LOCUS       NM_018340               6143 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens calcineurin like phosphoesterase domain containing 1
            (CPPED1), transcript variant 1, mRNA.
ACCESSION   NM_018340
VERSION     NM_018340.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6143)
  AUTHORS   Haapalainen,A.M., Karjalainen,M.K., Daddali,R., Ohlmeier,S.,
            Anttonen,J., Maatta,T.A., Salminen,A., Mahlman,M., Bergmann,U.,
            Makikallio,K., Ojaniemi,M., Hallman,M. and Ramet,M.
  TITLE     Expression of CPPED1 in human trophoblasts is associated with
            timing of term birth
  JOURNAL   J Cell Mol Med 22 (2), 968-981 (2018)
   PUBMED   29193784
  REMARK    GeneRIF: functions regulated by CPPED1 in trophoblasts at
            choriodecidual interphase have a role in the induction of term
            labour, but it may be independent of AKT1.
REFERENCE   2  (bases 1 to 6143)
  AUTHORS   Vaittinen,M., Kaminska,D., Kakela,P., Eskelinen,M., Kolehmainen,M.,
            Pihlajamaki,J., Uusitupa,M. and Pulkkinen,L.
  TITLE     Downregulation of CPPED1 expression improves glucose metabolism in
            vitro in adipocytes
  JOURNAL   Diabetes 62 (11), 3747-3750 (2013)
   PUBMED   23939394
  REMARK    GeneRIF: CPPED1 is involved in glucose uptake in adipocytes
REFERENCE   3  (bases 1 to 6143)
  AUTHORS   Hadler,K.S., Huber,T., Cassady,A.I., Weber,J., Robinson,J.,
            Burrows,A., Kelly,G., Guddat,L.W., Hume,D.A., Schenk,G. and
            Flanagan,J.U.
  TITLE     Identification of a non-purple tartrate-resistant acid phosphatase:
            an evolutionary link to Ser/Thr protein phosphatases?
  JOURNAL   BMC Res Notes 1, 78 (2008)
   PUBMED   18771593
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092324.3 and AC010333.7.
            
            On Nov 23, 2018 this sequence version replaced NM_018340.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006289.2, AK002013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381774.9/ ENSP00000371193.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC092324.3         136133-136313
            182-400             AC092324.3         158617-158835
            401-826             AC010333.7         3355-3780
            827-6143            AC010333.7         43289-48605
FEATURES             Location/Qualifiers
     source          1..6143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.12"
     gene            1..6143
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="calcineurin like phosphoesterase domain containing
                     1"
                     /db_xref="GeneID:55313"
                     /db_xref="HGNC:HGNC:25632"
                     /db_xref="MIM:615603"
     exon            1..181
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1056
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /EC_number="3.1.3.16"
                     /note="isoform a is encoded by transcript variant 1;
                     calcineurin-like phosphoesterase domain-containing protein
                     1; complete S-transactivated protein 1;
                     serine/threonine-protein phosphatase CPPED1"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase CPPED1
