LOCUS       NM_017437              13003 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cleavage and polyadenylation specific factor 2
            (CPSF2), transcript variant 1, mRNA.
ACCESSION   NM_017437
VERSION     NM_017437.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13003)
  AUTHORS   Boreikaite,V., Elliott,T.S., Chin,J.W. and Passmore,L.A.
  TITLE     RBBP6 activates the pre-mRNA 3' end processing machinery in humans
  JOURNAL   Genes Dev 36 (3-4), 210-224 (2022)
   PUBMED   35177536
REFERENCE   2  (bases 1 to 13003)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 13003)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   4  (bases 1 to 13003)
  AUTHORS   Sung,T.Y., Kim,M., Kim,T.Y., Kim,W.G., Park,Y., Song,D.E.,
            Park,S.Y., Kwon,H., Choi,Y.M., Jang,E.K., Jeon,M.J., Shong,Y.K.,
            Hong,S.J. and Kim,W.B.
  TITLE     Negative Expression of CPSF2 Predicts a Poorer Clinical Outcome in
            Patients with Papillary Thyroid Carcinoma
  JOURNAL   Thyroid 25 (9), 1020-1025 (2015)
   PUBMED   26148673
  REMARK    GeneRIF: CPSF2 may have a role in Papillary Thyroid Carcinoma
REFERENCE   5  (bases 1 to 13003)
  AUTHORS   Misra,A., Ou,J., Zhu,L.J. and Green,M.R.
  TITLE     Global Promotion of Alternative Internal Exon Usage by mRNA 3' End
            Formation Factors
  JOURNAL   Mol Cell 58 (5), 819-831 (2015)
   PUBMED   25921069
  REMARK    GeneRIF: CPSF2 and SYMPK, are RBFOX2 cofactors for both inclusion
            and exclusion of internal exons.
REFERENCE   6  (bases 1 to 13003)
  AUTHORS   Schul,W., Groenhout,B., Koberna,K., Takagaki,Y., Jenny,A.,
            Manders,E.M., Raska,I., van Driel,R. and de Jong,L.
  TITLE     The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are
            concentrated in nuclear domains closely associated with coiled
            bodies and newly synthesized RNA
  JOURNAL   EMBO J 15 (11), 2883-2892 (1996)
   PUBMED   8654386
REFERENCE   7  (bases 1 to 13003)
  AUTHORS   Murthy,K.G. and Manley,J.L.
  TITLE     The 160-kD subunit of human cleavage-polyadenylation specificity
            factor coordinates pre-mRNA 3'-end formation
  JOURNAL   Genes Dev 9 (21), 2672-2683 (1995)
   PUBMED   7590244
REFERENCE   8  (bases 1 to 13003)
  AUTHORS   Jenny,A., Hauri,H.P. and Keller,W.
  TITLE     Characterization of cleavage and polyadenylation specificity factor
            and cloning of its 100-kilodalton subunit
  JOURNAL   Mol Cell Biol 14 (12), 8183-8190 (1994)
   PUBMED   7969155
REFERENCE   9  (bases 1 to 13003)
  AUTHORS   Thuresson,A.C., Astrom,J., Astrom,A., Gronvik,K.O. and Virtanen,A.
  TITLE     Multiple forms of poly(A) polymerases in human cells
  JOURNAL   Proc Natl Acad Sci U S A 91 (3), 979-983 (1994)
   PUBMED   8302877
REFERENCE   10 (bases 1 to 13003)
  AUTHORS   Bienroth,S., Keller,W. and Wahle,E.
  TITLE     Assembly of a processive messenger RNA polyadenylation complex
  JOURNAL   EMBO J 12 (2), 585-594 (1993)
   PUBMED   8440247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB081880.1, BC060854.1, BC070095.1, AB037788.1 and AL121773.5.
