LOCUS       NM_153634               3431 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens copine 8 (CPNE8), mRNA.
ACCESSION   NM_153634
VERSION     NM_153634.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3431)
  AUTHORS   Zhang,P., Cao,X., Guan,M., Li,D., Xiang,H., Peng,Q., Zhou,Y.,
            Weng,C., Fang,X., Liu,X., Mao,H., Li,Q., Liu,G. and Lu,L.
  TITLE     CPNE8 Promotes Gastric Cancer Metastasis by Modulating Focal
            Adhesion Pathway and Tumor Microenvironment
  JOURNAL   Int J Biol Sci 18 (13), 4932-4949 (2022)
   PUBMED   35982908
  REMARK    GeneRIF: CPNE8 Promotes Gastric Cancer Metastasis by Modulating
            Focal Adhesion Pathway and Tumor Microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3431)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3431)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3431)
  AUTHORS   den Hoed,M., Eijgelsheim,M., Esko,T., Brundel,B.J., Peal,D.S.,
            Evans,D.M., Nolte,I.M., Segre,A.V., Holm,H., Handsaker,R.E.,
            Westra,H.J., Johnson,T., Isaacs,A., Yang,J., Lundby,A., Zhao,J.H.,
            Kim,Y.J., Go,M.J., Almgren,P., Bochud,M., Boucher,G.,
            Cornelis,M.C., Gudbjartsson,D., Hadley,D., van der Harst,P.,
            Hayward,C., den Heijer,M., Igl,W., Jackson,A.U., Kutalik,Z.,
            Luan,J., Kemp,J.P., Kristiansson,K., Ladenvall,C., Lorentzon,M.,
            Montasser,M.E., Njajou,O.T., O'Reilly,P.F., Padmanabhan,S., St
            Pourcain,B., Rankinen,T., Salo,P., Tanaka,T., Timpson,N.J.,
            Vitart,V., Waite,L., Wheeler,W., Zhang,W., Draisma,H.H.,
            Feitosa,M.F., Kerr,K.F., Lind,P.A., Mihailov,E., Onland-Moret,N.C.,
            Song,C., Weedon,M.N., Xie,W., Yengo,L., Absher,D., Albert,C.M.,
            Alonso,A., Arking,D.E., de Bakker,P.I., Balkau,B., Barlassina,C.,
            Benaglio,P., Bis,J.C., Bouatia-Naji,N., Brage,S., Chanock,S.J.,
            Chines,P.S., Chung,M., Darbar,D., Dina,C., Dorr,M., Elliott,P.,
            Felix,S.B., Fischer,K., Fuchsberger,C., de Geus,E.J., Goyette,P.,
            Gudnason,V., Harris,T.B., Hartikainen,A.L., Havulinna,A.S.,
            Heckbert,S.R., Hicks,A.A., Hofman,A., Holewijn,S.,
            Hoogstra-Berends,F., Hottenga,J.J., Jensen,M.K., Johansson,A.,
            Junttila,J., Kaab,S., Kanon,B., Ketkar,S., Khaw,K.T., Knowles,J.W.,
            Kooner,A.S., Kors,J.A., Kumari,M., Milani,L., Laiho,P.,
            Lakatta,E.G., Langenberg,C., Leusink,M., Liu,Y., Luben,R.N.,
            Lunetta,K.L., Lynch,S.N., Markus,M.R., Marques-Vidal,P., Mateo
            Leach,I., McArdle,W.L., McCarroll,S.A., Medland,S.E., Miller,K.A.,
            Montgomery,G.W., Morrison,A.C., Muller-Nurasyid,M., Navarro,P.,
            Nelis,M., O'Connell,J.R., O'Donnell,C.J., Ong,K.K., Newman,A.B.,
            Peters,A., Polasek,O., Pouta,A., Pramstaller,P.P., Psaty,B.M.,
            Rao,D.C., Ring,S.M., Rossin,E.J., Rudan,D., Sanna,S., Scott,R.A.,
            Sehmi,J.S., Sharp,S., Shin,J.T., Singleton,A.B., Smith,A.V.,
            Soranzo,N., Spector,T.D., Stewart,C., Stringham,H.M., Tarasov,K.V.,
