LOCUS       NM_014427               2667 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens copine 7 (CPNE7), transcript variant 2, mRNA.
ACCESSION   NM_014427 XM_942720 XM_946337 XM_946338
VERSION     NM_014427.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Xu,W., Tang,Y., Yang,Y., Wang,C., Liu,C., Zhang,J., Zhao,L. and
            Wang,G.
  TITLE     Depletion of CPNE7 sensitizes colorectal cancer to 5-fluorouracil
            by downregulating ATG9B expression
  JOURNAL   J Cell Mol Med 28 (8), e18261 (2024)
   PUBMED   38526029
  REMARK    GeneRIF: Depletion of CPNE7 sensitizes colorectal cancer to
            5-fluorouracil by downregulating ATG9B expression.
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Kong,H.J., Kang,D.H., Ahn,T.S., Kim,K.S., Kim,T.W., Lee,S.H.,
            Lee,D.W., Ryu,J.S. and Beak,M.J.
  TITLE     The Role of CPNE7 (Copine-7) in Colorectal Cancer Prognosis and
            Metastasis
  JOURNAL   Int J Mol Sci 24 (23), 16704 (2023)
   PUBMED   38069026
  REMARK    GeneRIF: The Role of CPNE7 (Copine-7) in Colorectal Cancer
            Prognosis and Metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Oh,H.J., Choung,H.W., Lee,H.K., Park,S.J., Lee,J.H., Lee,D.S.,
            Seo,B.M. and Park,J.C.
  TITLE     CPNE7, a preameloblast-derived factor, regulates odontoblastic
            differentiation of mesenchymal stem cells
  JOURNAL   Biomaterials 37, 208-217 (2015)
   PUBMED   25453951
  REMARK    GeneRIF: These results suggest Cpne7 is a diffusible signaling
            molecule that is secreted by preameloblasts, and regulates the
            differentiation of mesenchymal cells of dental or non-dental origin
            into odontoblasts.
REFERENCE   5  (bases 1 to 2667)
  AUTHORS   Perestenko,P.V., Pooler,A.M., Noorbakhshnia,M., Gray,A., Bauccio,C.
            and Jeffrey McIlhinney,R.A.
  TITLE     Copines-1, -2, -3, -6 and -7 show different calcium-dependent
            intracellular membrane translocation and targeting
  JOURNAL   FEBS J 277 (24), 5174-5189 (2010)
   PUBMED   21087455
REFERENCE   6  (bases 1 to 2667)
  AUTHORS   Savino,M., d'Apolito,M., Centra,M., van Beerendonk,H.M.,
            Cleton-Jansen,A.M., Whitmore,S.A., Crawford,J., Callen,D.F.,
            Zelante,L. and Savoia,A.
  TITLE     Characterization of copine VII, a new member of the copine family,
            and its exclusion as a candidate in sporadic breast cancers with
            loss of heterozygosity at 16q24.3
  JOURNAL   Genomics 61 (2), 219-226 (1999)
   PUBMED   10534407
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092123.4, AL539371.3,
            AJ133798.1 and BU739859.1.
            
            On May 31, 2019 this sequence version replaced NM_014427.4.
            
            Summary: This gene encodes a member of the copine family, which is
            composed of calcium-dependent membrane-binding proteins. The gene
            product contains two N-terminal C2 domains and one von Willebrand
            factor A domain. The encoded protein may be involved in membrane
            trafficking. Two alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ133798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC092123.4         9974-9983           c
            11-84               AL539371.3         2-75
            85-2665             AJ133798.1         74-2654
            2666-2667           BU739859.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..2667
                     /gene="CPNE7"
                     /note="copine 7"
                     /db_xref="GeneID:27132"
                     /db_xref="HGNC:HGNC:2320"
                     /db_xref="MIM:605689"
     exon            1..314
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2042
                     /gene="CPNE7"
                     /note="isoform b is encoded by transcript variant 2;
                     copine VII"
                     /codon_start=1
                     /product="copine-7 isoform b"
                     /protein_id="NP_055242.1"
                     /db_xref="CCDS:CCDS10980.1"
                     /db_xref="GeneID:27132"
                     /db_xref="HGNC:HGNC:2320"
                     /db_xref="MIM:605689"
                     /translation="MSAGSERGAAATPGGLPAPCASKVELRLSCRHLLDRDPLTKSDP
                     SVALLQQAQGQWVQVGRTEVVRSSLHPVFSKVFTVDYYFEEVQRLRFEVYDTHGPSGF
                     SCQEDDFLGGMECTLGQPAQKWLLQVVMRVSVDVLGPAGHCAKHFLCCTESSHLARTG
                     PSFLLRYDDLCLPWATAGAVRWWTCRGGHTQGWQIVAQKKVTRPLLLKFGRNAGKSTI
                     TVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRTEVVKN
                     NLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAFEEG
                     QAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTAS
                     NGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSH
