LOCUS       NM_152925               1952 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens copine 1 (CPNE1), transcript variant 1, mRNA.
ACCESSION   NM_152925
VERSION     NM_152925.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Zhu,S., Li,R., Yin,K. and Wu,L.
  TITLE     CPNE1, A Potential Therapeutic Target in Nasopharyngeal Carcinoma,
            Affects Cell Growth and Radiation Resistance
  JOURNAL   Radiat Res 201 (4), 310-316 (2024)
   PUBMED   38355101
  REMARK    GeneRIF: CPNE1, A Potential Therapeutic Target in Nasopharyngeal
            Carcinoma, Affects Cell Growth and Radiation Resistance.
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Song,Y., Song,B., Yu,Z., Li,A., Xia,L., Zhao,Y., Lu,Z. and Li,Z.
  TITLE     Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 316 (2023)
   PUBMED   38062811
  REMARK    GeneRIF: Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer.
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Yang,J., Wang,Y., Ge,R., Jia,X., Ge,C., Cen,Y. and Pan,D.
  TITLE     Overexpression of Copines-1 is associated with clinicopathological
            parameters and poor outcome in gastric cancer
  JOURNAL   J Clin Lab Anal 36 (11) (2022)
   PUBMED   36310511
  REMARK    GeneRIF: Overexpression of Copines-1 is associated with
            clinicopathological parameters and poor outcome in gastric cancer.
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Yang,W., Ng,P., Zhao,M., Wong,T.K., Yiu,S.M. and Lau,Y.L.
  TITLE     Promoter-sharing by different genes in human genome--CPNE1 and
            RBM12 gene pair as an example
  JOURNAL   BMC Genomics 9, 456 (2008)
   PUBMED   18831769
  REMARK    GeneRIF: CPNE1 shares a promoter and 5'UTR exons with RBM12. This
            genomic structure is conserved among multiple species.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   Tomsig,J.L., Sohma,H. and Creutz,C.E.
  TITLE     Calcium-dependent regulation of tumour necrosis factor-alpha
            receptor signalling by copine
  JOURNAL   Biochem J 378 (Pt 3), 1089-1094 (2004)
   PUBMED   14674885
  REMARK    GeneRIF: Copine I regulates tumour necrosis factor-alpha receptor
            signaling pathways.
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Cowland,J.B., Carter,D., Bjerregaard,M.D., Johnsen,A.H.,
            Borregaard,N. and Lollike,K.
  TITLE     Tissue expression of copines and isolation of copines I and III
            from the cytosol of human neutrophils
  JOURNAL   J Leukoc Biol 74 (3), 379-388 (2003)
   PUBMED   12949241
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Savino,M., d'Apolito,M., Centra,M., van Beerendonk,H.M.,
            Cleton-Jansen,A.M., Whitmore,S.A., Crawford,J., Callen,D.F.,
            Zelante,L. and Savoia,A.
  TITLE     Characterization of copine VII, a new member of the copine family,
            and its exclusion as a candidate in sporadic breast cancers with
            loss of heterozygosity at 16q24.3
  JOURNAL   Genomics 61 (2), 219-226 (1999)
   PUBMED   10534407
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Creutz,C.E., Tomsig,J.L., Snyder,S.L., Gautier,M.C., Skouri,F.,
            Beisson,J. and Cohen,J.
  TITLE     The copines, a novel class of C2 domain-containing,
            calcium-dependent, phospholipid-binding proteins conserved from
            Paramecium to humans
  JOURNAL   J Biol Chem 273 (3), 1393-1402 (1998)
   PUBMED   9430674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB091531.1 and BC001142.1.
            
            On Jun 2, 2019 this sequence version replaced NM_152925.2.
            
            Summary: Calcium-dependent membrane-binding proteins may regulate
            molecular events at the interface of the cell membrane and
            cytoplasm. This gene encodes a calcium-dependent protein that also
            contains two N-terminal type II C2 domains and an integrin A
            domain-like sequence in the C-terminus. However, the encoded
            protein does not contain a predicted signal sequence or
            transmembrane domains. This protein has a broad tissue distribution
            and it may function in membrane trafficking. This gene and the gene
            for RNA binding motif protein 12 overlap at map location 20q11.21.
