LOCUS       NM_001878                974 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens cellular retinoic acid binding protein 2 (CRABP2),
            transcript variant 1, mRNA.
ACCESSION   NM_001878
VERSION     NM_001878.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Liu,J., Tang,L., Chu,W. and Wei,L.
  TITLE     Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by
            HPV E6/E7, Leads to Aberrant Activation of the Integrin
            beta1/FAK/ERK Signaling Pathway and Aggravates the Malignant
            Phenotypes of Cervical Cancer
  JOURNAL   Biochem Genet 62 (4), 2686-2701 (2024)
   PUBMED   38001389
  REMARK    GeneRIF: Cellular Retinoic Acid Binding Protein 2 (CRABP2),
            Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the
            Integrin beta1/FAK/ERK Signaling Pathway and Aggravates the
            Malignant Phenotypes of Cervical Cancer.
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Guo,S., Huang,B., You,Z., Luo,Z., Xu,D., Zhang,J. and Lin,J.
  TITLE     FOXD2-AS1 promotes malignant cell behavior in oral squamous cell
            carcinoma via the miR-378 g/CRABP2 axis
  JOURNAL   BMC Oral Health 24 (1), 625 (2024)
   PUBMED   38807101
  REMARK    GeneRIF: FOXD2-AS1 promotes malignant cell behavior in oral
            squamous cell carcinoma via the miR-378 g/CRABP2 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 974)
  AUTHORS   Fu,X., Zhang,Q., Wang,Z., Xu,Y. and Dong,Q.
  TITLE     CRABP2 affects chemotherapy resistance of ovarian cancer by
            regulating the expression of HIF1alpha
  JOURNAL   Cell Death Dis 15 (1), 21 (2024)
   PUBMED   38195606
  REMARK    GeneRIF: CRABP2 affects chemotherapy resistance of ovarian cancer
            by regulating the expression of HIF1alpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Zeng,S., Chen,X.I., Yi,Q., Thakur,A., Yang,H., Yan,Y. and Liu,S.
  TITLE     CRABP2 regulates infiltration of cancer-associated fibroblasts and
            immune response in melanoma
  JOURNAL   Oncol Res 32 (2), 261-272 (2023)
   PUBMED   38186580
  REMARK    GeneRIF: CRABP2 regulates infiltration of cancer-associated
            fibroblasts and immune response in melanoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Mei,J., Cai,Y., Chen,L., Wu,Y., Liu,J., Qian,Z., Jiang,Y.,
            Zhang,P., Xia,T., Pan,X. and Zhang,Y.
  TITLE     The heterogeneity of tumour immune microenvironment revealing the
            CRABP2/CD69 signature discriminates distinct clinical outcomes in
            breast cancer
  JOURNAL   Br J Cancer 129 (10), 1645-1657 (2023)
   PUBMED   37715025
  REMARK    GeneRIF: The heterogeneity of tumour immune microenvironment
            revealing the CRABP2/CD69 signature discriminates distinct clinical
            outcomes in breast cancer.
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Thompson,J.R., Bratt,J.M. and Banaszak,L.J.
  TITLE     Crystal structure of cellular retinoic acid binding protein I shows
            increased access to the binding cavity due to formation of an
            intermolecular beta-sheet
  JOURNAL   J Mol Biol 252 (4), 433-446 (1995)
   PUBMED   7563063
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Astrom,A., Pettersson,U. and Voorhees,J.J.
  TITLE     Structure of the human cellular retinoic acid-binding protein II
            gene. Early transcriptional regulation by retinoic acid
  JOURNAL   J Biol Chem 267 (35), 25251-25255 (1992)
   PUBMED   1334086
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Elder,J.T., Astrom,A., Pettersson,U., Voorhees,J.J. and Trent,J.M.
  TITLE     Assignment of the human CRABP-II gene to chromosome 1q21 by
            nonisotopic in situ hybridization
  JOURNAL   Hum Genet 89 (5), 487-490 (1992)
   PUBMED   1321791
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Eller,M.S., Oleksiak,M.F., McQuaid,T.J., McAfee,S.G. and
            Gilchrest,B.A.
