LOCUS       NM_003909               4857 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens copine 3 (CPNE3), mRNA.
ACCESSION   NM_003909
VERSION     NM_003909.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4857)
  AUTHORS   Li,X., Zhong,H., Shi,Q., Ruan,R., Huang,C., Wen,Q., Zeng,S.,
            Xia,Y., Zeng,Q., Xiong,J., Wang,S., Chen,J., Lei,W. and Deng,J.
  TITLE     YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell
            progression
  JOURNAL   Cell Mol Life Sci 81 (1), 143 (2024)
   PUBMED   38493426
  REMARK    GeneRIF: YAP1-CPNE3 positive feedback pathway promotes gastric
            cancer cell progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4857)
  AUTHORS   Duan,T., Zhang,Z., Shi,J., Xiao,L., Yang,J., Yin,L., Zhang,X.,
            Geng,Z. and Lu,G.
  TITLE     [High expression of CPNE3 correlates with poor long-term prognosis
            of gastric cancer by inhibiting cell apoptosis via activating
            PI3K/AKT signaling]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (1), 129-137 (2024)
   PUBMED   38293984
  REMARK    GeneRIF: [High expression of CPNE3 correlates with poor long-term
            prognosis of gastric cancer by inhibiting cell apoptosis via
            activating PI3K/AKT signaling].
REFERENCE   3  (bases 1 to 4857)
  AUTHORS   Shi,D., Lin,B., Lai,J., Li,K. and Feng,Y.
  TITLE     Upregulation of CPNE3 suppresses invasion, migration and
            proliferation of glioblastoma cells through FAK pathway
            inactivation
  JOURNAL   J Mol Histol 52 (3), 589-596 (2021)
   PUBMED   33725213
  REMARK    GeneRIF: Upregulation of CPNE3 suppresses invasion, migration and
            proliferation of glioblastoma cells through FAK pathway
            inactivation.
REFERENCE   4  (bases 1 to 4857)
  AUTHORS   Chen,C., Wang,Z., Chen,C., Xue,G., Lu,S., Liu,H., Dong,Q. and
            Zhang,M.
  TITLE     CPNE3 moderates the association between anxiety and working memory
  JOURNAL   Sci Rep 11 (1), 6891 (2021)
   PUBMED   33767297
  REMARK    GeneRIF: CPNE3 moderates the association between anxiety and
            working memory.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4857)
  AUTHORS   Sun,B., Li,Y., Zhou,Y., Ng,T.K., Zhao,C., Gan,Q., Gu,X. and
            Xiang,J.
  TITLE     Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker
            for colorectal cancer
  JOURNAL   J Cell Physiol 234 (2), 1416-1425 (2019)
   PUBMED   30078189
  REMARK    GeneRIF: Exosomal CPNE3 levels are associated with the tumor extent
            and may serve as a diagnostic biomarker in colorectal cancer
            patients.
REFERENCE   6  (bases 1 to 4857)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4857)
  AUTHORS   Thomas,G., Jacobs,K.B., Yeager,M., Kraft,P., Wacholder,S., Orr,N.,
            Yu,K., Chatterjee,N., Welch,R., Hutchinson,A., Crenshaw,A.,
            Cancel-Tassin,G., Staats,B.J., Wang,Z., Gonzalez-Bosquet,J.,
            Fang,J., Deng,X., Berndt,S.I., Calle,E.E., Feigelson,H.S.,
            Thun,M.J., Rodriguez,C., Albanes,D., Virtamo,J., Weinstein,S.,
            Schumacher,F.R., Giovannucci,E., Willett,W.C., Cussenot,O.,
            Valeri,A., Andriole,G.L., Crawford,E.D., Tucker,M., Gerhard,D.S.,
            Fraumeni,J.F. Jr., Hoover,R., Hayes,R.B., Hunter,D.J. and
            Chanock,S.J.
  TITLE     Multiple loci identified in a genome-wide association study of
            prostate cancer
  JOURNAL   Nat Genet 40 (3), 310-315 (2008)
   PUBMED   18264096
  REMARK    GeneRIF: Susceptibility genes CPNE3, IL16 and CDH13 with moderate
            effects associated with susceptibility to prostate cancer.
