LOCUS       NM_020939               3342 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens copine 5 (CPNE5), transcript variant 1, mRNA.
ACCESSION   NM_020939
VERSION     NM_020939.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3342)
  AUTHORS   Zhu,P., Qian,T., Si,C., Liu,Y., Cui,L., Huang,W., Fu,L., Deng,C.
            and Zeng,T.
  TITLE     High expression of CPNE5 and CPNE9 predicts positive prognosis in
            multiple myeloma
  JOURNAL   Cancer Biomark 31 (1), 77-85 (2021)
   PUBMED   33780365
  REMARK    GeneRIF: High expression of CPNE5 and CPNE9 predicts positive
            prognosis in multiple myeloma.
REFERENCE   2  (bases 1 to 3342)
  AUTHORS   Umeda,S., Kanda,M., Koike,M., Tanaka,H., Miwa,T., Tanaka,C.,
            Kobayashi,D., Suenaga,M., Hayashi,M., Yamada,S., Nakayama,G. and
            Kodera,Y.
  TITLE     Copine 5 expression predicts prognosis following curative resection
            of esophageal squamous cell carcinoma
  JOURNAL   Oncol Rep 40 (6), 3772-3780 (2018)
   PUBMED   30272363
  REMARK    GeneRIF: Data revealed that CPNE5 mRNA expression was significantly
            lower in ESCC tissues and cell lines and correlated with
            significantly shorter overall survival. Multivariable analysis
            identified low CPNE5 expression to be an independent prognostic
            factor of OS. Analysis of recurrence patterns revealed that
            significantly more patients with local recurrence expressed lower
            levels of CPNE5 mRNA.
REFERENCE   3  (bases 1 to 3342)
  AUTHORS   Wang,K.S., Zuo,L., Pan,Y., Xie,C. and Luo,X.
  TITLE     Genetic variants in the CPNE5 gene are associated with alcohol
            dependence and obesity in Caucasian populations
  JOURNAL   J Psychiatr Res 71, 1-7 (2015)
   PUBMED   26522866
  REMARK    GeneRIF: Results provide the first evidence of genetic variants in
            the CPNE5 gene influencing both alcohol dependence and obesity
REFERENCE   4  (bases 1 to 3342)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3342)
  AUTHORS   den Hoed,M., Eijgelsheim,M., Esko,T., Brundel,B.J., Peal,D.S.,
            Evans,D.M., Nolte,I.M., Segre,A.V., Holm,H., Handsaker,R.E.,
            Westra,H.J., Johnson,T., Isaacs,A., Yang,J., Lundby,A., Zhao,J.H.,
            Kim,Y.J., Go,M.J., Almgren,P., Bochud,M., Boucher,G.,
            Cornelis,M.C., Gudbjartsson,D., Hadley,D., van der Harst,P.,
            Hayward,C., den Heijer,M., Igl,W., Jackson,A.U., Kutalik,Z.,
            Luan,J., Kemp,J.P., Kristiansson,K., Ladenvall,C., Lorentzon,M.,
            Montasser,M.E., Njajou,O.T., O'Reilly,P.F., Padmanabhan,S., St
            Pourcain,B., Rankinen,T., Salo,P., Tanaka,T., Timpson,N.J.,
            Vitart,V., Waite,L., Wheeler,W., Zhang,W., Draisma,H.H.,
            Feitosa,M.F., Kerr,K.F., Lind,P.A., Mihailov,E., Onland-Moret,N.C.,
            Song,C., Weedon,M.N., Xie,W., Yengo,L., Absher,D., Albert,C.M.,
            Alonso,A., Arking,D.E., de Bakker,P.I., Balkau,B., Barlassina,C.,
            Benaglio,P., Bis,J.C., Bouatia-Naji,N., Brage,S., Chanock,S.J.,
            Chines,P.S., Chung,M., Darbar,D., Dina,C., Dorr,M., Elliott,P.,
            Felix,S.B., Fischer,K., Fuchsberger,C., de Geus,E.J., Goyette,P.,
            Gudnason,V., Harris,T.B., Hartikainen,A.L., Havulinna,A.S.,
            Heckbert,S.R., Hicks,A.A., Hofman,A., Holewijn,S.,
            Hoogstra-Berends,F., Hottenga,J.J., Jensen,M.K., Johansson,A.,
            Junttila,J., Kaab,S., Kanon,B., Ketkar,S., Khaw,K.T., Knowles,J.W.,
            Kooner,A.S., Kors,J.A., Kumari,M., Milani,L., Laiho,P.,
            Lakatta,E.G., Langenberg,C., Leusink,M., Liu,Y., Luben,R.N.,
            Lunetta,K.L., Lynch,S.N., Markus,M.R., Marques-Vidal,P., Mateo
