LOCUS       NM_153635               2042 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens copine family member 9 (CPNE9), transcript variant 1,
            mRNA.
ACCESSION   NM_153635
VERSION     NM_153635.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Zhu,P., Qian,T., Si,C., Liu,Y., Cui,L., Huang,W., Fu,L., Deng,C.
            and Zeng,T.
  TITLE     High expression of CPNE5 and CPNE9 predicts positive prognosis in
            multiple myeloma
  JOURNAL   Cancer Biomark 31 (1), 77-85 (2021)
   PUBMED   33780365
  REMARK    GeneRIF: High expression of CPNE5 and CPNE9 predicts positive
            prognosis in multiple myeloma.
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Xie,H., Diber,A., Pollock,S., Nemzer,S., Safer,H., Meloon,B.,
            Olson,A., Hwang,J.J., Endress,G.A., Savitsky,K. and Gill-More,R.
  TITLE     Bridging expressed sequence alignments through targeted cDNA
            sequencing
  JOURNAL   Genomics 83 (4), 572-576 (2004)
   PUBMED   15028280
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM545574.1, BX453546.2, BU101942.1 and CA307982.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153635.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.110338.1,
                                           SRR3476690.899559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383832.8/ ENSP00000373343.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-767               BM545574.1         8-774
            768-1173            BX453546.2         26-431              c
            1174-1783           BU101942.1         1-610               c
            1784-2042           CA307982.1         18-276              c
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..2042
                     /gene="CPNE9"
                     /note="copine family member 9"
                     /db_xref="GeneID:151835"
                     /db_xref="HGNC:HGNC:24336"
     exon            1..232
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1826
                     /gene="CPNE9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     copine-like protein; copine-9; copine IX; copine family
                     member IX"
                     /codon_start=1
                     /product="copine-9 isoform 1"
                     /protein_id="NP_705899.2"
                     /db_xref="CCDS:CCDS2574.2"
                     /db_xref="GeneID:151835"
                     /db_xref="HGNC:HGNC:24336"
                     /translation="MSLGGASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQS
                     RASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDF
                     LGQAFLALGEVIGGQGSRVERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLD
                     KKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRT
                     VKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQFTVYEVLNPRKKCKKKKYVNSGTVT
                     LLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMAL
                     KAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPLNNNDEDPNCAGIEGVLESYFQ
                     SLRTVQLYGPTYFAPVINQVARAAAKISDGSQYYVLLIITDGVISDMTQTKEAIVSAS
                     SLPMSIIIVGVGPAMFEAMEELDGDDVRVSSRGRYAERDIVQFVPFRDYVDRSGNQVL
                     SMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPANPSPIPAPEQP"
     exon            233..273
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            274..320
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            321..424
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            425..461
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            462..464
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            465..541
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            542..605
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            606..709
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            710..814
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            815..856
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            857..932
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            933..986
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1048
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1095
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1277
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1405
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1508
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1566
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1640
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..2042
                     /gene="CPNE9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE9"
                     /note="hexamer: AATAAA"
     polyA_site      2042
                     /gene="CPNE9"
                     /note="major polyA site"
ORIGIN      
        1 actgtcaggg cgcgagcggc tggagcgcac gcagggctgg agcgagtgca gccgccgccg
       61 ccgccgacac cgcggcacat gggccggccc cgccgctgcc gtcgccccta gccccagcag
      121 ccctggtctc gcagcctcct gcggctctgg tcgcccgacc agccatgtct ctcggcggag
      181 cctccgagcg cagcgtcccg gccaccaaga ttgaaattac cgtgtcctgc cggaacctgc
      241 tagaccttga taccttctcc aagtccgacc ccatggtggt gctttacacg cagagccggg
      301 ccagccagga gtggcgggag ttcggacgga ccgaggtgat tgataacacg ctgaacccag
      361 acttcgtgcg caaattcgtc ctcgactatt tctttgagga aaagcaaaat ctgcgcttcg
      421 atgtgtacaa cgtggactcc aaaaccaaca tctccaaacc gaaggatttc ctgggacaag
      481 cgttcctggc cctgggagag gtgattggag gccagggcag ccgagtagag cgaaccctca
      541 cgggtgtacc aggcaagaag tgtgggacca tattgctgac tgcagaagag cttagcaatt
      601 gtcgggacat tgccaccatg cagctgtgtg caaacaagct ggacaagaag gacttctttg
      661 ggaaatcaga ccccttcctt gtgttctaca ggagcaatga ggatggcacg ttcaccatct
      721 gccacaagac agaggttgtg aaaaacacgc tgaatcctgt gtggcagccc ttcagcatcc
      781 ctgtgcgggc tctgtgcaat ggagactatg acagaacggt gaagattgat gtgtacgact
      841 gggaccggga tggaagccac gatttcattg gtgagttcac caccagctac cgggagctga
      901 gcaaggccca gaaccagttc acagtatatg aggttcttaa ccctcggaag aaatgtaaga
      961 agaagaaata tgtcaactca ggaactgtga cgctgctctc cttctctgtg gactctgaat
     1021 tcacttttgt tgattacatc aagggaggga cacagctgaa cttcacagta gccattgact
     1081 tcacggcttc caatgggaat cctctgcagc ctacctccct gcactacatg agtccctacc
     1141 agctcagcgc ctatgccatg gccctcaagg cagtgggaga gatcatccag gactatgaca
     1201 gtgataagct cttcccagct tatggctttg gggccaagct gcccccagag ggacggatct
     1261 cccaccagtt ccccctgaac aacaatgatg aggaccccaa ctgtgcgggc atcgagggtg
     1321 tgctggagag ctatttccag agcctgcgca cagtgcagct ctatgggccc acctactttg
     1381 ctcctgtcat caaccaagtg gccagggctg cagccaagat ctctgatggc tcccagtact
     1441 atgttctgct catcatcact gatggggtca tctctgacat gacgcagacc aaggaggcca
     1501 tcgtcagcgc ctcctcattg cccatgtcta tcattatcgt cggtgtagga ccagccatgt
     1561 ttgaggcaat ggaagagttg gacggtgatg atgtgcgcgt gtcctctagg ggacgctacg
     1621 cagagcggga catcgttcag ttcgtcccat tccgagacta tgttgaccgg tcggggaacc
     1681 aggtgttgag catggcccga ctggccaagg atgtgctggc cgagatcccg gagcagctgc
     1741 tgtcctatat gcgcaccaga gacatccagc ctcggccccc accccctgcc aaccccagcc
     1801 cgatcccagc tccagagcag ccctgaggat tccacatatc caatgcctca cagtctgcaa
     1861 gcctgctcac ccactgcttc tgctttaagc cagaggcacc tggaaccctg gacttcactg
     1921 ggagggccaa cttggaggat cagtgctggc tgacaagccc tccgcctcct tgcctgcaga
     1981 gggcctggca ctatcaccac ctctctgcct tcatgccaat aataaagctg atctttattc
     2041 ca
//