            Alternate splicing results in multiple transcript variants encoding
            different proteins. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) is the predominant transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.375835.1,
                                           SRR14038197.380851.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397443.7/ ENSP00000380585.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               DB091531.1         38-178
            142-1952            BC001142.1         324-2134
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..1952
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /note="copine 1"
                     /db_xref="GeneID:8904"
                     /db_xref="HGNC:HGNC:2314"
                     /db_xref="MIM:604205"
     exon            1..141
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1755
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /note="isoform a is encoded by transcript variant 1;
                     chromobindin 17; copine I"
                     /codon_start=1
                     /product="copine-1 isoform a"
                     /protein_id="NP_690902.1"
                     /db_xref="CCDS:CCDS13260.1"
                     /db_xref="GeneID:8904"
                     /db_xref="HGNC:HGNC:2314"
                     /db_xref="MIM:604205"
                     /translation="MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAEL
                     GRTERVRNCSSPEFSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLG
                     QIVSSQVLTLPLMLKPGKPAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDP
                     FLEFFRQGDGKWHLVYRSEVIKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSD
                     GSHDLIGTFHTSLAQLQAVPAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLD
                     YVMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDK
                     LFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFA
                     PIINHVARFAAQAAHQGTASQYFMLLLLTDGAVTDVEATREAVVRASNLPMSVIIVGV
                     GGADFEAMEQLDADGGPLHTRSGQAAARDIVQFVPYRRFQNAPREALAQTVLAEVPTQ
                     LVSYFRAQGWAPLKPLPPSAKDPAQAPQA"
     exon            142..270
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..450
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..525
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..597
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..678
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..768
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..855
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..942
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1002
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1136
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1191
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1243
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1377
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1614
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1952
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1931..1936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="CPNE1"
                     /gene_synonym="COPN1; CPN1"
                     /note="major polyA site"
ORIGIN      
        1 attttgtgaa gcggcgaagg aggtggtggc tgcgttgggc tccgggaagc cgttcgggct
       61 ggggctgtcg gccgcggggc ggaggcactc gcgcgggggg taattcgggg tctgggttct
      121 ggtgccgcgc agctttcccc gatggcccac tgcgtgacct tggttcagct gtccatttcc
      181 tgtgaccatc tcattgacaa ggacatcggc tccaagtctg acccactctg cgtcctttta
      241 caggatgtgg gagggggcag ctgggctgag cttggccgga ctgaacgggt gcggaactgc
      301 tcaagccctg agttctccaa gactctacag cttgagtacc gctttgagac agtccagaag
      361 ctacgctttg gaatctatga catagacaac aagacgccag agctgaggga tgatgacttc
      421 ctagggggtg ctgagtgttc cctaggacag attgtgtcca gccaggtact gactctcccc
      481 ttgatgctga agcctggaaa acctgctggg cgggggacca tcacggtctc agctcaggaa
      541 ttaaaggaca atcgtgtagt aaccatggag gtagaggcca gaaacctaga taagaaggac
      601 ttcctgggaa aatcagatcc atttctggag ttcttccgcc agggtgatgg gaaatggcac
      661 ctggtgtaca gatctgaggt catcaagaac aacctgaacc ctacatggaa gcgtttctca
      721 gtccccgttc agcatttctg tggtgggaac cccagcacac ccatccaggt gcaatgctcc
      781 gattatgaca gtgacgggtc acatgatctc atcggtacct tccacaccag cttggcccag
      841 ctgcaggcag tcccggctga gtttgaatgc atccaccctg agaagcagca gaaaaagaaa
      901 agctacaaga actctggaac tatccgtgtc aagatttgtc gggtagaaac agagtactcc
      961 tttctggact atgtgatggg aggctgtcag atcaacttca ctgtgggcgt ggacttcact
     1021 ggctccaatg gagacccctc ctcacctgac tccctacact acctgagtcc aacaggggtc
     1081 aatgagtacc tgatggcact gtggagtgtg ggcagcgtgg ttcaggacta tgactcagac
     1141 aagctgttcc ctgcatttgg atttggggcc caggttcccc ctgactggca ggtctcgcat
     1201 gaatttgcct tgaatttcaa ccccagtaac ccctactgtg caggcatcca gggcattgtg
     1261 gatgcctacc gccaagccct gccccaagtt cgcctctatg gccctaccaa ctttgcaccc
     1321 atcatcaacc atgtggccag gtttgcagcc caggctgcac atcaggggac tgcctcgcaa
     1381 tacttcatgc tgttgctgct gactgatggt gctgtgacgg atgtggaagc cacacgtgag
     1441 gctgtggtgc gtgcctcgaa cctgcccatg tcagtgatca ttgtgggtgt gggtggtgct
     1501 gactttgagg ccatggagca gctggacgct gatggtggac ccctgcatac acgttctggg
     1561 caggctgctg cccgcgacat tgtgcagttt gtaccctacc gccggttcca gaatgcccct
     1621 cgggaggcat tggcacagac cgtgctcgca gaagtgccca cacaactggt ctcatacttc
     1681 agggcccagg gttgggcccc gctcaagcca cttccaccct cagccaagga tcctgcacag
     1741 gccccccagg cctaggttcc cttggaggct gtggcaagtc ctcaatcctg tgtcccagag
     1801 gtccctctgg gccacaaccc aacccttctc actctcctca gtgctagcac tttgtatttt
     1861 ttgatacttt tatacttgtt tctgcttttg ctgctcttga tcccaccttt gctcctgaca
     1921 accctcattc aataaagacc agtgaagacc aa
//