                     isoform a"
                     /protein_id="NP_060810.2"
                     /db_xref="CCDS:CCDS42120.1"
                     /db_xref="GeneID:55313"
                     /db_xref="HGNC:HGNC:25632"
                     /db_xref="MIM:615603"
                     /translation="MSAAEAGGVFHRARGRTLAAFPAEKESEWKGPFYFILGADPQFG
                     LIKAWSTGDCDNGGDEWEQEIRLTEQAVQAINKLNPKPKFFVLCGDLIHAMPGKPWRT
                     EQTEDLKRVLRAVDRAIPLVLVSGNHDIGNTPTAETVEEFCRTWGDDYFSFWVGGVLF
                     LVLNSQFYENPSKCPSLKQAQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDDD
                     YYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNAGGTYQNLDMVVSSAIGCQLGRDPH
                     GLRVVVVTAEKIVHRYYSLDELSEKGIEDDLMDLIKKK"
     exon            182..400
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..826
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..6143
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="major polyA site"
     regulatory      2435..2440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2455
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="major polyA site"
     regulatory      3775..3780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="hexamer: GATAAA"
     polyA_site      3798
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
     regulatory      4479..4484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="hexamer: AATAAA"
     polyA_site      4497
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
     regulatory      6118..6123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
                     /note="hexamer: ATTAAA"
     polyA_site      6143
                     /gene="CPPED1"
                     /gene_synonym="CSTP1"
ORIGIN      
        1 gagatcaaag ggcgtcgccc aaagcgggac aggtccagcg gttgttctgt gtgaagtcgc
       61 gcggcttcca cccacgcagt gttctaagtg aaggccagaa actcgctcgc catgtcggct
      121 gcagaggcgg ggggtgtttt ccacagagcc aggggcagga ccctggccgc gtttcccgca
      181 gaaaaggaaa gcgaatggaa aggcccattc tacttcatcc tgggcgcaga cccacagttt
      241 gggctgatca aggcctggtc cactggggac tgtgacaatg gcggtgacga atgggaacag
      301 gagatccgtc taactgagca agccgtccag gccatcaaca agctgaaccc caaacccaaa
      361 ttcttcgttc tgtgcggcga cctcatccac gccatgccag ggaagccgtg gcggacggag
      421 cagacggagg acctgaagcg agtgcttagg gcagtggaca gggccatccc actggtcctt
      481 gtcagcggca accatgacat tggcaacacc cccacggccg agaccgtcga ggagttctgc
      541 cggacttggg gagatgacta cttcagcttc tgggtcgggg gcgtcctgtt cctggtcctc
      601 aactcccagt tctacgagaa cccctccaaa tgccccagcc tgaagcaggc tcaggaccag
      661 tggctggacg agcagctgag catcgcgagg cagcggcact gccagcatgc catcgtcttc
      721 cagcacatcc cgctgttcct ggagagcatc gacgaggacg acgactacta cttcaacctc
      781 agcaagtcca ctcggaagaa gttggcagac aagttcatcc acgcaggtgt caaagtcgtg
      841 ttctcaggcc actaccacag gaatgccggg ggtacctacc agaacctcga catggtggtg
      901 tcatctgcca ttggatgcca gctgggcaga gacccccacg ggctccgagt cgtggtggtc
      961 accgccgaga aaattgttca ccgatactac agtctagatg agctgagtga gaaaggaata
     1021 gaagacgatc tcatggattt gatcaagaaa aaatgacgct ccttcccgtt cccgttcact
