LOCUS       NM_001199753            2846 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens carnitine palmitoyltransferase 1C (CPT1C), transcript
            variant 4, mRNA.
ACCESSION   NM_001199753
VERSION     NM_001199753.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2846)
  AUTHORS   Zhou,Y., Chen,Y., Zhao,P., Xian,T., Gao,Y., Fan,S., Fang,J.H.,
            Huang,M. and Bi,H.
  TITLE     The YY1-CPT1C signaling axis modulates the proliferation and
            metabolism of pancreatic tumor cells under hypoxia
  JOURNAL   Biochem Pharmacol 227, 116422 (2024)
   PUBMED   38996932
  REMARK    GeneRIF: The YY1-CPT1C signaling axis modulates the proliferation
            and metabolism of pancreatic tumor cells under hypoxia.
REFERENCE   2  (bases 1 to 2846)
  AUTHORS   Zhao,H., Cheng,X., Yan,L., Mi,F., Wang,W., Hu,Y., Liu,X., Fan,Y.,
            Min,Q., Wang,Y., Zhang,W., Wu,Q. and Zhan,Q.
  TITLE     APC/C-regulated CPT1C promotes tumor progression by upregulating
            the energy supply and accelerating the G1/S transition
  JOURNAL   Cell Commun Signal 22 (1), 283 (2024)
   PUBMED   38783346
  REMARK    GeneRIF: APC/C-regulated CPT1C promotes tumor progression by
            upregulating the energy supply and accelerating the G1/S
            transition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2846)
  AUTHORS   Chen,P., Tian,J., Zhou,Y., Chen,Y., Zhang,H., Jiao,T., Huang,M.,
            Zhang,H., Huang,P., Yu,A.M., Gonzalez,F.J. and Bi,H.
  TITLE     Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on
            CPT1C-mediated Tumor Cell Senescence
  JOURNAL   Int J Biol Sci 19 (7), 2067-2080 (2023)
   PUBMED   37151873
  REMARK    GeneRIF: Metabolic Flux Analysis Reveals the Roles of Stearate and
            Oleate on CPT1C-mediated Tumor Cell Senescence.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2846)
  AUTHORS   Fado,R., Zagmutt,S., Herrero,L., Muley,H., Rodriguez-Rodriguez,R.,
            Bi,H., Serra,D. and Casals,N.
  TITLE     To be or not to be a fat burner, that is the question for cpt1c in
            cancer cells
  JOURNAL   Cell Death Dis 14 (1), 57 (2023)
   PUBMED   36693836
  REMARK    GeneRIF: To be or not to be a fat burner, that is the question for
            cpt1c in cancer cells.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2846)
  AUTHORS   Lohse,I., Reilly,P. and Zaugg,K.
  TITLE     The CPT1C 5'UTR contains a repressing upstream open reading frame
            that is regulated by cellular energy availability and AMPK
  JOURNAL   PLoS One 6 (9), e21486 (2011)
   PUBMED   21961029
  REMARK    GeneRIF: Data suggest that an involvement of CPT1C in cellular
            energy-sensing pathways and provide evidence for a role of CPT1C in
            hypothalamic regulation of energy homeostasis.
REFERENCE   6  (bases 1 to 2846)
  AUTHORS   Djouadi,F., Aubey,F., Schlemmer,D. and Bastin,J.
  TITLE     Peroxisome proliferator activated receptor delta (PPARdelta)
            agonist but not PPARalpha corrects carnitine palmitoyl transferase
            2 deficiency in human muscle cells
  JOURNAL   J Clin Endocrinol Metab 90 (3), 1791-1797 (2005)
   PUBMED   15613406
REFERENCE   7  (bases 1 to 2846)
  AUTHORS   Bonnefont,J.P., Djouadi,F., Prip-Buus,C., Gobin,S., Munnich,A. and
            Bastin,J.
  TITLE     Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and
            medical aspects
  JOURNAL   Mol Aspects Med 25 (5-6), 495-520 (2004)
   PUBMED   15363638
  REMARK    Review article
REFERENCE   8  (bases 1 to 2846)
  AUTHORS   Price,N., van der Leij,F., Jackson,V., Corstorphine,C., Thomson,R.,
            Sorensen,A. and Zammit,V.
  TITLE     A novel brain-expressed protein related to carnitine
            palmitoyltransferase I
  JOURNAL   Genomics 80 (4), 433-442 (2002)
   PUBMED   12376098
REFERENCE   9  (bases 1 to 2846)
  AUTHORS   van der Leij,F.R., Huijkman,N.C., Boomsma,C., Kuipers,J.R. and
            Bartelds,B.
  TITLE     Genomics of the human carnitine acyltransferase genes
  JOURNAL   Mol Genet Metab 71 (1-2), 139-153 (2000)
   PUBMED   11001805
  REMARK    Review article
REFERENCE   10 (bases 1 to 2846)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011495.8 and KF456599.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 19, 2020 this sequence version replaced NM_001199753.1.