            
            On May 17, 2019 this sequence version replaced NM_017437.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.204380.1,
                                           SRR1660803.13981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298875.9/ ENSP00000298875.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB081880.1         16-25
            11-968              BC060854.1         1-958
            969-1118            BC070095.1         954-1103
            1119-1906           BC060854.1         1107-1894
            1907-2213           BC070095.1         1892-2198
            2214-2923           BC060854.1         2201-2910
            2924-5057           AB037788.1         2063-4196
            5058-13003          AL121773.5         84243-92188
FEATURES             Location/Qualifiers
     source          1..13003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..13003
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="cleavage and polyadenylation specific factor 2"
                     /db_xref="GeneID:53981"
                     /db_xref="HGNC:HGNC:2325"
                     /db_xref="MIM:606028"
     exon            1..160
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            161..219
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            220..402
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..2602
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cleavage and polyadenylation specificity factor subunit 2;
                     CPSF 100kDa subunit; CPSF 100 kDa subunit; cleavage and
                     polyadenylation specificity factor 100 kDa subunit;
                     cleavage and polyadenylation specific factor 2, 100kDa"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 2 isoform 1"
                     /protein_id="NP_059133.1"
                     /db_xref="CCDS:CCDS9902.1"
                     /db_xref="GeneID:53981"
                     /db_xref="HGNC:HGNC:2325"
                     /db_xref="MIM:606028"
                     /translation="MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDI
                     IDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLY
                     QSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIW
                     KIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQ
                     LLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNV
                     VEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLE
                     CGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKITEIELRKRVKLEGKEL
                     EEYLEKEKLKKEAAKKLEQSKEADIDSSDESDIEEDIDQPSAHKTKHDLMMKGEGSRK
                     GSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGD
                     EPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHG
                     PPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK
                     DAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVEAPSDSSVIAQQKAMKSL
                     FGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGG
