LOCUS       NM_181654               1966 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens complexin 4 (CPLX4), mRNA.
ACCESSION   NM_181654
VERSION     NM_181654.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Reim,K., Wegmeyer,H., Brandstatter,J.H., Xue,M., Rosenmund,C.,
            Dresbach,T., Hofmann,K. and Brose,N.
  TITLE     Structurally and functionally unique complexins at retinal ribbon
            synapses
  JOURNAL   J Cell Biol 169 (4), 669-680 (2005)
   PUBMED   15911881
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK123184.1, AC067859.7 and
            BM661846.1.
            
            On Nov 22, 2018 this sequence version replaced NM_181654.3.
            
            Summary: This gene likely encodes a member of the complexin family.
            The encoded protein may be involved in synaptic vesicle exocytosis.
            [provided by RefSeq, Jan 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK123184.1, AB593158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299721.3/ ENSP00000299721.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1766              AK123184.1         1-1766
            1767-1800           AC067859.7         161365-161398       c
            1801-1946           AK123184.1         1800-1945
            1947-1966           BM661846.1         15-34               c
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.32"
     gene            1..1966
                     /gene="CPLX4"
                     /gene_synonym="CPX-IV; CPXIV"
                     /note="complexin 4"
                     /db_xref="GeneID:339302"
                     /db_xref="HGNC:HGNC:24330"
                     /db_xref="MIM:609586"
     exon            1..354
                     /gene="CPLX4"
                     /gene_synonym="CPX-IV; CPXIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..670
                     /gene="CPLX4"
                     /gene_synonym="CPX-IV; CPXIV"
                     /note="complexin IV; CPX IV"
                     /codon_start=1
                     /product="complexin-4"
                     /protein_id="NP_857637.1"
                     /db_xref="CCDS:CCDS11973.1"
                     /db_xref="GeneID:339302"
                     /db_xref="HGNC:HGNC:24330"
                     /db_xref="MIM:609586"
                     /translation="MAFLMKSMISNQVKNLGFGGGSEENKEEGGASDPAAAQGMTREE
                     YEEYQKQMIEEKMERDAAFTQKKAERACLRVHLREKYRLPKSEMDENQIQMAGDDVDL
                     PEDLRKMVDEDQEEEEDKDSILGQIQNLQNMDLDTIKEKAQATFTEIKQTAEQKCSVM
                     "
     exon            355..442
                     /gene="CPLX4"
                     /gene_synonym="CPX-IV; CPXIV"
                     /inference="alignment:Splign:2.1.0"
     exon            443..1966
                     /gene="CPLX4"
                     /gene_synonym="CPX-IV; CPXIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1948..1953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPLX4"
                     /gene_synonym="CPX-IV; CPXIV"
                     /note="hexamer: AATGAA"
     polyA_site      1966
                     /gene="CPLX4"
                     /gene_synonym="CPX-IV; CPXIV"
                     /note="major polyA site"
ORIGIN      
        1 agcttacggc cgacaaacca ctcttctcta tcagtatgcc cttgaataga tgaggttgtg
       61 caaagtcctt tgctcttaaa tgtattgctg tcattgagaa tatttggagg ttttctcttg
      121 ggtttgtttg gatttttttt ttcagctttt gtctgaattt tggttttatt tttctggggc
      181 agagaaaatg gctttcctta tgaaaagtat gataagtaac caggtaaaga atttaggatt
      241 tggtggtggg tctgaagaaa ataaagaaga aggaggtgca tctgatcctg cagcagctca
      301 agggatgact agagaggagt atgaggagta tcaaaagcaa atgattgagg agaagatgga
      361 aagagatgct gcatttacac agaaaaaggc agaaagggca tgcctcagag ttcatctcag
      421 agaaaaatac aggctcccaa agagtgaaat ggatgagaat caaatccaga tggctggaga
      481 tgatgtggat ttacctgaag atctccggaa aatggtagat gaagatcaag aagaggaaga
      541 agataaagat tctattcttg ggcagataca gaatctccag aacatggact tggataccat
      601 aaaagaaaaa gcccaggcca ccttcactga aatcaagcag acagcggagc agaagtgttc
      661 cgtgatgtga ggggtgggag gggtggaggg agggaaccag ccatccttgg aaaagaccac
      721 tctcttgtgg gacgtttcaa gcagtacatg ttttaatgta gtgaacacag ttaggaaaac
      781 cacgatgatc cattgacaga caataatttg gttgttctaa atattcctgg cagagcattt
      841 agctaacacc ttgcagcggg aaccttactt tccttttagt tataaatgag ataaactgga
      901 aaatttcagt tgtaaatgat gatgcagaac acatatctgc ttaaagacct tgagatgagc
      961 caggaagaaa caaaagcaag gggcatttcc tctccaactt tcttccttgg aggccaagtt
     1021 ctcaccctgt ccaactattc gcaggacacc aggtcccttc agagagaaat gtggagagtc
     1081 aaggtgtcta ctgggagccg ggtttcccac agggagctga gtctacagac tccagggcaa
     1141 tcaaaggtca ccacccccac ccctcacctc taggatcctt gaatttgtca atgatactca
     1201 tcaagtatgc ttggatcctt tggtccttgg atgcttctca gccaagtggc ggtagcacag
     1261 atgtggtgaa caatgacgaa ttgaggcagg gaatagacct cactagccct ttgcaatgga
     1321 gatcatcgtt ctagtggcca tgtgaagaat ggaaccaagg gaggcacaat tagaggcaga
     1381 gggaaaccag gcagacggct gctctttttg agttgagctt aactctcctt gtctgaactt
     1441 ggtgatagca atgggaacaa agtgggtaga ctaacagaga gcattaagaa gttaaatcaa
     1501 tctctctctg tctcctccca acctctctct ctctttcatc cccttctctc cctatctctc
     1561 tttttttttt cttctcctgt cccttcccat cccacccctt tagactacct tccagtaaat
     1621 cacactgtca tttggtgcca caagctttca gggtagacac tgatttttcc cccctaatat
     1681 ctgctctctt tcaaaaggaa taattcaaaa gacttaggac aattaccact gaaacacttc
     1741 gagctattta gctaaagccc accaaaccaa aacaaaatac tgattttttt tttttttttt
     1801 ggtgactctg ttcatacagt gaataaagat ctatcaaagg aaaaggaaac tgagaccgaa
     1861 aacttagggt ctaagttgtt ctaaacccag ggttctcaaa tgtgttgtac aaaaagtttc
     1921 atgtaataaa attaagcaaa taaaacaaat gaatagaggt ccaaaa
//
