LOCUS       NM_001006658            4139 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens complement C3d receptor 2 (CR2), transcript variant 1,
            mRNA.
ACCESSION   NM_001006658
VERSION     NM_001006658.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4139)
  AUTHORS   Marques,E.R.M.D.C., Hsieh,R., Lourenco,S.V. and Nico,M.M.S.
  TITLE     Oral lupus erythematosus: Immunohistochemical evaluation of CD1a,
            CD21, CD123, and langerin expression in dendritic cells
  JOURNAL   J Cutan Pathol 51 (5), 368-378 (2024)
   PUBMED   38287771
  REMARK    GeneRIF: Oral lupus erythematosus: Immunohistochemical evaluation
            of CD1a, CD21, CD123, and langerin expression in dendritic cells.
REFERENCE   2  (bases 1 to 4139)
  AUTHORS   Diep,N.T., Giang,N.T., Diu,N.T.T., Nam,N.M., Khanh,L.V.,
            Quang,H.V., Hang,N.T., Mao,C.V., Son,H.V., Hieu,N.L., Linh,P.T.,
            Sklan,E.H., Toan,N.L. and Tong,H.V.
  TITLE     Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms
            and plasma protein levels are associated with the Dengue disease
            severity
  JOURNAL   Sci Rep 13 (1), 17377 (2023)
   PUBMED   37833411
  REMARK    GeneRIF: Complement receptor type 1 and 2 (CR1 and CR2) gene
            polymorphisms and plasma protein levels are associated with the
            Dengue disease severity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4139)
  AUTHORS   Jin,H., Kong,Z., Jiang,B., Tu,M., Xu,J., Cheng,J., Liu,W., Zhang,Z.
            and Li,Y.
  TITLE     Identification and Characterization of chCR2, a Protein That Binds
            Chicken Complement Component 3d
  JOURNAL   J Immunol 210 (9), 1408-1418 (2023)
   PUBMED   36971659
  REMARK    GeneRIF: Identification and Characterization of chCR2, a Protein
            That Binds Chicken Complement Component 3d.
REFERENCE   4  (bases 1 to 4139)
  AUTHORS   Keller,B., Strohmeier,V., Harder,I., Unger,S., Payne,K.J.,
            Andrieux,G., Boerries,M., Felixberger,P.T., Landry,J.J.M.,
            Nieters,A., Rensing-Ehl,A., Salzer,U., Frede,N., Usadel,S.,
            Elling,R., Speckmann,C., Hainmann,I., Ralph,E., Gilmour,K.,
            Wentink,M.W.J., van der Burg,M., Kuehn,H.S., Rosenzweig,S.D.,
            Kolsch,U., von Bernuth,H., Kaiser-Labusch,P., Gothe,F.,
            Hambleton,S., Vlagea,A.D., Garcia Garcia,A., Alsina,L., Markelj,G.,
            Avcin,T., Vasconcelos,J., Guedes,M., Ding,J.Y., Ku,C.L., Shadur,B.,
            Avery,D.T., Venhoff,N., Thiel,J., Becker,H., Erazo-Borras,L.,
            Trujillo-Vargas,C.M., Franco,J.L., Fieschi,C., Okada,S., Gray,P.E.,
            Uzel,G., Casanova,J.L., Fliegauf,M., Grimbacher,B., Eibel,H.,
            Ehl,S., Voll,R.E., Rizzi,M., Stepensky,P., Benes,V., Ma,C.S.,
            Bossen,C., Tangye,S.G. and Warnatz,K.
  TITLE     The expansion of human T-bethighCD21low B cells is T cell dependent
  JOURNAL   Sci Immunol 6 (64), eabh0891 (2021)
   PUBMED   34623902
  REMARK    GeneRIF: The expansion of human T-bet(high)CD21(low) B cells is T
            cell dependent.
REFERENCE   5  (bases 1 to 4139)
  AUTHORS   Kovacs,K.G., Macsik-Valent,B., Matko,J., Bajtay,Z. and Erdei,A.