                     VLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV"
     exon            403..562
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            563..668
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            669..798
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            799..914
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1102
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1393
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1494
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1695
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1848
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2074
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2374
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2509
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..13003
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="hexamer: AATAAA"
     polyA_site      2923
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="major polyA site"
     regulatory      4227..4232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="hexamer: GATAAA"
     polyA_site      4252
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
     regulatory      5033..5038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="hexamer: ATTAAA"
     polyA_site      5058
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="major polyA site"
     regulatory      6556..6561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="hexamer: ACTAAA"
     regulatory      6564..6569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="hexamer: ATTATA"
     polyA_site      6575
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
     polyA_site      6585
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
     regulatory      12983..12988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
                     /note="hexamer: AATAAA"
     polyA_site      13003
                     /gene="CPSF2"
                     /gene_synonym="CPSF100"
ORIGIN      
        1 gctagtctcc agctccaaaa tggcggctgc cactgtgggg cttctgccgg ccggtagtcc
       61 ctggcgctgc tgacccagca tcggcttttc tacgtcttga acctggattc gcctaggggt
      121 tgggaagggc tgtggacggc gttgggggag gcctgacgag attaataaag aactcttcag
      181 aattcctggt gtttcatcat atatacgact aagatatcaa ctcttctagc ttgctgtttc
      241 tggaccaaaa aaaatgacgt ctattatcaa attaactacc ctttctgggg tccaagaaga
      301 atctgccctt tgctatcttc tccaagttga tgagtttaga tttttattgg actgtggctg
      361 ggatgagcac ttttctatgg atattattga ttccctgagg aagcatgttc accagattga
      421 tgcagtgctg ttgtctcacc ctgatcctct ccaccttggt gccctcccgt atgctgtcgg
      481 aaagttgggt ctgaactgtg ctatctatgc aaccattcct gtttataaaa tgggacagat
      541 gttcatgtat gatctttatc agtctcgaca caatacagaa gattttacac tctttacatt
      601 agatgatgtg gatgcagcct ttgataaaat acagcagcta aaattctctc agattgtgaa
      661 tttgaaaggt aaaggacatg gcctgtctat cacacctctg ccagctggtc atatgatagg
      721 tggaacaata tggaaaatag tcaaagatgg agaagaagaa attgtttatg cagttgactt
      781 caaccacaag agggagatcc atttaaatgg atgttccctg gaaatgctaa gcaggccttc
