LOCUS       NM_198148               3544 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens carboxypeptidase X, M14 family member 2 (CPXM2), mRNA.
ACCESSION   NM_198148 XM_058409
VERSION     NM_198148.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3544)
  AUTHORS   Grabowski,K., Herlan,L., Witten,A., Qadri,F., Eisenreich,A.,
            Lindner,D., Schadlich,M., Schulz,A., Subrova,J., Mhatre,K.N.,
            Primessnig,U., Plehm,R., van Linthout,S., Escher,F., Bader,M.,
            Stoll,M., Westermann,D., Heinzel,F.R. and Kreutz,R.
  TITLE     Cpxm2 as a novel candidate for cardiac hypertrophy and failure in
            hypertension
  JOURNAL   Hypertens Res 45 (2), 292-307 (2022)
   PUBMED   34916661
  REMARK    GeneRIF: Cpxm2 as a novel candidate for cardiac hypertrophy and
            failure in hypertension.
REFERENCE   2  (bases 1 to 3544)
  AUTHORS   Zhao,X., Li,R., Wang,Q., Wu,M. and Wang,Y.
  TITLE     Overexpression of carboxypeptidase X M14 family member 2 predicts
            an unfavorable prognosis and promotes proliferation and migration
            of osteosarcoma
  JOURNAL   Diagn Pathol 14 (1), 118 (2019)
   PUBMED   31651348
  REMARK    GeneRIF: imply an active role for Carboxypeptidase X, M14 family
            member 2 in promoting tumor aggressiveness via epithelial to
            mesenchymal transition (EMT) modulation in osteosarcoma
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3544)
  AUTHORS   Niu,G., Yang,Y., Ren,J., Song,T., Hu,Z., Chen,L., Hong,R., Xia,J.,
            Ke,C. and Wang,X.
  TITLE     Overexpression of CPXM2 predicts an unfavorable prognosis and
            promotes the proliferation and migration of gastric cancer
  JOURNAL   Oncol Rep 42 (4), 1283-1294 (2019)
   PUBMED   31364750
  REMARK    GeneRIF: Results imply an active role for CPXM2 in promoting tumor
            aggressiveness via epithelial to mesenchymal transition (EMT)
            modulation in GCs.
REFERENCE   4  (bases 1 to 3544)
  AUTHORS   Gil-Varea,E., Urcelay,E., Vilarino-Guell,C., Costa,C., Midaglia,L.,
            Matesanz,F., Rodriguez-Antiguedad,A., Oksenberg,J.,
            Espino-Paisan,L., Dessa Sadovnick,A., Saiz,A., Villar,L.M.,
            Garcia-Merino,J.A., Ramio-Torrenta,L., Trivino,J.C., Quintana,E.,
            Robles,R., Sanchez-Lopez,A., Arroyo,R., Alvarez-Cermeno,J.C.,
            Vidal-Jordana,A., Malhotra,S., Fissolo,N., Montalban,X. and
            Comabella,M.
  TITLE     Exome sequencing study in patients with multiple sclerosis reveals
            variants associated with disease course
  JOURNAL   J Neuroinflammation 15 (1), 265 (2018)
   PUBMED   30217166
  REMARK    GeneRIF: The Genetic variants located in CPXM2 have the potential
            to modulate disease course in MS patients and may be used as
            disease activity biomarkers to identify patients with divergent
            disease courses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3544)
  AUTHORS   Chen,Y.C., Hsiao,C.J., Jung,C.C., Hu,H.H., Chen,J.H., Lee,W.C.,
            Chiou,J.M., Chen,T.F., Sun,Y., Wen,L.L., Yip,P.K., Chu,Y.M.,
            Chen,C.J. and Yang,H.I.