  TITLE     The molecular cloning and expression of two CRABP cDNAs from human
            skin
  JOURNAL   Exp Cell Res 198 (2), 328-336 (1992)
   PUBMED   1309505
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Astrom,A., Tavakkol,A., Pettersson,U., Cromie,M., Elder,J.T. and
            Voorhees,J.J.
  TITLE     Molecular cloning of two human cellular retinoic acid-binding
            proteins (CRABP). Retinoic acid-induced expression of CRABP-II but
            not CRABP-I in adult human skin in vivo and in skin fibroblasts in
            vitro
  JOURNAL   J Biol Chem 266 (26), 17662-17666 (1991)
   PUBMED   1654334
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312007.1 and BC001109.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001878.3.
            
            Summary: This gene encodes a member of the retinoic acid (RA, a
            form of vitamin A) binding protein family and lipocalin/cytosolic
            fatty-acid binding protein family. The protein is a
            cytosol-to-nuclear shuttling protein, which facilitates RA binding
            to its cognate receptor complex and transfer to the nucleus. It is
            involved in the retinoid signaling pathway, and is associated with
            increased circulating low-density lipoprotein cholesterol.
            Alternatively spliced transcript variants encoding the same protein
            have been found for this gene.[provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB593017.1, SRR5189658.57720.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMN03267750
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368222.8/ ENSP00000357205.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               AK312007.1         1-554
            555-974             BC001109.2         541-960
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..974
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /note="cellular retinoic acid binding protein 2"
                     /db_xref="GeneID:1382"
                     /db_xref="HGNC:HGNC:2339"
                     /db_xref="MIM:180231"
     exon            1..207
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..554
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /note="cellular retinoic acid-binding protein II"
                     /codon_start=1
                     /product="cellular retinoic acid-binding protein 2"
                     /protein_id="NP_001869.1"
                     /db_xref="CCDS:CCDS1152.1"
                     /db_xref="GeneID:1382"
                     /db_xref="HGNC:HGNC:2339"
                     /db_xref="MIM:180231"
                     /translation="MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEI
                     KQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLK
                     GEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE"
     exon            208..386
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            387..503
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /inference="alignment:Splign:2.1.0"
     exon            504..974
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      950..955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /note="hexamer: ATTAAA"
     polyA_site      974
                     /gene="CRABP2"
                     /gene_synonym="CRABP-II; RBP6"
                     /note="major polyA site"
ORIGIN      
        1 agctttgggg ttgtccctgg acttgtcttg gttccagaac ctgacgaccc ggcgacggcg
       61 acgtctcttt tgactaaaag acagtgtcca gtgctccagc ctaggagtct acggggaccg
      121 cctcccgcgc cgccaccatg cccaacttct ctggcaactg gaaaatcatc cgatcggaaa
      181 acttcgagga attgctcaaa gtgctggggg tgaatgtgat gctgaggaag attgctgtgg
      241 ctgcagcgtc caagccagca gtggagatca aacaggaggg agacactttc tacatcaaaa
      301 cctccaccac cgtgcgcacc acagagatta acttcaaggt tggggaggag tttgaggagc
      361 agactgtgga tgggaggccc tgtaagagcc tggtgaaatg ggagagtgag aataaaatgg
      421 tctgtgagca gaagctcctg aagggagagg gccccaagac ctcgtggacc agagaactga
      481 ccaacgatgg ggaactgatc ctgaccatga cggcggatga cgttgtgtgc accagggtct
      541 acgtccgaga gtgagtggcc acaggtagaa ccgcggccga agcccaccac tggccatgct
      601 caccgccctg cttcactgcc ccctccgtcc caccccctcc ttctaggata gcgctcccct
      661 taccccagtc acttctgggg gtcactggga tgcctcttgc agggtcttgc tttctttgac
      721 ctcttctctc ctcccctaca ccaacaaaga ggaatggctg caagagccca gatcacccat
      781 tccgggttca ctccccgcct ccccaagtca gcagtcctag ccccaaacca gcccagagca
      841 gggtctctct aaaggggact tgagggcctg agcaggaaag actggccctc tagcttctac
      901 cctttgtccc tgtagcctat acagtttaga atatttattt gttaatttta ttaaaatgct
      961 ttaaaaaaat aaaa
//
