LOCUS       NM_000651               9937 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens complement C3b/C4b receptor 1 (Knops blood group)
            (CR1), transcript variant S, mRNA.
ACCESSION   NM_000651 XM_001126036
VERSION     NM_000651.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9937)
  AUTHORS   Hardy,M.P., Mansour,M., Rowe,T. and Wymann,S.
  TITLE     The Molecular Mechanisms of Complement Receptor 1-It Is Complicated
  JOURNAL   Biomolecules 13 (10), 1522 (2023)
   PUBMED   37892204
  REMARK    GeneRIF: The Molecular Mechanisms of Complement Receptor 1-It Is
            Complicated.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9937)
  AUTHORS   Covas,D.T., de Oliveira,F.S., Rodrigues,E.S., Abe-Sandes,K.,
            Silva,W.A. Jr. and Fontes,A.M.
  TITLE     Knops blood group haplotypes among distinct Brazilian populations
  JOURNAL   Transfusion 47 (1), 147-153 (2007)
   PUBMED   17207243
REFERENCE   3  (bases 1 to 9937)
  AUTHORS   Xiang,L., Rundles,J.R., Hamilton,D.R. and Wilson,J.G.
  TITLE     Quantitative alleles of CR1: coding sequence analysis and
            comparison of haplotypes in two ethnic groups
  JOURNAL   J Immunol 163 (9), 4939-4945 (1999)
   PUBMED   10528197
REFERENCE   4  (bases 1 to 9937)
  AUTHORS   Herrera,A.H., Xiang,L., Martin,S.G., Lewis,J. and Wilson,J.G.
  TITLE     Analysis of complement receptor type 1 (CR1) expression on
            erythrocytes and of CR1 allelic markers in Caucasian and African
            American populations
  JOURNAL   Clin Immunol Immunopathol 87 (2), 176-183 (1998)
   PUBMED   9614933
REFERENCE   5  (bases 1 to 9937)
  AUTHORS   Petty,A.C., Green,C.A., Poole,J. and Daniels,G.L.
  TITLE     Analysis of Knops blood group antigens on CR1 (CD35) by the MAIEA
            test and by immunoblotting
  JOURNAL   Transfus Med 7 (1), 55-62 (1997)
   PUBMED   9089986
REFERENCE   6  (bases 1 to 9937)
  AUTHORS   Vik,D.P. and Wong,W.W.
  TITLE     Structure of the gene for the F allele of complement receptor type
            1 and sequence of the coding region unique to the S allele
  JOURNAL   J Immunol 151 (11), 6214-6224 (1993)
   PUBMED   8245463
REFERENCE   7  (bases 1 to 9937)
  AUTHORS   Rao,N., Ferguson,D.J., Lee,S.F. and Telen,M.J.
  TITLE     Identification of human erythrocyte blood group antigens on the
            C3b/C4b receptor
  JOURNAL   J Immunol 146 (10), 3502-3507 (1991)
   PUBMED   1827486
REFERENCE   8  (bases 1 to 9937)
  AUTHORS   Moulds,J.M., Nickells,M.W., Moulds,J.J., Brown,M.C. and
            Atkinson,J.P.
  TITLE     The C3b/C4b receptor is recognized by the Knops, McCoy,
            Swain-langley, and York blood group antisera
  JOURNAL   J Exp Med 173 (5), 1159-1163 (1991)
   PUBMED   1708809
REFERENCE   9  (bases 1 to 9937)
  AUTHORS   Wong,W.W. and Farrell,S.A.
  TITLE     Proposed structure of the F' allotype of human CR1. Loss of a C3b
            binding site may be associated with altered function
  JOURNAL   J Immunol 146 (2), 656-662 (1991)
   PUBMED   1670949
REFERENCE   10 (bases 1 to 9937)
  AUTHORS   Hourcade,D., Miesner,D.R., Bee,C., Zeldes,W. and Atkinson,J.P.
  TITLE     Duplication and divergence of the amino-terminal coding region of
            the complement receptor 1 (CR1) gene. An example of concerted
            (horizontal) evolution within a gene
  JOURNAL   J Biol Chem 265 (2), 974-980 (1990)
   PUBMED   2295627
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL691452.10 and AL137789.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 27, 2019 this sequence version replaced NM_000651.5.
