LOCUS       NM_033048               1626 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens CPX chromosome region candidate 1 (CPXCR1), transcript
            variant 1, mRNA.
ACCESSION   NM_033048
VERSION     NM_033048.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Antunez-Ortiz,D.L., Flores-Alfaro,E., Burguete-Garcia,A.I.,
            Bonnefond,A., Peralta-Romero,J., Froguel,P., Espinoza-Rojo,M. and
            Cruz,M.
  TITLE     Copy Number Variations in Candidate Genes and Intergenic Regions
            Affect Body Mass Index and Abdominal Obesity in Mexican Children
  JOURNAL   Biomed Res Int 2017, 2432957 (2017)
   PUBMED   28428959
  REMARK    GeneRIF: Our results indicate a possible contribution of CNVs in
            LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c,
            15q21.1a, and 22q11.21d to the development of obesity, particularly
            abdominal obesity in Mexican children.
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Lyons,P.A., Rayner,T.F., Trivedi,S., Holle,J.U., Watts,R.A.,
            Jayne,D.R., Baslund,B., Brenchley,P., Bruchfeld,A., Chaudhry,A.N.,
            Cohen Tervaert,J.W., Deloukas,P., Feighery,C., Gross,W.L.,
            Guillevin,L., Gunnarsson,I., Harper,L., Hruskova,Z., Little,M.A.,
            Martorana,D., Neumann,T., Ohlsson,S., Padmanabhan,S., Pusey,C.D.,
            Salama,A.D., Sanders,J.S., Savage,C.O., Segelmark,M.,
            Stegeman,C.A., Tesar,V., Vaglio,A., Wieczorek,S., Wilde,B.,
            Zwerina,J., Rees,A.J., Clayton,D.G. and Smith,K.G.
  TITLE     Genetically distinct subsets within ANCA-associated vasculitis
  JOURNAL   N Engl J Med 367 (3), 214-223 (2012)
   PUBMED   22808956
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Braybrook,C., Warry,G., Howell,G., Mandryko,V., Arnason,A.,
            Bjornsson,A., Ross,M.T., Moore,G.E. and Stanier,P.
  TITLE     Physical and transcriptional mapping of the X-linked cleft palate
            and ankyloglossia (CPX) critical region
  JOURNAL   Hum Genet 108 (6), 537-545 (2001)
   PUBMED   11499681
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031116.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_033048.5.
            
            Summary: This gene is one of several genes identified in a region
            of the X chromosome associated with an X-linked cleft palate (CPX)
            disorder. The encoded protein contains a motif similar to a motif
            found in zinc-finger proteins. Mutation analysis of this gene has
            not revealed any mutation which causes the CPX disorder. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027614.2, BU570042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276127.9/ ENSP00000276127.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL031116.2         103789-103933
            146-251             AL031116.2         105882-105987
            252-1626            AL031116.2         109971-111345
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.31"
     gene            1..1626
                     /gene="CPXCR1"
                     /gene_synonym="CT77"
                     /note="CPX chromosome region candidate 1"
                     /db_xref="GeneID:53336"
                     /db_xref="HGNC:HGNC:2332"
                     /db_xref="MIM:301055"
     exon            1..145
                     /gene="CPXCR1"
                     /gene_synonym="CT77"
                     /inference="alignment:Splign:2.1.0"
     exon            146..251
                     /gene="CPXCR1"
