LOCUS       NM_153636               2442 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens copine 7 (CPNE7), transcript variant 1, mRNA.
ACCESSION   NM_153636 XM_001134342 XM_001134343
VERSION     NM_153636.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Xu,W., Tang,Y., Yang,Y., Wang,C., Liu,C., Zhang,J., Zhao,L. and
            Wang,G.
  TITLE     Depletion of CPNE7 sensitizes colorectal cancer to 5-fluorouracil
            by downregulating ATG9B expression
  JOURNAL   J Cell Mol Med 28 (8), e18261 (2024)
   PUBMED   38526029
  REMARK    GeneRIF: Depletion of CPNE7 sensitizes colorectal cancer to
            5-fluorouracil by downregulating ATG9B expression.
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Kong,H.J., Kang,D.H., Ahn,T.S., Kim,K.S., Kim,T.W., Lee,S.H.,
            Lee,D.W., Ryu,J.S. and Beak,M.J.
  TITLE     The Role of CPNE7 (Copine-7) in Colorectal Cancer Prognosis and
            Metastasis
  JOURNAL   Int J Mol Sci 24 (23), 16704 (2023)
   PUBMED   38069026
  REMARK    GeneRIF: The Role of CPNE7 (Copine-7) in Colorectal Cancer
            Prognosis and Metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Oh,H.J., Choung,H.W., Lee,H.K., Park,S.J., Lee,J.H., Lee,D.S.,
            Seo,B.M. and Park,J.C.
  TITLE     CPNE7, a preameloblast-derived factor, regulates odontoblastic
            differentiation of mesenchymal stem cells
  JOURNAL   Biomaterials 37, 208-217 (2015)
   PUBMED   25453951
  REMARK    GeneRIF: These results suggest Cpne7 is a diffusible signaling
            molecule that is secreted by preameloblasts, and regulates the
            differentiation of mesenchymal cells of dental or non-dental origin
            into odontoblasts.
REFERENCE   5  (bases 1 to 2442)
  AUTHORS   Perestenko,P.V., Pooler,A.M., Noorbakhshnia,M., Gray,A., Bauccio,C.
            and Jeffrey McIlhinney,R.A.
  TITLE     Copines-1, -2, -3, -6 and -7 show different calcium-dependent
            intracellular membrane translocation and targeting
  JOURNAL   FEBS J 277 (24), 5174-5189 (2010)
   PUBMED   21087455
REFERENCE   6  (bases 1 to 2442)
  AUTHORS   Savino,M., d'Apolito,M., Centra,M., van Beerendonk,H.M.,
            Cleton-Jansen,A.M., Whitmore,S.A., Crawford,J., Callen,D.F.,
            Zelante,L. and Savoia,A.
  TITLE     Characterization of copine VII, a new member of the copine family,
            and its exclusion as a candidate in sporadic breast cancers with
            loss of heterozygosity at 16q24.3
  JOURNAL   Genomics 61 (2), 219-226 (1999)
   PUBMED   10534407
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092123.4, AL539371.3,
            BC064577.1, AJ133798.1 and BU739859.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153636.2.
            
            Summary: This gene encodes a member of the copine family, which is
            composed of calcium-dependent membrane-binding proteins. The gene
            product contains two N-terminal C2 domains and one von Willebrand
            factor A domain. The encoded protein may be involved in membrane
            trafficking. Two alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            segment compared to variant 2. The resulting isoform (a) has the
            same N- and C-termini but is shorter compared to isoform b.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064577.1, BC035334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319518.13/ ENSP00000317374.8
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC092123.4         9974-9983           c
            11-33               AL539371.3         2-24
            34-1777             BC064577.1         1-1744
            1778-2440           AJ133798.1         1992-2654
            2441-2442           BU739859.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..2442
                     /gene="CPNE7"
                     /note="copine 7"
                     /db_xref="GeneID:27132"
                     /db_xref="HGNC:HGNC:2320"
                     /db_xref="MIM:605689"
     exon            1..314
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1817
                     /gene="CPNE7"
                     /note="isoform a is encoded by transcript variant 1;
                     copine VII"
                     /codon_start=1
                     /product="copine-7 isoform a"
                     /protein_id="NP_705900.1"
                     /db_xref="CCDS:CCDS10981.1"
                     /db_xref="GeneID:27132"
                     /db_xref="HGNC:HGNC:2320"
                     /db_xref="MIM:605689"
                     /translation="MSAGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDP
                     SVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGF
                     SCQEDDFLGGMECTLGQIVAQKKVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELS
                     FRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLC
                     SCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRS
                     YKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTASNGDPRNSCSLHYINPYQ
                     PNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSHDFAINFNPEDDECEGIQ
                     GVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKASQYYILLILTDGVVTDM
                     ADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSPRGEPALRDIVQFVPF
                     RELKNASPAALAKCVLAEVPKQVVEYYSHRGLPPRSLGVPAGEASPGCTP"
     exon            315..497
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            498..572
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            573..647
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            648..731
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            732..821
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            822..920
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1007
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1067
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1201
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1256
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1308
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1442
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1679
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..2442
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2418..2423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE7"
                     /note="hexamer: AATAAA"
     polyA_site      2442
                     /gene="CPNE7"
                     /note="major polyA site"
ORIGIN      
        1 acgtgcgccc gcgcccggca ggcgttcagg gaagcgcggc cacgcctggg ccggccacca
       61 tttcccgggc gccgcggcgg cgccgactcg cgggcagcgg cccctcagtg cgcccagccg
      121 ggcccccgaa cgccgggagc atgagcgcgg gctcggagcg cggggcggcg gcaacccccg
      181 ggggtttgcc cgcgccctgc gcctcgaagg tggagctgcg gctcagctgc cggcacctgc
      241 tggaccgcga cccgctcacc aagtccgacc ccagcgtggc gttgctgcag caggcgcagg
      301 gccagtgggt gcaggtgggc agaaccgagg tggtccggag cagcctgcat cccgtgttct
      361 ccaaggtctt cacggtggac tactacttcg aggaggtgca gaggctgcgc tttgaggtgt
      421 acgacacgca tgggcccagc ggcttcagct gtcaggagga cgatttcctg gggggcatgg
      481 agtgcaccct ggggcagatt gtggcccaga agaaggtgac ccgcccgctg ctgctcaagt
      541 ttggcaggaa cgctggcaag tccaccatca cggtgatcgc cgaggacatc tcggggaaca
      601 acggctacgt ggagctctcc ttccgggcca ggaagctgga cgacaaggac ctcttcagca
      661 agtccgaccc cttcctggag ctctacaggg tcaacgacga ccagggcttg cagctggtgt
      721 acaggacgga ggtggtgaag aacaacctga acccggtgtg ggaggccttc aaagtctctc
      781 tgagttccct ctgcagctgc gaggagacaa ggcctctaaa gtgcctggtc tgggattacg
      841 actctcgagg aaagcacgac ttcatcggag aattctctac caccttcgag gagatgcaga
      901 aggcctttga ggaggggcag gcccagtggg actgtgtgaa ccccaaatac aagcagaaga
      961 gacgcagtta taagaactca ggagtggtcg tcctggctga cctcaagttc cacagggtgt
     1021 actccttcct ggactatatc atgggcggct gccagatcca cttcaccgtg gccattgact
     1081 tcaccgcctc caatggagac ccgcggaaca gctgctccct gcactacatc aacccctacc
     1141 agccgaacga gtacctgaag gcactggtgt ccgtgggcga gatctgccag gactatgaca
     1201 gtgacaagag gttttccgct ttggggtttg gagcccggat ccctcccaag tatgaggtgt
     1261 cccatgactt tgccatcaat ttcaaccctg aggacgatga gtgtgaaggc atccagggcg
     1321 tggtggaggc ctaccagaac tgcctgccca gggtccagct ctacggcccc accaacgtgg
     1381 cgcccatcat ctccaaggtg gcacgcgtgg cggcggccga ggagagcacc gggaaagcct
     1441 ctcaatacta catcctgctg atcctgacgg acggcgtggt gaccgacatg gccgacacac
     1501 gggaggccat tgtgcgtgcc tcacgcctgc ccatgtccat catcatcgtg ggcgtgggca
     1561 acgccgactt caccgacatg caggtcctgg acggcgacga cggcgtcctg cgctccccac
     1621 ggggtgagcc cgcgctccgg gacatcgtac agttcgtgcc cttccgggag ctcaagaacg
     1681 catcccctgc ggcgctggcc aagtgcgtgc tggccgaggt cccgaagcag gtggtggagt
     1741 actacagcca cagaggcctg cccccgagaa gcctgggtgt ccctgccgga gaggccagcc
     1801 caggctgcac accgtgaaga tgtggagggc gtagggtggg ggcagtgagg aatgggtccg
     1861 tacagcctct gtctgcaaca tgcttggggt cccttaagct ccctccgacc tcccagaagc
     1921 ctccagtccc caccaggccc cactcccagt cctcctggga tcctgctggc ttgggcccgg
     1981 ctctggggcc cccaaggccg aagggtgaca aaatacaggc ccccatgcct ggccctgcct
     2041 gagccaggtg ggtggaggga gggagatcat gagggacttg gagggagctg ggagttcatc
     2101 cacgggagac cctgccccga tgagaagggg cagggactgg gggctctgct ttgcgtctaa
     2161 cctttgtggg ggagggccag caaggcagtc cccccacgcc cgagaaagcc tgggggaccc
     2221 agacacctgt ccccacagtc aaagcctggg gacccagaca tcctgtcccc acagtcagcc
     2281 tcctgtccct gctggtgccc ccacacccac ctaccctgtg ctttttgccg tcgggcctct
     2341 gcacctgggt ccatggggtc tgcggggtct gcggggtctg cctggcctgt gggttctgcc
     2401 ggtggggctt caggagtaat aaagtgtcac cctatccttg ta
//