      841 cctacttatc acagattcat tcaatgctac atatgtacag cctagaagaa aacagagaga
      901 tgagcagctt ctgacaaatg tcctggaaac acttcgaggt gatggaaatg tgttaatagc
      961 agtggacaca gcaggcagag ttttggaact tgctcaactt cttgatcaga tttggaggac
     1021 taaagatgca ggattgggtg tttactcatt ggcactccta aataatgtca gttacaatgt
     1081 ggtggagttt tctaagtccc aggtagaatg gatgagtgat aaattgatga gatgttttga
     1141 agacaaaaga aataatccgt ttcagtttcg ccatctctct ttatgtcatg gtctttctga
     1201 cttggcccgt gtacctagcc ctaaagttgt acttgccagc caacctgacc tggaatgcgg
     1261 attttcaagg gatctcttta ttcagtggtg tcaggaccct aaaaactcaa tcattctaac
     1321 ctacagaact actcctggga ctttagcacg tttcctaatt gataatcctt ctgaaaaaat
     1381 tacagaaata gagttgagga aacgtgtgaa gcttgaaggg aaagaacttg aagaatactt
     1441 ggaaaaagag aaactaaaga aagaagctgc caaaaagctt gagcagtcaa aagaggcaga
     1501 tatagattcc agtgatgaga gtgatattga ggaagatatt gaccagccat cagctcataa
     1561 gacgaagcat gacttgatga tgaaaggtga aggcagtcgt aaaggaagtt ttttcaaaca
     1621 ggcaaaaaag tcctatccta tgtttcctgc cccagaagaa agaattaaat gggatgaata
     1681 tggagagatt atcaaaccag aggatttctt agtgccagag cttcaagcta ctgaagaaga
     1741 aaaaagcaaa ttagaatctg gtttgacaaa tggagatgaa cctatggatc aggatttatc
     1801 tgatgttcct actaaatgta tttctacaac agagtctatt gaaataaaag cccgggttac
     1861 ctacatagac tatgaaggac gctctgatgg ggattccatt aaaaaaatca ttaatcagat
     1921 gaaaccacga cagttgatca tcgtccatgg cccaccagag gccagtcaag atctggcaga
     1981 gtgctgtcgc gcctttggtg ggaaagatat taaagtgtac atgccaaagc tacatgaaac
     2041 agttgatgcc actagtgaaa ctcacatcta ccaggtgagg ttaaaagact cacttgtcag
     2101 ctctcttcag ttttgtaagg caaaagatgc tgaattagct tggatagatg gtgtcttaga
     2161 tatgagagtt tccaaagtgg acacaggggt tattttagaa gaaggagaac taaaggatga
     2221 tggagaagac tcagagatgc aagtggaagc tccctcagat tctagcgtta tagcacaaca
     2281 aaaggccatg aaaagtctgt tcggagatga tgaaaaagaa acaggtgaag aaagtgagat
     2341 cattcctact ttggaaccct tgccacctca tgaggttcct ggacatcagt cagtttttat
     2401 gaatgaacca aggctgtcag acttcaagca agttctctta cgggagggga ttcaagctga
     2461 atttgtagga ggtgtacttg tttgcaacaa tcaagtagca gtccgcagaa cggaaactgg
     2521 acgcattgga ttagaaggct gcctttgtca agatttttat aggataagag accttttata
     2581 tgaacaatat gccattgtat aaaggacatg atgtcaagaa gtatctgctt gacctttcta
     2641 agaaaaaggg attcttatct tactctgagc ttttgatgtt ttgttttgta acatacaaaa
     2701 agaatctgcc agaaaaactt acatgtatca gatttttaaa aatataaata gagaacattt
     2761 tgcaaatgct caaatgagca ttctatcttt tggctttcag agtgatagag ctcctaacag
     2821 gtgtacaggc ccaagagttg aaggtgattg gttttcttta cagactcctt gttctctaga
     2881 agggcttttt acttgaataa aacaatgcaa cttagcaaac caatttatgg ccttagagaa
     2941 acatttttgc atgagttctt acaaactgtt tgttatattt tctggaatga taagtgagaa
     3001 ttatttagaa aagacatgct ccaaaaaaaa aacaaaactg ataaaacagt ttttcgaaac
     3061 ttacttttaa aagcatacgt gctatgactc tctccagttt gaatatgcaa ttgttttcac
     3121 aggcaggatg tctgttttct gcctgtattt cccagtgatt tactctaggg taaggtagta
     3181 cacatttggt tcagaaatta atttttattt ctcctatatc ttgttttatc aagattttgt