  TITLE     Performance Metrics for Selecting Single Nucleotide Polymorphisms
            in Late-onset Alzheimer's Disease
  JOURNAL   Sci Rep 6, 36155 (2016)
   PUBMED   27805002
  REMARK    GeneRIF: Performance metrics were used to select SNPs in stage 1,
            which were then genotyped to another dataset (stage 2). Four SNPs
            (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and
            rs12965520) were identified for LOAD by both traditional P-values
            (without correcting for multiple tests) and performance metrics.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3544)
  AUTHORS   Julia,A., Domenech,E., Chaparro,M., Garcia-Sanchez,V., Gomollon,F.,
            Panes,J., Manosa,M., Barreiro-De Acosta,M., Gutierrez,A.,
            Garcia-Planella,E., Aguas,M., Munoz,F., Esteve,M., Mendoza,J.L.,
            Vera,M., Marquez,L., Tortosa,R., Lopez-Lasanta,M., Alonso,A.,
            Gelpi,J.L., Garcia-Montero,A.C., Bertranpetit,J., Absher,D.,
            Myers,R.M., Gisbert,J.P. and Marsal,S.
  TITLE     A genome-wide association study identifies a novel locus at 6q22.1
            associated with ulcerative colitis
  JOURNAL   Hum Mol Genet 23 (25), 6927-6934 (2014)
   PUBMED   25082827
REFERENCE   7  (bases 1 to 3544)
  AUTHORS   Siedlinski,M., Cho,M.H., Bakke,P., Gulsvik,A., Lomas,D.A.,
            Anderson,W., Kong,X., Rennard,S.I., Beaty,T.H., Hokanson,J.E.,
            Crapo,J.D. and Silverman,E.K.
  CONSRTM   COPDGene Investigators; ECLIPSE Investigators
  TITLE     Genome-wide association study of smoking behaviours in patients
            with COPD
  JOURNAL   Thorax 66 (10), 894-902 (2011)
   PUBMED   21685187
REFERENCE   8  (bases 1 to 3544)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3544)
  AUTHORS   Xin,X., Day,R., Dong,W., Lei,Y. and Fricker,L.D.
  TITLE     Identification of mouse CPX-2, a novel member of the
            metallocarboxypeptidase gene family: cDNA cloning, mRNA
            distribution, and protein expression and characterization
  JOURNAL   DNA Cell Biol 17 (10), 897-909 (1998)
   PUBMED   9809751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358565.1 and AC009987.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_198148.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.69107.1, AY358565.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241305.4/ ENSP00000241305.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1722              AY358565.1         178-1899
            1723-1780           AC009987.17        64721-64778
            1781-2396           AY358565.1         1958-2573
            2397-2419           AC009987.17        80009-80031
            2420-3544           AY358565.1         2597-3721
FEATURES             Location/Qualifiers
     source          1..3544
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..3544
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /note="carboxypeptidase X, M14 family member 2"
                     /db_xref="GeneID:119587"
                     /db_xref="HGNC:HGNC:26977"
                     /db_xref="MIM:617348"
     exon            1..452
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2419
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /note="4632435C11Rik; carboxypeptidase-like protein X2;
                     carboxypeptidase Hlo; inactive carboxypeptidase-like
                     protein X2; cytosolic carboxypeptidase; carboxypeptidase X
                     (M14 family), member 2"
