LOCUS       NM_001030005            2002 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens complexin 3 (CPLX3), mRNA.
ACCESSION   NM_001030005
VERSION     NM_001030005.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Amin,N., Byrne,E., Johnson,J., Chenevix-Trench,G., Walter,S.,
            Nolte,I.M., Vink,J.M., Rawal,R., Mangino,M., Teumer,A., Keers,J.C.,
            Verwoert,G., Baumeister,S., Biffar,R., Petersmann,A., Dahmen,N.,
            Doering,A., Isaacs,A., Broer,L., Wray,N.R., Montgomery,G.W.,
            Levy,D., Psaty,B.M., Gudnason,V., Chakravarti,A., Sulem,P.,
            Gudbjartsson,D.F., Kiemeney,L.A., Thorsteinsdottir,U.,
            Stefansson,K., van Rooij,F.J., Aulchenko,Y.S., Hottenga,J.J.,
            Rivadeneira,F.R., Hofman,A., Uitterlinden,A.G., Hammond,C.J.,
            Shin,S.Y., Ikram,A., Witteman,J.C., Janssens,A.C., Snieder,H.,
            Tiemeier,H., Wolfenbuttel,B.H., Oostra,B.A., Heath,A.C.,
            Wichmann,E., Spector,T.D., Grabe,H.J., Boomsma,D.I., Martin,N.G.
            and van Duijn,C.M.
  CONSRTM   kConFab Investigators
  TITLE     Genome-wide association analysis of coffee drinking suggests
            association with CYP1A1/CYP1A2 and NRCAM
  JOURNAL   Mol Psychiatry 17 (11), 1116-1129 (2012)
   PUBMED   21876539
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Li,F., Pincet,F., Perez,E., Giraudo,C.G., Tareste,D. and
            Rothman,J.E.
  TITLE     Complexin activates and clamps SNAREpins by a common mechanism
            involving an intermediate energetic state
  JOURNAL   Nat Struct Mol Biol 18 (8), 941-946 (2011)
   PUBMED   21785413
  REMARK    GeneRIF: CPX acts sequentially on assembling SNAREpins, first
            facilitating zippering by nearly doubling the distance at which v-
            and t-SNAREs can engage and then clamping them into a half-zippered
            fusion-incompetent state.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Cornelis,M.C., Monda,K.L., Yu,K., Paynter,N., Azzato,E.M.,
            Bennett,S.N., Berndt,S.I., Boerwinkle,E., Chanock,S.,
            Chatterjee,N., Couper,D., Curhan,G., Heiss,G., Hu,F.B.,
            Hunter,D.J., Jacobs,K., Jensen,M.K., Kraft,P., Landi,M.T.,
            Nettleton,J.A., Purdue,M.P., Rajaraman,P., Rimm,E.B., Rose,L.M.,
            Rothman,N., Silverman,D., Stolzenberg-Solomon,R., Subar,A.,
            Yeager,M., Chasman,D.I., van Dam,R.M. and Caporaso,N.E.
  TITLE     Genome-wide meta-analysis identifies regions on 7p21 (AHR) and
            15q24 (CYP1A2) as determinants of habitual caffeine consumption
  JOURNAL   PLoS Genet 7 (4), e1002033 (2011)
   PUBMED   21490707
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Reim,K., Wegmeyer,H., Brandstatter,J.H., Xue,M., Rosenmund,C.,
            Dresbach,T., Hofmann,K. and Brose,N.
  TITLE     Structurally and functionally unique complexins at retinal ribbon
            synapses
  JOURNAL   J Cell Biol 169 (4), 669-680 (2005)
   PUBMED   15911881
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Ohira,M., Morohashi,A., Inuzuka,H., Shishikura,T., Kawamoto,T.,
            Kageyama,H., Nakamura,Y., Isogai,E., Takayasu,H., Sakiyama,S.,
            Suzuki,Y., Sugano,S., Goto,T., Sato,S. and Nakagawara,A.
  TITLE     Expression profiling and characterization of 4200 genes cloned from
            primary neuroblastomas: identification of 305 genes differentially
            expressed between favorable and unfavorable subsets
  JOURNAL   Oncogene 22 (35), 5525-5536 (2003)
   PUBMED   12934113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK024055.1, BC018026.1, AU253913.2 and AC091230.23.