     1081 tttcacttgc actatttttt tattttgcca gaaacagcag ctgcacacaa cctcttgctg
     1141 aaatataaaa atagcccagg caggtttgtg aatttatgtc cttttgcata aatcagagag
     1201 ctggggccct gtcctgaatt atattcaaaa tagaactgca tttcctttaa aatggagcga
     1261 atgatcctgg aaatcagttt ttaaaatatt agactatctc tgcatggatg tttgaataaa
     1321 ttctcctaat gctgtgtttc tcaactccac ttttgaattg gattgtattc tggttagcat
     1381 atggtcaaag tctgcctatc gacctcaatt ccaatctgac agccaagtat gatctttgat
     1441 aattccttaa acaaactaca cctgattgta ttaaattgtg gtcacgattc ccaaaacgct
     1501 aggcaaaaca aagttcatct cctttccttt ccagcggaac gaacagctgt ctcccttgtt
     1561 gtgagagcca tgcagactta ttttgacaag gagccaagta ggcaccattt actgttcaat
     1621 tctgagactt ctgatgatag gaacagaatg cagttgatac agctcggagc ttaaatttgc
     1681 cttcctgggt gcctagaaaa gtcacctttg cacataaatt ggccatttct gaaaatctcc
     1741 tccaagagac tgaaaccaaa gctctaaaac gccgcttctt cagtctctgg ggagcacgtt
     1801 gagttggttc acatccacat tctggctgtg tagccactcc acagatgggt ggtctcttgg
     1861 gatcagaatg cccctccact catgagactc ttcattttgt ccactttgac aggaaaagtg
     1921 ggaatgtatg cagagctctc aaaagaaaca aaaaaggcca aaacggtgcc ttcagccaca
     1981 tcctctgaat tggccctgac ttggactaaa tgcactaatg caaaatccct tgacaaaagc
     2041 gcataggtta tttcaaacca gcattgtttt ttatgtaacc tgttttaccg catcttctca
     2101 gcagcttctg accactgctc aattttctcc tttacagcca ttgttctggt ggacaaataa
     2161 cctaggtact ccaaatcctg gcaggaaaaa tatacagcat tatgaaacag cactcagtaa
     2221 tcctaaaatg atttccaaag ctggttacac atgacctgca aagtctatta aattaaaaga
     2281 ctttctcatt acagagttta gtcaacgtag caaaaccatg ggaaattaaa tggaaagata
     2341 attaaatatg taaattcata aggaacaaaa gacgagaagt taattataca ataggctggt
     2401 gacaccagag ttcattgtta tgtgccacaa gaaaattaaa ttttttaaaa aactagaacg
     2461 ctcttctttt agtgttttgc tgaaatcctg ttttgtattt gtttctttac aacaggtgta
     2521 ggtataggag gtcaagaaaa ggagttcggt aaagggcata gctaataaca accacacatt
     2581 gggccaggca cagtggctta cgcctgtaat cccagcactt tgggaggctg agacgggcag
     2641 atcacctgag atcaggagtt tgagaacagc ctggccaaca tggtgaaact ccatctctac
     2701 taaaaataca aaaattagcc aggcatgctg gtgcacacct gtaatcccag ctactcggga
     2761 ggctgaggca ggagatcgct ggaactcagg aggcagaggt tgcagtgagc caagatcatg
     2821 ccactgcact ccagcctggg caacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa
     2881 ccacacacac acacattgag acttgagatg tggtgacact tggatcataa acagagggct
     2941 tcgattccag gatgggggtt cctccagggg gaaatgaaaa ggagctctca ctctgttctt
     3001 acgtatgcac aatgctctga attgtggcac atgggtttgc agaaggataa tggagataat
     3061 tgaaagtaat gaaaatgaaa ccaaatctcc ttccccaaaa acttaaaaga actgattcaa
     3121 aagtacccca agaatatgca aagaaaaggg aatcacatca acagatgatt ggataaagaa
     3181 catgtggtat gtatacataa tggaatacta ttcagccact aaaaagaatg aaaccatgtc
     3241 ttttgcagca acctggatgg aactggaggc tgttatctta agtgaaataa cttagaagta
     3301 gaaagtcgaa tacttcatgt tctcactcat aaatgggagc tacataaagt gtacccatga
     3361 acatagagtg tggaacaaac attggagact cagaagggtg ggaggagggt aagggatgag
     3421 aaagtacctg atgggtacag tgtacacttt tctggtgttg gttgcaggaa aagcctggac
     3481 ttcaccactt cgcaatatat ccgtgtaaca aaactgcact tgtacgcctt atatttatac
     3541 aaatttaatt ttttaaaagg gaagagagaa tcatattaat ttctcaccac tttttaagta
