LOCUS       NM_024913               5304 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cadherin like and PC-esterase domain containing 1
            (CPED1), transcript variant 1, mRNA.
ACCESSION   NM_024913
VERSION     NM_024913.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5304)
  AUTHORS   Kemp,J.P., Medina-Gomez,C., Estrada,K., St Pourcain,B., Heppe,D.H.,
            Warrington,N.M., Oei,L., Ring,S.M., Kruithof,C.J., Timpson,N.J.,
            Wolber,L.E., Reppe,S., Gautvik,K., Grundberg,E., Ge,B., van der
            Eerden,B., van de Peppel,J., Hibbs,M.A., Ackert-Bicknell,C.L.,
            Choi,K., Koller,D.L., Econs,M.J., Williams,F.M., Foroud,T.,
            Zillikens,M.C., Ohlsson,C., Hofman,A., Uitterlinden,A.G., Davey
            Smith,G., Jaddoe,V.W., Tobias,J.H., Rivadeneira,F. and Evans,D.M.
  TITLE     Phenotypic dissection of bone mineral density reveals skeletal site
            specificity and facilitates the identification of novel loci in the
            genetic regulation of bone mass attainment
  JOURNAL   PLoS Genet 10 (6), e1004423 (2014)
   PUBMED   24945404
  REMARK    GeneRIF: Variants at the CPED1 locus were strongly associated with
            bone mineral density at the skull and upper limb sites, but not
            with lower limb-bone mineral density.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5304)
  AUTHORS   Medina-Gomez,C., Kemp,J.P., Estrada,K., Eriksson,J., Liu,J.,
            Reppe,S., Evans,D.M., Heppe,D.H., Vandenput,L., Herrera,L.,
            Ring,S.M., Kruithof,C.J., Timpson,N.J., Zillikens,M.C.,
            Olstad,O.K., Zheng,H.F., Richards,J.B., St Pourcain,B., Hofman,A.,
            Jaddoe,V.W., Smith,G.D., Lorentzon,M., Gautvik,K.M.,
            Uitterlinden,A.G., Brommage,R., Ohlsson,C., Tobias,J.H. and
            Rivadeneira,F.
  TITLE     Meta-analysis of genome-wide scans for total body BMD in children
            and adults reveals allelic heterogeneity and age-specific effects
            at the WNT16 locus
  JOURNAL   PLoS Genet 8 (7), e1002718 (2012)
   PUBMED   22792070
REFERENCE   3  (bases 1 to 5304)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat Genet 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5304)
  AUTHORS   Dauwerse,J.G., Ruivenkamp,C.A., Hansson,K., Marijnissen,G.M.,
            Peters,D.J., Breuning,M.H. and Hilhorst-Hofstee,Y.
  TITLE     A complex chromosome 7q rearrangement identified in a patient with
            mental retardation, anxiety disorder, and autistic features
  JOURNAL   Am J Med Genet A 152A (2), 427-433 (2010)
   PUBMED   20082467
REFERENCE   5  (bases 1 to 5304)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     Novel eukaryotic enzymes modifying cell-surface biopolymers
  JOURNAL   Biol Direct 5, 1 (2010)
   PUBMED   20056006
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5304)
  AUTHORS   Tayo,B.O., Luke,A., Zhu,X., Adeyemo,A. and Cooper,R.S.
