LOCUS       NM_019609               2376 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens carboxypeptidase X, M14 family member 1 (CPXM1),
            transcript variant 1, mRNA.
ACCESSION   NM_019609
VERSION     NM_019609.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Pervaz,S., Ullah,A., Adu-Gyamfi,E.A., Lamptey,J., Sah,S.K.,
            Wang,M.J. and Wang,Y.X.
  TITLE     Role of CPXM1 in Impaired Glucose Metabolism and Ovarian
            Dysfunction in Polycystic Ovary Syndrome
  JOURNAL   Reprod Sci 30 (2), 526-543 (2023)
   PUBMED   35697923
  REMARK    GeneRIF: Role of CPXM1 in Impaired Glucose Metabolism and Ovarian
            Dysfunction in Polycystic Ovary Syndrome.
            Erratum:[Reprod Sci. 2023 Jan;30(1):332. doi:
            10.1007/s43032-022-01021-x.. PMID: 35799025]
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Kim,Y.H., Barclay,J.L., He,J., Luo,X., O'Neill,H.M., Keshvari,S.,
            Webster,J.A., Ng,C., Hutley,L.J., Prins,J.B. and Whitehead,J.P.
  TITLE     Identification of carboxypeptidase X (CPX)-1 as a positive
            regulator of adipogenesis
  JOURNAL   FASEB J 30 (7), 2528-2540 (2016)
   PUBMED   27006448
  REMARK    GeneRIF: These findings establish CPX-1 as a positive regulator of
            adipogenesis situated downstream of FGF-1/BAMBI that may contribute
            to hyperplastic adipose tissue expansion via affecting
            extracellular matrix remodeling.
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Kim,Y.H., O'Neill,H.M. and Whitehead,J.P.
  TITLE     Carboxypeptidase X-1 (CPX-1) is a secreted collagen-binding
            glycoprotein
  JOURNAL   Biochem Biophys Res Commun 468 (4), 894-899 (2015)
   PUBMED   26603934
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Lei,Y., Xin,X., Morgan,D., Pintar,J.E. and Fricker,L.D.
  TITLE     Identification of mouse CPX-1, a novel member of the
            metallocarboxypeptidase gene family with highest similarity to
            CPX-2
  JOURNAL   DNA Cell Biol 18 (2), 175-185 (1999)
   PUBMED   10073577
  REMARK    GeneRIF: This paper deals with mouse CPXM.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB252546.1 and BC063430.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019609.4.
            
            Summary: This gene likely encodes a member of the carboxypeptidase
            family of proteins. Cloning of a comparable locus in mouse
            indicates that the encoded protein contains a discoidin domain and
            a carboxypeptidase domain, but the protein appears to lack residues
            necessary for carboxypeptidase activity.[provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063430.1, SRR1660803.201077.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380605.3/ ENSP00000369979.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               DB252546.1         20-193
            175-2376            BC063430.1         171-2372
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2376
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /note="carboxypeptidase X, M14 family member 1"
                     /db_xref="GeneID:56265"
                     /db_xref="HGNC:HGNC:15771"
                     /db_xref="MIM:609555"
     exon            1..227
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2260
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /EC_number="3.4.17.10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; metallocarboxypeptidase CPX-1;
                     carboxypeptidase-like protein X1; carboxypeptidase X (M14
                     family), member 1"
                     /codon_start=1
                     /product="probable carboxypeptidase X1 isoform 1
                     precursor"
                     /protein_id="NP_062555.1"
                     /db_xref="CCDS:CCDS13033.1"
                     /db_xref="GeneID:56265"
                     /db_xref="HGNC:HGNC:15771"
                     /db_xref="MIM:609555"
                     /translation="MWGLLLALAAFAPAVGPALGAPRNSVLGLAQPGTTKVPGSTPAL
                     HSSPAQPPAETANGTSEQHVRIRVIKKKKVIMKKRKKLTLTRPTPLVTAGPLVTPTPA
                     GTLDPAEKQETGCPPLGLESLRVSDSRLEASSSQSFGLGPHRGRLNIQSGLEDGDLYD
                     GAWCAEEQDADPWFQVDAGHPTRFSGVITQGRNSVWRYDWVTSYKVQFSNDSRTWWGS
                     RNHSSGMDAVFPANSDPETPVLNLLPEPQVARFIRLLPQTWLQGGAPCLRAEILACPV
                     SDPNDLFLEAPASGSSDPLDFQHHNYKAMRKLMKQVQEQCPNITRIYSIGKSYQGLKL
                     YVMEMSDKPGEHELGEPEVRYVAGMHGNEALGRELLLLLMQFLCHEFLRGNPRVTRLL
