LOCUS       NM_175710               1829 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens complement C3b/C4b receptor 1 like (CR1L), mRNA.
ACCESSION   NM_175710 XM_114735 XM_936931
VERSION     NM_175710.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1829)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1829)
  AUTHORS   Maehara,N., Arai,S., Mori,M., Iwamura,Y., Kurokawa,J., Kai,T.,
            Kusunoki,S., Taniguchi,K., Ikeda,K., Ohara,O., Yamamura,K.I. and
            Miyazaki,T.
  TITLE     Circulating AIM prevents hepatocellular carcinoma through
            complement activation
  JOURNAL   Cell Rep 9 (1), 61-74 (2014)
   PUBMED   25284781
REFERENCE   3  (bases 1 to 1829)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 1829)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 1829)
  AUTHORS   Kullo,I.J., Ding,K., Shameer,K., McCarty,C.A., Jarvik,G.P.,
            Denny,J.C., Ritchie,M.D., Ye,Z., Crosslin,D.R., Chisholm,R.L.,
            Manolio,T.A. and Chute,C.G.
  TITLE     Complement receptor 1 gene variants are associated with erythrocyte
            sedimentation rate
  JOURNAL   Am J Hum Genet 89 (1), 131-138 (2011)
   PUBMED   21700265
REFERENCE   6  (bases 1 to 1829)
  AUTHORS   Sabatti,C., Service,S.K., Hartikainen,A.L., Pouta,A., Ripatti,S.,
            Brodsky,J., Jones,C.G., Zaitlen,N.A., Varilo,T., Kaakinen,M.,
            Sovio,U., Ruokonen,A., Laitinen,J., Jakkula,E., Coin,L.,
            Hoggart,C., Collins,A., Turunen,H., Gabriel,S., Elliot,P.,
            McCarthy,M.I., Daly,M.J., Jarvelin,M.R., Freimer,N.B. and
            Peltonen,L.
  TITLE     Genome-wide association analysis of metabolic traits in a birth
            cohort from a founder population
  JOURNAL   Nat Genet 41 (1), 35-46 (2009)
   PUBMED   19060910
REFERENCE   7  (bases 1 to 1829)
  AUTHORS   Logar,C.M., Chen,W., Schmitt,H., Yu,C.Y. and Birmingham,D.J.
  TITLE     A human CR1-like transcript containing sequence for a binding
            protein for iC4 is expressed in hematopoietic and fetal lymphoid
            tissue
  JOURNAL   Mol Immunol 40 (11), 831-840 (2004)
   PUBMED   14687939
  REMARK    GeneRIF: CR1L transcript appears to be limited to hematopoietic and
            fetal lymphoid tissue.
REFERENCE   8  (bases 1 to 1829)
  AUTHORS   Hourcade,D., Miesner,D.R., Bee,C., Zeldes,W. and Atkinson,J.P.
  TITLE     Duplication and divergence of the amino-terminal coding region of
            the complement receptor 1 (CR1) gene. An example of concerted
            (horizontal) evolution within a gene
  JOURNAL   J Biol Chem 265 (2), 974-980 (1990)
   PUBMED   2295627
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX094042.1, BC109191.1, AY114160.1, DB337938.1, BE842176.1,
            BE842163.1 and AL365178.10.