            Leach,I., McArdle,W.L., McCarroll,S.A., Medland,S.E., Miller,K.A.,
            Montgomery,G.W., Morrison,A.C., Muller-Nurasyid,M., Navarro,P.,
            Nelis,M., O'Connell,J.R., O'Donnell,C.J., Ong,K.K., Newman,A.B.,
            Peters,A., Polasek,O., Pouta,A., Pramstaller,P.P., Psaty,B.M.,
            Rao,D.C., Ring,S.M., Rossin,E.J., Rudan,D., Sanna,S., Scott,R.A.,
            Sehmi,J.S., Sharp,S., Shin,J.T., Singleton,A.B., Smith,A.V.,
            Soranzo,N., Spector,T.D., Stewart,C., Stringham,H.M., Tarasov,K.V.,
            Uitterlinden,A.G., Vandenput,L., Hwang,S.J., Whitfield,J.B.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilson,J.F., Witteman,J.C.,
            Wong,A., Wong,Q., Jamshidi,Y., Zitting,P., Boer,J.M., Boomsma,D.I.,
            Borecki,I.B., van Duijn,C.M., Ekelund,U., Forouhi,N.G., Froguel,P.,
            Hingorani,A., Ingelsson,E., Kivimaki,M., Kronmal,R.A., Kuh,D.,
            Lind,L., Martin,N.G., Oostra,B.A., Pedersen,N.L., Quertermous,T.,
            Rotter,J.I., van der Schouw,Y.T., Verschuren,W.M., Walker,M.,
            Albanes,D., Arnar,D.O., Assimes,T.L., Bandinelli,S., Boehnke,M., de
            Boer,R.A., Bouchard,C., Caulfield,W.L., Chambers,J.C., Curhan,G.,
            Cusi,D., Eriksson,J., Ferrucci,L., van Gilst,W.H., Glorioso,N., de
            Graaf,J., Groop,L., Gyllensten,U., Hsueh,W.C., Hu,F.B.,
            Huikuri,H.V., Hunter,D.J., Iribarren,C., Isomaa,B., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kiemeney,L.A., van der Klauw,M.M.,
            Kooner,J.S., Kraft,P., Iacoviello,L., Lehtimaki,T., Lokki,M.L.,
            Mitchell,B.D., Navis,G., Nieminen,M.S., Ohlsson,C., Poulter,N.R.,
            Qi,L., Raitakari,O.T., Rimm,E.B., Rioux,J.D., Rizzi,F., Rudan,I.,
            Salomaa,V., Sever,P.S., Shields,D.C., Shuldiner,A.R., Sinisalo,J.,
            Stanton,A.V., Stolk,R.P., Strachan,D.P., Tardif,J.C.,
            Thorsteinsdottir,U., Tuomilehto,J., van Veldhuisen,D.J.,
            Virtamo,J., Viikari,J., Vollenweider,P., Waeber,G., Widen,E.,
            Cho,Y.S., Olsen,J.V., Visscher,P.M., Willer,C., Franke,L.,
            Erdmann,J., Thompson,J.R., Pfeufer,A., Sotoodehnia,N.,
            Newton-Cheh,C., Ellinor,P.T., Stricker,B.H., Metspalu,A.,
            Perola,M., Beckmann,J.S., Smith,G.D., Stefansson,K., Wareham,N.J.,
            Munroe,P.B., Sibon,O.C., Milan,D.J., Snieder,H., Samani,N.J. and
            Loos,R.J.
  CONSRTM   Global BPgen Consortium; CARDIoGRAM Consortium; PR GWAS Consortium;
            QRS GWAS Consortium; QT-IGC Consortium; CHARGE-AF Consortium
  TITLE     Identification of heart rate-associated loci and their effects on
            cardiac conduction and rhythm disorders
  JOURNAL   Nat Genet 45 (6), 621-631 (2013)
   PUBMED   23583979
REFERENCE   6  (bases 1 to 3342)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 3342)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 3342)
  AUTHORS   Tripodis,N., Mason,R., Humphray,S.J., Davies,A.F., Herberg,J.A.,
            Trowsdale,J., Nizetic,D., Senger,G. and Ragoussis,J.
  TITLE     Physical map of human 6p21.2-6p21.3: region flanking the
            centromeric end of the major histocompatibility complex
  JOURNAL   Genome Res 8 (6), 631-643 (1998)
   PUBMED   9647638
REFERENCE   9  (bases 1 to 3342)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA265730.1, DB320492.1,
            AI989513.1, BC053872.1, BC036840.1 and Z85996.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020939.1.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene is one of several genes that encode a
            calcium-dependent protein containing two N-terminal type II C2
            domains and an integrin A domain-like sequence in the C-terminus.