     3241 tgtggcattt caatgtaaat tataacacca tcatttgagt atacataatt caaaagaact
     3301 acttgatgca gtatagtctt aagggttctg catacatttt agaaacatct tagccgtaag
     3361 ttaggtcctg tgttaaactg tttagtgctc tgtttttaag aaaacaaatg ttgaacctca
     3421 cacttttatg tggtgacagt gtaatttaat taaaaggtgt aaatgttttc atctcttagg
     3481 cttgctgtct cctaaggtca cccaagcagt ggttggattt tatacacatt actactaaaa
     3541 taatactgaa gttggataag gttatccttt ctgtatttgc gtctttcttg tgactaacca
     3601 ccctgatata gtattaacca ctgtgttcaa gagtaaaaac aatatatgca attttcattg
     3661 aacttaaaga gtgaaaacca tgtaaactat tgaaactatt gtaatccatt aatgcttttt
     3721 tagaatggca gaccttgatg tttatttctc aaatggttaa gccctcttct ttactcttaa
     3781 tttttttttg agacagagtc acccaggctg gagtgcagtg gtgagatttt ggctcactat
     3841 aacctcttcc tccagggttc aagtgattct cccacctcag cctcccaagt agctgggact
     3901 acgggcacat gccactgcac ctggctaatt tttatatttt tggtagagac agggtttcac
     3961 catgttggcc aggctggtct caaactcctg acctcaagcg atccacccac ctaggcctcc
     4021 caaagtgctg ggattacagg catgaatcac cacaactagc ctacccttag atttttggaa
     4081 ggatcgatct tatttaacta tgtgtggaac aacccagtaa tatcagactc gaattactat
     4141 ttcattctat ttcaaatgct tataaagcta ctattgtaga ttatagtgtt aatgcaaagt
     4201 ttacagactt ttgatatgga aaaccagata aaacaatgtt acaaaaggca aatataaaga
     4261 gtatgttttc tttttagtgc tttggaaaaa tttcacttaa actcttatta ctgtatagat
     4321 taagccctat aatgctattt atattccagg ggaacgaaaa tctgaatttg ttttatgatt
     4381 taaagcatct ggtttgcata ttgtattgta atactgatac agtttggctg tgtccccacc
     4441 aaattgaatt gtgttaatag ttcccataat ccctacgtgt tgtgggaggg acccagtggg
     4501 cagtaattta atcatggtgg tggttaccct catgctgttc ttgtgatggt gagttctcat
     4561 gagatctgat gggtgttttt ttttgttttg ttttttgttt tttgagatgg agttttgctc
     4621 ttgttgccca gactggagtg caatggcaca cgatctcggc tcaccgcaac ctctgcctcc
     4681 tgggttcaag cgattctcct gcctcagcat ctcgagtagc tgggattaca ggcatgcacc
     4741 accacgccca gctaattttg tatttttagt agagacgggg tttctccatg ttggttaggc
     4801 tggcctcaaa ctcccgacct caggtgatcc gcccgcctgg gcctcccaaa gtgctgggat
     4861 tacaggcgtg agccactgct cctggcccaa gatctgatgg ttttgtaagg gaattttccc
     4921 cctttgcttg gcacttcttc ctgctgccat gtgaagaagg atgtgtttgc ttccccttcc
     4981 accatgattg taagtttcat gaggcctccc cagcctgtgg gactgtgagt caattaaacg
     5041 tgtttacttt ataaattacc cagtctcagg caattcttta tagcagtgtg agaacagact
     5101 aatatgaata ccaatactga aaaattgttt cttgcctcac cttgtcctat gaacaggaat
     5161 taaattttaa agtattgcct taagatggct gtgctaaata ataatcattg caagagcaat
     5221 acttttacct gtttctagat gacaatatta ctaaaatttc tcaaatgaag actttgtttt
     5281 agcttcaatt acttcagaaa atataaattt taaagatgac tatgagataa atcatgaact
     5341 cagtggaatt ttcagatgag atggggcgcg ttcagggtgg tatgactgta gacggaattt
     5401 tcagatcttt gttatttaga agcaagtata ggtataacgt ggactatcaa ctgatatctg
     5461 caaataattt ggttaaaatg aaatttgatt gtagtatttg ttgctgtagg attataaatg
     5521 tcaaatatca ttgtaaacat ttctatattt ttagaaatat cttgggtggc ctgaaacaga
     5581 agtgaggaaa tcaatttttt aaggtgagcc atttggcttt tttaaaaaat tgagattcaa
     5641 cttacatacc ataaagttca ctcttctaaa gtgtacaatt cattggtgtt agtatattta