            
            Summary: This gene encodes a member of the carnitine/choline
            acetyltransferase family. The encoded protein regulates the
            beta-oxidation and transport of long-chain fatty acids into
            mitochondria, and may play a role in the regulation of feeding
            behavior and whole-body energy homeostasis. Alternatively spliced
            transcript variants encoding multiple protein isoforms have been
            observed for this gene. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3534776.1, AK290092.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598293.6/ ENSP00000473028.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            regulatory uORF        :: PMID: 21961029
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC011495.8         116926-117150
            226-294             AC011495.8         117631-117699
            295-449             AC011495.8         118049-118203
            450-589             AC011495.8         123136-123275
            590-761             AC011495.8         126494-126665
            762-863             AC011495.8         127127-127228
            864-1001            AC011495.8         127307-127444
            1002-1079           AC011495.8         130520-130597
            1080-1187           AC011495.8         130817-130924
            1188-1272           AC011495.8         131024-131108
            1273-1468           AC011495.8         131719-131914
            1469-1651           AC011495.8         132041-132223
            1652-1757           AC011495.8         133328-133433
            1758-1874           AC011495.8         134533-134649
            1875-2039           AC011495.8         136130-136294
            2040-2174           AC011495.8         136533-136667
            2175-2223           KF456599.1         512-560
            2224-2327           AC011495.8         137668-137771
            2328-2441           AC011495.8         138546-138659
            2442-2534           AC011495.8         138782-138874
            2535-2846           AC011495.8         139230-139541
FEATURES             Location/Qualifiers
     source          1..2846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2846
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /note="carnitine palmitoyltransferase 1C"
                     /db_xref="GeneID:126129"
                     /db_xref="HGNC:HGNC:18540"
                     /db_xref="MIM:608846"
     exon            1..225
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      125..226
                     /regulatory_class="uORF"
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21961029]"
                     /note="this uORF is predicted to encode a 33 aa peptide
                     (PMID:21961029)"
     exon            226..294
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            295..449
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2720
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /EC_number="3.1.2.22"
                     /note="isoform 2 is encoded by transcript variant 4;
                     carnitine palmitoyltransferase I related C; palmitoyl
                     thioesterase CPT1C"
                     /codon_start=1
                     /product="palmitoyl thioesterase CPT1C isoform 2"
                     /protein_id="NP_001186682.1"
                     /db_xref="CCDS:CCDS12779.1"
                     /db_xref="GeneID:126129"
                     /db_xref="HGNC:HGNC:18540"
                     /db_xref="MIM:608846"
                     /translation="MAEAHQAVGFRPSLTSDGAEVELSAPVLQEIYLSGLRSWKRHLS
                     RFWNDFLTGVFPASPLSWLFLFSAIQLAWFLQLDPSLGLMEKIKELLPDWGGQHHGLR
                     GVLAAALFASCLWGALIFTLHVALRLLLSYHGWLLEPHGAMSSPTKTWLALVRIFSGR
                     HPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPILSDEDFDWTAVLAQEFLRLQASLLQ
                     WYLRLKSWWASNYVSDWWEEFVYLRSRNPLMVNSNYYMMDFLYVTPTPLQAARAGNAV
                     HALLLYRHRLNRQEIPPTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVA
                     VFHRGRFFRMGTHSRNSLLSPRALEQQFQRILDDPSPACPHEEHLAALTAAPRGTWAQ
                     VRTSLKTQAAEALEAVEGAAFFVSLDAEPAGLTREDPAASLDAYAHALLAGRGHDRWF
                     DKSFTLIVFSNGKLGLSVEHSWADCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPT
                     LPQPQRLQWDLPDQIHSSISLALRGAKILSENVDCHVVPFSLFGKSFIRRCHLSSDSF
                     IQIALQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACNFVRAMEDKEKTDP
                     QCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYIVSRFLHLQSPFLTQVHSEQWQLS
                     TSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHGYGVSYIFMGDGMITFHISSKKSST
                     KTDSHRLGQHIEDALLDVASLFQAGQHFKRRFRGSGKENSRHRCGFLSRQTGASKASM
                     TSTDF"
     exon            450..589