                     /codon_start=1
                     /product="inactive carboxypeptidase-like protein X2
                     precursor"
                     /protein_id="NP_937791.2"
                     /db_xref="CCDS:CCDS7637.1"
                     /db_xref="GeneID:119587"
                     /db_xref="HGNC:HGNC:26977"
                     /db_xref="MIM:617348"
                     /translation="MSRPGTATPALALVLLAVTLAGVGAQGAALEDPDYYGQEIWSRE
                     PYYARPEPELETFSPPLPAGPGEEWERRPQEPRPPKRATKPKKAPKREKSAPEPPPPG
                     KHSNKKVMRTKSSEKAANDDHSVRVAREDVRESCPPLGLETLKITDFQLHASTVKRYG
                     LGAHRGRLNIQAGINENDFYDGAWCAGRNDLQQWIEVDARRLTRFTGVITQGRNSLWL
                     SDWVTSYKVMVSNDSHTWVTVKNGSGDMIFEGNSEKEIPVLNELPVPMVARYIRINPQ
                     SWFDNGSICMRMEILGCPLPDPNNYYHRRNEMTTTDDLDFKHHNYKEMRQLMKVVNEM
                     CPNITRIYNIGKSHQGLKLYAVEISDHPGEHEVGEPEFHYIAGAHGNEVLGRELLLLL
                     VQFVCQEYLARNARIVHLVEETRIHVLPSLNPDGYEKAYEGGSELGGWSLGRWTHDGI
                     DINNNFPDLNTLLWEAEDRQNVPRKVPNHYIAIPEWFLSENATVAAETRAVIAWMEKI
                     PFVLGGNLQGGELVVAYPYDLVRSPWKTQEHTPTPDDHVFRWLAYSYASTHRLMTDAR
                     RRVCHTEDFQKEEGTVNGASWHTVAGSLNDFSYLHTNCFELSIYVGCDKYPHESQLPE
                     EWENNRESLIVFMEQVHRGIKGLVRDSHGKGIPNAIISVEGINHDIRTANDGDYWRLL
                     NPGEYVVTAKAEGFTASTKNCMVGYDMGATRCDFTLSKTNMARIREIMEKFGKQPVSL
                     PARRLKLRGQKRRQRG"
     exon            453..551
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            552..661
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            662..801
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            802..886
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1037
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1126
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1250
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1447
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1627
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1925
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2065
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2165
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..3544
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3524..3529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /note="hexamer: AATAAA"
     polyA_site      3544
                     /gene="CPXM2"
                     /gene_synonym="CPX2; UNQ676"
                     /note="major polyA site"
ORIGIN      
        1 acacgcgcag ccagccggcc gcctcccgcg cccaagcgcg ccgctctgct gtgccctgcg
       61 cccttgcccc gcgccagctt ctgcgcccgc agcccgcccg gcgcccccgg tgaccgtgac
      121 cctgccctgg gcgcggggcg gagcaggcat gtcccgcccg gggaccgcta ccccagcgct
      181 ggccctggtg ctcctggcag tgaccctggc cggggtcgga gcccagggcg cagccctcga
      241 ggaccctgat tattacgggc aggagatctg gagccgggag ccctactacg cgcgcccgga
      301 gcccgagctc gagaccttct ctccgccgct gcctgcgggg cccggggagg agtgggagcg
      361 gcgcccgcag gagcccaggc cgcccaagag ggccaccaag cccaagaaag ctcccaagag
      421 ggagaagtcg gctccggagc cgcctccacc aggtaaacac agcaacaaaa aagttatgag
      481 aaccaagagc tctgagaagg ctgccaacga tgatcacagt gtccgtgtgg cccgtgaaga
      541 tgtcagagag agttgcccac ctcttggtct ggaaacctta aaaatcacag acttccagct
      601 ccatgcctcc acggtgaagc gctatggcct gggggcacat cgagggagac tcaacatcca
      661 ggcgggcatt aatgaaaatg atttttatga cggagcgtgg tgcgcgggaa gaaatgacct
      721 ccagcagtgg attgaagtgg atgctcggcg cctgaccaga ttcactggtg tcatcactca