            
            Summary: This gene is a member of the receptors of complement
            activation (RCA) family and is located in the 'cluster RCA' region
            of chromosome 1. The genome is polymorphic at this locus with
            allele-specific splice variants encoding different isoforms, based
            on the presence/absence of long homologous repeats (LHRs). The gene
            encodes a monomeric single-pass type I membrane glycoprotein found
            on erythrocytes, leukocytes, glomerular podocytes, and splenic
            follicular dendritic cells. The Knops blood group system is a
            system of antigens located on this protein. The protein mediates
            cellular binding to particles and immune complexes that have
            activated complement. Decreases in expression of this protein
            and/or mutations in this gene have been associated with gallbladder
            carcinomas, mesangiocapillary glomerulonephritis, systemic lupus
            erythematosus, sarcoidosis and Alzheimer's disease. Mutations in
            this gene have also been associated with a reduction in Plasmodium
            falciparum rosetting, conferring protection against severe malaria.
            [provided by RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000367049.9/
                                                ENSP00000356016.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AL691452.10        30629-30860
            233-412             AL691452.10        40376-40555
            413-512             AL691452.10        41186-41285
            513-598             AL691452.10        46041-46126
            599-997             AL691452.10        58083-58481
            998-1174            AL691452.10        61225-61401
            1175-1277           AL691452.10        61493-61595
            1278-1363           AL691452.10        63188-63273
            1364-1582           AL691452.10        66652-66870
            1583-1762           AL691452.10        67881-68060
            1763-1862           AL691452.10        68669-68768
            1863-1948           AL691452.10        74453-74538
            1949-2347           AL691452.10        76654-77052
            2348-2524           AL691452.10        79780-79956
            2525-2627           AL691452.10        80048-80150
            2628-2713           AL691452.10        81743-81828
            2714-2932           AL691452.10        85207-85425
            2933-3112           AL691452.10        86436-86615
            3113-3212           AL691452.10        87224-87323
            3213-3298           AL691452.10        93010-93095
            3299-3697           AL691452.10        95211-95609
            3698-3874           AL691452.10        98336-98512
            3875-3977           AL691452.10        98604-98706
            3978-4063           AL691452.10        100310-100395
            4064-4282           AL691452.10        102296-102514
            4283-4462           AL691452.10        103531-103710
            4463-4562           AL691452.10        104319-104418
            4563-4648           AL137789.11        3777-3862
            4649-5047           AL137789.11        5987-6385
            5048-5224           AL137789.11        8422-8598
            5225-5327           AL137789.11        8693-8795
            5328-5413           AL137789.11        10100-10185
            5414-5641           AL137789.11        12831-13058
            5642-5821           AL137789.11        15568-15747
            5822-5921           AL137789.11        16857-16956
            5922-6007           AL137789.11        35433-35518
            6008-6406           AL137789.11        37472-37870
            6407-6583           AL137789.11        39859-40035
            6584-6686           AL137789.11        40121-40223
            6687-6772           AL137789.11        42586-42671
            6773-7000           AL137789.11        44757-44984
            7001-7177           AL137789.11        46253-46429
            7178-7363           AL137789.11        48062-48247
            7364-7387           AL137789.11        50155-50178
            7388-7463           AL137789.11        51175-51250