  TITLE     Revisiting the Coreceptor Function of Complement Receptor Type 2
            (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits the
            Activation, Proliferation, and Antibody Production of Human B Cells
  JOURNAL   Front Immunol 12, 620427 (2021)
   PUBMED   33868238
  REMARK    GeneRIF: Revisiting the Coreceptor Function of Complement Receptor
            Type 2 (CR2, CD21); Coengagement With the B-Cell Receptor Inhibits
            the Activation, Proliferation, and Antibody Production of Human B
            Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4139)
  AUTHORS   Birkenbach,M., Tong,X., Bradbury,L.E., Tedder,T.F. and Kieff,E.
  TITLE     Characterization of an Epstein-Barr virus receptor on human
            epithelial cells
  JOURNAL   J Exp Med 176 (5), 1405-1414 (1992)
   PUBMED   1383386
REFERENCE   7  (bases 1 to 4139)
  AUTHORS   Bradbury,L.E., Kansas,G.S., Levy,S., Evans,R.L. and Tedder,T.F.
  TITLE     The CD19/CD21 signal transducing complex of human B lymphocytes
            includes the target of antiproliferative antibody-1 and Leu-13
            molecules
  JOURNAL   J Immunol 149 (9), 2841-2850 (1992)
   PUBMED   1383329
REFERENCE   8  (bases 1 to 4139)
  AUTHORS   Levy,E., Ambrus,J., Kahl,L., Molina,H., Tung,K. and Holers,V.M.
  TITLE     T lymphocyte expression of complement receptor 2 (CR2/CD21): a role
            in adhesive cell-cell interactions and dysregulation in a patient
            with systemic lupus erythematosus (SLE)
  JOURNAL   Clin Exp Immunol 90 (2), 235-244 (1992)
   PUBMED   1424280
REFERENCE   9  (bases 1 to 4139)
  AUTHORS   Gauffre,A., Viron,A., Barel,M., Hermann,J., Puvion,E. and Frade,R.
  TITLE     Nuclear localization of the Epstein-Barr virus/C3d receptor (CR2)
            in the human Burkitt B lymphoma cell, Raji
  JOURNAL   Mol Immunol 29 (9), 1113-1120 (1992)
   PUBMED   1323059
REFERENCE   10 (bases 1 to 4139)
  AUTHORS   Yefenof,E., Klein,G., Jondal,M. and Oldstone,M.B.
  TITLE     Surface markers on human B and T-lymphocytes. IX. Two-color
            immunofluorescence studies on the association between ebv receptors
            and complement receptors on the surface of lymphoid cell lines
  JOURNAL   Int J Cancer 17 (6), 693-700 (1976)
   PUBMED   181330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU133057.1, AK301496.1,
            Y00649.1, AW303499.1 and BQ004295.1.
            
            On Sep 18, 2019 this sequence version replaced NM_001006658.2.
            
            Summary: This gene encodes a membrane protein, which functions as a
            receptor for Epstein-Barr virus (EBV) binding on B and T
            lymphocytes. Genetic variations in this gene are associated with
            susceptibility to systemic lupus erythematosus type 9 (SLEB9).
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, Sep
            2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223627.1, AK301496.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367057.8/ ENSP00000356024.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               AU133057.1         99-634
            537-3275            AK301496.1         533-3271
            3276-3813           Y00649.1           3060-3597
            3814-4135           AW303499.1         3-324               c
            4136-4139           BQ004295.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..4139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..4139
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /note="complement C3d receptor 2"
                     /db_xref="GeneID:1380"
                     /db_xref="HGNC:HGNC:2336"
                     /db_xref="MIM:120650"
     exon            1..149
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..3370
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement receptor type 2; EBV receptor;
                     complement component (3d/Epstein Barr virus) receptor 2;
                     complement component 3d receptor 2"
                     /codon_start=1
                     /product="complement receptor type 2 isoform 1 precursor"
                     /protein_id="NP_001006659.1"