      781 agggaggaac tccctctggc tgagtgactg ggtgacatcc tataaggtca tggtgagcaa
      841 tgacagccac acgtgggtca ctgttaagaa tggatctgga gacatgatat ttgagggaaa
      901 cagtgagaag gagatccctg ttctcaatga gctacccgtc cccatggtgg cccgctacat
      961 ccgcataaac cctcagtcct ggtttgataa tgggagcatc tgcatgagaa tggagatcct
     1021 gggctgccca ctgccagatc ctaataatta ttatcaccgc cggaacgaga tgaccaccac
     1081 tgatgacctg gattttaagc accacaatta taaggaaatg cgccagttga tgaaagttgt
     1141 gaatgaaatg tgtcccaata tcaccagaat ttacaacatt ggaaaaagcc accagggcct
     1201 gaagctgtat gctgtggaga tctcagatca ccctggggag catgaagtcg gtgagcccga
     1261 gttccactac atcgcggggg cccacggcaa tgaggtgctg ggccgggagc tgctgctgct
     1321 gctggtgcag ttcgtgtgtc aggagtactt ggcccggaat gcgcgcatcg tccacctggt
     1381 ggaggagacg cggattcacg tcctcccctc cctcaacccc gatggctacg agaaggccta
     1441 cgaagggggc tcggagctgg gaggctggtc cctgggacgc tggacccacg atggaattga
     1501 catcaacaac aactttcctg atttaaacac gctgctctgg gaggcagagg atcgacagaa
     1561 tgtccccagg aaagttccca atcactatat tgcaatccct gagtggtttc tgtcggaaaa
     1621 tgccacggtg gctgccgaga ccagagcagt catagcctgg atggaaaaaa tcccttttgt
     1681 gctgggcggc aacctgcagg gcggcgagct ggtggtggcg tacccctacg acctggtgcg
     1741 gtccccctgg aagacgcagg aacacacccc cacccccgac gaccacgtgt tccgctggct
     1801 ggcctactcc tatgcctcca cacaccgcct catgacagac gcccggagga gggtgtgcca
     1861 cacggaggac ttccagaagg aggagggcac tgtcaatggg gcctcctggc acaccgtcgc
     1921 tggaagtctg aacgatttca gctaccttca tacaaactgc ttcgaactgt ccatctacgt
     1981 gggctgtgat aaatacccac atgagagcca gctgcccgag gagtgggaga ataaccggga
     2041 atctctgatc gtgttcatgg agcaggttca tcgtggcatt aaaggcttgg tgagagattc
     2101 acatggaaaa ggaatcccaa acgccattat ctccgtagaa ggcattaacc atgacatccg
     2161 aacagccaac gatggggatt actggcgcct cctgaaccct ggagagtatg tggtcacagc
     2221 aaaggccgaa ggtttcactg catccaccaa gaactgtatg gttggctatg acatgggggc
     2281 cacaaggtgt gacttcacac ttagcaaaac caacatggcc aggatccgag agatcatgga
     2341 gaagtttggg aagcagcccg tcagcctgcc agccaggcgg ctgaagctgc gggggcagaa
     2401 gagacgacag cgtgggtgac cctcctgggc ccttgagact cgtctgggac ccatgcaaat
     2461 taaaccaacc tggtagtagc tccatagtgg actcactcac tgttgtttcc tctgtaattc
     2521 aagaagtgcc tggaagagag ggtgcattgt gaggcaggtc ccaaaaggga aggctggagg
     2581 ctgaggctgt tttcttttct ttgttcccat ttatccaaat aacttggaca gagcagcaga
     2641 gaaaagctga tgggagtgag agaactcagc aagccaacct gggaatcaga gagagaagga
     2701 gaaggagggg agcctgtccg ttcagagcct ctggctgcat agaaaaggat tctggtgctt
     2761 cccctgtttg cgtggcagca agggttccac gtgcatttgc aatttgcaca gctaaaattg
     2821 cagcatttcc ccagctgggc tgtcccaaat gttaccattt gagatgctcc caggcgtcct
     2881 aagagaatcc accctctctg gccctgggac attgcaagct gctacaaata aattctgtgt
     2941 tcttttgaca atagcgtcat tgccaagtgc acatcagtga gcctcttgaa tctgtttagt
     3001 ctcctttttc aacaaaggag tgtgttcaga aaaggagaga gaggctgaga tcattcagga
     3061 gtttgttggg cagcaagcat ggagcttctt gcacaaattc tgggtccata aacaaccccc
     3121 aaagtccctg ctgatccagt agccctggag gttccccagg tagggagagc cagaggtgcc
     3181 agccttcctg aagggccaga aaatttagcc tggatctcct cttttacctg ctaggactgg
     3241 aaagagccag aagtggggtg gcctgaagcc ctctctctgc ttgaggtatt gcccctgtgt
     3301 ggaattgagt gctcatgggt tggcctcata tcagcctggg agttattttt gatatgtaga
     3361 atgccagatc ttccagatta ggctaaatgt aatgaaaacc tcttaggatt atctgtggag
     3421 catcagtttg ggaagaatta ttgaattatc ttgcaagaaa aaagtatgtc tcactttttg
     3481 ttaatgttgc tgcctcattg acctgggaaa aatgaaaaaa aaaaataaag caaatggtaa
     3541 gacc
//