                     /gene_synonym="CT77"
                     /inference="alignment:Splign:2.1.0"
     exon            252..1626
                     /gene="CPXCR1"
                     /gene_synonym="CT77"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1165
                     /gene="CPXCR1"
                     /gene_synonym="CT77"
                     /note="cancer/testis antigen 77"
                     /codon_start=1
                     /product="CPX chromosomal region candidate gene 1 protein"
                     /protein_id="NP_149037.5"
                     /db_xref="CCDS:CCDS14458.1"
                     /db_xref="GeneID:53336"
                     /db_xref="HGNC:HGNC:2332"
                     /db_xref="MIM:301055"
                     /translation="MSYPTKEGSDTAGNAHKNSENEPPNDCSTDIESPSADPNMIYQV
                     ETNPINREPGTATSQEDVVPQAAENSELETEIQKDQREEDLKEELLLLQTPIPRKLVS
                     HKPLNDRSRSHSGKVEMKANNFPINHKTRFRLSTSWRVPFINSHEIRSMILHLLCDRY
                     FSQAAGCQNTMWVKRKYIACLYHPNSFTHHERAITFRRPSRVHYYRPLTERMTSGKFC
                     KSTDTKGKCRFRAIVRSVLFVSQIQIESIFNIKGFVDILTYIHTMNVMITNTNNGWKY
                     FCPICGRLFNTYSELRQHSCSSSGN"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPXCR1"
                     /gene_synonym="CT77"
                     /note="hexamer: AATAAA"
     polyA_site      1626
                     /gene="CPXCR1"
                     /gene_synonym="CT77"
                     /note="major polyA site"
ORIGIN      
        1 aggagtaagt ggagaggtag agggcagaag aaaaggggtc aagaaggcag gaccccgtga
       61 agcacacctt tcctaaggat tttgacgaat gagaatgaag ataaactgtg agttgaaagt
      121 gaaagagaaa gcataaggga tcttaggtgc atctgacaag ccttagatga cctccagcaa
      181 cttcagttct caccgaatta ctgcatttca gccttactga gaagcagcca gtcatactat
      241 cctcaaattt taacccagga tgagttatcc tactaaagaa ggaagtgata cagctggaaa
      301 tgctcacaaa aattctgaaa atgagcctcc taatgactgt agtacagaca tagagtctcc
      361 atctgctgat cccaatatga tctatcaggt agaaaccaac ccaataaaca gggagccagg
      421 cacagcaacc tcccaggaag atgttgttcc tcaagcagca gaaaacagcg agctcgaaac
      481 agagatccaa aaagatcaac gagaagaaga tctaaaagaa gagcttcttc tacttcagac
      541 ccccattccc agaaaattgg tctctcacaa gcccttaaat gatagatcaa gatcccactc
      601 agggaaagtt gagatgaaag caaacaattt ccccataaat cacaaaactc gttttcgact
      661 ttcaacttca tggagagtcc catttattaa cagtcatgag ataagaagta tgattctcca
      721 tctgctatgt gatagatatt tctctcaggc tgcagggtgt cagaatacca tgtgggtaaa
      781 gcgaaaatat atagcatgtc tttaccatcc aaatagtttc acccatcacg agagagccat
      841 aacatttaga aggccttcga gggtgcacta ctaccgtccc ctcactgaga gaatgacatc
      901 aggaaaattt tgcaaatcaa ctgacactaa agggaaatgt agattccgtg ctattgtgag
      961 gtctgtgctc tttgtgtcac agatacaaat tgaaagtatt tttaatataa aaggttttgt
     1021 ggatatattg acatatatcc ataccatgaa tgttatgatc acaaacacca ataatggttg
     1081 gaaatacttt tgtcccatct gtggaaggct ttttaacact tactctgaat taagacaaca
     1141 ttcatgcagc tcttctggga attaaattaa attggggtaa attcatttta aaatataact
     1201 tctaaaattc ataatttgac tactaaagta agacaaaatt gcatgaacat aaattttagt
     1261 attattagag ggagtagcag aaaggaacac aaactaatag tacctctcag taagaaatac
     1321 ctatggggag tgaggaaaca tctgtttata ctttgctttt acaagtacat cattgaaata
     1381 tcagacctgt catctatatt gagtcagcat ttgaaccaag taaatgtttt cactgtctta
     1441 acatctattt ctgtagatgt aaatattgtt aacataaaag aatccaagtt aacaggatcc
     1501 tgactaagat agcaaacata tattggaagg ccagacaaag ttctaccaag tgtttccaga
     1561 gattctgcta catgtattat ctgaaatgtt ctccatatat tcaataaaaa ccaatttgaa
     1621 gacata
//
