LOCUS       NM_001876               5238 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens carnitine palmitoyltransferase 1A (CPT1A), transcript
            variant 1, mRNA.
ACCESSION   NM_001876
VERSION     NM_001876.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5238)
  AUTHORS   Liu,S., Chen,X., Zhang,L. and Lu,B.
  TITLE     CPT1A mediates the succinylation of SP5 which activates
            transcription of PDPK1 to promote the viability and glycolysis of
            prostate cancer cells
  JOURNAL   Cancer Biol Ther 25 (1), 2329372 (2024)
   PUBMED   38494680
  REMARK    GeneRIF: CPT1A mediates the succinylation of SP5 which activates
            transcription of PDPK1 to promote the viability and glycolysis of
            prostate cancer cells.
REFERENCE   2  (bases 1 to 5238)
  AUTHORS   Praveen,Z., Choi,S.W., Lee,J.H., Park,J.Y., Oh,H.J., Kwon,I.J.,
            Park,J.H. and Kim,M.K.
  TITLE     Oral Microbiome and CPT1A Function in Fatty Acid Metabolism in Oral
            Cancer
  JOURNAL   Int J Mol Sci 25 (20), 10890 (2024)
   PUBMED   39456670
  REMARK    GeneRIF: Oral Microbiome and CPT1A Function in Fatty Acid
            Metabolism in Oral Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5238)
  AUTHORS   Wu,Y., Huang,J., Liu,L., Zhang,X., Zhang,W. and Li,Q.
  TITLE     CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia
            via CPT1A-mediated fatty acid oxidation
  JOURNAL   J Mol Med (Berl) 102 (8), 1037-1049 (2024)
   PUBMED   38904677
  REMARK    GeneRIF: CircHIPK3/miR-124 affects angiogenesis in early-onset
            preeclampsia via CPT1A-mediated fatty acid oxidation.
REFERENCE   4  (bases 1 to 5238)
  AUTHORS   Liu,Y., Wang,F., Yan,G., Tong,Y., Guo,W., Li,S., Qian,Y., Li,Q.,
            Shu,Y., Zhang,L., Zhang,Y. and Xia,Q.
  TITLE     CPT1A loss disrupts BCAA metabolism to confer therapeutic
            vulnerability in TP53-mutated liver cancer
  JOURNAL   Cancer Lett 595, 217006 (2024)
   PUBMED   38823763
  REMARK    GeneRIF: CPT1A loss disrupts BCAA metabolism to confer therapeutic
            vulnerability in TP53-mutated liver cancer.
REFERENCE   5  (bases 1 to 5238)
  AUTHORS   Zhang,Y., Zhang,Z., Huang,L., Wang,C., Yang,P., Zhang,L. and
            Liao,X.
  TITLE     Augmenter of liver regeneration knockout aggravates tubular
            ferroptosis and macrophage activation by regulating carnitine
            palmitoyltransferase-1A-induced lipid metabolism in diabetic
            nephropathy
  JOURNAL   Acta Physiol (Oxf) 240 (7), e14159 (2024)
   PUBMED   38767438
  REMARK    GeneRIF: Augmenter of liver regeneration knockout aggravates
            tubular ferroptosis and macrophage activation by regulating
            carnitine palmitoyltransferase-1A-induced lipid metabolism in
            diabetic nephropathy.
REFERENCE   6  (bases 1 to 5238)
  AUTHORS   IJlst,L., Mandel,H., Oostheim,W., Ruiter,J.P., Gutman,A. and
            Wanders,R.J.
  TITLE     Molecular basis of hepatic carnitine palmitoyltransferase I
            deficiency
  JOURNAL   J Clin Invest 102 (3), 527-531 (1998)
   PUBMED   9691089
REFERENCE   7  (bases 1 to 5238)
  AUTHORS   Paumen,M.B., Ishida,Y., Han,H., Muramatsu,M., Eguchi,Y.,
            Tsujimoto,Y. and Honjo,T.
  TITLE     Direct interaction of the mitochondrial membrane protein carnitine
            palmitoyltransferase I with Bcl-2
  JOURNAL   Biochem Biophys Res Commun 231 (3), 523-525 (1997)
   PUBMED   9070836
REFERENCE   8  (bases 1 to 5238)
  AUTHORS   Britton,C.H., Mackey,D.W., Esser,V., Foster,D.W., Burns,D.K.,
            Yarnall,D.P., Froguel,P. and McGarry,J.D.
  TITLE     Fine chromosome mapping of the genes for human liver and muscle
            carnitine palmitoyltransferase I (CPT1A and CPT1B)
  JOURNAL   Genomics 40 (1), 209-211 (1997)
   PUBMED   9070950
REFERENCE   9  (bases 1 to 5238)
  AUTHORS   Britton,C.H., Schultz,R.A., Zhang,B., Esser,V., Foster,D.W. and
            McGarry,J.D.