                     /db_xref="CCDS:CCDS31007.1"
                     /db_xref="GeneID:1380"
                     /db_xref="HGNC:HGNC:2336"
                     /db_xref="MIM:120650"
                     /translation="MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVG
                     TVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKI
                     RGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMI
                     HNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSL
                     GRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFC
                     PSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGT
                     WSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIR
                     CNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES
                     IQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQE
                     CQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEF
                     SLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYND
                     TVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVS
                     GMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETCQHVRQSLQELPAGSRVELV
                     NTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFL
                     YGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGY
                     KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPP
                     KTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCS
                     SPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSR
                     SLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDPY
                     NPAS"
     exon            150..536
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            537..725
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            726..825
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            826..908
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1316
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1493
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1584
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1661
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..2069
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2246
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2331
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2414
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2807
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..2993
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3179
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3180..3203
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3279
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3388
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..4139
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4112..4117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /note="hexamer: AATAAA"
     polyA_site      4139
                     /gene="CR2"
                     /gene_synonym="C3DR; CD21; CR; CVID7; SLEB9"
                     /note="major polyA site"
ORIGIN      
        1 agctgcttgc tgctccagcc ttgccctccc agagctgccg gacgctcgcg ggtctcggaa
       61 cgcatcccgc cgcgggggct tcggccgtgg catgggcgcc gcgggcctgc tcggggtttt
      121 cttggctctc gtcgcaccgg gggtcctcgg gatttcttgt ggctctcctc cgcctatcct
      181 aaatggccgg attagttatt attctacccc cattgctgtt ggtaccgtga taaggtacag
      241 ttgttcaggt accttccgcc tcattggaga aaaaagtcta ttatgcataa ctaaagacaa
      301 agtggatgga acctgggata aacctgctcc taaatgtgaa tatttcaata aatattcttc
      361 ttgccctgag cccatagtac caggaggata caaaattaga ggctctacac cctacagaca
      421 tggtgattct gtgacatttg cctgtaaaac caacttctcc atgaacggaa acaagtctgt
      481 ttggtgtcaa gcaaataata tgtgggggcc gacacgacta ccaacctgtg taagtgtttt
      541 ccctctcgag tgtccagcac ttcctatgat ccacaatgga catcacacaa gtgagaatgt
      601 tggctccatt gctccaggat tgtctgtgac ttacagctgt gaatctggtt acttgcttgt
      661 tggagaaaag atcattaact gtttgtcttc gggaaaatgg agtgctgtcc cccccacatg
      721 tgaagaggca cgctgtaaat ctctaggacg atttcccaat gggaaggtaa aggagcctcc
      781 aattctccgg gttggtgtaa ctgcaaactt tttctgtgat gaagggtatc gactgcaagg
