LOCUS       NM_031311               2087 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens carboxypeptidase vitellogenic like (CPVL), transcript
            variant 1, mRNA.
ACCESSION   NM_031311
VERSION     NM_031311.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Wang,X., Chen,L., Huang,K., Lin,Y., Hong,Y. and Lin,Z.
  TITLE     CPVL suppresses metastasis of nasopharyngeal carcinoma through
            inhibiting epithelial-mesenchymal transition
  JOURNAL   J Cancer Res Clin Oncol 149 (18), 16473-16488 (2023)
   PUBMED   37712963
  REMARK    GeneRIF: CPVL suppresses metastasis of nasopharyngeal carcinoma
            through inhibiting epithelial-mesenchymal transition.
REFERENCE   2  (bases 1 to 2087)
  AUTHORS   Kanazawa,T., Ikeda,M., Glatt,S.J., Tsutsumi,A., Kikuyama,H.,
            Kawamura,Y., Nishida,N., Miyagawa,T., Hashimoto,R., Takeda,M.,
            Sasaki,T., Tokunaga,K., Koh,J., Iwata,N. and Yoneda,H.
  TITLE     Genome-wide association study of atypical psychosis
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (7), 679-686 (2013)
   PUBMED   24132900
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Hu,C., Zhang,R., Yu,W., Wang,J., Wang,C., Pang,C., Ma,X., Bao,Y.,
            Xiang,K. and Jia,W.
  TITLE     CPVL/CHN2 genetic variant is associated with diabetic retinopathy
            in Chinese type 2 diabetic patients
  JOURNAL   Diabetes 60 (11), 3085-3089 (2011)
   PUBMED   21911749
  REMARK    GeneRIF: genetic association studies in a Chinese population with
            type 2 diabetes: An SNP in CPVL (rs39059) is associated with
            diabetic retinopathy in a Chinese population of type 2 diabetic
            patients.
REFERENCE   5  (bases 1 to 2087)
  AUTHORS   Maeda,S., Araki,S., Babazono,T., Toyoda,M., Umezono,T., Kawai,K.,
            Imanishi,M., Uzu,T., Watada,H., Suzuki,D., Kashiwagi,A.,
            Iwamoto,Y., Kaku,K., Kawamori,R. and Nakamura,Y.
  TITLE     Replication study for the association between four Loci identified
            by a genome-wide association study on European American subjects
            with type 1 diabetes and susceptibility to diabetic nephropathy in
            Japanese subjects with type 2 diabetes
  JOURNAL   Diabetes 59 (8), 2075-2079 (2010)
   PUBMED   20460425
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2087)
  AUTHORS   Meigs,J.B., Manning,A.K., Fox,C.S., Florez,J.C., Liu,C.,
            Cupples,L.A. and Dupuis,J.
  TITLE     Genome-wide association with diabetes-related traits in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S16 (2007)
   PUBMED   17903298
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2087)
  AUTHORS   Mahoney,J.A., Ntolosi,B., DaSilva,R.P., Gordon,S. and McKnight,A.J.
  TITLE     Cloning and characterization of CPVL, a novel serine
            carboxypeptidase, from human macrophages
  JOURNAL   Genomics 72 (3), 243-251 (2001)
   PUBMED   11401439
REFERENCE   8  (bases 1 to 2087)
  AUTHORS   Ignatovich,O., Tomlinson,I.M., Popov,A.V., Bruggemann,M. and
            Winter,G.
  TITLE     Dominance of intrinsic genetic factors in shaping the human
            immunoglobulin Vlambda repertoire
  JOURNAL   J Mol Biol 294 (2), 457-465 (1999)
   PUBMED   10610771
REFERENCE   9  (bases 1 to 2087)
  AUTHORS   Wang,X. and Stollar,B.D.
