LOCUS       NM_004378                738 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cellular retinoic acid binding protein 1 (CRABP1),
            mRNA.
ACCESSION   NM_004378
VERSION     NM_004378.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Sakata,K., Kanda,M., Shimizu,D., Nakamura,S., Inokawa,Y.,
            Hattori,N., Hayashi,M., Tanaka,C., Nakayama,G. and Kodera,Y.
  TITLE     Expression of cellular retinoic acid binding protein 1 predicts
            peritoneal recurrence of gastric cancer
  JOURNAL   Int J Oncol 60 (6) (2022)
   PUBMED   35417033
  REMARK    GeneRIF: Expression of cellular retinoic acid binding protein 1
            predicts peritoneal recurrence of gastric cancer.
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Enikeev,A.D., Komelkov,A.V., Axelrod,M.E., Galetsky,S.A.,
            Kuzmichev,S.A. and Tchevkina,E.M.
  TITLE     CRABP1 and CRABP2 Protein Levels Correlate with Each Other but Do
            Not Correlate with Sensitivity of Breast Cancer Cells to Retinoic
            Acid
  JOURNAL   Biochemistry (Mosc) 86 (2), 217-229 (2021)
   PUBMED   33832420
  REMARK    GeneRIF: CRABP1 and CRABP2 Protein Levels Correlate with Each Other
            but Do Not Correlate with Sensitivity of Breast Cancer Cells to
            Retinoic Acid.
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Lin,Y.L., Lin,Y.W., Nhieu,J., Zhang,X. and Wei,L.N.
  TITLE     Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding
            Protein 1 Gene Regulation in Motor Neuron Differentiation and
            Diseases
  JOURNAL   Int J Mol Sci 21 (11), 4125 (2020)
   PUBMED   32527063
  REMARK    GeneRIF: Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid
            Binding Protein 1 Gene Regulation in Motor Neuron Differentiation
            and Diseases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 738)
  AUTHORS   Flagiello,D., Apiou,F., Gibaud,A., Poupon,M.F., Dutrillaux,B. and
            Malfoy,B.
  TITLE     Assignment of the genes for cellular retinoic acid binding protein
            1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and
            1q21.3, respectively, by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 76 (1-2), 17-18 (1997)
   PUBMED   9154115
REFERENCE   7  (bases 1 to 738)
  AUTHORS   Liu,W., Hellman,P., Li,Q., Yu,W.R., Juhlin,C., Nordlinder,H.,
            Rollman,O., Akerstrom,G., Torma,H. and Melhus,H.
  TITLE     Biosynthesis and function of all-trans- and 9-cis-retinoic acid in
            parathyroid cells
  JOURNAL   Biochem Biophys Res Commun 229 (3), 922-929 (1996)
   PUBMED   9005841
REFERENCE   8  (bases 1 to 738)
  AUTHORS   Eller,M.S., Oleksiak,M.F., McQuaid,T.J., McAfee,S.G. and
            Gilchrest,B.A.
  TITLE     The molecular cloning and expression of two CRABP cDNAs from human
            skin
  JOURNAL   Exp Cell Res 198 (2), 328-336 (1992)
   PUBMED   1309505
REFERENCE   9  (bases 1 to 738)
  AUTHORS   Astrom,A., Tavakkol,A., Pettersson,U., Cromie,M., Elder,J.T. and
            Voorhees,J.J.
  TITLE     Molecular cloning of two human cellular retinoic acid-binding
            proteins (CRABP). Retinoic acid-induced expression of CRABP-II but
            not CRABP-I in adult human skin in vivo and in skin fibroblasts in
            vitro
  JOURNAL   J Biol Chem 266 (26), 17662-17666 (1991)
   PUBMED   1654334
REFERENCE   10 (bases 1 to 738)
  AUTHORS   Ong,D.E.
  TITLE     Cellular retinoid-binding proteins
  JOURNAL   Arch Dermatol 123 (12), 1693-1695a (1987)
   PUBMED   2825608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU132726.1, BC022069.1 and
            AI863257.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004378.2.
            
            Summary: This gene encodes a specific binding protein for a vitamin
            A family member and is thought to play an important role in
            retinoic acid-mediated differentiation and proliferation processes.
            It is structurally similar to the cellular retinol-binding
            proteins, but binds only retinoic acid at specific sites within the
            nucleus, which may contribute to vitamin A-directed differentiation
            in epithelial tissue. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.48515.1, BC022069.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299529.7/ ENSP00000299529.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AU132726.1         30-164
            136-409             BC022069.1         141-414
            410-738             AI863257.1         16-344              c
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..738
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /note="cellular retinoic acid binding protein 1"
                     /db_xref="GeneID:1381"
                     /db_xref="HGNC:HGNC:2338"
                     /db_xref="MIM:180230"
     exon            1..146
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..490
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /note="cellular retinoic acid-binding protein I"
                     /codon_start=1
                     /product="cellular retinoic acid-binding protein 1"
                     /protein_id="NP_004369.1"
                     /db_xref="CCDS:CCDS10301.1"
                     /db_xref="GeneID:1381"
                     /db_xref="HGNC:HGNC:2338"
                     /db_xref="MIM:180230"
                     /translation="MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEI
                     RQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLATWENENKIHCTQTLLE
                     GDGPKTYWTRELANDELILTFGADDVVCTRIYVRE"
     exon            147..325
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            326..439
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /inference="alignment:Splign:2.1.0"
     exon            440..738
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      714..719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /note="hexamer: ATTAAA"
     polyA_site      738
                     /gene="CRABP1"
                     /gene_synonym="CRABP; CRABP-I; CRABPI; RBP5"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgcc ttgcgagctc agagtgtgcc cgctgcgccg ccgctgtccg tacctgccgc
       61 cgccgccacc gccaccatgc ccaacttcgc cggcacctgg aagatgcgca gcagcgagaa
      121 tttcgacgag ctgctcaagg cactgggtgt gaacgccatg ctgaggaaag tggccgtagc
      181 ggctgcgtcc aagccgcacg tggagatccg ccaggacggg gatcagttct acatcaagac
      241 atccaccacg gtgcgcacca ctgagatcaa cttcaaggtc ggagaaggct ttgaggagga
      301 gaccgtggac ggacgcaagt gcaggagttt agccacttgg gagaatgaga acaagatcca
      361 ctgcacgcaa actcttcttg aaggggacgg ccccaaaacc tactggaccc gtgagctggc
      421 caacgatgaa cttatcctga cgtttggcgc cgatgacgtg gtctgcacca gaatttatgt
      481 ccgagagtga aggcagctgg cttgctccta ctttcaggaa gggatgcagg ctcccctgag
      541 gaatatgtca tagttctgag ctgccagtgg accgcccttt tcccctacca atattaggtg
      601 atcccgtttt ccccatgaca atgttgtagt gtcccccacc cccacccccc aggccttggt
      661 gcctcttgta tccctagtgc tccatagttt ggcatttgca cggtttcgaa gtcattaaac
      721 tggttagacg tgtctcaa
//