  TITLE     Human liver mitochondrial carnitine palmitoyltransferase I:
            characterization of its cDNA and chromosomal localization and
            partial analysis of the gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 1984-1988 (1995)
   PUBMED   7892212
REFERENCE   10 (bases 1 to 5238)
  AUTHORS   Bennett,M.J. and Santani,A.B.
  TITLE     Carnitine Palmitoyltransferase 1A Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301700
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000808.6 and AP003732.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001876.3.
            
            Summary: The mitochondrial oxidation of long-chain fatty acids is
            initiated by the sequential action of carnitine
            palmitoyltransferase I (which is located in the outer membrane and
            is detergent-labile) and carnitine palmitoyltransferase II (which
            is located in the inner membrane and is detergent-stable), together
            with a carnitine-acylcarnitine translocase. CPT I is the key enzyme
            in the carnitine-dependent transport across the mitochondrial inner
            membrane and its deficiency results in a decreased rate of fatty
            acid beta-oxidation. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4447950.1,
                                           SRR14038195.1627492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000265641.10/
                                                  ENSP00000265641.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AP000808.6         2691-2832           c
            143-296             AP003732.4         70641-70794         c
            297-436             AP003732.4         67744-67883         c
            437-608             AP003732.4         62774-62945         c
            609-710             AP003732.4         59307-59408         c
            711-848             AP003732.4         54525-54662         c
            849-926             AP003732.4         52163-52240         c
            927-1034            AP003732.4         50111-50218         c
            1035-1122           AP003732.4         48622-48709         c
            1123-1318           AP003732.4         40122-40317         c
            1319-1507           AP003732.4         37078-37266         c
            1508-1613           AP003732.4         35947-36052         c
            1614-1730           AP003732.4         30623-30739         c
            1731-1895           AP003732.4         28572-28736         c
            1896-2030           AP003732.4         17934-18068         c
            2031-2183           AP003732.4         16842-16994         c
            2184-2297           AP003732.4         15532-15645         c
            2298-2390           AP003732.4         14876-14968         c
            2391-5238           AP003732.4         10190-13037         c
FEATURES             Location/Qualifiers
     source          1..5238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..5238
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /note="carnitine palmitoyltransferase 1A"
                     /db_xref="GeneID:1374"
                     /db_xref="HGNC:HGNC:2328"
                     /db_xref="MIM:600528"
     exon            1..142
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..296
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2477
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /EC_number="2.3.1.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     carnitine palmitoyltransferase I, liver; CPT I; CPTI-L;
                     succinyltransferase CPT1A; carnitine palmitoyltransferase
                     1A (liver)"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, liver
                     isoform isoform 1"
                     /protein_id="NP_001867.2"
                     /db_xref="CCDS:CCDS8185.1"
                     /db_xref="GeneID:1374"
                     /db_xref="HGNC:HGNC:2328"
                     /db_xref="MIM:600528"
                     /translation="MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFI
                     RFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTK
                     NVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGR
                     KPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQ
                     WYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAI
                     HAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHI
                     VVYHRGRYFKVWLYHDGRLLKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWA
                     RCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSLLHGRCYD
                     RWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDI
                     NPNIPYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSP
                     DAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQ
                     TVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPW
                     RLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKF
                     SCPETDSHRFGRHLKEAMTDIITLFGLSSNSKK"
     exon            297..436
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..608
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..710
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..848
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..926
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1034
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1122
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1318
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1507
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1613
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1730
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1895
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2030
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2183
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2297
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2390
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..5238
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5210..5215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /note="hexamer: AATAAA"
     polyA_site      5238
                     /gene="CPT1A"
                     /gene_synonym="CPT1; CPT1-L; L-CPT1"
                     /note="major polyA site"
ORIGIN      
        1 aatccgctgc tgccggcgtc gggtgcgctc ggcctcgccc gcggccctcc ttccccggct
       61 cccgctcgcc gctcgttcac tccaccgccg ccgccgccgc cgccgctgcc gctgccgctg
      121 ccgcacctcc gtagctgact cggtactctc tgaagatggc agaagctcac caagctgtgg
      181 cctttcagtt cacggtcact ccggacggga ttgacctgcg gctgagccat gaagctctta
      241 gacaaatcta tctctctgga cttcattcct ggaaaaagaa gttcatcaga ttcaagaacg
      301 gcatcatcac tggcgtgtac ccggcaagcc cctccagttg gcttatcgtg gtggtgggcg
      361 tgatgacaac gatgtacgcc aagatcgacc cctcgttagg aataattgca aaaatcaatc
      421 ggactctgga aacggccaac tgcatgtcca gccagacgaa gaacgtggtc agcggcgtgc
      481 tgtttggcac cggcctgtgg gtggccctca tcgtcaccat gcgctactcc ctgaaagtgc
      541 tgctctccta ccacgggtgg atgttcactg agcacggcaa gatgagtcgt gccaccaaga
      601 tctggatggg tatggtcaag atcttttcag gccgaaaacc catgttgtac agcttccaga
      661 catcgctgcc tcgcctgccg gtcccggctg tcaaagacac tgtgaacagg tatctacagt
      721 cggtgaggcc tcttatgaag gaagaagact tcaaacggat gacagcactt gctcaagatt
      781 ttgctgtcgg tcttggacca agattacagt ggtatttgaa gttaaaatcc tggtgggcta
      841 caaattacgt gagcgactgg tgggaggagt acatctacct ccgaggacga gggccgctca
      901 tggtgaacag caactattat gccatggatc tgctgtatat ccttccaact cacattcagg
      961 cagcaagagc cggcaacgcc atccatgcca tcctgcttta caggcgcaaa ctggaccggg
     1021 aggaaatcaa accaattcgt cttttgggat ccacgattcc actctgctcc gctcagtggg
     1081 agcggatgtt taatacttcc cggatcccag gagaggagac agacaccatc cagcacatga
     1141 gagacagcaa gcacatcgtc gtgtaccatc gaggacgcta cttcaaggtc tggctctacc
     1201 atgatgggcg gctgctgaag ccccgggaga tggagcagca gatgcagagg atcctggaca
     1261 atacctcgga gcctcagccc ggggaggcca ggctggcagc cctcaccgca ggagacagag
     1321 ttccctgggc caggtgtcgt caggcctatt ttggacgtgg gaaaaataag cagtctcttg
     1381 atgctgtgga gaaagcagcg ttctttgtga cgttagatga aactgaagaa ggatacagaa
     1441 gtgaagaccc ggatacgtca atggacagct acgccaaatc tctactacac ggccgatgtt
     1501 acgacaggtg gtttgacaag tcgttcacgt ttgttgtctt caaaaacggg aagatgggcc
     1561 tcaacgctga acactcctgg gcagatgcgc cgatcgtggc ccacctttgg gagtacgtca
     1621 tgtccattga cagcctccag ctgggctatg cggaggatgg gcactgcaaa ggcgacatca
     1681 atccgaacat tccgtacccc accaggctgc agtgggacat cccgggggaa tgtcaagagg
     1741 ttatagagac ctccctgaac accgcaaatc ttctggcaaa cgacgtggat ttccattcct
