LOCUS       NM_152246               2603 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens carnitine palmitoyltransferase 1B (CPT1B), transcript
            variant 3, mRNA.
ACCESSION   NM_152246
VERSION     NM_152246.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2603)
  AUTHORS   Watanabe,L.M., Pereira,V.A.B., Noronha,N.Y., de Souza Pinhel,M.A.,
            Wolf,L.S., de Oliveira,C.C., Placa,J.R., Noma,I.H.Y., da Silva
            Rodrigues,G., de Souza,V.C.O., Junior,F.B. and Nonino,C.B.
  TITLE     The influence of serum selenium in differential epigenetic and
            transcriptional regulation of CPT1B gene in women with obesity
  JOURNAL   J Trace Elem Med Biol 83, 127376 (2024)
   PUBMED   38183920
  REMARK    GeneRIF: The influence of serum selenium in differential epigenetic
            and transcriptional regulation of CPT1B gene in women with obesity.
REFERENCE   2  (bases 1 to 2603)
  AUTHORS   Qu,H., Jiang,J., Zhan,X., Liang,Y., Guo,Q., Liu,P., Lu,L., Yang,Y.,
            Xu,W., Zhang,Y., Lan,S., Chen,Z., Lu,Y., Ou,Y. and Qin,Y.
  TITLE     Integrating artificial intelligence in osteosarcoma prognosis: the
            prognostic significance of SERPINE2 and CPT1B biomarkers
  JOURNAL   Sci Rep 14 (1), 4318 (2024)
   PUBMED   38383657
  REMARK    GeneRIF: Integrating artificial intelligence in osteosarcoma
            prognosis: the prognostic significance of SERPINE2 and CPT1B
            biomarkers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2603)
  AUTHORS   Yang,Y., Peng,Y., Yu,B. and Wang,H.
  TITLE     ABHD5-CPT1B: An Important Way of Regulating Placental Lipid
            Metabolism in Gestational Diabetes Mellitus
  JOURNAL   Arch Med Res 55 (1), 102925 (2024)
   PUBMED   38042031
  REMARK    GeneRIF: ABHD5-CPT1B: An Important Way of Regulating Placental
            Lipid Metabolism in Gestational Diabetes Mellitus.
REFERENCE   4  (bases 1 to 2603)
  AUTHORS   van der Leij,F.R., Cox,K.B., Jackson,V.N., Huijkman,N.C.,
            Bartelds,B., Kuipers,J.R., Dijkhuizen,T., Terpstra,P., Wood,P.A.,
            Zammit,V.A. and Price,N.T.
  TITLE     Structural and functional genomics of the CPT1B gene for
            muscle-type carnitine palmitoyltransferase I in mammals
  JOURNAL   J Biol Chem 277 (30), 26994-27005 (2002)
   PUBMED   12015320
  REMARK    GeneRIF: Genetic analysis, comparison, and tissue distribution of
            CPT1b
REFERENCE   5  (bases 1 to 2603)
  AUTHORS   Yamazaki,N., Shinohara,Y., Kajimoto,K., Shindo,M. and Terada,H.
  TITLE     Novel expression of equivocal messages containing both regions of
            choline/ethanolamine kinase and muscle type carnitine
            palmitoyltransferase I
  JOURNAL   J Biol Chem 275 (41), 31739-31746 (2000)
   PUBMED   10918069
REFERENCE   6  (bases 1 to 2603)
  AUTHORS   Yu,G.S., Lu,Y.C. and Gulick,T.
  TITLE     Co-regulation of tissue-specific alternative human carnitine
            palmitoyltransferase Ibeta gene promoters by fatty acid enzyme
            substrate
  JOURNAL   J Biol Chem 273 (49), 32901-32909 (1998)
   PUBMED   9830040
REFERENCE   7  (bases 1 to 2603)
  AUTHORS   Yamazaki,N., Yamanaka,Y., Hashimoto,Y., Shinohara,Y., Shima,A. and
            Terada,H.
  TITLE     Structural features of the gene encoding human muscle type
            carnitine palmitoyltransferase I
  JOURNAL   FEBS Lett 409 (3), 401-406 (1997)
   PUBMED   9224698
REFERENCE   8  (bases 1 to 2603)
  AUTHORS   van der Leij,F.R., Takens,J., van der Veen,A.Y., Terpstra,P. and
            Kuipers,J.R.