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            590..761
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            762..863
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1001
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1079
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1187
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1272
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1468
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1651
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1757
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1874
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2039
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2174
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2327
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2441
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2534
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2846
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /note="hexamer: AATAAA"
     polyA_site      2846
                     /gene="CPT1C"
                     /gene_synonym="CATL1; CPT I-C; CPT1-B; CPT1P; CPTI-B;
                     CPTIC; SPG73"
                     /note="major polyA site"
ORIGIN      
        1 gaatacccgg ctagggacac gagagagagg aatcggggtt tctgggtgac ggtgatctcg
       61 gggtgggcag gactccaaag gcccgtcgac ccggtggtgg actccttgca ctgggattgg
      121 acatatgcaa gcgggagatt tggggccggc gctcaaaatc ggggggcggg ggtggactcg
      181 ggtttggacc ccaggatccg atcagcggac ccttgattca acgtgaggtc ccgaattgac
      241 gtccttccct caaaacctcc gggtctacaa accaggaccc tcaagaccct tcagggctcc
      301 agcgtgacat ggctgaagcg caccaggccg tgggcttccg accctcgctg acctcggacg
      361 gggctgaagt ggaactcagt gcccctgtgc tgcaggagat ctacctctct ggcctgcgct
      421 cctggaaaag gcatctctca cgtttctgga atgactttct caccggtgtg tttcctgcca
      481 gccccctcag ttggcttttc ctcttcagtg ccatccagct tgcctggttc ctccagctgg
      541 atccttcctt aggactgatg gagaagatca aagagttgct gcctgactgg ggtggacaac
      601 accacgggct ccggggggtc ctggcagccg cgctgtttgc ctcgtgtttg tggggagccc
      661 tgatcttcac actgcacgtg gccctgaggc tgcttctgtc ctaccacggc tggcttcttg
      721 agccccacgg agccatgtcc tcccccacca agacctggct ggccctggtc cgcatcttct
      781 ctggccgcca cccgatgctg ttcagttacc agcgctccct gccacgccag cccgtgccct
      841 ctgtgcagga caccgtgcgc aagtacctgg agtcggtccg gcccatcctc tccgacgagg
      901 acttcgactg gaccgcggtc ctggcgcagg aattcctgag gctgcaggcg tcgctgctgc
      961 agtggtacct gcggctcaag tcctggtggg cgtccaatta tgtcagtgac tggtgggagg
     1021 aatttgtgta cctgcgctcc cgaaatccgc tgatggtgaa cagcaactat tacatgatgg
     1081 acttcctgta tgtcacaccc acgcctctgc aggcagctcg cgctgggaat gccgtccatg
     1141 ccctcctcct gtaccgccac cgcctgaacc gccaggagat acccccgact ttgctgatgg
     1201 gaatgcgccc cttatgctct gcccagtacg agaagatctt caacaccacg cggattccag
     1261 gggtccaaaa agactacatc cgccacctcc atgacagcca acacgtggct gtcttccacc
     1321 ggggccgatt cttccgcatg gggacccact cccgaaacag cctgctttcc ccgagagccc
     1381 tggagcagca gtttcagaga atcctggatg atccctcacc ggcctgcccc cacgaggaac
     1441 atctggcagc tctgacagct gctcccaggg gcacgtgggc ccaggtgcgg acatccctga
     1501 agacccaggc agcggaggcc ctggaggcgg tggaaggggc cgctttcttt gtgtcactgg
     1561 atgctgagcc cgcggggctc accagggagg acccggcagc gtcgttggat gcctacgccc
     1621 atgctctgct ggccggccgg ggccatgatc gctggtttga caaatccttc accctaatcg
     1681 tcttctctaa cgggaagctg ggcctcagcg tggagcactc ctgggccgac tgccccatct
     1741 caggacacat gtgggagttc actctggcta cagaatgctt tcagctgggc tactcaacag
     1801 acggccactg caaggggcac ccggacccca cactacccca gccccagcgg ctgcaatggg
     1861 accttccaga ccagatccac tcctccatct ctctagccct gaggggagcc aagatcttgt
     1921 ctgaaaatgt cgactgccat gtcgttccat tctccctatt tggcaagagc ttcatccgac
     1981 gctgccacct ctcttcagac agcttcatcc agatcgcctt gcaactggcc cacttccggg
     2041 acaggggtca attctgcctg acttatgagt cggccatgac tcgcttattc ctggaaggcc
     2101 ggacggagac ggtgcggtct tgcacgaggg aggcctgcaa ctttgtcagg gccatggagg
     2161 acaaagagaa gacggaccca cagtgcctcg ccctgttccg cgtggcagtg gacaagcacc
     2221 aggctctgct gaaggcagcc atgagcgggc agggagttga ccgccacctg tttgcgctgt
     2281 acatcgtgtc ccgattcctc cacctgcagt cgcccttcct gacccaggtc cattcggagc
     2341 agtggcagct gtccaccagc cagatccctg ttcagcaaat gcatctgttt gacgtccaca
     2401 attacccgga ctatgtttcc tcaggcggtg gattcgggcc tgctgatgac catggttatg
     2461 gtgtttctta tatcttcatg ggggatggca tgatcacctt ccacatctcc agcaaaaaat
     2521 caagcacaaa aacggattcc cacaggctgg ggcagcacat tgaggacgca ctgctggatg
     2581 tggcctccct gttccaggcg ggacagcatt ttaagcgccg gttcagaggg tcagggaagg
     2641 agaactccag gcacaggtgt ggatttctct cccgccagac tggggcctcc aaggcctcaa
     2701 tgacatccac cgacttctga ctccttccag caggcagctg gcctctccaa ggaataaggg
     2761 tgaaattgcc acagctggct gacacaggac aggggcaact ggtttggcaa ccccacatcc
     2821 aggccaataa agatgtgtga gctggg
//