                     DFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKA
                     SQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLR
                     SPRGEPALRDIVQFVPFRELKNASPAALAKCVLAEVPKQVVEYYSHRGLPPRSLGVPA
                     GEASPGCTP"
     exon            315..497
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            498..637
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            638..722
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            723..797
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            798..872
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            873..956
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1046
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1145
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1232
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1292
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1426
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1481
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1533
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1667
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1904
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2667
                     /gene="CPNE7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2643..2648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE7"
                     /note="hexamer: AATAAA"
     polyA_site      2667
                     /gene="CPNE7"
                     /note="major polyA site"
ORIGIN      
        1 acgtgcgccc gcgcccggca ggcgttcagg gaagcgcggc cacgcctggg ccggccacca
       61 tttcccgggc gccgcggcgg cgccgactcg cgggcagcgg cccctcagtg cgcccagccg
      121 ggcccccgaa cgccgggagc atgagcgcgg gctcggagcg cggggcggcg gcaacccccg
      181 ggggtttgcc cgcgccctgc gcctcgaagg tggagctgcg gctcagctgc cggcacctgc
      241 tggaccgcga cccgctcacc aagtccgacc ccagcgtggc gttgctgcag caggcgcagg
      301 gccagtgggt gcaggtgggc agaaccgagg tggtccggag cagcctgcat cccgtgttct
      361 ccaaggtctt cacggtggac tactacttcg aggaggtgca gaggctgcgc tttgaggtgt
      421 acgacacgca tgggcccagc ggcttcagct gtcaggagga cgatttcctg gggggcatgg
      481 agtgcaccct ggggcagcca gcccaaaagt ggcttctgca agtcgtgatg agagtgtctg
      541 ttgatgtgct gggccctgct ggacactgcg ctaagcactt cctgtgctgc acggaatcct
      601 cacaccttgc caggacgggt ccttcttttt tattgaggta tgatgacctc tgcctcccct
      661 gggcgactgc tggcgccgtg aggtggtgga cgtgcagggg tggccacacg cagggatggc
      721 agattgtggc ccagaagaag gtgacccgcc cgctgctgct caagtttggc aggaacgctg
      781 gcaagtccac catcacggtg atcgccgagg acatctcggg gaacaacggc tacgtggagc
      841 tctccttccg ggccaggaag ctggacgaca aggacctctt cagcaagtcc gaccccttcc
      901 tggagctcta cagggtcaac gacgaccagg gcttgcagct ggtgtacagg acggaggtgg
      961 tgaagaacaa cctgaacccg gtgtgggagg ccttcaaagt ctctctgagt tccctctgca
     1021 gctgcgagga gacaaggcct ctaaagtgcc tggtctggga ttacgactct cgaggaaagc
     1081 acgacttcat cggagaattc tctaccacct tcgaggagat gcagaaggcc tttgaggagg
     1141 ggcaggccca gtgggactgt gtgaacccca aatacaagca gaagagacgc agttataaga
     1201 actcaggagt ggtcgtcctg gctgacctca agttccacag ggtgtactcc ttcctggact
     1261 atatcatggg cggctgccag atccacttca ccgtggccat tgacttcacc gcctccaatg
     1321 gagacccgcg gaacagctgc tccctgcact acatcaaccc ctaccagccg aacgagtacc
     1381 tgaaggcact ggtgtccgtg ggcgagatct gccaggacta tgacagtgac aagaggtttt
     1441 ccgctttggg gtttggagcc cggatccctc ccaagtatga ggtgtcccat gactttgcca
     1501 tcaatttcaa ccctgaggac gatgagtgtg aaggcatcca gggcgtggtg gaggcctacc
     1561 agaactgcct gcccagggtc cagctctacg gccccaccaa cgtggcgccc atcatctcca
     1621 aggtggcacg cgtggcggcg gccgaggaga gcaccgggaa agcctctcaa tactacatcc
     1681 tgctgatcct gacggacggc gtggtgaccg acatggccga cacacgggag gccattgtgc
     1741 gtgcctcacg cctgcccatg tccatcatca tcgtgggcgt gggcaacgcc gacttcaccg
     1801 acatgcaggt cctggacggc gacgacggcg tcctgcgctc cccacggggt gagcccgcgc
     1861 tccgggacat cgtacagttc gtgcccttcc gggagctcaa gaacgcatcc cctgcggcgc
     1921 tggccaagtg cgtgctggcc gaggtcccga agcaggtggt ggagtactac agccacagag
     1981 gcctgccccc gagaagcctg ggtgtccctg ccggagaggc cagcccaggc tgcacaccgt
     2041 gaagatgtgg agggcgtagg gtgggggcag tgaggaatgg gtccgtacag cctctgtctg
     2101 caacatgctt ggggtccctt aagctccctc cgacctccca gaagcctcca gtccccacca
     2161 ggccccactc ccagtcctcc tgggatcctg ctggcttggg cccggctctg gggcccccaa
     2221 ggccgaaggg tgacaaaata caggccccca tgcctggccc tgcctgagcc aggtgggtgg
     2281 agggagggag atcatgaggg acttggaggg agctgggagt tcatccacgg gagaccctgc
     2341 cccgatgaga aggggcaggg actgggggct ctgctttgcg tctaaccttt gtgggggagg
     2401 gccagcaagg cagtcccccc acgcccgaga aagcctgggg gacccagaca cctgtcccca
     2461 cagtcaaagc ctggggaccc agacatcctg tccccacagt cagcctcctg tccctgctgg
     2521 tgcccccaca cccacctacc ctgtgctttt tgccgtcggg cctctgcacc tgggtccatg
     2581 gggtctgcgg ggtctgcggg gtctgcctgg cctgtgggtt ctgccggtgg ggcttcagga
     2641 gtaataaagt gtcaccctat ccttgta
//