            7464-7568           AL137789.11        58699-58803
            7569-9937           AL137789.11        67579-69947
FEATURES             Location/Qualifiers
     source          1..9937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..9937
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /note="complement C3b/C4b receptor 1 (Knops blood group)"
                     /db_xref="GeneID:1378"
                     /db_xref="HGNC:HGNC:2334"
                     /db_xref="MIM:120620"
     exon            1..232
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..7581
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /note="isoform S precursor is encoded by transcript
                     variant S; C3-binding protein; CD35 antigen; complement
                     receptor type 1; C3b/C4b receptor; Knops blood group
                     antigen; complement component (3b/4b) receptor 1 (Knops
                     blood group); complement receptor 1"
                     /codon_start=1
                     /product="complement receptor type 1 isoform S precursor"
                     /protein_id="NP_000642.3"
                     /db_xref="CCDS:CCDS44308.1"
                     /db_xref="GeneID:1378"
                     /db_xref="HGNC:HGNC:2334"
                     /db_xref="MIM:120620"
                     /translation="MGASSPRSPEPVGPPAPGLPFCCGGSLLAVVVLLALPVAWGQCN
                     APEWLPFARPTNLTDEFEFPIGTYLNYECRPGYSGRPFSIICLKNSVWTGAKDRCRRK
                     SCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPI
                     CDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSN
                     DDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPR
                     RVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRG
                     AASMRCTPQGDWSPAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQL
                     KGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTC
                     DPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQT
                     NASDFPIGTSLKYECRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVH
                     VITDIQVGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIAN
                     GDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQC
                     IIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPEL
                     PSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSP
                     AAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGME
                     SLWNSSVPVCEQIFCPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIG
                     ESTIRCTSDPQGNGVWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYE
                     CRPEYYGRPFSITCLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYS
                     CTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYG
                     SVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG
                     ILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVL
                     HAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTCEVKSCDDFM
                     GQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIF
                     CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNG
                     VWSSPAPRCGILGHCQAPDHFLFAKLKTQTNASDFPIGTSLKYECRPEYYGRPFSITC
                     LDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQVGSRINYSCTTGHRLIGHSSAE
                     CILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGR
                     KVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNE
                     VVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSP
                     GQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCAVKSCDDFLGQLPHGRVLFPLNL
                     QLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSLWNNSVPVCEHIFCPNPPAILNGRHTG
                     TPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWSSPAPRCELSVR
                     AGHCKTPEQFPFASPTIPINDFEFPVGTSLNYECRPGYFGKMFSISCLENLVWSSVED
                     NCRRKSCGPPPEPFNGMVHINTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWD
                     KKAPICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSI
                     YCTSKDDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFV
                     MVGSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPS
                     YDLRGAASLHCTPQGDWSPEAPRCTVKSCDDFLGQLPHGRVLLPLNLQLGAKVSFVCD
                     EGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPFGDIPYGKE
                     ISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQN
                     GHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLF
                     MNGISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDA
                     LIVGTLSGTIFFILLIIFLSWIILKHRKGNNAHENPKEVAIHLHSQGGSSVHPRTLQT
                     NEENSRVLP"
     exon            233..412
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            413..512
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            513..598
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            599..997
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1174
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1277
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1363
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1582
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1762
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1862
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1948
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2347
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2524
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2627
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2713
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2932
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3112
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3212
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            3213..3298
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3697
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3874
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..3977
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            3978..4063
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4282
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4462
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..4562
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4648
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            4649..5047
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            5048..5224
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5327
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5413
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            5414..5641
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            5642..5821
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            5822..5921
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            5922..6007
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            6008..6406
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            6407..6583
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            6584..6686
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            6687..6772
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            6773..7000
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            7001..7177
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            7178..7363
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            7364..7387
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            7388..7463
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            7464..7568
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     exon            7569..9937
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8790..8795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /note="hexamer: AATAAA"
     polyA_site      8816
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
     regulatory      9911..9916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /note="hexamer: AATAAA"
     polyA_site      9937
                     /gene="CR1"
                     /gene_synonym="C3BR; C4BR; CD35; KN"
