LOCUS       NM_152727               2601 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens copine 2 (CPNE2), mRNA.
ACCESSION   NM_152727
VERSION     NM_152727.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Martins-de-Souza,D., Schmitt,A., Roder,R., Lebar,M.,
            Schneider-Axmann,T., Falkai,P. and Turck,C.W.
  TITLE     Sex-specific proteome differences in the anterior cingulate cortex
            of schizophrenia
  JOURNAL   J Psychiatr Res 44 (14), 989-991 (2010)
   PUBMED   20381070
  REMARK    GeneRIF: This protein has been found differentially expressed in
            the anterior cingulate cortex in women patients with schizophrenia.
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Cowland,J.B., Carter,D., Bjerregaard,M.D., Johnsen,A.H.,
            Borregaard,N. and Lollike,K.
  TITLE     Tissue expression of copines and isolation of copines I and III
            from the cytosol of human neutrophils
  JOURNAL   J Leukoc Biol 74 (3), 379-388 (2003)
   PUBMED   12949241
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB504175.1, CN283840.1,
            BG830959.1, AF492484.1, CB306539.1 and AC009090.12.
            
            On Nov 23, 2018 this sequence version replaced NM_152727.5.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene is one of several genes that encode a
            calcium-dependent protein containing two N-terminal type II C2
            domains and an integrin A domain-like sequence in the C-terminus.
            Sequence analysis identified multiple alternatively spliced
            transcript variants but their full-length natures could not be
            determined. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.244188.1, AF492484.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290776.13/ ENSP00000290776.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DB504175.1         42-50
            10-15               CN283840.1         25-30
            16-750              BG830959.1         2-736
            751-2185            AF492484.1         742-2176
            2186-2198           CB306539.1         15-27               c
            2199-2601           AC009090.12        115209-115611       c
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..2601
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /note="copine 2"
                     /db_xref="GeneID:221184"
                     /db_xref="HGNC:HGNC:2315"
                     /db_xref="MIM:604206"
     exon            1..208
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..423
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1890
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /note="copine II"
                     /codon_start=1
                     /product="copine-2"
                     /protein_id="NP_689940.3"
                     /db_xref="CCDS:CCDS10774.1"
                     /db_xref="GeneID:221184"
                     /db_xref="HGNC:HGNC:2315"
                     /db_xref="MIM:604206"
                     /translation="MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKS
                     DPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSS
                     MRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLS
                     LAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLC
                     DGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKN
                     YKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMG
                     TNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVD
                     GIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILLIITDGVISDM
                     EETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAARDIVQFVPF
                     REFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA"
     exon            424..603
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..678
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..750
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..834
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..924
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1023