            
            On Nov 23, 2018 this sequence version replaced NM_001030005.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB072900.1, AK024055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395018.6/ ENSP00000378464.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK024055.1         18-27
            11-1433             BC018026.1         11-1433
            1434-1732           AK024055.1         1451-1749
            1733-1733           AU253913.2         303-303             c
            1734-1995           AK024055.1         1751-2012
            1996-2002           AC091230.23        42165-42171         c
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2002
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /note="complexin 3"
                     /db_xref="GeneID:594855"
                     /db_xref="HGNC:HGNC:27652"
                     /db_xref="MIM:609585"
     exon            1..241
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..554
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /note="complexin III; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="complexin-3"
                     /protein_id="NP_001025176.1"
                     /db_xref="CCDS:CCDS32294.1"
                     /db_xref="GeneID:594855"
                     /db_xref="HGNC:HGNC:27652"
                     /db_xref="MIM:609585"
                     /translation="MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEY
                     EEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELP
                     RELAKMIEEDTEEEEEKASVLGQLASLPGLNLGSLKDKAQATLGDLKQSAEKCHVM"
     exon            242..329
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /inference="alignment:Splign:2.1.0"
     exon            330..2002
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1414..1419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /note="hexamer: AATAAA"
     polyA_site      1439
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /note="major polyA site"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /note="hexamer: TATAAA"
     polyA_site      1971
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
                     /note="hexamer: AATAAA"
     polyA_site      2002
                     /gene="CPLX3"
                     /gene_synonym="CPX-III; CPXIII; Nbla11589"
ORIGIN      
        1 agtgctgaag taggcgcgga cgtgcccggt gcctggcgcg tggtagcagg cgcccggtgc
       61 cccggccggc gaagaccatg gcgttcatgg tgaagaccat ggtgggcggc cagctgaaga
      121 acctcactgg gagcctggga ggcggcgagg ataagggaga tggggacaag tcggcagccg
      181 aagctcaggg catgagccgg gaggagtacg aggagtatca gaagcaactc gtggaagaga
      241 agatggagcg ggatgcacag ttcacacaga ggaaggcaga gcgggccaca ctgcggagcc
      301 acttccgaga caaataccgg ctacccaaga acgagacaga tgagagccag atccagatgg
      361 caggtggaga cgtggagctg ccccgggagc tggccaagat gatcgaggag gacacagagg
      421 aggaggagga gaaggcctca gtccttgggc agctggccag ccttcctggc ttgaacctgg
      481 gctcactcaa ggacaaggcc caggccacac tgggggatct caagcaatca gctgagaagt
      541 gtcacgtcat gtgaccactt ccccggggtt acccactggg ctgggccccc atgagggcta
      601 agagtgtgtc aacttccagg gacccatact ccatttgggg ctttgtttcc cttgccccat
      661 cctagttcca agacctttcc catccatgcc ccaagcctat cttctggttt cttcctctcc
      721 gctgggagta aagtccccat cttcactcta cccttcagga ccctccccac cagctcagcc
      781 tgtggaggcc tcccaagatt gtaggaatag gcccatccct ctctggccat ggccccaagt
      841 tcctgcacac aggagcaccc acagagagac acacacagga cacaaaaccc ctggcacgtt
      901 cagagacaga agccacagat acatcccggc acagacagac acacacgagg ccagctccct
      961 tgcgtgtcca gcccctccag acaccaccac tcagaaactc tgagagagag catgggcaga
     1021 caccctcagc agacaggagg cctgagttcc agtctccacc tttattgttc ttgaaagccc
     1081 ctgctctctc tgagccttat ttcatcatct gtaaaatggg aatgtcctga atgacttcta
     1141 aggctctttc tggcttgaac tgtcagagcc aagcccacat ccctccttgg gcagggcagc
     1201 agctgctgcc acagcctcca gcggctgcca ctgtgggctc tgggagccgg agcgatgctg
     1261 tgtgagaggc agagtgccaa ggatgaagct ggcactgaac agtaagcggc tccaggcctc
     1321 ctctgggccc agggcccagc caatttctgt tctgttcctg tagaacgctc tctggattcc
     1381 atagctggaa tctcctctct tagctcagtg aaaaataaaa atcccaaatg gtgtgcctac
     1441 cttcccactt cttactggct tccaggagtc ttggagttca tagccccccg agcctgcctt
     1501 aaaggggtgt cctccacccc ccacctacag cttcacagga ggggagaagg catccagtgc
     1561 taggagtaga agtgtctcca gctctgttct cttggggccc tgggtgaagg tggggtctgg
     1621 ggcttatgaa ataggtctgg gctttgagga ggatggagca gcctcattat gtggggaaga
     1681 tggggcctct ggggcgtcac tgagaccaca ggtggggccg gggctggacc gcagctgtct
     1741 tgggtgcctg tgcctacacc cctcctcacc ctagagacgg aagatgtgca aaaagaaaga
     1801 aggaagggca actgcattcc agccccacac tgtgatgact ttgagcctgt cctttccctc
     1861 cttgagcctg tcttgcttgt cccctgtaaa atgaacagtc cccctctccc ccaaatagta
     1921 ataatacatg tttcaaaggg tgaccattta taaagcatat gacaaaccat atcaataaat
     1981 gtaactcatt cttttaaaaa aa
//