     5701 cagagttgta caactattac cactatataa tcccagaaca ctttcatcac tccaaaaaga
     5761 aacaccatac ccactaccag tcactcctca tgcccccttc ctatgacccc tggcagccat
     5821 taatctactt tctgtctcct tgaatttgga ttttctggac acttcataaa aattgaataa
     5881 tacaatatat gaacttttat gtttgacttc tttcacttag cataatgttt tcagagtgca
     5941 tcactgttgt aacatgtatc agtacccttt ttgtgactga atattattcc accgaatgga
     6001 tataccacat tttacttatc cattcaaccg ttgatgtaca tttgagttga ttccaaattt
     6061 tggctattaa gaatgctgct ctgaacattc atgtgcaagt tttttttttt ttgtatgtac
     6121 atatgttttc aattttcttg gatatatatc taagaattag aattgctgga tcatacagta
     6181 attctgctta accttttgag gagctgccag gctgttttcc aaagtggcta caacattttg
     6241 catttccacc agcatgtgtt tgagggttcc attttctcct cattcttgac aacatttatt
     6301 actccctttt taaattttag tcatcatagt gtgggtgaag aagtgtctca ctgaggtttt
     6361 gatttgcatt tccttaatga ctgatgatgt ggagcctctt tccatgtgtt tattgacttt
     6421 ttatatattt tggagtaata tctgttcata tcctttgtcc attttcaatt tgtttatgtt
     6481 catatccttt gtccattttc aatttgttta tctttactgt tgagatgtaa gagttttttt
     6541 atatattttc tggatactaa accattatat attgatttgc aagtatttta ttccattctg
     6601 tggcttgtct tttcactttc ttcgtagtgt agtttgaagc acaaaagttt ttaattttga
     6661 taaagtccag tttgtttttt tcccttcagt tctttgtgct tggttttata tctttttttt
     6721 tttttttttt tttttttgag atggagtctt gctttgtcac ccaggctgga gtgcagtggc
     6781 gcggtctcag ctcactgcaa cctctgcctc ccagattaaa gggattctcc tgcctcagcc
     6841 tcctgagtac tgggattaca ggcacccacc accatgcctg gctaaatttt tgtattttta
     6901 gtaaagacat ggttttgcca tgttggccag gctggtcctg aactcctaac ctcaagtgat
     6961 ccaccaacct tggcccccaa aagtgctgag attacaggtg tgagccacct tgcctggcct
     7021 tggttttata tcttaaaagc tattccttca ttcaaagtca cgaaggttta cacttaattt
     7081 ttttctatct aaaaaaccat tgcttcatct aaagtcatga agatttacac tctttttttt
     7141 tctaacagtt ttacagttta ggctcttatc attaggtctt tcatttattt tgaattatta
     7201 tcattattat tattttcttt ttgaggcagg gtctcactct gtcacgcagg cttgtgtgca
     7261 ttggtgcaat cacagctcac tgcagcttca gccttctggc ctcaagcagt cctcccacct
     7321 cagcctccca agtagctgag attacaagtg tgtgccacca tgcctgacta atttttaaaa
     7381 tttttttgtg aagacagttt ctcactctgt tgcccaagct ggtcatctca aacttccaga
     7441 ctcaaacaat actcccactt tggctgccca aagtgctggg attacaggca tgagtcacca
     7501 ttcctggcat taatttttgt atatggtgtg aggtaggggt ccagtttcat ttttttgcat
     7561 gtggatatcc agttgtccca gcatcatttg ttgaaaagac tatttcttca ttgatttttt
     7621 tctgccaccc ctgtttaaaa tcagttgccc atgagtgtat gggtttgttc ctggacttga
     7681 aattatgttt cattgatcta tatatctatg ctagtaccac atgtcttcat tactgtagct
     7741 ttgtagtaac ttttgaaatt ggggaagtgt gagttcccca actttagttc tccttcagga
     7801 ttgttttggc tattctgggt ctcttgcatt ttcatgtgag tttagattct gcttatcgat
     7861 ttcttttttt tctttttttt tttttttgag atagcatctt gctttgtcac ccaggctgga
     7921 gtgctatggc tcaatctcag ctcactgcaa cctccgcctc ctgggttcga gagattctcc
     7981 tgcctcagcc tccagagtag ttaggactac aggcgcgtgc caccatgcca ggctaatttt
     8041 tgtattttta atagagatga ggtttcatca tgctgaccag gctggtctcg aactcctgac
     8101 atcaagtaac ccggctgcct cagcctccca aagtgctggg attacagtcg tgagccacca