                     /note="major polyA site"
ORIGIN      
        1 acactctggg cgcggagcac aatgattggt cactcctatt ttcgctgagc ttttcctctt
       61 atttcagttt tcttcgagat caaatctggt ttgtagatgt gcttggggag aatgggggcc
      121 tcttctccaa gaagcccgga gcctgtcggg ccgccggcgc ccggtctccc cttctgctgc
      181 ggaggatccc tgctggcggt tgtggtgctg cttgcgctgc cggtggcctg gggtcaatgc
      241 aatgccccag aatggcttcc atttgccagg cctaccaacc taactgatga atttgagttt
      301 cccattggga catatctgaa ctatgaatgc cgccctggtt attccggaag accgttttct
      361 atcatctgcc taaaaaactc agtctggact ggtgctaagg acaggtgcag acgtaaatca
      421 tgtcgtaatc ctccagatcc tgtgaatggc atggtgcatg tgatcaaagg catccagttc
      481 ggatcccaaa ttaaatattc ttgtactaaa ggataccgac tcattggttc ctcgtctgcc
      541 acatgcatca tctcaggtga tactgtcatt tgggataatg aaacacctat ttgtgacaga
      601 attccttgtg ggctaccccc caccatcacc aatggagatt tcattagcac caacagagag
      661 aattttcact atggatcagt ggtgacctac cgctgcaatc ctggaagcgg agggagaaag
      721 gtgtttgagc ttgtgggtga gccctccata tactgcacca gcaatgacga tcaagtgggc
      781 atctggagcg gccccgcccc tcagtgcatt atacctaaca aatgcacgcc tccaaatgtg
      841 gaaaatggaa tattggtatc tgacaacaga agcttatttt ccttaaatga agttgtggag
      901 tttaggtgtc agcctggctt tgtcatgaaa ggaccccgcc gtgtgaagtg ccaggccctg
      961 aacaaatggg agccggagct accaagctgc tccagggtat gtcagccacc tccagatgtc
     1021 ctgcatgctg agcgtaccca aagggacaag gacaactttt cacctgggca ggaagtgttc
     1081 tacagctgtg agcccggcta cgacctcaga ggggctgcgt ctatgcgctg cacaccccag
     1141 ggagactgga gccctgcagc ccccacatgt gaagtgaaat cctgtgatga cttcatgggc
     1201 caacttctta atggccgtgt gctatttcca gtaaatctcc agcttggagc aaaagtggat
     1261 tttgtttgtg atgaaggatt tcaattaaaa ggcagctctg ctagttactg tgtcttggct
     1321 ggaatggaaa gcctttggaa tagcagtgtt ccagtgtgtg aacaaatctt ttgtccaagt
     1381 cctccagtta ttcctaatgg gagacacaca ggaaaacctc tggaagtctt tccctttggg
     1441 aaaacagtaa attacacatg cgacccccac ccagacagag ggacgagctt cgacctcatt
     1501 ggagagagca ccatccgctg cacaagtgac cctcaaggga atggggtttg gagcagccct
     1561 gcccctcgct gtggaattct gggtcactgt caagccccag atcattttct gtttgccaag
     1621 ttgaaaaccc aaaccaatgc atctgacttt cccattggga catctttaaa gtacgaatgc
     1681 cgtcctgagt actacgggag gccattctct atcacatgtc tagataacct ggtctggtca
     1741 agtcccaaag atgtctgtaa acgtaaatca tgtaaaactc ctccagatcc agtgaatggc
     1801 atggtgcatg tgatcacaga catccaggtt ggatccagaa tcaactattc ttgtactaca
     1861 gggcaccgac tcattggtca ctcatctgct gaatgtatcc tctcgggcaa tgctgcccat
     1921 tggagcacga agccgccaat ttgtcaacga attccttgtg ggctaccccc caccatcgcc
     1981 aatggagatt tcattagcac caacagagag aattttcact atggatcagt ggtgacctac
     2041 cgctgcaatc ctggaagcgg agggagaaag gtgtttgagc ttgtgggtga gccctccata
     2101 tactgcacca gcaatgacga tcaagtgggc atctggagcg gcccggcccc tcagtgcatt
     2161 atacctaaca aatgcacgcc tccaaatgtg gaaaatggaa tattggtatc tgacaacaga
     2221 agcttatttt ccttaaatga agttgtggag tttaggtgtc agcctggctt tgtcatgaaa
     2281 ggaccccgcc gtgtgaagtg ccaggccctg aacaaatggg agccggagct accaagctgc
     2341 tccagggtat gtcagccacc tccagatgtc ctgcatgctg agcgtaccca aagggacaag
     2401 gacaactttt cacccgggca ggaagtgttc tacagctgtg agcccggcta cgacctcaga
     2461 ggggctgcgt ctatgcgctg cacaccccag ggagactgga gccctgcagc ccccacatgt
     2521 gaagtgaaat cctgtgatga cttcatgggc caacttctta atggccgtgt gctatttcca
     2581 gtaaatctcc agcttggagc aaaagtggat tttgtttgtg atgaaggatt tcaattaaaa
     2641 ggcagctctg ctagttactg tgtcttggct ggaatggaaa gcctttggaa tagcagtgtt
     2701 ccagtgtgtg aacaaatctt ttgtccaagt cctccagtta ttcctaatgg gagacacaca
     2761 ggaaaacctc tggaagtctt tccctttggg aaaacagtaa attacacatg cgacccccac
     2821 ccagacagag ggacgagctt cgacctcatt ggagagagca ccatccgctg cacaagtgac
     2881 cctcaaggga atggggtttg gagcagccct gcccctcgct gtggaattct gggtcactgt
     2941 caagccccag atcattttct gtttgccaag ttgaaaaccc aaaccaatgc atctgacttt
     3001 cccattggga catctttaaa gtacgaatgc cgtcctgagt actacgggag gccattctct
     3061 atcacatgtc tagataacct ggtctggtca agtcccaaag atgtctgtaa acgtaaatca
     3121 tgtaaaactc ctccagatcc agtgaatggc atggtgcatg tgatcacaga catccaggtt
     3181 ggatccagaa tcaactattc ttgtactaca gggcaccgac tcattggtca ctcatctgct