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1110
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1170
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1304
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1359
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1411
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1545
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1782
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2601
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /note="hexamer: AATAAA"
     polyA_site      2198
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /note="major polyA site"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
                     /note="hexamer: AATAAA"
     polyA_site      2601
                     /gene="CPNE2"
                     /gene_synonym="COPN2; CPN2"
ORIGIN      
        1 gcccgcccgc ccggcccggg aggaggaccg gaccccgagc ggctgggagc gcacgcgagc
       61 gggccgtggc cgcgcgggca gcgccctgag cctgtcccgc gcccgcgggc ccggccgagc
      121 aggagcagct cccggggatg cccgggcggc tcggagcgcg ggcagcggca gccgtgcggt
      181 gagggcggtg gcgcccgcgg gacctgcgac tgccaggaac tcctgccacc gccaccggct
      241 cccatggccc acatacccag tgggggtgcc ccagcagcgg gggcagcccc catgggcccc
      301 cagtattgcg tgtgcaaggt ggagctgtca gtgagtggcc agaacctact ggaccgggat
      361 gttacctcca agtccgaccc cttctgtgtc ctctttacag agaacaatgg cagatggatc
      421 gagtacgaca ggacagaaac cgcgatcaac aacctcaacc ccgccttctc caagaagttc
      481 gtgcttgact accacttcga ggaggtacag aagctcaagt tcgcgctctt tgaccaggac
      541 aagtccagta tgcggctgga cgagcatgac ttcctgggcc agttctcctg cagcctgggc
      601 acgatcgtct ccagcaagaa gatcactagg cctctgctgc tgctgaatga caagcctgcg
      661 gggaagggct tgattacgat cgctgcccag gagctgtccg acaaccgcgt catcacacta
      721 agcctggcgg gcaggaggct ggacaagaag gacctctttg ggaagtcaga cccctttctg
      781 gagttttata agccaggaga cgatggcaag tggatgctgg tccacaggac tgaggtgatc
      841 aagtacacac tggaccctgt gtggaagcca ttcacagtgc ccttggtgtc cctgtgtgat
      901 ggggacatgg agaagcccat ccaggtcatg tgctacgact atgacaatga cgggggccat
      961 gacttcatcg gcgagttcca gacctcagtg tcacagatgt gtgaggctcg agacagcgtc
     1021 ccgctggagt tcgagtgcat caaccccaag aagcagagga agaagaagaa ctataaaaac
     1081 tcgggcatca tcatcctgcg atcctgcaag ataaaccgag actactcctt ccttgactac
     1141 atcctgggag gctgccagct catgttcacc gttggaatag actttacagc ctccaacggg
     1201 aatcccctcg acccttcctc tttgcactat atcaacccta tgggcaccaa cgaatatctg
     1261 tcggccatct gggctgttgg gcagatcatt caggactacg acagtgataa gatgtttcca
     1321 gctctgggat tcggggccca gttaccccca gactggaagg tctcccatga gtttgccatc
     1381 aacttcaacc ccaccaaccc cttctgctca ggtgtggatg gtattgccca ggcgtactca
     1441 gcttgcctgc cccacatccg cttctacggt cctaccaatt tctcccccat cgtcaaccac
     1501 gtggcccggt ttgcggccca ggccacacaa cagcggacgg ccacgcagta cttcatcctc
     1561 ctcatcatca cggacggggt catcagtgac atggaggaga cacggcatgc cgtggtgcag
     1621 gcttccaagc tgcccatgtc catcatcatc gtgggcgtgg gcaatgcgga cttcgctgcc
     1681 atggagttcc tggatgggga cagccgcatg ctgcgctccc acacggggga ggaggcagcc
     1741 cgcgatattg tgcagttcgt tccctttcga gagttccgca acgcagcaaa agagaccttg
     1801 gccaaagctg tgctggcgga gctgccccaa caagttgtgc agtatttcaa gcataaaaac
     1861 ctgcccccca ccaactcgga gcccgcctga gctccagtgc ccagcagcag catgtcagct
     1921 gagcctcctg ccctccccca ggaacatgca cgctcactct gcttccttgt gggtggcctt
     1981 tttttaccga tccccttttt tattttttac aaccggacct ccacccccaa cttcctccag
     2041 cccagctggg cttcctttgt tggagtcaac tgttgatgct tccaggccaa actggcttcc
     2101 tctcctcctc tccccacctt tgccattctt aagtattgaa tgtactttgt ataattttag
     2161 tggaattgtt attgagaata aaatttttac aatcataact ggctttttcc aagtaactag
     2221 ctgcagactc tgatgaaaga aacatgtcct tggtgcatac gtgtcgtagc ctgcacctaa
     2281 ttaattcctg ctgttttttt aatactgtga ctgtgttcta tttgttatat gctcagggta
     2341 acaaatgagt ttcagacgtc cctgcgtcag ctccttcctc agcagggacc tgacgggctc
     2401 actgatctaa gaaaggaaat ggaaaatgaa aatccacccc acaagtctaa taagttggtg
     2461 tagtcacttc tgcatgggga catgcattcc agatgataac ctgttaaatc actgccagtt
     2521 aacagtgata acctgttaaa ctggcacaga acctggcaca ttgtacaaac tcaataaata
     2581 ttcatggatg aatagaatga a
//
