LOCUS       NM_001029885            2154 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ceramide-1-phosphate transfer protein (CPTP), mRNA.
ACCESSION   NM_001029885 NM_030575 XM_496335
VERSION     NM_001029885.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Zhang,Y., Ji,S., Zhang,X., Lu,M., Hu,Y., Han,Y., Shui,G., Lam,S.M.
            and Zou,X.
  TITLE     Human CPTP promotes growth and metastasis via sphingolipid
            metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer
            cells
  JOURNAL   Int J Biol Sci 18 (13), 4963-4983 (2022)
   PUBMED   35982909
  REMARK    GeneRIF: Human CPTP promotes growth and metastasis via sphingolipid
            metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Gao,Y.G., McDonald,J., Malinina,L., Patel,D.J. and Brown,R.E.
  TITLE     Ceramide-1-phosphate transfer protein promotes sphingolipid
            reorientation needed for binding during membrane interaction
  JOURNAL   J Lipid Res 63 (1), 100151 (2022)
   PUBMED   34808193
  REMARK    GeneRIF: Ceramide-1-phosphate transfer protein promotes
            sphingolipid reorientation needed for binding during membrane
            interaction.
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Zhang,Y., Zhang,X., Lu,M. and Zou,X.
  TITLE     Ceramide-1-phosphate and its transfer proteins in eukaryotes
  JOURNAL   Chem Phys Lipids 240, 105135 (2021)
   PUBMED   34499882
  REMARK    GeneRIF: Ceramide-1-phosphate and its transfer proteins in
            eukaryotes.
            Review article
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Gao,Y.G., Zhai,X., Boldyrev,I.A., Molotkovsky,J.G., Patel,D.J.,
            Malinina,L. and Brown,R.E.
  TITLE     Ceramide-1-phosphate transfer protein (CPTP) regulation by
            phosphoinositides
  JOURNAL   J Biol Chem 296, 100600 (2021)
   PUBMED   33781749
  REMARK    GeneRIF: Ceramide-1-phosphate transfer protein (CPTP) regulation by
            phosphoinositides.
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Mishra,S.K., Gao,Y.G., Deng,Y., Chalfant,C.E., Hinchcliffe,E.H. and
            Brown,R.E.
  TITLE     CPTP: A sphingolipid transfer protein that regulates autophagy and
            inflammasome activation
  JOURNAL   Autophagy 14 (5), 862-879 (2018)
   PUBMED   29164996
  REMARK    GeneRIF: These findings identify human CPTP as an endogenous
            regulator of early-stage autophagosome assembly and
            inflammasome-driven, pro-inflammatory cytokine generation and
            release.
REFERENCE   6  (bases 1 to 2154)
  AUTHORS   Simanshu,D.K., Kamlekar,R.K., Wijesinghe,D.S., Zou,X., Zhai,X.,
            Mishra,S.K., Molotkovsky,J.G., Malinina,L., Hinchcliffe,E.H.,
            Chalfant,C.E., Brown,R.E. and Patel,D.J.
  TITLE     Non-vesicular trafficking by a ceramide-1-phosphate transfer
            protein regulates eicosanoids
  JOURNAL   Nature 500 (7463), 463-467 (2013)
   PUBMED   23863933
  REMARK    GeneRIF: a ubiquitously expressed lipid transfer protein, human
            GLTPD1, named here CPTP, is shown to specifically transfer C1P
            between membranes.
REFERENCE   7  (bases 1 to 2154)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 2154)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2154)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139287.24.
