LOCUS       NM_001286606            2166 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calcium release activated channel regulator 2B
            (CRACR2B), transcript variant 1, mRNA.
ACCESSION   NM_001286606 XM_005252875
VERSION     NM_001286606.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2166)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2166)
  AUTHORS   Lee,J.H., Cho,M.H., Hersh,C.P., McDonald,M.L., Crapo,J.D.,
            Bakke,P.S., Gulsvik,A., Comellas,A.P., Wendt,C.H., Lomas,D.A.,
            Kim,V. and Silverman,E.K.
  CONSRTM   COPDGene and ECLIPSE Investigators
  TITLE     Genetic susceptibility for chronic bronchitis in chronic
            obstructive pulmonary disease
  JOURNAL   Respir Res 15 (1), 113 (2014)
   PUBMED   25241909
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2166)
  AUTHORS   Srikanth,S., Jung,H.J., Kim,K.D., Souda,P., Whitelegge,J. and
            Gwack,Y.
  TITLE     A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that
            stabilizes CRAC channels in T cells
  JOURNAL   Nat Cell Biol 12 (5), 436-446 (2010)
   PUBMED   20418871
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP006621.1, BC073821.1, GU952799.1, AK097334.1 and BU621015.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001286606.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.269690.1, GU952799.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525077.2/ ENSP00000435299.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AP006621.1         122814-123154
            342-689             BC073821.1         95-442
            690-1889            GU952799.1         1-1200
            1890-2165           AK097334.1         2165-2440
            2166-2166           BU621015.1         24-24               c
FEATURES             Location/Qualifiers
     source          1..2166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..2166
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /note="calcium release activated channel regulator 2B"
                     /db_xref="GeneID:283229"
                     /db_xref="HGNC:HGNC:28703"
                     /db_xref="MIM:614177"
     exon            1..854
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             690..1889
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     EF-hand calcium-binding domain-containing protein 4A; CRAC
                     channel regulator 2B; calcium release-activated calcium
                     channel regulator 2B; EF-hand calcium binding domain 4A;
                     CRAC regulator 2B; Ca2+ release-activated Ca2+ (CRAC)
                     channel regulator 2B"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 4A isoform 1"
                     /protein_id="NP_001273535.1"
                     /db_xref="CCDS:CCDS65995.1"
                     /db_xref="GeneID:283229"
                     /db_xref="HGNC:HGNC:28703"
                     /db_xref="MIM:614177"
                     /translation="MASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKE
                     AKGFITKHDLQGLQSDLPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQ
                     GANPCRTPEETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTL
                     WARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEET
                     EQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRELEQQLHAQAAEHLE
                     AQAQNSQLWRAHEALRTQLEGAQEQIRRLESEARGRQEQTQRDVVAVSRNMQKEKVSL
                     LRQLELLRELNTRLRDDRDACEARRAGSSCRKALTTARLPGPTCCCCCCWARPPRRGS
                     GHLPSAR"
     exon            855..966
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1147
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1294
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1382
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1475
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1642
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1714
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2166
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2147..2152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="CRACR2B"
                     /gene_synonym="EFCAB4A"
                     /note="major polyA site"
ORIGIN      
        1 agtgttgtgg ggcaagggtg ttaggtctcg aatctggaag tgttcctgag tggggcgtca
       61 gaggcgaagg gctctgcagg ctgggacctt gcccctgcac tctgtgggct cagttgtggg
      121 gagggagggg ccggtgggca ggagggagaa gtctgccctg cctgccagct gtcatgaggc
      181 tgggccacac aggcccaggc caggggctaa ggacttggtc aggactggct gagccctcac
      241 ttgggatcag atctccagtt gcagagtgtg aggggctcct ccctcactga ccccaagcct
      301 gctcctctca gctttcagga ccccaccttc cttatcacca ggtcttctcc actggcccct
      361 gagattgcca tcacctccag ctcctcctct cctgaagttg gcagcccctc ctgggttcca
      421 gcctcctgag atgccagacc cactggggca gtacccacag gccctgagcc tacatcaacc
      481 accccagtga caccccaagc ctgcagcatt ttccaccccc agccccctgg tcccaccttg
      541 ccttccgccc accttcccac ctgctgcagg gagggccctc ggctgagcct tcagacacac
      601 ttgcacccca tccgctcccc tcctgaattt cttctgaccc tcccttggct tcacagcacc
      661 tgaaggccag gctgaggccc cctgctctca tggccagccc tggaaagcct ggggctgatg
      721 aggcccagga ggaggagggg gaactcgagg ggggctctgc agggccgcgg gctgcaatac
      781 tggagcaggc tgaggagctg tttctgctgt gtgacaagga ggctaagggc ttcatcacca
      841 agcacgacct gcagggtctc cagagcgacc tgcccctcac gccagagcag ctggaggctg
      901 tgtttgaaag tctggaccgg gctcacactg gcttcctcac cgccagggag ttctgcctgg
      961 gcctggggat gtttgtgggg gtggcgtcag cccagggagc gaacccctgc aggactcccg
     1021 aggagacctt tgagtcgggc gggctcgacg tgcagggcac ggcgggctct ctggatgagg
     1081 aggaggaaga ggaggagcga ttccacactg tgctggagca gctgggggtg gccccggtcc
     1141 tgggcaagca gcgggctgtg aggacgctct gggccaggct gcagcgcgag cgccccgagc
     1201 tgctgggctc tttcgaggat gttctgatac gcgcgtcggc ctgcctggag gaggcggccc
     1261 gggagcgcga cggcctggag caggcgctgc ggaggcgcga gagcgagcac gagagggagg
     1321 tgcgcgctct gtacgaggag acggagcagc ttcgggagca gagccggcgc ccgccgagtc
     1381 agaacttcgc ccgcggggag cggagaagcc gtctggagct ggagctgcag agccgcgagc
     1441 aggacctgga acgcgcgggc ctgcggcagc gggagttaga gcagcagctg cacgcccagg
     1501 ctgcggagca cctggaggca caggcccaga actcccagct gtggcgggcg cacgaggcgc
     1561 tgcgaacgca gctggagggg gcgcaggagc agatccgcag gctggagagc gaagcacgag
     1621 gccgccagga gcaaacccaa cgagacgtgg tcgccgtctc caggaacatg cagaaagaga
     1681 aagtcagcct gctacggcaa ctggagctgc tcagggagct gaatacacgg ctgcgggatg
     1741 acagggacgc ctgcgaggcc aggcgggcgg gcagcagctg caggaaggct ctgacaacag
     1801 cccgcctgcc tgggcccacc tgctgctgct gctgttgctg ggctcggccc cccagacgcg
     1861 gctctggcca ccttcccagt gcccggtgac cagccccgag tgactcacgg accatgagct
     1921 agaagctgcc cttgcaggag gcttgtcatg ggtcgggggt gcccactcag gatgcaggct
     1981 ctccccagtg ggccccaggc tcgcctgact gaagacatga aggacctagc ctaggagtgg
     2041 tcagggtccc gggagtggcc agggtcccgt gtgtgccctc tgccagtctt cgctctgtcc
     2101 ccgttcaatc aaccccatct cagttcagca gaaaaccccc tcgtcaaata aaacccactg
     2161 actgca
//