  TITLE     Localization and intron usage analysis of the human CPT1B gene for
            muscle type carnitine palmitoyltransferase I
  JOURNAL   Biochim Biophys Acta 1352 (2), 123-128 (1997)
   PUBMED   9199240
REFERENCE   9  (bases 1 to 2603)
  AUTHORS   Britton,C.H., Mackey,D.W., Esser,V., Foster,D.W., Burns,D.K.,
            Yarnall,D.P., Froguel,P. and McGarry,J.D.
  TITLE     Fine chromosome mapping of the genes for human liver and muscle
            carnitine palmitoyltransferase I (CPT1A and CPT1B)
  JOURNAL   Genomics 40 (1), 209-211 (1997)
   PUBMED   9070950
REFERENCE   10 (bases 1 to 2603)
  AUTHORS   Yamazaki,N., Shinohara,Y., Shima,A., Yamanaka,Y. and Terada,H.
  TITLE     Isolation and characterization of cDNA and genomic clones encoding
            human muscle type carnitine palmitoyltransferase I
  JOURNAL   Biochim Biophys Acta 1307 (2), 157-161 (1996)
   PUBMED   8679700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB961274.1, Y08682.1 and
            BU615917.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_152246.2.
            
            Summary: The protein encoded by this gene, a member of the
            carnitine/choline acetyltransferase family, is the rate-controlling
            enzyme of the long-chain fatty acid beta-oxidation pathway in
            muscle mitochondria. This enzyme is required for the net transport
            of long-chain fatty acyl-CoAs from the cytoplasm into the
            mitochondria. Multiple transcript variants encoding different
            isoforms have been found for this gene, and read-through
            transcripts are expressed from the upstream locus that include
            exons from this gene. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (3) differs in the 3' UTR compared
            to variant 1. Variants 1, 2, 3, 6, and 8 all encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y08682.1, SRR18074967.2670692.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000312108.12/
                                                  ENSP00000312189.8
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CB961274.1         66-75
            11-2563             Y08682.1           1-2553
            2564-2603           BU615917.1         18-57               c
FEATURES             Location/Qualifiers
     source          1..2603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..2603
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /note="carnitine palmitoyltransferase 1B"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:HGNC:2329"
                     /db_xref="MIM:601987"
     exon            1..42
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            43..202
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2380
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /EC_number="2.3.1.21"
                     /note="isoform a is encoded by transcript variant 3;
                     carnitine palmitoyltransferase I-like protein; carnitine
                     palmitoyltransferase 1B (muscle); carnitine
                     O-palmitoyltransferase 1B"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform isoform a"
                     /protein_id="NP_689452.1"
                     /db_xref="CCDS:CCDS14098.1"
                     /db_xref="GeneID:1375"
                     /db_xref="HGNC:HGNC:2329"
                     /db_xref="MIM:601987"
                     /translation="MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLI
                     RIKNGILRGVYPGSPTSWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQ
                     TRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLS
                     SRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPR
                     LQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGN
                     IIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRH
                     VAVYHKGRFFKLWLYEGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEW
                     AQARQAFFSSGKNKAALEAIERAAFFVALDEESYSYDPEDEASLSLYGKALLHGNCYN
                     RWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKP
                     NPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSP
                     DAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSH
                     TKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPW
                     RLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKF
                     SSSETNAQRFGNHIRKALLDIADLFQVPKAYS"
     exon            203..342