      841 cccaccttct agtcggtgtg taattgctgg acagggagtt gcttggacca aaatgccagt
      901 atgtgaagaa attttttgcc catcacctcc ccctattctc aatggaagac atataggcaa
      961 ctcactagca aatgtctcat atggaagcat agtcacttac acttgtgacc cggacccaga
     1021 ggaaggagtg aacttcatcc ttattggaga gagcactctc cgttgtacag ttgatagtca
     1081 gaagactggg acctggagtg gccctgcccc acgctgtgaa ctttctactt ctgcggttca
     1141 gtgtccacat ccccagatcc taagaggccg aatggtatct gggcagaaag atcgatatac
     1201 ctataacgac actgtgatat ttgcttgcat gtttggcttc accttgaagg gcagcaagca
     1261 aatccgatgc aatgcccaag gcacatggga gccatctgca ccagtctgtg aaaaggaatg
     1321 ccaggcccct cctaacatcc tcaatgggca aaaggaagat agacacatgg tccgctttga
     1381 ccctggaaca tctataaaat atagctgtaa ccctggctat gtgctggtgg gagaagaatc
     1441 catacagtgt acctctgagg gggtgtggac accccctgta ccccaatgca aagtggcagc
     1501 gtgtgaagct acaggaaggc aactcttgac aaaaccccag caccaatttg ttagaccaga
     1561 tgtcaactct tcttgtggtg aagggtacaa gttaagtggg agtgtttatc aggagtgtca
     1621 aggcacaatt ccttggttta tggagattcg tctttgtaaa gaaatcacct gcccaccacc
     1681 ccctgttatc tacaatgggg cacacaccgg gagttcctta gaagattttc catatggaac
     1741 cacggtcact tacacatgta accctgggcc agaaagagga gtggaattca gcctcattgg
     1801 agagagcacc atccgttgta caagcaatga tcaagaaaga ggcacctgga gtggccctgc
     1861 tcccctgtgt aaactttccc tccttgctgt ccagtgctca catgtccata ttgcaaatgg
     1921 atacaagata tctggcaagg aagccccata tttctacaat gacactgtga cattcaagtg
     1981 ttatagtgga tttactttga agggcagtag tcagattcgt tgcaaagctg ataacacctg
     2041 ggatcctgaa ataccagttt gtgaaaaagg ctgccagtca cctcctgggc tccaccatgg
     2101 tcgtcataca ggtggaaata cggtcttctt tgtctctggg atgactgtag actacacttg
     2161 tgaccctggc tatttgcttg tgggaaacaa atccattcac tgtatgcctt caggaaattg
     2221 gagtccttct gccccacggt gtgaagaaac atgccagcat gtgagacaga gtcttcaaga
     2281 acttccagct ggttcacgtg tggagctagt taatacgtcc tgccaagatg ggtaccagtt
     2341 gactggacat gcttatcaga tgtgtcaaga tgctgaaaat ggaatttggt tcaaaaagat
     2401 tccactttgt aaagttattc actgtcaccc tccaccagtg attgtcaatg ggaagcacac
     2461 aggcatgatg gcagaaaact ttctatatgg aaatgaagtc tcttatgaat gtgaccaagg
     2521 attctatctc ctgggagaga aaaaattgca gtgcagaagt gattctaaag gacatggatc
     2581 ttggagcggg ccttccccac agtgcttacg atctcctcct gtgactcgct gccctaatcc
     2641 agaagtcaaa catgggtaca agctcaataa aacacattct gcatattccc acaatgacat
     2701 agtgtatgtt gactgcaatc ctggcttcat catgaatggt agtcgcgtga ttaggtgtca
     2761 tactgataac acatgggtgc caggtgtgcc aacttgtatc aaaaaagcct tcatagggtg
     2821 tccacctccg cctaagaccc ctaacgggaa ccatactggt ggaaacatag ctcgattttc
     2881 tcctggaatg tcaatcctgt acagctgtga ccaaggctac ctgctggtgg gagaggcact
     2941 ccttctttgc acacatgagg gaacctggag ccaacctgcc cctcattgta aagaggtaaa
     3001 ctgtagctca ccagcagata tggatggaat ccagaaaggg ctggaaccaa ggaaaatgta
     3061 tcagtatgga gctgttgtaa ctctggagtg tgaagatggg tatatgctgg aaggcagtcc
     3121 ccagagccag tgccaatcgg atcaccaatg gaaccctccc ctggcggttt gcagatcccg
     3181 ttcacttgct cctgtccttt gtggtattgc tgcaggtttg atacttctta ccttcttgat
     3241 tgtcattacc ttatacgtga tatcaaaaca cagagcacgc aattattata cagatacaag
     3301 ccagaaagaa gcttttcatt tagaagcacg agaagtatat tctgttgatc catacaaccc
     3361 agccagctga tcagaagaca aactggtgtg tgcctcattg cttggaattc agcggaatat
     3421 tgattagaaa gaaactgctc taatatcagc aagtctcttt atatggcctc aagatcaatg
     3481 aaatgatgtc ataagcgatc acttcctata tgcacttatt ctcaagaaga acatctttat
     3541 ggtaaagatg ggagcccagt ttcactgcca tatactcttc aaggactttc tgaagcctca
     3601 cttatgagat gcctgaagcc aggccatggc tataaacaat tacatggctc taaaaagttt
     3661 tgcccttttt aaggaaggca ctaaaaagag ctgtcctggt atctagaccc atcttctttt
     3721 tgaaatcagc atactcaatg ttactatctg cttttggtta taatgtgttt ttaattatct
     3781 aaagtatgaa gcattttctg gggttatgat ggctttacct ttattaggaa gtatggtttt
     3841 attttgatag tagcttcctc ctctggtggt gttaatcatt tcatttttac ccttacttgg
     3901 tttgagtttc tctcacatta ctgtatatac tttgcctttc cataatcact cagtgattgc
     3961 aatttgcaca agttttttta aattatggga atcaagattt aatcctagag atttggtgta
     4021 caattcaggc tttggatgtt tctttagcag ttttgtgata agttctagtt gcttgtaaaa
     4081 tttcacttaa taatgtgtac attagtcatt caataaattg taattgtaaa gaaaacata
//