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 4857)
  AUTHORS   Cowland,J.B., Carter,D., Bjerregaard,M.D., Johnsen,A.H.,
            Borregaard,N. and Lollike,K.
  TITLE     Tissue expression of copines and isolation of copines I and III
            from the cytosol of human neutrophils
  JOURNAL   J Leukoc Biol 74 (3), 379-388 (2003)
   PUBMED   12949241
REFERENCE   9  (bases 1 to 4857)
  AUTHORS   Caudell,E.G., Caudell,J.J., Tang,C.H., Yu,T.K., Frederick,M.J. and
            Grimm,E.A.
  TITLE     Characterization of human copine III as a phosphoprotein with
            associated kinase activity
  JOURNAL   Biochemistry 39 (42), 13034-13043 (2000)
   PUBMED   11041869
REFERENCE   10 (bases 1 to 4857)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB135485.1, AF077226.2,
            AC103817.6, AC013751.6 and AI031907.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003909.4.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene encodes a protein which contains two type II
            C2 domains in the amino-terminus and an A domain-like sequence in
            the carboxy-terminus. The A domain mediates interactions between
            integrins and extracellular ligands. [provided by RefSeq, Aug
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.190754.1,
                                           SRR1803615.59833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517490.6/ ENSP00000477590.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                DB135485.1         9-102
            95-1769             AF077226.2         1-1675
            1770-1786           AC103817.6         1-17                c
            1787-4513           AC013751.6         29145-31871
            4514-4857           AI031907.1         20-363              c
FEATURES             Location/Qualifiers
     source          1..4857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..4857
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /note="copine 3"
                     /db_xref="GeneID:8895"
                     /db_xref="HGNC:HGNC:2316"
                     /db_xref="MIM:604207"
     exon            1..107
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            108..145
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            146..287
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1769
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /note="copine III"
                     /codon_start=1
                     /product="copine-3"
                     /protein_id="NP_003900.1"
                     /db_xref="CCDS:CCDS6243.1"
                     /db_xref="GeneID:8895"
                     /db_xref="HGNC:HGNC:2316"
                     /db_xref="MIM:604207"
                     /translation="MAAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYE
                     VERTERIKNCLNPQFSKTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTL
                     GQIVSSKKLTRPLVMKTGRPAGKGSITISAEEIKDNRVVLFEMEARKLDNKDLFGKSD
                     PYLEFHKQTSDGNWLMVHRTEVVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYD
                     NDGSHDLIGTFQTTMTKLKEASRSSPVEFECINEKKRQKKKSYKNSGVISVKQCEITV
                     ECTFLDYIMGGCQLNFTVGVDFTGSNGDPRSPDSLHYISPNGVNEYLTALWSVGLVIQ
                     DYDADKMFPAFGFGAQIPPQWQVSHEFPMNFNPSNPYCNGIQGIVEAYRSCLPQIKLY
                     GPTNFSPIINHVARFAAAATQQQTASQYFVLLIITDGVITDLDETRQAIVNASRLPMS
                     IIIVGVGGADFSAMEFLDGDGGSLRSPLGEVAIRDIVQFVPFRQFQNAPKEALAQCVL
                     AEIPQQVVGYFNTYKLLPPKNPATKQQKQ"
     exon            288..467
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            468..542