     3241 gaatgtatcc tctcgggcaa tgctgcccat tggagcacga agccgccaat ttgtcaacga
     3301 attccttgtg ggctaccccc caccatcgcc aatggagatt tcattagcac caacagagag
     3361 aattttcact atggatcagt ggtgacctac cgctgcaatc ctggaagcgg agggagaaag
     3421 gtgtttgagc ttgtgggtga gccctccata tactgcacca gcaatgacga tcaagtgggc
     3481 atctggagcg gcccggcccc tcagtgcatt atacctaaca aatgcacgcc tccaaatgtg
     3541 gaaaatggaa tattggtatc tgacaacaga agcttatttt ccttaaatga agttgtggag
     3601 tttaggtgtc agcctggctt tgtcatgaaa ggaccccgcc gtgtgaagtg ccaggccctg
     3661 aacaaatggg agccggagct accaagctgc tccagggtat gtcagccacc tccagatgtc
     3721 ctgcatgctg agcgtaccca aagggacaag gacaactttt cacccgggca ggaagtgttc
     3781 tacagctgtg agcccggcta tgacctcaga ggggctgcgt ctatgcgctg cacaccccag
     3841 ggagactgga gccctgcagc ccccacatgt gaagtgaaat cctgtgatga cttcatgggc
     3901 caacttctta atggccgtgt gctatttcca gtaaatctcc agcttggagc aaaagtggat
     3961 tttgtttgtg atgaaggatt tcaattaaaa ggcagctctg ctagttattg tgtcttggct
     4021 ggaatggaaa gcctttggaa tagcagtgtt ccagtgtgtg aacaaatctt ttgtccaagt
     4081 cctccagtta ttcctaatgg gagacacaca ggaaaacctc tggaagtctt tccctttgga
     4141 aaagcagtaa attacacatg cgacccccac ccagacagag ggacgagctt cgacctcatt
     4201 ggagagagca ccatccgctg cacaagtgac cctcaaggga atggggtttg gagcagccct
     4261 gcccctcgct gtggaattct gggtcactgt caagccccag atcattttct gtttgccaag
     4321 ttgaaaaccc aaaccaatgc atctgacttt cccattggga catctttaaa gtacgaatgc
     4381 cgtcctgagt actacgggag gccattctct atcacatgtc tagataacct ggtctggtca
     4441 agtcccaaag atgtctgtaa acgtaaatca tgtaaaactc ctccagatcc agtgaatggc
     4501 atggtgcatg tgatcacaga catccaggtt ggatccagaa tcaactattc ttgtactaca
     4561 gggcaccgac tcattggtca ctcatctgct gaatgtatcc tctcaggcaa tactgcccat
     4621 tggagcacga agccgccaat ttgtcaacga attccttgtg ggctaccccc aaccatcgcc
     4681 aatggagatt tcattagcac caacagagag aattttcact atggatcagt ggtgacctac
     4741 cgctgcaatc ttggaagcag agggagaaag gtgtttgagc ttgtgggtga gccctccata
     4801 tactgcacca gcaatgacga tcaagtgggc atctggagcg gccccgcccc tcagtgcatt
     4861 atacctaaca aatgcacgcc tccaaatgtg gaaaatggaa tattggtatc tgacaacaga
     4921 agcttatttt ccttaaatga agttgtggag tttaggtgtc agcctggctt tgtcatgaaa
     4981 ggaccccgcc gtgtgaagtg ccaggccctg aacaaatggg agccagagtt accaagctgc
     5041 tccagggtgt gtcagccgcc tccagaaatc ctgcatggtg agcatacccc aagccatcag
     5101 gacaactttt cacctgggca ggaagtgttc tacagctgtg agcctggcta tgacctcaga
     5161 ggggctgcgt ctctgcactg cacaccccag ggagactgga gccctgaagc cccgagatgt
     5221 gcagtgaaat cctgtgatga cttcttgggt caactccctc atggccgtgt gctatttcca
     5281 cttaatctcc agcttggggc aaaggtgtcc tttgtctgtg atgaagggtt tcgcttaaag
     5341 ggcagttccg ttagtcattg tgtcttggtt ggaatgagaa gcctttggaa taacagtgtt
     5401 cctgtgtgtg aacatatctt ttgtccaaat cctccagcta tccttaatgg gagacacaca
     5461 ggaactccct ctggagatat tccctatgga aaagaaatat cttacacatg tgacccccac
     5521 ccagacagag ggatgacctt caacctcatt ggggagagca ccatccgctg cacaagtgac
     5581 cctcatggga atggggtttg gagcagccct gcccctcgct gtgaactttc tgttcgtgct
     5641 ggtcactgta aaaccccaga gcagtttcca tttgccagtc ctacgatccc aattaatgac
     5701 tttgagtttc cagtcgggac atctttgaat tatgaatgcc gtcctgggta ttttgggaaa
     5761 atgttctcta tctcctgcct agaaaacttg gtctggtcaa gtgttgaaga caactgtaga
     5821 cgaaaatcat gtggacctcc accagaaccc ttcaatggaa tggtgcatat aaacacagat
     5881 acacagtttg gatcaacagt taattattct tgtaatgaag ggtttcgact cattggttcc
     5941 ccatctacta cttgtctcgt ctcaggcaat aatgtcacat gggataagaa ggcacctatt
     6001 tgtgagatca tatcttgtga gccacctcca accatatcca atggagactt ctacagcaac
     6061 aatagaacat cttttcacaa tggaacggtg gtaacttacc agtgccacac tggaccagat
     6121 ggagaacagc tgtttgagct tgtgggagaa cggtcaatat attgcaccag caaagatgat
     6181 caagttggtg tttggagcag ccctccccct cggtgtattt ctactaataa atgcacagct
     6241 ccagaagttg aaaatgcaat tagagtacca ggaaacagga gtttctttac cctcactgag
     6301 atcatcagat ttagatgtca gcccgggttt gtcatggtag ggtcccacac tgtgcagtgc
     6361 cagaccaatg gcagatgggg gcccaagctg ccacactgct ccagggtgtg tcagccgcct
     6421 ccagaaatcc tgcatggtga gcatacccta agccatcagg acaacttttc acctgggcag
     6481 gaagtgttct acagctgtga gcccagctat gacctcagag gggctgcgtc tctgcactgc
     6541 acgccccagg gagactggag ccctgaagcc cctagatgta cagtgaaatc ctgtgatgac