     8161 tactcagcct aagattcagc ttaccaattt ctgcaaaaaa gcccactcat ttttaatagg
     8221 aggtaaaaag cagttgacat ttataactta gagtctttta atgttagtgc tgaaagggac
     8281 tagagagctc atctaattca acccacttat tttagtattg aatgaatgac cctgtacaag
     8341 gaaagggatt tgcttgagat ccacacagct gtttaaaggc agagttggga ttggaaccaa
     8401 gtcttagaga atccattgtt gcttctacac tgcattattg ctttggttcc ctagtgtaca
     8461 ttcactttgc ttaggagtga tatgttcagt ttatcttctc taagaatggc agctgttatt
     8521 taggacagtg gcatgctgag aaatagattg atttctattc tatactgtgt ccagtaaagg
     8581 tcgggggaga aagagtaaat cttatcttct tctgtacttt tctttgatta atgtaagagt
     8641 ctagagtttt atcagaagat tattgtcctt taaaatattg atggactgat tatcacttaa
     8701 agggtataaa cagtgggtag taattcagtg attgagaggt taattgcagg tttttttttt
     8761 ttttttttct ggtaaccata gaatgaatgt agaatgaatt tggattcaat aatgggaact
     8821 aaggtcaggc gtggtggctc acacctgtaa tcccagcact ttgggaggcc gaggcgggtg
     8881 gatcatctga ggtcaggagt tccagaccag cctggccaac atggtgaaac ctcatctcta
     8941 ctaaaattac gaaaaattag tcaggtgtgg tgacgggtgc ctataatccc agctacttgg
     9001 gaggctgagg cagtagaatc gcttgaaccc gggatgcgga agttgcagtg agccaagatc
     9061 acgccactgt actccatctt gggcgacaga gcgcaactct gtctccaaaa aaaaaaaaaa
     9121 aaaagggcag ggggagcggc tagagaagga acattcaaat cttcccacgt gggcaagttc
     9181 caagcaaatg tttatttttt tacctcctct ttggtttttg tctcacttga agcactttgt
     9241 gtttatggga aaataccaaa aattaccaaa atttaaaaac ccagggcttt gctggaagtg
     9301 agggtatctt cttggctttt cccttttcct ccccaccact atacgcacat gcacacacag
     9361 ctctattttt tggtgctttt cgttcattat tcactccatt tcattttagc tcttgaagtc
     9421 aaaatgggat tccaaagagc aaaatagaag tttggagagt ttgaaatctc tcctcgtggc
     9481 tggacgccgt ggctcacacc tgtgatccca gcactttggg aggccaaggc aggcatactg
     9541 cttgaactca ggagttcaag accagcctgg ggaacatggt aaaaccctgt ctctacaaaa
     9601 aatagaaaaa ttagctgggc atggtggctg tagtcccagc tatttgggag gctgaggtgg
     9661 gaggatcact tgagcctggg gaggttgaga ctgcactgag tcttgaatga atgaatccat
     9721 ctctctttct ctctccatat agtcaaagag aaccaaaaat gtatgtgctt tttttgtgaa
     9781 attgttaagg attccatgat cctactaaaa tttttgataa tgataatttc aagtggagaa
     9841 tatataaagg actcgtgagg ccttcctacc tcattttctg aggttatgtt gactttaata
     9901 tccaatgtat cataggtgtt ttcttttttc tctgacaatt gttatgttaa aaacaaaaag
     9961 aagcacatac tgtacagtca aaactatcag acgtaactct gtgggaaact ttattccaag
    10021 ggtgctgcca ctgcccttgt tttaaatatt tttggaactt catttctctt caggtctatt
    10081 taataagctt gttaggaata ttgtaaatta ttttagaaac acattgtggt ctcagcctca
    10141 tgtggcattg ccacttgtta ctacatgacc cccccacacc ccctaaaaaa gaaaaaggac
    10201 tttaaaaacc ctctcaggac aaacatttgc taccgtggtt gattttttaa ttttacatta
    10261 actatttaat atcagactat aactaaaata caagtagtgg aattatactt ttataaagta
    10321 tcaaattatg tagatgatga cgaagttata aggttactat aatttccaac ttcacccata
    10381 ggtcatggta tagttgaaat ttcatattta aatatcaaaa cataaatgtc taaagagatt
    10441 gtgtaaattc tttatcagtt ataaggaaaa accaaattca aattcttaag gtttttctta
    10501 tatgtgattt tttttttttt tttttttttg agacaaactt gcagggagag aattatgtgg