  TITLE     Immunoglobulin VH gene expression in human aging
  JOURNAL   Clin Immunol 93 (2), 132-142 (1999)
   PUBMED   10527689
  REMARK    Erratum:[Clin Immunol 2000 Mar;94(3):219]
REFERENCE   10 (bases 1 to 2087)
  AUTHORS   Striebich,C.C., Falta,M.T., Wang,Y., Bill,J. and Kotzin,B.L.
  TITLE     Selective accumulation of related CD4+ T cell clones in the
            synovial fluid of patients with rheumatoid arthritis
  JOURNAL   J Immunol 161 (8), 4428-4436 (1998)
   PUBMED   9780222
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK075433.1 and AC005162.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031311.4.
            
            Summary: The protein encoded by this gene is a carboxypeptidase and
            bears strong sequence similarity to serine carboxypeptidases.
            Carboxypeptidases are a large class of proteases that act to cleave
            a single amino acid from the carboxy termini of proteins or
            peptides. The exact function of this protein, however, has not been
            determined. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 5. Variants 1-12 all encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.21304.1, AY358549.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265394.10/ ENSP00000265394.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-977               AK075433.1         2-978
            978-978             AC005162.1         95344-95344         c
            979-1422            AK075433.1         980-1423
            1423-1423           AC005162.1         54159-54159         c
            1424-1560           AK075433.1         1425-1561
            1561-2087           AC005162.1         18801-19327         c
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..2087
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /note="carboxypeptidase vitellogenic like"
                     /db_xref="GeneID:54504"
                     /db_xref="HGNC:HGNC:14399"
                     /db_xref="MIM:609780"
     exon            1..109
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            110..288
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1550
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /note="isoform b precursor is encoded by transcript
                     variant 1; vitellogenic carboxypeptidase-like protein;
                     VCP-like protein; probable serine carboxypeptidase CPVL;
                     carboxypeptidase WUG; CP-Mac carboxypeptidase"
                     /codon_start=1
                     /product="probable serine carboxypeptidase CPVL isoform b
                     precursor"
                     /protein_id="NP_112601.3"
                     /db_xref="CCDS:CCDS5419.1"
                     /db_xref="GeneID:54504"
                     /db_xref="HGNC:HGNC:14399"
                     /db_xref="MIM:609780"
                     /translation="MVGAMWKVIVSLVLLMPGPCDGLFRSLYRSVSMPPKGDSGQPLF
                     LTPYIEAGKIQKGRELSLVGPFPGLNMKSYAGFLTVNKTYNSNLFFWFFPAQIQPEDA
                     PVVLWLQGGPGGSSMFGLFVEHGPYVVTSNMTLRDRDFPWTTTLSMLYIDNPVGTGFS
                     FTDDTHGYAVNEDDVARDLYSALIQFFQIFPEYKNNDFYVTGESYAGKYVPAIAHLIH
                     SLNPVREVKINLNGIAIGDGYSDPESIIGGYAEFLYQIGLLDEKQKKYFQKQCHECIE
                     HIRKQNWFEAFEILDKLLDGDLTSDPSYFQNVTGCSNYYNFLRCTEPEDQLYYVKFLS
                     LPEVRQAIHVGNQTFNDGTIVEKYLREDTVQSVKPWLTEIMNNYKVLIYNGQLDIIVA
                     AALTERSLMGMDWKGSQEYKKAEKKVWKIFKSDSEVAGYIRQAGDFHQVIIRGGGHIL
                     PYDQPLRAFDMINRFIYGKGWDPYVG"
     exon            289..407
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            408..522
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            523..581
