgagaaa
//