     6601 ttcctgggcc aactccctca tggccgtgtg ctacttccac ttaatctcca gcttggggca
     6661 aaggtgtcct ttgtttgcga tgaagggttc cgattaaaag gcaggtctgc tagtcattgt
     6721 gtcttggctg gaatgaaagc cctttggaat agcagtgttc cagtgtgtga acaaatcttt
     6781 tgtccaaatc ctccagctat ccttaatggg agacacacag gaactccctt tggagatatt
     6841 ccctatggaa aagaaatatc ttacgcatgc gacacccacc cagacagagg gatgaccttc
     6901 aacctcattg gggagagctc catccgctgc acaagtgacc ctcaagggaa tggggtttgg
     6961 agcagccctg cccctcgctg tgaactttct gttcctgctg cctgcccaca tccacccaag
     7021 atccaaaacg ggcattacat tggaggacac gtatctctat atcttcctgg gatgacaatc
     7081 agctacattt gtgaccccgg ctacctgtta gtgggaaagg gcttcatttt ctgtacagac
     7141 cagggaatct ggagccaatt ggatcattat tgcaaagaag taaattgtag cttcccactg
     7201 tttatgaatg gaatctcgaa ggagttagaa atgaaaaaag tatatcacta tggagattat
     7261 gtgactttga agtgtgaaga tgggtatact ctggaaggca gtccctggag ccagtgccag
     7321 gcggatgaca gatgggaccc tcctctggcc aaatgtacct ctcgtacaca tgatgctctc
     7381 atagttggca ctttatctgg tacgatcttc tttattttac tcatcatttt cctctcttgg
     7441 ataattctaa agcacagaaa aggcaataat gcacatgaaa accctaaaga agtggctatc
     7501 catttacatt ctcaaggagg cagcagcgtt catccccgaa ctctgcaaac aaatgaagaa
     7561 aatagcaggg tccttccttg acaaagtact atacagctga agaacatctc gaatacaatt
     7621 ttggtgggaa aggagccaat tgatttcaac agaatcagat ctgagcttca taaagtcttt
     7681 gaagtgactt cacagagacg cagacatgtg cacttgaaga tgctgcccct tccctggtac
     7741 ctagcaaagc tcctgcctct ttgtgtgcgt cactgtgaaa cccccaccct tctgcctcgt
     7801 gctaaacgca cacagtatct agtcagggga aaagactgca tttaggagat agaaaatagt
     7861 ttggattact taaaggaata aggtgttgcc tggaatttct ggtttgtaag gtggtcactg
     7921 ttctttttta aaatatttgt aatatggaat gggctcagta agaagagctt ggaaaatgca
     7981 gaaagttatg aaaaataagt cacttataat tatgctacct actgataacc actcctaata
     8041 ttttgattca ttttctgcct atcttctttc acatatgtgt ttttttacat acgtactttt
     8101 cccccttagt ttgtttcctt ttattttata gagcagaacc ctagtctttt aaacagttta
     8161 gagtgaaata tatgctatat cagtttttac tttctctagg gagaaaaatt aatttactag
     8221 aaaggcatga aatgatcatg ggaagagtgg ttaagactac tgaagagaaa tatttggaaa
     8281 ataagatttc gatatcttct ttttttttga gatggagtct ggctctgtct cccaggctgg
     8341 agtgcagtgg cgtaatctcg gctcactgca agctccgcct cccgggttga caccattttc
     8401 ctgcctcagc ctcctgagta gttgggatta ccagtagatg ggactacagg cacctgccaa
     8461 cacgcccggc taattttttt gtatttttag tagagacggg gtttcaccat gttagccagg
     8521 atggtctgga tctcctgacc tcgtgatcca cctgcctcgg cctcccaaag tgctgcgatt
     8581 acaggcatga gccaccgcgc ctggccgctt tcgatatttt ctaaacttta attcaaaagc
     8641 actttgtgct gtgttctata taaaaaacat aataaaaatt gaaatgaaag aataattgtt
     8701 attataaaag tactagctta cttttgtatg gattcagaat atactaaatt aactttttaa
     8761 aacacaactt ttaaaaaatg tatcaaaata ataaacgtgt tctgatattt ttaaaataag
     8821 tgaccttgtg ttctttaacc agtccacatc tttagagaac aaaaatgtgt tatgatatta
     8881 tgggccatgc taatgacctc tagaaaacat cagaatattt ctggatattt aataatagct
     8941 ttatatatga ctaatgctca tttctatgta attctgttta atagttgctt taaaggtgaa
     9001 ttttgccaca tttactttga cagcagtata aggagtgaga tagacatgaa cctgaatttc
     9061 aatttaaaat catggaagag agggaaaaaa aaccagctta agaaaaatca actgataaac
     9121 tgcaagaaaa aaatgcaact tacatcacaa aagctaattg ctttattatt tagagagtac
     9181 ttaaaaatta aagaccaaac ttctctccac ccaacaaaaa tgggcaaagg acatacagct
     9241 aggtcaccaa gaaagaaggg caaataggtg gtgagtatat gtaaagatac ttgataggac
     9301 ttttgcttag ttgaatcttt agcaaatctc ttttatttct tgggattttg aagaagtaat
     9361 ttttaaagga ggactagaaa ctaagtgatt gggaattggc ctttttagaa ttaaaatttc
     9421 ccattacaag aaaaaaaaat cctgtgttct tttttttttc cagaatggag taggtcagtg
     9481 agcaatgtga ttaataaata tttcaatgtc tgtgactttt gatttatttt ggagacaggg
     9541 tcttgctctg ttacccaggc tggagtgcag tggtgctatc taggcttact gcaacctcac
     9601 ctgtcacttt ttaattgcaa gaaagctgaa aggttttttt ctattatatc agttataatg
     9661 ataaatactg tatatactaa ctatgagtaa aatactatat tgcctaactt gtattattaa
     9721 gcaattctgc taacctgtga ccttacattt tcatctgaaa agcaggggct ggacaccaat
     9781 tgccctatga agctattgct agtcctaaca ttctttgttt tgtttgcttt tttggcacac
     9841 ttaagtgtgt actatgaagt ttatgatgct ttaatgaaat tttctgtctc taccattgta
     9901 atgagaaagg aataaaatac tttattttgc aaatcta
//