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            582..661
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            662..728
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            729..851
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            852..983
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1082
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1256
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1439
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..2087
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /note="hexamer: AATAAA"
     polyA_site      1676
                     /gene="CPVL"
                     /gene_synonym="HVLP"
     polyA_site      1691
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /note="major polyA site"
     regulatory      2066..2071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPVL"
                     /gene_synonym="HVLP"
                     /note="hexamer: AATAAA"
     polyA_site      2087
                     /gene="CPVL"
                     /gene_synonym="HVLP"
ORIGIN      
        1 gtgactgggt ggggctgcct cacttctgcc tgatttggga agcgctgcaa ggacaaccgg
       61 ctggggtcct tgcgcgccgc ggctcaggga ggagcaccga ctgcgccgca ccctgagaga
      121 tggttggtgc catgtggaag gtgattgttt cgctggtcct gttgatgcct ggcccctgtg
      181 atgggctgtt tcgctcccta tacagaagtg tttccatgcc acctaaggga gactcaggac
      241 agccattatt tctcacccct tacattgaag ctgggaagat ccaaaaagga agagaattga
      301 gtttggtcgg ccctttccca ggactgaaca tgaagagtta tgccggcttc ctcaccgtga
      361 ataagactta caacagcaac ctcttcttct ggttcttccc agctcagata cagccagaag
      421 atgccccagt agttctctgg ctacagggtg ggccgggagg ttcatccatg tttggactct
      481 ttgtggaaca tgggccttat gttgtcacaa gtaacatgac cttgcgtgac agagacttcc
      541 cctggaccac aacgctctcc atgctttaca ttgacaatcc agtgggcaca ggcttcagtt
      601 ttactgatga tacccacgga tatgcagtca atgaggacga tgtagcacgg gatttataca
      661 gtgcactaat tcagtttttc cagatatttc ctgaatataa aaataatgac ttttatgtca
      721 ctggggagtc ttatgcaggg aaatatgtgc cagccattgc acacctcatc cattccctca
      781 accctgtgag agaggtgaag atcaacctga acggaattgc tattggagat ggatattctg
      841 atcccgaatc aattataggg ggctatgcag aattcctgta ccaaattggc ttgttggatg
      901 agaagcaaaa aaagtacttc cagaagcagt gccatgaatg catagaacac atcaggaagc
      961 agaactggtt tgaggccttt gaaatactgg ataaactact agatggcgac ttaacaagtg
     1021 atccttctta cttccagaat gttacaggat gtagtaatta ctataacttt ttgcggtgca
     1081 cggaacctga ggatcagctt tactatgtga aatttttgtc actcccagag gtgagacaag
     1141 ccatccacgt ggggaatcag acttttaatg atggaactat agttgaaaag tacttgcgag
     1201 aagatacagt acagtcagtt aagccatggt taactgaaat catgaataat tataaggttc
     1261 tgatctacaa tggccaactg gacatcatcg tggcagctgc cctgacagag cgctccttga
     1321 tgggcatgga ctggaaagga tcccaggaat acaagaaggc agaaaaaaaa gtttggaaga
     1381 tctttaaatc tgacagtgaa gtggctggtt acatccggca agcgggtgac ttccatcagg
     1441 taattattcg aggtggagga catattttac cctatgacca gcctctgaga gcttttgaca
     1501 tgattaatcg attcatttat ggaaaaggat gggatcctta tgttggataa actaccttcc
     1561 caaaagagaa catcagaggt tttcattgct gaaaagaaaa tcgtaaaaac agaaaatgtc
     1621 ataggaataa aaaaattatc ttttcatatc tgcaagattt ttttcatcaa taaaaattat
     1681 ccttgaaaca agtgagcttt tgtttttggg gggagatgtt tactacaaaa ttaacatgag
     1741 tacatgagta agaattacat tatttaactt aaaggatgaa aggtatggat gatgtgacac
     1801 tgagacaaga tgtataaatg aaattttagg gtcttgaata ggaagtttta atttcttcta
     1861 agagtaagtg aaaagtgcag ttgtaacaaa caaagctgta acatcttttt ctgccaataa
     1921 cagaagtttg gcatgccgtg aaggtgtttg gaaatattat tggataagaa tagctcaatt
     1981 atcccaaata aatggatgaa gctataatag ttttggggaa aagattctca aatgtataaa
     2041 gtcttagaac aaaagaattc tttgaaataa aaatattata tataaaa
//