            Several alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. More variants may
            exist, but their full-length natures could not be determined.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.869485.1, AB046819.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244751.7/ ENSP00000244751.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               DA265730.1         1-531
            532-825             DB320492.1         110-403             c
            826-922             AI989513.1         20-116              c
            923-1296            BC053872.1         126-499
            1297-3339           BC036840.1         513-2555
            3340-3342           Z85996.1           65274-65276         c
FEATURES             Location/Qualifiers
     source          1..3342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..3342
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /note="copine 5"
                     /db_xref="GeneID:57699"
                     /db_xref="HGNC:HGNC:2318"
                     /db_xref="MIM:604209"
     exon            1..162
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1849
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /note="isoform a is encoded by transcript variant 1;
                     copine V"
                     /codon_start=1
                     /product="copine-5 isoform a"
                     /protein_id="NP_065990.1"
                     /db_xref="CCDS:CCDS4825.1"
                     /db_xref="GeneID:57699"
                     /db_xref="HGNC:HGNC:2318"
                     /db_xref="MIM:604209"
                     /translation="MEQPEDMASLSEFDSLAGSIPATKVEITVSCRNLLDKDMFSKSD
                     PLCVMYTQGMENKQWREFGRTEVIDNTLNPDFVRKFIVDYFFEEKQNLRFDLYDVDSK
                     SPDLSKHDFLGQAFCTLGEIVGSPGSRLEKPLTIGAFSLNSRTGKPMPAVSNGGVPGK
                     KCGTIILSAEELSNCRDVATMQFCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKT
                     EVMKNTLNPVWQTFSIPVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELAR
                     GQSQFNIYEVVNPKKKMKKKKYVNSGTVTLLSFAVESECTFLDYIKGGTQINFTVAID
                     FTASNGNPSQSTSLHYMSPYQLNAYALALTAVGEIIQHYDSDKMFPALGFGAKLPPDG
                     RVSHEFPLNGNQENPSCCGIDGILEAYHRSLRTVQLYGPTNFAPVVTHVARNAAAVQD
                     GSQYSVLLIITDGVISDMAQTKEAIVNAAKLPMSIIIVGVGQAEFDAMVELDGDDVRI
                     SSRGKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVLAEIPDQLVSYMKAQGIRPR
                     PPPAAPTHSPSQSPARTPPASPLHTHI"
     exon            163..203
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            204..250
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            251..354
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            355..394
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            395..471
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            472..531
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            532..595
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..699
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            700..804
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            805..846
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            847..922
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            923..976
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1038
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1085
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1267
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1395
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1498
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1556
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1630
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..3342
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3319..3324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /note="hexamer: AGTAAA"
     polyA_site      3342
                     /gene="CPNE5"
                     /gene_synonym="COPN5; CPN5"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctccg gaggaggcgt gaatcgcgca gggattgact aatttggggt ggggggtgcg