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..520
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..622
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..760
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            761..838
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..946
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1031
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1227
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1413
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1519
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1636
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1801
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1936
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2089
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2203
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2296
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2382
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2603
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /note="hexamer: AATAAA"
     polyA_site      2603
                     /gene="CPT1B"
                     /gene_synonym="CPT1-M; CPT1M; CPTI; CPTI-M; M-CPT1;
                     MCCPT1; MCPT1"
                     /note="major polyA site"
ORIGIN      
        1 agagtggctg gccccacgca cggacaggag tgaacccgag ctgtgccgac caacccccag
       61 gatggcggaa gctcaccagg ccgtggcctt ccagttcacg gtgaccccag acggggtcga
      121 cttccggctc agtcgggagg ccctgaaaca cgtctacctg tctgggatca actcctggaa
      181 gaaacgcctg atccgcatca agaatggcat cctcaggggc gtgtaccctg gcagccccac
      241 cagctggctg gtcgtcatca tggcaacagt gggttcctcc ttctgcaacg tggacatctc
      301 cttggggctg gtcagttgca tccagagatg cctccctcag gggtgtggcc cctaccagac
      361 cccgcagacc cgggcacttc tcagcatggc catcttctcc acgggcgtct gggtgacggg
      421 catcttcttc ttccgccaaa ccctgaagct gcttctctgc taccatgggt ggatgtttga
      481 gatgcatggc aagaccagca acttgaccag gatctgggct atgtgtatcc gccttctatc
      541 cagccggcac cctatgctct acagcttcca gacatctctg cccaagcttc ctgtgcccag
      601 ggtgtcagcc acaattcagc ggtacctaga gtctgtgcgc cccttgttgg atgatgagga
      661 atattaccgc atggagttgc tggccaaaga attccaggac aagactgccc ccaggctgca
      721 gaaatacctg gtgctcaagt catggtgggc aagtaactat gtgagtgact ggtgggaaga
      781 gtacatctac cttcgaggca ggagccctct catggtgaac agcaactatt atgtcatgga
      841 ccttgtgctc atcaagaata cagacgtgca ggcagcccgc ctgggaaaca tcatccacgc
      901 catgatcatg tatcgccgta aactggaccg tgaagaaatc aagcctgtga tggcactggg
      961 catagtgcct atgtgctcct accagatgga gaggatgttc aacaccactc ggatcccggg
     1021 caaggacaca gatgtgctac agcacctctc agacagccgg cacgtggctg tctaccacaa
     1081 gggacgcttc ttcaagctgt ggctctatga gggcgcccgt ctgctcaagc ctcaggatct
     1141 ggagatgcag ttccagagga tcctggacga cccctcccca cctcagcctg gggaggagaa
     1201 gctggcagcc ctcactgcag gaggaagggt ggagtgggcg caggcacgcc aggccttctt
     1261 tagctctgga aagaataagg ctgccttgga ggccatcgag cgtgccgctt tcttcgtggc
     1321 cctggatgag gaatcctact cctatgaccc cgaagatgag gccagcctca gcctctatgg
     1381 caaggccctg ctacatggca actgctacaa caggtggttt gacaaatcct tcactctcat
     1441 ttccttcaag aatggccagt tgggtctcaa tgcagagcat gcgtgggcag atgctcccat
     1501 cattgggcac ctctgggagt ttgtcctggg cacagacagc ttccacctgg gctacacgga
     1561 gaccgggcac tgcctgggca aaccgaaccc tgcgctcgca cctcctacac ggctgcagtg
     1621 ggacattcca aaacagtgcc aggcggtcat cgagagttcc taccaggtgg ccaaggcgtt
     1681 ggcagacgac gtggagttgt actgcttcca gttcctgccc tttggcaaag gcctcatcaa
     1741 gaagtgccgg accagccctg atgcctttgt gcagatcgcg ctgcagctgg ctcacttccg
     1801 ggacaggggt aagttctgcc tgacctatga ggcctcaatg accagaatgt tccgggaggg
     1861 acggactgag actgtgcgtt cctgtaccag cgagtccaca gcctttgtgc aggccatgat
     1921 ggaggggtcc cacacaaaag cagacctgcg agatctcttc cagaaggctg ctaagaagca
     1981 ccagaatatg taccgcctgg ccatgaccgg ggcagggatc gacaggcacc tcttctgcct
     2041 ttacttggtc tccaagtacc taggagtcag ctctcctttc cttgctgagg tgctctcgga
     2101 accctggcgt ctctccacca gccagatccc ccaatcccag atccgcatgt tcgacccaga
     2161 gcagcacccc aatcacctgg gcgctggagg tggctttggc cctgtagcag atgatggcta
     2221 tggagtttcc tacatgattg caggcgagaa cacgatcttc ttccacatct ccagcaagtt
     2281 ctcaagctca gagacgaacg cccagcgctt tggaaaccac atccgcaaag ccctgctgga
     2341 cattgctgat cttttccaag ttcccaaggc ctacagctga agcccttagg tacctgtgtt
     2401 ttgtttggga actcggaggc cctccccctc ccccagctca gaccacagag gtggcaagag
     2461 aagggctgaa gctggaagac tgttcatgag ggacttgtgt gacctgcttt gaaatgtgtg
     2521 actctgctga gtgacgtagg ctctgagata gctgtccacg cccacgtgtt tgcttggaat
     2581 aaatacttgc ctcagaacct tca
//