            
            On May 17, 2019 this sequence version replaced NM_175710.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000508064.7/ ENSP00000421736.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BX094042.1         21-61
            42-1304             BC109191.1         1-1263
            1305-1429           AY114160.1         1036-1160
            1430-1463           BC109191.1         1389-1422
            1464-1515           DB337938.1         309-360
            1516-1679           BC109191.1         1475-1638
            1680-1808           BE842176.1         16-144              c
            1809-1817           BE842163.1         10-18               c
            1818-1829           AL365178.10        8549-8560
FEATURES             Location/Qualifiers
     source          1..1829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..1829
                     /gene="CR1L"
                     /note="complement C3b/C4b receptor 1 like"
                     /db_xref="GeneID:1379"
                     /db_xref="HGNC:HGNC:2335"
                     /db_xref="MIM:605886"
     exon            1..198
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1811
                     /gene="CR1L"
                     /note="complement component receptor 1-like protein;
                     complement C4b-binding protein CR-1-like protein;
                     complement component (3b/4b) receptor 1-like"
                     /codon_start=1
                     /product="complement component receptor 1-like protein
                     precursor"
                     /protein_id="NP_783641.1"
                     /db_xref="CCDS:CCDS44310.1"
                     /db_xref="GeneID:1379"
                     /db_xref="HGNC:HGNC:2335"
                     /db_xref="MIM:605886"
                     /translation="MAPPVRLERPFPSRRFPGLLLAALVLLLSSFSDQCNVPEWLPFA
                     RPTNLTDDFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTSAKDKCKRKSCRNPPDP
                     VNGMAHVIKDIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVCDRIICGL
                     PPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVGIWS
                     GPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVKCQALN
                     KWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYLHCTP
                     QGDWSPAAPRCEVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYC
                     VLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHS
                     SAECILSGNTAHWSMKPPICQQIFCPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHP
                     DRGMTFNLIGESTIRRTSEPHGNGVWSSPAPRCELPVGAGSHDALIVGKFYEVFAEEF
                     CHL"
     exon            199..378
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            379..478
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            479..564
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            565..963
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1140
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1243
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1329
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1429
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1515
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1743
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1829
                     /gene="CR1L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtgtcca ctaaccggac tcagaaggga cttccctgct cggctggctt tcggtttctc
       61 tgctcacctc cggataaatc acggggtctc ccgcgccgct catggcgcct cccgtccgtc
      121 tcgagcgtcc ctttccttcc cggcgctttc ctgggttgct tctggcggcc ctggtgttgc
      181 tgctgtcctc cttctccgat caatgcaatg tcccggaatg gcttccattt gccaggccta
      241 ccaacctaac tgatgacttt gagtttccca ttgggacata tctgaactat gaatgccgcc
      301 ctggttattc cggaagaccg ttttctatca tctgcctaaa aaactcagtc tggacaagtg
      361 ctaaggacaa gtgcaaacgt aaatcatgtc gtaatcctcc agatcctgtg aatggcatgg
      421 cacatgtgat caaagacatc cagttcagat cccaaattaa atattcttgt cctaaaggat
      481 accgactcat tggttcctcg tctgccacat gcatcatctc aggcaacact gtcatttggg
      541 ataataaaac acctgtttgt gacagaatta tttgtgggct accccccacc atcgccaatg
      601 gagatttcac tagcatcagc agagagtatt ttcactatgg atcagtggtg acctaccact
      661 gcaatcttgg aagcagaggg aaaaaggtgt ttgagcttgt gggtgagccc tccatatact
      721 gcaccagcaa agatgatcaa gtgggcatct ggagtggccc agcccctcag tgcattatac
      781 ctaacaaatg cacgcctcca aatgtggaaa atggaatatt ggtatctgac aacagaagct
      841 tattttcctt aaatgaagtt gtggagttta ggtgtcagcc tggctttggc atgaaagggc
      901 cctcccatgt gaagtgccag gccctgaaca aatgggagcc agagttacca agctgctcca
      961 gggtatgtca gccacctcca gatgtcctgc atgctgagcg tacccaaagg gacaaggaca
     1021 acttttcacc cgggcaggaa gtgttctaca gctgtgagcc cggctacgac ctcagaggat
     1081 ctacgtattt gcactgcaca ccccagggag actggagccc tgcagccccc agatgtgaag
     1141 tgaaatcctg tgatgacttc ctgggccaac ttcctaatgg ccatgtgcta tttccactta
     1201 atctccagct tggagcaaaa gtggattttg tttgtgatga aggatttcaa ttaaaaggca
     1261 gctctgctag ttactgtgtt ttggctggaa tggaaagcct ttggaatagc agtgttccag
     1321 tgtgtgaacg taaatcatgt gaaactcctc cagttccagt gaatggcatg gtgcatgtga
     1381 tcacagacat ccatgttgga tccagaatca actattcttg tactacaggg caccgactca
     1441 ttggtcactc atctgctgaa tgtatcctct cgggcaatac tgcccattgg agcatgaagc
     1501 caccaatttg tcaacaaatc ttttgtccaa atcctccagc tatccttaat gggagacaca
     1561 caggaactcc ccttggagat attccctatg gaaaagaagt atcttacaca tgtgaccccc
     1621 acccagacag agggatgacc ttcaacctca ttggggagag caccatccgc cgcacaagtg
     1681 aacctcatgg gaatggggtt tggagcagcc ctgcccctcg ctgtgaactt cctgttggtg
     1741 ctggttcaca tgatgctctt atagttggta agttttatga agtgtttgct gaggaattct
     1801 gtcatcttta acagtaagta cctacttat
//