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            543..614
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            615..698
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            699..788
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            789..887
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            888..974
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1034
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1168
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1223
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1275
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1409
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1646
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..4857
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4722..4727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /note="hexamer: AATATA"
     polyA_site      4772
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /note="major polyA site"
     regulatory      4833..4838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
                     /note="hexamer: AATAAA"
     polyA_site      4857
                     /gene="CPNE3"
                     /gene_synonym="CPN3; PRO1071"
ORIGIN      
        1 gccagtccag ccctaggttc tcctgaatcc ctgcggtccc agcgtcgctc cggacgctgc
       61 caacctgttc tccaccgtcg ctcgacttcc acctctaaga ctcccacgaa actcaggttg
      121 aataattcat caaattacac aactgaactc aagacatggc tgcccagtgt gtcacaaagg
      181 tggcgctgaa tgtttcctgt gccaatcttt tggataaaga tatagggtca aagtcagacc
      241 ctttatgtgt gttgtttttg aatacaagtg gtcaacagtg gtatgaggtt gagcgcacag
      301 aaaggattaa gaattgcttg aatccccaat tttccaagac atttattatt gattactact
      361 ttgaagtggt tcagaaattg aaatttgggg tttatgacat cgacaacaaa actattgagc
      421 tgagtgatga tgacttctta ggggaatgtg aatgtaccct tggacaaatt gtttccagca
      481 agaagctaac tcgaccactg gtgatgaaaa ctggcagacc tgcaggaaaa gggagcatta
      541 cgatttcagc tgaagaaata aaagataata gagtggtctt gtttgaaatg gaagccagaa
      601 aactggataa taaggatcta tttggaaagt cagacccata cctggaattc cacaagcaga
      661 catctgatgg aaactggcta atggttcatc ggacagaggt tgttaaaaac aacttgaatc
      721 ctgtttggag gcctttcaag atctctctta actcactgtg ttacggagat atggacaaaa
      781 ccattaaggt ggagtgttat gattatgaca atgatgggtc acatgatctc attggaacat
      841 ttcagaccac catgacaaaa ctgaaagaag cctccagaag ctcacctgtt gaatttgaat
      901 gcataaatga gaaaaaaagg caaaagaaaa aaagctacaa gaattcaggt gttatcagtg
      961 tgaaacagtg tgagattaca gtagaatgca cattccttga ctatataatg ggaggatgtc
     1021 agctgaattt tactgtggga gtggacttca ctggctccaa tggtgaccca aggtctccag
     1081 actcccttca ttacatcagc cccaatggcg ttaatgagta tttgactgct ctctggtctg
     1141 tgggactggt cattcaagat tatgatgctg ataagatgtt tccagctttt ggttttggcg
     1201 ctcagatacc tcctcagtgg caggtatcac atgaatttcc aatgaacttc aacccatcca
     1261 atccctactg caatggaatc caaggcattg tagaggcgta tcggtcttgt cttcctcaga
     1321 taaaactcta tggaccaact aatttttctc caatcataaa tcacgtggcc aggtttgctg
     1381 ctgcagccac gcaacagcag acagcttctc aatattttgt gcttttgatt attactgatg
     1441 gtgtgatcac agaccttgat gaaaccagac aagctatagt taatgcctcc aggctgccta
     1501 tgtccatcat aattgttgga gttggaggtg ctgacttcag cgccatggag tttctggatg
     1561 gtgatggtgg aagtctccgc tccccattgg gcgaagtggc catcagagat attgtccagt
     1621 ttgtgccttt cagacagttc cagaatgctc caaaagaagc acttgctcag tgtgtcttgg
     1681 cagagattcc ccagcaggtg gtgggctact tcaatacata caaactcctt cctcccaaga
     1741 acccagccac gaaacaacag aagcagtgac cacttcaaca gaattctttt gtgttatgtg
     1801 gagcaatgcc atctctcacc ccaaatcgtg tatctgtcat tctacgtact ttttaccccc
     1861 agcatttatg atgtaaatct ctttctctat ggattatatc tgtttaaagc attctttcta