     1801 tcccattcgt agcctttggt aaaggaatca tcaagaaatg tcgcacgagc ccagacgcct
     1861 ttgtgcagct ggccctccag ctggcgcact acaaggacat gggcaagttt tgcctcacat
     1921 acgaggcctc catgacccgg ctcttccgag aggggaggac ggagaccgtg cgctcctgca
     1981 ccactgagtc atgcgacttc gtgcgggcca tggtggaccc ggcccagacg gtggaacaga
     2041 ggctgaagtt gttcaagttg gcgtctgaga agcatcagca tatgtatcgc ctcgccatga
     2101 ccggctctgg gatcgatcgt cacctcttct gcctttacgt ggtgtctaaa tatctcgctg
     2161 tggagtcccc tttccttaag gaagttttat ctgagccttg gagattatca acaagccaga
     2221 cccctcagca gcaagtggag ctgtttgact tggagaataa cccagagtac gtgtccagcg
     2281 gagggggctt tggaccggtt gctgatgacg gctatggtgt gtcgtacatc cttgtgggag
     2341 agaacctcat caatttccac atttcttcca agttctcttg ccctgagacg gattctcatc
     2401 gctttggaag gcacctgaaa gaagcaatga ctgacatcat cactttgttt ggtctcagtt
     2461 ctaattccaa aaagtaattc cactggagct gctgggaagg aaaacgagct cttctgatgc
     2521 aaaccaaatg aaaaataggc attaatcctg accttagctc gggatgaaac actgctctta
     2581 aaaaaactca gttttccttc cagaaaatgt gggtgttttt ttttcctaga acagtatctc
     2641 tcccctgtga agcataaccc cactacttcc agacttgccc tcccttgggg gacatctgat
     2701 aaagtctccc ctgatgtctc cgcatcggct tggatttatt aagggatgca aatcttgttg
     2761 agttaatgaa ggaattagta gggttgtggc ttcacacaca gtggaatgga aatggtgtgc
     2821 tttctcagtg gcaaccgaag gcctagtgct taagggcatt tagcatcatc caagcagggt
     2881 aaacttttgt tttgttaaaa gaaaaatgtg ttattcaagt tggtgtcccc agttgtagct
     2941 aacacatctg gaatgcacta accaaaatgc tgtgctttgg agacctgctt ttgtcaccgt
     3001 gggtaaccgt tcccgtctgg tccagtagcc tgtgtttgcc tctccacatt tgaagcaagc
     3061 aggatgcaag gtcttcagtt ttactgacct tgtatgtctt caagtcttca caacccagtg
     3121 ccttaaaaat gaaaggccct aaatgtaagg gagatggaga gaaagattta ttttgtagag
     3181 tctttgggtg gaattgtggg tatactgttc ccttcacaat tgactgagta tggataaccg
     3241 tacataagca tttgctacac cccaccagcc ccctccccct cagaaacacc agttccttcc
     3301 caagggcagc tgtgccagac tcccctcccg ggactgcctt cttgtcatca taagcaacaa
     3361 aagaaataac aggcacatgt cataaaaggg gagcaagggc cgtgatggtc agataattca
     3421 ctcaagaata aaacatgaca cgtgcctcag gaggatctct ttcccaaagt gacagcaagg
     3481 agggcagggc atcggccacc aagcggggac tagcaagtga ggaaggggag ggcagcccac
     3541 cgtggtgagg agagagtggc tccacgaccc caagggatgg ccttctcctc ccacccggtg
     3601 aggggaaaga ctcaccagag ggtgatggag acagtatgcc ggctcacctt ggtgaccagc
     3661 caagatgtct caagtgacag tgctaggtgt tcacccagcc tgtccttcag ataggagtgc
     3721 cttcacgaaa gcgtctcatg gaccacaaag caattatgca ctgagtcatc ttcagtattt
     3781 aatgcaaaaa tgaagcatca tggaatgaaa ttcccactgt ctgtcatgac aagcttagct
     3841 gtccattgtt ttaaattgtg tatttatttt tttgaccact tggttctagt tgggcctgac
     3901 tccttcagag tgctgcaccc cgatagtaca acagcgatgg ctgaactgtt ggagtcgatg
     3961 gaaggtgctt gccggagaac acgtgccttt tttttttttt ttttttttga gatggagttt
     4021 cactcttgtt gcccaggctg gagtgcagtg gtgcaatctc ggctcactgc agcatctgcc
     4081 ttgcaggttc aagcgattct cctgtctcag cctcccaagt agctgggatt acacgcccaa
     4141 caccatgccc tgctaatttt tgtattttta gtagagacgg ggtttcatca tattggtcag
     4201 gctggtctcg aactcctgac ctcaggtgat ccacctgcct cagcctccca aagtgctggg
     4261 attacaggca tgagccacca tgcgcggccc acatgcatgt tttatgtatg tatacttcat
     4321 gatgtaaaaa tcccaccttt atgggccaaa gatttttttt ctcctgaaag caagaaaaaa
     4381 tgaaaacaaa agacaaaaaa aaaaaaaaaa gcgtccaggc gcggtggctc atgcgtgtaa
     4441 tcccagcact ttgggaggcc aaggcgggcg gatcacgagg tcaggagatg gagaccatcc
     4501 tggctaacac ggtgaaaccc cgtctctact aaaaattcaa aaaatgagcc gggcgtggtg
     4561 gcgggcgcct gtagtcccag ctactcagga ggctgaggca ggagaatggc gtgaacccgg
     4621 gaggcggagc ttgcagtgag ccgagatcgc tccactgcac tccagcctgg gcgacagagc
     4681 gagactccgt ctaaaaaaaa aagcaaaaac aaaccaacaa caaaagcccc tgactgtccg
     4741 tcaagcaggc agcggggatg tagctctctc tgccctgggc aagaatagca cttcccgtta
     4801 aaagccagca gccggcgtca gtccctatca gagccagcta gatcatgcac tgttgaccac
     4861 tgagcaatct gtgttacact agagttcaca gggcattttg agtgtagacg tgagtgctta
     4921 aacatatttg ggtttctctc tcaggtttta aatgtttcaa atgtaattgt tgctcatcag
     4981 tgcagttatc aatgcaattt tatattcctt gaggggagaa agaggggtct tattgtacat
     5041 gtccaagggg ggtgataaga gtattatctg tttaatttaa ttggaacaaa ccattgtctt
     5101 aacgcagcca tggtttgaat ttgttatctt gggctgaccg gtgcatgtaa atacagtatg
     5161 ctctttggat gtaaatctta gaaatgcagt gtgaatgtag gttatcatta ataaaacatt
     5221 aaccccagtc tactacaa
//