       61 gtgggcgatg gagcagcctg aggacatggc gtcgctgagc gagttcgact ccttggcggg
      121 cagcatcccg gccaccaagg tggagatcac cgtgtcctgc aggaacctcc tggacaaaga
      181 catgttttcc aagtccgacc cactgtgcgt catgtatacc caagggatgg agaacaagca
      241 gtggcgggag tttgggcgca ccgaagtcat cgacaacacg ctcaatcctg acttcgtgcg
      301 caagttcatt gtggattact ttttcgagga gaagcagaac ctccgttttg atctatacga
      361 cgttgactct aagagtcctg atttatccaa acacgatttc ctgggccagg ccttctgcac
      421 ccttggagag attgtggggt cccctgggag ccgcctggaa aagcccctca cgataggcgc
      481 attcagcctg aattccagga cgggcaaacc catgccagct gtgtccaacg gtggtgtccc
      541 aggaaagaaa tgtggcacca tcatcctgtc cgctgaggag ctcagcaact gtagggatgt
      601 cgccaccatg cagttctgtg ccaacaagct ggacaagaaa gatttctttg ggaaatctga
      661 ccccttcttg gtattctaca gaagcaacga ggatggaacg ttcaccattt gccacaagac
      721 cgaggtcatg aagaacaccc taaatccagt ctggcaaact ttctccattc ccgtgagagc
      781 cctctgcaac ggcgactacg atcggaccat caaggtggag gtgtacgact gggatcggga
      841 cggcagccat gacttcattg gggagttcac caccagttac cgggagctgg cccgtgggca
      901 gagccaattc aacatctatg aggtggtaaa cccgaaaaag aaaatgaaga aaaagaaata
      961 cgtgaattct ggcacagtca ccctgctttc ctttgctgtg gagtcagagt gcaccttcct
     1021 tgactacatc aaaggaggga cccagatcaa cttcactgtg gccattgatt tcactgcctc
     1081 caatgggaac ccctcacagt ccacatccct gcactacatg agcccctacc agctgaacgc
     1141 ctacgcgctg gcgctgactg ccgtcggaga gatcatccag cactacgaca gtgacaagat
     1201 gttccctgcc ctgggcttcg gggccaagct gcccccggat ggcagagtgt cccacgagtt
     1261 cccactgaat ggcaaccagg agaacccctc atgctgtggc atcgacggca tcctggaggc
     1321 ctaccaccgc agcctgcgca ctgtgcagct gtacggcccc accaactttg cccccgtggt
     1381 cacccacgtg gccaggaatg cagcggccgt gcaggatggc tcccagtact cggtgctgct
     1441 catcattact gatggggtca tctcggacat ggcgcagacc aaggaggcca ttgtcaacgc
     1501 tgccaagctc cccatgtcca tcattatcgt cggcgtgggc caggcagagt tcgacgccat
     1561 ggtggagctg gatggcgacg acgtgcggat ctcctcccgg gggaagctgg ctgaacgcga
     1621 catcgtccag tttgtaccct tccgggacta cgtggaccgc acaggcaacc acgtgctgag
     1681 catggcccgc ctggcccgag acgtgctggc agagatccct gaccaactgg tgtcctacat
     1741 gaaggcacag ggcattcgcc cgcgtccccc acccgcagca ccaacccact cgccctcgca
     1801 gtccccagcc cgcacgcccc ctgcgtcccc cctgcacacg cacatctgaa cctggtctca
     1861 gcaggcaggt ggctggggcc tgggagaggc caggtgaatg ggaggccagg gccccagact
     1921 ccccgaagtt ggcctgcccg gcctttggga catctgtgtg cctgggaggc tgccaggggg
     1981 tggggcttct gaagacccct cctcaatttc ttggcctcac ttattgccca aacccaggga
     2041 gttagggggg tacgggtgaa agaggggtac acagggaccc agcccttctc ttcttcccca
     2101 atacctggct ctaacccagc caggaaggtg taaacaataa gggtgattgg ggtccctgtc
     2161 gcccaccccc ggcaatccta tttgcttacc tgtcaccctg aagcctgggc ttggcctcct
     2221 ccagcccccc atctccgtcc catcctccca tggtgtctac tcctgtccct gagccccgcc
     2281 ctgtggtcta tcctgtgccc gatttccagt gaaccccatg aagctgatgg gtttgcagga
     2341 aggcctgaac atgtgcaccc tcccagggac actggatgcg ctgggagccc cggggacccc
     2401 atggggtgct gtaatcatgg accgtaggcc atgtgatggg cctgaagtgg aggctgctca
     2461 gcacagagcc ctttctggtg cctctcgaac tcagtacgat gcaagttcta gacacacaga
     2521 tggcctgtgg aggcctctcc ctggtgtggg cccacaggta cttccatggt tgactcctgg
     2581 cttcaggaat cccttcctcc ctccagaggc ttcccagggc cctcggtgcc cacgcctctg
     2641 cccatctgga ggcctgagta aggagtggct cagccccacg ttcccacact gctcctgctc
     2701 tttgccctgt atcccatgag gctaggagac aggagtcctg ggtttgagcc ctgcctcccc
     2761 ccactgccta atgtgggaac ccaagcaagg cccttctacc ttttgggcct cagtttccat
     2821 gtctgtacca caagagggtt gaccagatgg ccccaggttt tcctttaggt ctgacatcct
     2881 gagggtcatt catcccatgc ccagttcccc ccatcctact cctaacagat gtgaccctac
     2941 ttgaggccgc cttggctttt gggtcaccct gtctcatccc atcaccccaa acatacccta
     3001 gtccttcagc ctggggctct ggcatctgag cccgagctcc tgcccctgct gtgggaaagg
     3061 tggggaagaa ggggatctcc ctcccgggcc cacccagctg cccagccttt gcccactcgg
     3121 ggagcagatc atgcatgcca atccctgttg ccgcatggag ctcctcagcc cactgacctc
     3181 tccgtgcctg gtgcaggcca ggcccccgtc ttccgcctgc ctctgcttcc ccgtcatgca
     3241 tggtggtggt gtttctacgg tgtctggttc tgtgcccgtc tctgagacag tctctgtgtg
     3301 gaatttgcct taaactgaag taaatttggt tcttttagta aa
//