     1921 ggttattttg gggggacagt gccaagtcca tctttgccca gtcaattcag tgattgatag
     1981 caatttacat taattgcagt aaagctcttt ggattagaaa ttagtgtggg gaaagcttat
     2041 tctgttgttg tttttgttta ctttcatatg atgaaaatgc tgtgtttaag tgtttgtcaa
     2101 taggaagaat ggaaaactgt tgggatgatg tggtttgcag gttgctgtgc ctgattcaca
     2161 gtgtatgttg tataagccaa tgtccatacc tgattatgag agcttcttaa attatatgat
     2221 atcaaatttg ttcctgtaac tctgtataca gtgcttttct gcaaggtaaa aataacctgt
     2281 ctatgcatct gatttttgct acagtttaga cactgtggtt tacaaaacag catgcactca
     2341 acttgggact ttatgaaaag tactgaatga gcaggaaaag gcacatactc agttttttaa
     2401 atgtacaatc aacaagtaaa aataacctca tgtaagtaag ccatttttat ttgcctttct
     2461 agatatttta ttttattgtg gaaaactgta aacatggtca gatttggctt tttttttcat
     2521 taactgagca agactttcag gatattgtag atgcacagat ggtaggttgt cctgaattct
     2581 acattattag attactttaa ttgagatttg ttaaaacggt taggactgtt ttgtccagga
     2641 aagataagag gaccaaacat ataaggtgaa attcagaatt ccgtttcctt ctaactaatg
     2701 aaaaactgct tactaaaaaa aaattttata ctttccttgc taaggtccca tatattgatt
     2761 tgtacagatc cacttagtca ttttctcctt tttttaagaa ccattttcat ctgattttta
     2821 aactcacgat accagttatc tgttaatcaa aattgcattt tacaatttaa taatgtgata
     2881 tttcctatgt ctacagcata ccttattagg tataaaacct actgcaactt agaaaaagga
     2941 aagaaaaaag aaaacttttc caactgctgc attaagatag ggtggatttt atgtgctttt
     3001 tttttttaag agttgaattt cttttcctga cttttacctt ttacagcgta ttacttagtg
     3061 aacattacat tttcagaata gatcctaata ttttattgag ggcctatgtg ctaaaaacta
     3121 tgcatatcta tatattggcc aattatcttt aataatttac cttttgaaat tgcatgttta
     3181 tcatatatcc ttaagtggac acatacagtg ccatgttgat gtgcctctca gttttattga
     3241 aaagctgccc cacagcccat gtctcttgtt ctctgcaatg cctcaaggga gtgagctctc
     3301 aaccacagat agctgtggct tctcagaagc agctcattgc caaggccagg ctgagagggg
     3361 acctgcttgc tgtggtggtt gcctagccca gatgagcatt tacctaccac cttcccactt
     3421 ggctagctgt cctttggata tgtgctgtta actggggaag gcatctaact agtagcctgc
     3481 tactccatag tatggctcaa tagatgacac atcattttga cattatcaat aggagaaaag
     3541 aaaactaacc cttcttctga ttgtttggag ccatagttgt ctcagatgtt ctaattctct
     3601 ttgtatgctt ggaaacagca tagatatgtt gctgtggttt tcagaatttt ctcttttaat
     3661 cacaagaagc cttttaaaaa atgacttaca catattctca atgtacagta aaacagacag
     3721 aagtgagctt atctgtttga tgctgtggca gggtcccagt cactgggcat atcctccttc
     3781 tccttaacca gctccacagc agcccctgag tcacctgcac aaggtgcttg ggaactgctg
     3841 gttatgagca ttcctggttt tcttcagcca aataacaggt aatcactgtc aattggattt
     3901 ggtcttcatt attttatatt ctgattttat cagaattatt ctattttaaa attgttttaa
     3961 aatttaaaac atttaattca tgatcatgtt catcagtaga tgctattatt cataagaact
     4021 gtgattccag caaactaggg taattggtgc ctttttacag ttttgaataa aagcatttac
     4081 aatttctaaa ttatcagttt tcacagtttc agcactcaac ctcatcatac gctgatttaa
     4141 tattgtttta cattaaaata gtccttttcc ctgttgtgcc accattcatt taagtgctgt
     4201 ttgttcttaa aatgcattta aagaaaaatt acccatattg actttcacac ctcatataat
     4261 cagatctatt acaaatatat atcggagtga cggtgcccag gatagatgta atatttctta
     4321 cagatgctgg cacagaggaa ataatatacc agctaatcta gtcacctaac cttgtggtta
     4381 gaattgcaat tttaagacca gaaaaatttg aagtctgatc agagatttac aactgttcat
     4441 tatagtggtg ccttaggcaa tctttccaaa gtaaattcag ggccccattg ctacttatgc
     4501 catatttgga catacttttt ttttcttcaa ttttgtaaac ttcctggaaa gctgtcttca
     4561 ctaagtatcc cctagtctct atatatgtgg ttagtagtca tggaaatgac acataaagta
     4621 cgccagaagt ttgatggaac gtgttagaaa ctgttttgtg cttttatgga tgtcatactt
     4681 gacaatacat gtgtaagtta ctaatatatg aattgatgct aaatatatct tacatttgaa
     4741 ttccttttgg ataaagttat ttcttgatgt gacagagtag tgtgttttca tttttattct
     4801 ttacatgtga ccaaaacaat agaaaagtta aaaataaaat atagtgtttt aggtggc
//