            Uitterlinden,A.G., Vandenput,L., Hwang,S.J., Whitfield,J.B.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilson,J.F., Witteman,J.C.,
            Wong,A., Wong,Q., Jamshidi,Y., Zitting,P., Boer,J.M., Boomsma,D.I.,
            Borecki,I.B., van Duijn,C.M., Ekelund,U., Forouhi,N.G., Froguel,P.,
            Hingorani,A., Ingelsson,E., Kivimaki,M., Kronmal,R.A., Kuh,D.,
            Lind,L., Martin,N.G., Oostra,B.A., Pedersen,N.L., Quertermous,T.,
            Rotter,J.I., van der Schouw,Y.T., Verschuren,W.M., Walker,M.,
            Albanes,D., Arnar,D.O., Assimes,T.L., Bandinelli,S., Boehnke,M., de
            Boer,R.A., Bouchard,C., Caulfield,W.L., Chambers,J.C., Curhan,G.,
            Cusi,D., Eriksson,J., Ferrucci,L., van Gilst,W.H., Glorioso,N., de
            Graaf,J., Groop,L., Gyllensten,U., Hsueh,W.C., Hu,F.B.,
            Huikuri,H.V., Hunter,D.J., Iribarren,C., Isomaa,B., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kiemeney,L.A., van der Klauw,M.M.,
            Kooner,J.S., Kraft,P., Iacoviello,L., Lehtimaki,T., Lokki,M.L.,
            Mitchell,B.D., Navis,G., Nieminen,M.S., Ohlsson,C., Poulter,N.R.,
            Qi,L., Raitakari,O.T., Rimm,E.B., Rioux,J.D., Rizzi,F., Rudan,I.,
            Salomaa,V., Sever,P.S., Shields,D.C., Shuldiner,A.R., Sinisalo,J.,
            Stanton,A.V., Stolk,R.P., Strachan,D.P., Tardif,J.C.,
            Thorsteinsdottir,U., Tuomilehto,J., van Veldhuisen,D.J.,
            Virtamo,J., Viikari,J., Vollenweider,P., Waeber,G., Widen,E.,
            Cho,Y.S., Olsen,J.V., Visscher,P.M., Willer,C., Franke,L.,
            Erdmann,J., Thompson,J.R., Pfeufer,A., Sotoodehnia,N.,
            Newton-Cheh,C., Ellinor,P.T., Stricker,B.H., Metspalu,A.,
            Perola,M., Beckmann,J.S., Smith,G.D., Stefansson,K., Wareham,N.J.,
            Munroe,P.B., Sibon,O.C., Milan,D.J., Snieder,H., Samani,N.J. and
            Loos,R.J.
  CONSRTM   Global BPgen Consortium; CARDIoGRAM Consortium; PR GWAS Consortium;
            QRS GWAS Consortium; QT-IGC Consortium; CHARGE-AF Consortium
  TITLE     Identification of heart rate-associated loci and their effects on
            cardiac conduction and rhythm disorders
  JOURNAL   Nat Genet 45 (6), 621-631 (2013)
   PUBMED   23583979
REFERENCE   5  (bases 1 to 3431)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   6  (bases 1 to 3431)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   7  (bases 1 to 3431)
  AUTHORS   Ramsey,H., Zhang,D.E., Richkind,K., Burcoglu-O'Ral,A. and Hromas,R.
  TITLE     Fusion of AML1/Runx1 to copine VIII, a novel member of the copine
            family, in an aggressive acute myelogenous leukemia with t(12;21)
            translocation
  JOURNAL   Leukemia 17 (8), 1665-1666 (2003)
   PUBMED   12886257
REFERENCE   8  (bases 1 to 3431)
  AUTHORS   Maitra,R., Grigoryev,D.N., Bera,T.K., Pastan,I.H. and Lee,B.
  TITLE     Cloning, molecular characterization, and expression analysis of
            Copine 8
  JOURNAL   Biochem Biophys Res Commun 303 (3), 842-847 (2003)
   PUBMED   12670487
REFERENCE   9  (bases 1 to 3431)
  AUTHORS   Tomsig,J.L. and Creutz,C.E.