    10561 catgaggagg attgagaatg ttgttcattt tatctaatta ctgcctatta agaaaagctt
    10621 cacatttatt tcagctattc tattgaatac ttttacctaa gataatgaaa ccgttaagta
    10681 gagatttttc taatagtata aaaatcagtg taggcccagc acagtggttc acacctgtaa
    10741 tcccagcacc ttgggaggct aaaggcagga ggattgcttg agctcaggag tttgagacca
    10801 acctgggcaa catagtgaga actcatctct attaaaaatc agaaaaattg gccaggtgtg
    10861 gtggctcatg cctgtagtcc cagttactca ggaggctgag gcaggaggat cccttgagat
    10921 tgaggcttca gtgagctaat gatcgcgcca ctgcactcca gcctgggtga cagagtgaga
    10981 ccctgtctca aaaacaacaa aaatctcagt gtgacaaatt cctaacagct caaatactac
    11041 ttgtcttatt tgttaactat tttgaaataa ttttaaactt acagaaaagt agaatagttc
    11101 aaaagatcct gtatatcctt cccctagatt cttctattgt taacatcttg ccatattttc
    11161 cataccactc tctagctatg tattcacatt attttttgaa ctgtttgtta ctaagttgca
    11221 attgtgatgt cccattagta ctaaatactt aagtgtatac tttttaaaaa caaggacact
    11281 cctacataac cacagtactt aaaatcagga aaccagcatt gataaaattc taccatttga
    11341 tccacgaacc ccattcaaat gttgccattt actccaaaaa tatccttaca ataacccttt
    11401 ccttttttgg tccacagtcc aatcaggatg aagcacgcat ttagttacat tttcccttta
    11461 gtcttcctca atctggagcg gttccttggt ttttcctttt ttgtgacctt gacatttttg
    11521 aagaatgcag gccaggtact ttgtagaatg atgtgcactt tgggtttgtc tgatatttcc
    11581 tcaagattag attcaggttg tgaatttttg gcaggaatac cagagaggtg atgctgtctt
    11641 cttctctgca ttgtatcagg aggcacatca tgtcaatttt ttccattact ggtgatgtta
    11701 atttttaaca gttggttacg atgttttcaa gatttctcca ctgttagtat tttctccact
    11761 tgtatttgtt ttttggtata aacttaaaaa gtacagcatg atgttttggt atatgtatcc
    11821 atagtgaaat gattattaca ggtattaatt aatgaggaat tacgtatttt gtgggtagct
    11881 attttgagac tctcaatatc ctatttctca aaattttacc ctttactttt agcatccatt
    11941 gatgatcctt gtctggatca gttattgcca aatggtagtt ttcttttctt ttcttttctt
    12001 ttgagacagt gtcttgctct gttgcccagg ctacagtgca gtgatgagat catagcccac
    12061 tgcagcctca aactcctggg ctcatgccat tttcccctca gcttttggag ttagctggga
    12121 ctacaggcat gcatcaccac acccagatta tttttaaagt ttttgtagaa acggggtctc
    12181 ttcttcccca tttattcaat atttatatca gtatagaaca tgggtccctg ttttatcatc
    12241 tgtaagttat gatttatttt gatgccccca ttgtccaaga tttgactagc gagagcactt
    12301 tccagctagc tcctgtgtcc tttggacata ccccatggtt cattgagcac ttccttgctt
    12361 tctggcacca caagatgttc caggctcgtc ttctattttc cctaccccgc tcctgacatc
    12421 agccatttct ccaaagagtc ctggttcata ttagtggaga atggtattta aaaccaagat
    12481 ccggatgcta aaggctgtgc tcattgcccc tgtgctagca ttgccactgt gcgttctccc
    12541 agtggacaaa tttggaaata tatgcgtcta tgcttgttac ctcatccatc catatatata
    12601 ttaaaaacaa gtacacactg atacctattt cacatctact ccacagagtt tattctagtc
    12661 ttctcccttt ccacaattgt atcttctcca ccctatattt aaaaactgga cttccagagt
    12721 ctccaataca ttggcttatt tgttcatttt ccctgtgatt aaccaacctc ctgaccacgt
    12781 ggctggctcc tttgctccat ctctgcccct caccccctac cgtacatcac tgctgtgagg
    12841 accaagtttc ctccctttcc tcgatccatg acagcacctg ccagttgaac cccacagtgg
    12901 gaattttaaa gaaggcactt ttggctcaga tggcagtgcc aaagcaggca ttccaattca
    12961 catggtgctc tagcaattgt gaaataaaca gattctgaag gtc
//