                     SEMRIHLLPSMNPDGYEIAYHRGSELVGWAEGRWNNQSIDLNHNFADLNTPLWEAQDD
                     GKVPHIVPNHHLPLPTYYTLPNATVAPETRAVIKWMKRIPFVLSANLHGGELVVSYPF
                     DMTRTPWAARELTPTPDDAVFRWLSTVYAGSNLAMQDTSRRPCHSQDFSVHGNIINGA
                     DWHTVPGSMNDFSYLHTNCFEVTVELSCDKFPHENELPQEWENNKDALLTYLEQVRMG
                     IAGVVRDKDTELGIADAVIAVDGINHDVTTAWGGDYWRLLTPGDYMVTASAEGYHSVT
                     RNCRVTFEEGPFPCNFVLTKTPKQRLRELLAAGAKVPPDLRRRLERLRGQKD"
     exon            228..395
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            396..505
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            506..645
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            646..736
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            737..887
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            888..976
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1100
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1297
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1477
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1775
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1915
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2018
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2376
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2355..2360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /note="hexamer: ATTAAA"
     polyA_site      2376
                     /gene="CPXM1"
                     /gene_synonym="CPX1; CPXM"
                     /note="major polyA site"
ORIGIN      
        1 gagaccgacc cgccacccgc cgtagcccgc gcgcccctgg cactcaatcc ccgccatgtg
       61 ggggctcctg ctcgccctgg ccgccttcgc gccggccgtc ggcccggctc tgggggcgcc
      121 caggaactcg gtgctgggcc tcgcgcagcc cgggaccacc aaggtcccag gctcgacccc
      181 ggccctgcat agcagcccgg cacagccgcc ggcggagaca gctaacggga cctcagaaca
      241 gcatgtccgg attcgagtca tcaagaagaa aaaggtcatt atgaagaagc ggaagaagct
      301 aactctaact cgccccaccc cactggtgac tgccgggccc cttgtgaccc ccactccagc
      361 agggaccctc gaccccgctg agaaacaaga aacaggctgt cctcctttgg gtctggagtc
      421 cctgcgagtt tcagatagcc ggcttgaggc atccagcagc cagtcctttg gtcttggacc
      481 acaccgagga cggctcaaca ttcagtcagg cctggaggac ggcgatctat atgatggagc
      541 ctggtgtgct gaggagcagg acgccgatcc atggtttcag gtggacgctg ggcaccccac
      601 ccgcttctcg ggtgttatca cacagggcag gaactctgtc tggaggtatg actgggtcac
      661 atcatacaag gtccagttca gcaatgacag tcggacctgg tggggaagta ggaaccacag
      721 cagtgggatg gacgcagtat ttcctgccaa ttcagaccca gaaactccag tgctgaacct
      781 cctgccggag ccccaggtgg cccgcttcat tcgcctgctg ccccagacct ggctccaggg
      841 aggcgcgcct tgcctccggg cagagatcct ggcctgccca gtctcagacc ccaatgacct
      901 attccttgag gcccctgcgt cgggatcctc tgaccctcta gactttcagc atcacaatta
      961 caaggccatg aggaagctga tgaagcaggt acaagagcaa tgccccaaca tcacccgcat
     1021 ctacagcatt gggaagagct accagggcct gaagctgtat gtgatggaaa tgtcggacaa
     1081 gcctggggag catgagctgg gggagcctga ggtgcgctac gtggctggca tgcatgggaa
     1141 cgaggccctg gggcgggagt tgcttctgct cctgatgcag ttcctgtgcc atgagttcct
     1201 gcgagggaac ccacgggtga cccggctgct ctctgagatg cgcattcacc tgctgccctc
     1261 catgaaccct gatggctatg agatcgccta ccaccggggt tcagagctgg tgggctgggc
     1321 cgagggccgc tggaacaacc agagcatcga tcttaaccat aattttgctg acctcaacac
     1381 accactgtgg gaagcacagg acgatgggaa ggtgccccac atcgtcccca accatcacct
     1441 gccattgccc acttactaca ccctgcccaa tgccaccgtg gctcctgaaa cgcgggcagt
     1501 aatcaagtgg atgaagcgga tcccctttgt gctaagtgcc aacctccacg ggggtgagct
     1561 cgtggtgtcc tacccattcg acatgactcg caccccgtgg gctgcccgcg agctcacgcc
     1621 cacaccagat gatgctgtgt ttcgctggct cagcactgtc tatgctggca gtaatctggc
     1681 catgcaggac accagccgcc gaccctgcca cagccaggac ttctccgtgc acggcaacat
     1741 catcaacggg gctgactggc acacggtccc cgggagcatg aatgacttca gctacctaca
     1801 caccaactgc tttgaggtca ctgtggagct gtcctgtgac aagttccctc acgagaatga
     1861 attgccccag gagtgggaga acaacaaaga cgccctcctc acctacctgg agcaggtgcg
     1921 catgggcatt gcaggagtgg tgagggacaa ggacacggag cttgggattg ctgacgctgt
     1981 cattgccgtg gatgggatta accatgacgt gaccacggcg tggggcgggg attattggcg
     2041 tctgctgacc ccaggggact acatggtgac tgccagtgcc gagggctacc attcagtgac
     2101 acggaactgt cgggtcacct ttgaagaggg ccccttcccc tgcaatttcg tgctcaccaa
     2161 gactcccaaa cagaggctgc gcgagctgct ggcagctggg gccaaggtgc ccccggacct
     2221 tcgcaggcgc ctggagcggc taaggggaca gaaggattga tacctgcggt ttaagagccc
     2281 tagggcaggc tggacctgtc aagacgggaa ggggaagagt agagagggag ggacaaagtg
     2341 aggaaaaggt gctcattaaa gctaccgggc acctta
//