  TITLE     Biochemical characterization of copine: a ubiquitous
            Ca2+-dependent, phospholipid-binding protein
  JOURNAL   Biochemistry 39 (51), 16163-16175 (2000)
   PUBMED   11123945
REFERENCE   10 (bases 1 to 3431)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX538055.1, BC046366.1,
            AK094998.1 and R51494.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153634.2.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene is one of several genes that encode a
            calcium-dependent protein containing two N-terminal type II C2
            domains and an integrin A domain-like sequence in the C-terminus.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307908.1, BX538055.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331366.10/ ENSP00000329748.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1042              BX538055.1         42-1083
            1043-2015           BC046366.1         387-1359
            2016-3276           AK094998.1         1629-2889
            3277-3357           BX538055.1         3329-3409
            3358-3431           R51494.1           22-95               c
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3431
                     /gene="CPNE8"
                     /note="copine 8"
                     /db_xref="GeneID:144402"
                     /db_xref="HGNC:HGNC:23498"
     exon            1..155
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1752
                     /gene="CPNE8"
                     /note="copine VIII"
                     /codon_start=1
                     /product="copine-8"
                     /protein_id="NP_705898.1"
                     /db_xref="CCDS:CCDS8733.1"
                     /db_xref="GeneID:144402"
                     /db_xref="HGNC:HGNC:23498"
                     /translation="MDSRYNSTAGIGDLNQLSAAIPATRVEVSVSCRNLLDRDTFSKS
                     DPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRKFILDYFFEERENLRFDLYDVDS
                     KSPNLSKHDFLGQVFCTLGEIVGSQGSRLEKPIVGIPGKKCGTIILTAEELNCCRDAV
                     LMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHKTEVVKNTLNPVWQAFKISVR
                     ALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRGQSQFNVYEVVNPKKKGKK
                     KKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTASNGNPAQPTSLHYMNP
                     YQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHEFALNGNPQNPYCDG
                     IEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVKDGSQYFVLLIVTDGVISDMA
                     QTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSRGKYAERDIVQFVPFRD
                     YIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPYTPPTHVLQTQI"
     exon            156..196
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            197..243
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            244..347
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            348..387
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            388..464
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            465..528
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            529..632
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            633..737
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            738..779
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            780..855
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            856..909
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            910..971
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1018
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1200
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1328
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1431
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1489
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1563
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..3431
                     /gene="CPNE8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3256..3261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE8"
                     /note="hexamer: ATTAAA"
     polyA_site      3276
                     /gene="CPNE8"
                     /note="major polyA site"
     regulatory      3412..3417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE8"
                     /note="hexamer: AATAAA"