     3601 agcaaacagc agtatttccc agaggcaaga ggttcagcaa gaagtcagga aatgtttttg
     3661 tagataagca tctatcattc tgatgggcca tgactagtgt gttcacttgt aattcctttg
     3721 cctttaaaaa aagagaatga tatcaaaaaa taagtgcctt atactgtgaa aaacgataaa
     3781 aggacttcct gattctaagt gctatggttt tgaatgttta ttatgtgttt taagtgcttt
     3841 ggctcagaaa ggtgggggtc acgtggccaa ggtcgcctaa ctcatcttgg tggagaaaga
     3901 acggatgtag atggcccaag gcttgagtcc atgctccata acactgtcct gtcttggaaa
     3961 acgtttctca gaggtgaaag gttgcaccag ctcagccagt ggcaacacac tgagtacggt
     4021 attcagcacc ttggacagcg ttagctggag gcccagggat ttcctcccag ctctgcaaag
     4081 cctagaccag accctgattg caccaggttc agggggcaga agcttgtcca aagagcagat
     4141 ggttccaggg ggaggatttt tactggggga gatttagaaa ccgaactgaa ccataatgag
     4201 tcacgggaca cagccctgtc tgcagcagta actgtccgca gctctagctg ctccatgtct
     4261 ggagttacca ccacagggtg taggaaacca ccagctgtct caaggcaagg aatgtcacct
     4321 aatgctcccc tttccaatta atcactttaa ttggaggaaa aaacaaaaac acaaggacat
     4381 gttacggggg aaggtttttt aaagtgatct caaattggat tgcaaaggct caagtgactt
     4441 tgggaatggg gctggggaga tgatcattta ctttttacaa taaataattt tatctcacat
     4501 ctttagtcaa gtttctccta agtttgggga gaatggggaa aaaatgtagt aagctttatg
     4561 ggactagcaa cagaacgttt tatcctattt tgtgattttc agtattaaga gattattgat
     4621 cacttgcaga gttacaaggc aagcactagt ttaaatctga attagactag ggccattgac
     4681 cttatatacc tgtaaaagac actacggtgt atacaactgt agaaacaata tacacatagt
     4741 agtttaatat tacagtctgt attccaatgc agaatctttt gagaaaaggt tgccaaaaca
     4801 tcatttgcat ttacttgaac ccttttttag acagaatctt gctctatcac ccaggctgga
     4861 gtgcagtggt gtgatcacag ctcactgcag ccttgaactc ttgggctcaa ccaaccttcc
     4921 cacctcagcc tcccaaatta gctgggacta taggctcgtg tcaccacatc taatttttta
     4981 tttttatatt tgtggagttg aaggtcttgc tctgttaccc aggctggtct tgaactcctg
     5041 gccccaagca gtccttccac cttggcctcc caaagtgttg ggattacagg cgttggccac
     5101 tgtacccagc cttacttgaa ctcttaatac ttattcccaa gtggtaccta aaatggtttt
     5161 gtgcagtcac aatattaggt agcaatatta tattgagctg gaggaaaaag aagatttagg
     5221 agtaaattgc caaggcaagt tctgttaaaa gctttctgta atagacatca gggatttttt
     5281 ttattcaggt aacctcaaca gttttgattg cacatgtaac atagtacttg acaggtaata
     5341 ctgattttta taacttcata aaatattctc aagccatgga ggagctctta tgtatttttt
     5401 aatgagtaca cacacacaca cacacacaca cacacacaca cacatatagt aaaagtggag
     5461 gattcttttc ttggaataat gatttctagc atttatctag aaaagatttt gctgactaaa
     5521 ttttcctttt cctccagtgg atttttaaac atcagtgcat gcacataaat acagattgga
     5581 tttttccttt aggctttatc tatgtaaatg aagtcgatta aatgtgaata atcatgttac
     5641 ccttcattat tctgaccatt atgtttgaga agtagatttc ttcactaaag gggctttgca
     5701 gcacacttag aatgagtgag ccactgtgcc tctctagaaa ctggcttctt gtcatcattt
     5761 caacatccac tcaaacgctc acccctgaaa gtggccttcc tgcttgatat ggtttggctc
     5821 tgtgtctcca cccaaattgg tttggctctg tgtccccact gaaatctcat ctcgaattgt
     5881 aatccccata atccccatgt gtcaagggac ggacctggtg ggaggtaatt ggatcatgga
     5941 ggcagtttct cccatgctat tcttgtgata gtgagttctc atgacactga tggttttgtg
     6001 tttgatagct ccttcacact ctttctttcc tgttgccatg taagacatgc ctgcttcccc
     6061 ttccaccagg attgtaagtt tcctgaggcc tccccagcca tgcggaactg tgagtctatt
     6121 aaatctcttt tctttgtaaa tta
//