            
            On Nov 22, 2018 this sequence version replaced NM_001029885.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.827296.1,
                                           SRR3476690.456880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343938.9/ ENSP00000343890.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AL139287.24        24755-25055
            302-498             AL139287.24        26789-26985
            499-2154            AL139287.24        27194-28849
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2154
                     /gene="CPTP"
                     /gene_synonym="GLTPD1"
                     /note="ceramide-1-phosphate transfer protein"
                     /db_xref="GeneID:80772"
                     /db_xref="HGNC:HGNC:28116"
                     /db_xref="MIM:615467"
     exon            1..301
                     /gene="CPTP"
                     /gene_synonym="GLTPD1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..498
                     /gene="CPTP"
                     /gene_synonym="GLTPD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1021
                     /gene="CPTP"
                     /gene_synonym="GLTPD1"
                     /note="glycolipid transfer protein domain-containing
                     protein 1; GLTP domain-containing protein 1; glycolipid
                     transfer protein domain containing 1"
                     /codon_start=1
                     /product="ceramide-1-phosphate transfer protein"
                     /protein_id="NP_001025056.1"
                     /db_xref="CCDS:CCDS30555.1"
                     /db_xref="GeneID:80772"
                     /db_xref="HGNC:HGNC:28116"
                     /db_xref="MIM:615467"
                     /translation="MDDSETGFNLKVVLVSFKQCLDEKEEVLLDPYIASWKGLVRFLN
                     SLGTIFSFISKDVVSKLRIMERLRGGPQSEHYRSLQAMVAHELSNRLVDLERRSHHPE
                     SGCRTVLRLHRALHWLQLFLEGLRTSPEDARTSALCADSYNASLAAYHPWVVRRAVTV
                     AFCTLPTREVFLEAMNVGPPEQAVQMLGEALPFIQRVYNVSQKLYAEHSLLDLP"
     exon            499..2154
                     /gene="CPTP"
                     /gene_synonym="GLTPD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPTP"
                     /gene_synonym="GLTPD1"
                     /note="hexamer: AATAAA"
     polyA_site      2154
                     /gene="CPTP"
                     /gene_synonym="GLTPD1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcccgca cggcggctac ggcctaggtg agcggctcgg actcggcggc cgcacctgcc
       61 caacccaacc cgcacggtcc ggaagtcgcc gaggggccgg gagcgggagg ggacgtcgtc
      121 ctagagggcc ggagcgggcg ggcggccgag gacccggctc ccgcgcagga cggagccgtg
      181 gctcaggtcg gcccctcccc aacaccaccc cgggcctccg ccccttcctg ggcctctcgg
      241 tggagcaggg acccgaaccg gtgcccatcc agtccggtgc catctgaagc ccccttccca
      301 gaaaatgagc cacagagcaa gctgacccca gcgacacagc cccccagccc tactgtattt
      361 ccgttcctat caaaaaatgg atgactcgga gacaggtttc aatctgaaag tcgtcctggt
      421 cagtttcaag cagtgtctcg atgagaagga agaggtcttg ctggacccct acattgccag
      481 ctggaagggc ctggtcaggt ttctgaacag cctgggcacc atcttctcat tcatctccaa
      541 ggacgtggtc tccaagctgc ggatcatgga gcgcctcagg ggcggcccgc agagcgagca
      601 ctaccgcagc ctgcaggcca tggtggccca cgagctgagc aaccggctgg tggacctgga
      661 gcgccgctcc caccacccgg agtctggctg ccggacggtg ctgcgcctgc accgcgccct
      721 gcactggctg cagctgttcc tggagggcct gcgtaccagc cccgaggacg cacgcacctc
      781 cgcgctctgc gccgactcct acaacgcctc gctggccgcc taccacccct gggtcgtgcg
      841 ccgcgccgtc accgtggcct tctgcacgct gcccacacgc gaggtcttcc tggaggccat
      901 gaacgtgggg cccccggagc aggccgtgca gatgctaggc gaggccctcc ccttcatcca
      961 gcgtgtctac aacgtctccc agaagctcta cgccgagcac tccctgctgg acctgcccta
     1021 ggggcgggaa gccagggccg caccggcttt cctgctgcag atctgggctg cggtggccag
     1081 ggccgtgagt cccgtggcag agccttctgg gcgctgcggg aacaggagat cctctgtcgc
     1141 ccctgtgagc tgagctggtt aggaaccaca gactgtgaca gagaaggtgg cgaccagccc
     1201 agaagaggcc caccctctcg gtccggaaca agacgcctcg gccacggctc cccctcggcc
     1261 tattacacgc gtgcgcagcc aggcctcgcc agggtgcggt gcagagcaga gcaggcaggg
     1321 gtgggggccg ggcctgcaag agcccgaaag gtcgccaccc cctagcctgt ggggtgcatc
     1381 tgcgaaccag ggtgaagtca caggtcccgg ggtgtggagg ctccatcctt tctcctttct
     1441 gccagccgat gtgtcctcat ctcaggcccg tgcctgggac cccgtgtctg cccaggtggg
     1501 cagccttgag cccaggggac tcagtgccct ccatgccctg gctggcagaa accctcaaca
     1561 gcagtctggg cactgtgggg ctctccccgc ctctcctgcc ttgtttgccc ctcagcgtgc
     1621 caggcagact gggggcagga cagccggaag ctgagaccaa ggctcctcac agaagggccc
     1681 aggaagtccc cgcccttggg acagcctcct ccgtagcccc tgcacggcac cagttccccg
     1741 agggacgcag caggccgcct cccgcagcgg ccgtgggtct gcacagccca gcccagccca
     1801 aggcccccag gagctgggac tctgctacac ccagtgaaat gctgtgtccc ttctcccccg
     1861 tgccccttga tgccccctcc ccacagtgct caggagaccc gtggggcacg gaacaggagg
     1921 gtctggaccc tgtggcccag ccaaaggcta ccagacagcc acaaccagcc cagccaccat
     1981 ccagtgcctg gggcctggcc actggctctt cacagtggac cccagcacct cggggtggca
     2041 gagggacggc ccccacggcc cagcagacat gcgagcttcc agagtgcaat ctatgtgatg
     2101 tcttccaacg ttaataaatc acacagcctc ccaggaggga gacgctgggg tgca
//