     polyA_site      3431
                     /gene="CPNE8"
ORIGIN      
        1 agtccgcccg agctgtggtt gtgggcgccg gacaagtcca aggcgcctcc tcccaatatg
       61 gacagccgct acaacagcac tgcgggcatc ggggacttga accagctgag cgctgccatc
      121 ccggccacgc gggtggaggt gtccgtgtcc tgcagaaatc ttcttgacag agacacattt
      181 tctaaatctg atccaatttg tgtcttatat gtacaaggag ttggaaataa agaatggaga
      241 gagtttggaa gaactgaagt aattgataat actttaaatc ctgattttgt aagaaagttt
      301 attctggact acttttttga agaaagagag aatcttcgtt ttgacttgta tgatgttgat
      361 tcaaagagcc ccaacttatc caaacatgac tttctgggac aagtgttttg tacattggga
      421 gagatcgttg gttcacaggg aagtcgcctg gaaaaaccaa tagtaggaat tccagggaag
      481 aaatgtggta caatcatact tacagcagag gaattaaact gttgcaggga tgccgttttg
      541 atgcaatttt gtgcgaacaa attggacaag aaggacttct ttggaaaatc agatcctttc
      601 cttgtatttt atcgaagtaa tgaagatggc agttttacaa tttgtcacaa gacagaagtt
      661 gtcaaaaaca ctctaaatcc agtatggcaa gcattcaaga tctcagtcag agcattatgt
      721 aatggagact atgacagaac aatcaaagta gaggtgtatg actgggaccg agatggaagt
      781 catgatttca ttggagaatt tacaacaagc tatagggaac tttctagagg gcagtcacaa
      841 ttcaacgtat atgaggtggt gaatcccaaa aagaaaggaa aaaagaaaaa atatactaat
      901 tctggaacag taactttact ctctttcttg gtagaaacag aagtttcatt ccttgactac
      961 attaagggag ggacgcaaat caatttcaca gtggctattg attttacagc atcaaacggc
     1021 aaccctgctc agcccacttc cctccactac atgaatcctt accaactgaa tgcctatggt
     1081 atggcactaa aagcagtggg agaaattgtt caagattatg acagtgataa aatgtttcca
     1141 gctctaggat ttggtgcaaa actgcctcca gatggaagga tatctcacga atttgctttg
     1201 aatgggaatc ctcaaaaccc ctactgtgat ggcattgagg gggtcatgga ggcttattac
     1261 aggagtctga aatctgtaca actatatggg cccaccaact ttgctcctgt aattaatcat
     1321 gtagcaagat atgcttcttc tgtaaaggat ggctcccagt attttgtgct tctgattgtt
     1381 acagatggtg ttatctcaga tatggcccag actaaggagt ccatagttaa tgcctcaaaa
     1441 cttccaatgt caataattat agtaggtgtt ggaccagcag aatttgatgc aatggtcgaa
     1501 ttggatggag atgatgtaag agtctcctct agaggaaaat atgctgaaag agacattgtg
     1561 cagtttgtgc cattcaggga ttatattgac agaagtggaa accacatact gagcatggct
     1621 agattggcta aagatgtcct agctgagatc cctgagcagt ttctctccta tatgagagcc
     1681 cgaggaatca agccatcacc tgcgcctccc ccatacaccc cacctacaca tgtgttacag
     1741 actcaaatat gactgtgctc tgaaatgcta atgtcaacta caaatcaaaa gtgctgagtt
     1801 aatgctttgt gcctggtgct ctgtaatgaa ccaggcaatg agatagtttt ctcagtttgg
     1861 tttcagcagt taatgtgctt tcttggatcc aaatttaaat atcttcctaa accaaaactg
     1921 taaatatggt tgttgcatga gcaacagaaa aaattgttta aatgcttgaa gcaaagtatg
     1981 gatgtcttct ctaaatcttt ctttcttttt ttttttaaca gaaacagcta atttccaatg
     2041 tattgttggg aaaaagcaca aactgtgttt ttaactcaaa tattgtcttc gactgctatg
     2101 tgtataggaa agcagtctct gtatcaatgt ttacatgtta ctacttttta aatttcaata
     2161 cttttataac tgttcttaaa aataagagtt ttaaatactg aatcctttgt cttctaaatt
     2221 gcaatagcta taatcacaag agcaatatct ctttgaatga ctgtctggac aaacacaatt
     2281 gcaaataagg gaagggaaaa atgcttttct atttttcagt aactggattg tcttaagaaa
     2341 ctacatctgc ttaataaaca atttctcagc aatgtttgct gggtatggga gtttaagccc
     2401 ggcagatgtg tctcctggtt gaacatgcat ttttcatgga gtttgggttc taaatttaga
     2461 ctgcagttgg tttgtatttt gtaacactaa gtagaaatta taaaaagtca aacattgtga
     2521 tctataaatg cacagaaaat actttgtaaa aagtagcatc cttatataat aatgctattt
     2581 agaaagactg aaaccaagac tatttaactg tgaactatgt agcagatgtt ttaaactttt
     2641 tattccatta tatcttgtct agatatttta attcaaaggg atactggctc tcttgatcgg
     2701 aatttcttgt tatcaccatt ccacgttgcc acacaaggtg cacaggctgg aagtcttttg
     2761 tgaaattccc agttaaatat atacaactat gtgacttagt gcacaacaca tttgtgaaat
     2821 aacctactcc tatatactga cctgcctgtc cacgaataat tgtaaagggt ttttgcatgt
     2881 acagttttta caagaattac agttttgtga agttgtgtct aaattaaagc atttctttag
     2941 aacaaatggc cttaaattct cacggaattc ctggaaatga ttgtgaattg ccttcaaata
     3001 atagaaaagt gtatttattt gtgtgtgtgt gtgtgtcaaa aatgtaactg ctttataata
     3061 ttttttcctt acctatatat tctatttaat acttggttta tttctactgt acattgtttt
     3121 ctttgtccca agttgaccta gggtgacttt tataagcatg aaactatttt actggaaaga
     3181 aaaatatata catccacata tctaacagta tcaatgttat ataactatgt aataattgtt
     3241 gatttttaat tatgtattaa aatctttaaa tcataactat ttgctttgta cgtttcatgt
     3301 atgaatgaca atagtttgat gatttccttt actgatctta aatatttatg ccactacagt
     3361 gtattaccta cagattttta aatttagctt tatttatcaa cccaaaaaac aaataaataa
     3421 gatcaatatt c
//