  TITLE     Association of regions on chromosomes 6 and 7 with blood pressure
            in Nigerian families
  JOURNAL   Circ Cardiovasc Genet 2 (1), 38-45 (2009)
   PUBMED   20031566
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5304)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 5304)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 5304)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ082412.1, AL832638.2, AL832619.2, AK130323.1 and BI496654.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024913.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832619.2, AL832638.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310396.10/ ENSP00000309772.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               BQ082412.1         15-192
            179-1719            AL832638.2         17-1557
            1720-2354           AL832619.2         1689-2323
            2355-2555           AL832638.2         2193-2393
            2556-2816           AL832619.2         2525-2785
            2817-3813           AL832638.2         2655-3651
            3814-5302           AK130323.1         885-2373
            5303-5304           BI496654.1         269-270
FEATURES             Location/Qualifiers
     source          1..5304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.31"
     gene            1..5304
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /note="cadherin like and PC-esterase domain containing 1"
                     /db_xref="GeneID:79974"
                     /db_xref="HGNC:HGNC:26159"
                     /db_xref="MIM:620637"
     exon            1..202
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            203..682
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..3514
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cadherin-like and PC-esterase domain-containing
                     protein 1"
                     /codon_start=1
                     /product="cadherin-like and PC-esterase domain-containing
                     protein 1 isoform 1 precursor"
                     /protein_id="NP_079189.4"
                     /db_xref="CCDS:CCDS34739.1"
                     /db_xref="GeneID:79974"
                     /db_xref="HGNC:HGNC:26159"
                     /db_xref="MIM:620637"
                     /translation="MVCRPVFPCRRRFCPRPFLVGLVVAICLFYQTLTLRGSRKLTAA
                     APGAVPHTSTETQASRCKKGFSQDKQCFLLSGNAQETRKVKESMETHFGSHGRRAILY
                     RPPFYSKTELQLHQHILTQHGYTVVIAEERLNAGLGPGLLEQGDLGSWDLLICLSSKK
                     AEGTPCISKEVMCQLGLHQKANRLPEIQQPLCRKEGLCQIVRRFPELQLPVSPSVCLD
                     QGMQLKPSTSSHLLKTVKPRVWKPGDWSREQLNETTVLAPHETIFRAEDLSVILKAYV
                     LVTSLTPLRAFIHSTGTVWNPPKKKRFTVKLQTFFETFLRASSPQQAFDIMKEAIGKL
                     LLAAEVFSETSTLGPKTFHRCRFCFQLLTFDIGYGSFMYPVVLQVHEHLNFQDYDNMD
                     FEDQNTEEFLLNDTFNFLFPNESSLSIFSEIFQRLYRSDVFKGENYQKELNQCLSLEE
                     INSIMTFIKELGSLGQFQLLFPSTTPGIQSLMHEFYDVANPVGNPGSVLTQYWSLLNV
                     FEQFQFMNKKTQPHPLEWNSFTEDKNIEKPQVPFDAIENKKAAVPQIKNENKEIHCSD
                     DENTPCHIKQIFTHPHLELNPDFHPKIKDYYCEVPFDVVTVTIGVETPKCLCKVHLYE
                     QAGPSFASYPLGLGMNKISIFVVDESPAHGETLITYKLTIYREDRPSLPLFEAFTACG
                     FVQDCGLLIHPEETCGLQPISSDYIEAILQSELKRCPSGDMKGQWIVPCLSCSDNRTC
                     DWREITWQPHNCQYGVLTKPQLQQCLGGRKILFIGDSTNRGIMYYLIERLNETLQEWQ
                     KVHGTKFYHNVNGGKTLISYSYYPQFWISPSLRPTFENALEHLLQRSRPLENTGQTVL
                     VVGGVQWLNSNHLQIIHKVLKRENLLNILVIIKTLGIGFHLPVDGVHFLTQSEVQNLW
                     KENLIILDTAKKHGYEVVDTFTITMGRYKEFLQGKCGCHFHEVVKSKLSKEYNFIKMK
                     RSRNHIMGRYFSNQSKLQQGTVTNFRSPYHVRGPINQVCSEILLSRMCANKRTM"
     exon            683..866
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            867..973
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1049
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1182
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1351
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1494
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1567
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1735
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1840
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2010
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2081
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2132
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2319
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2488
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2606
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2743
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2964
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3066
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3154
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3301
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..5304
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5285..5290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /note="hexamer: AATAAA"
     polyA_site      5304
                     /gene="CPED1"
                     /gene_synonym="C7orf58"
                     /note="major polyA site"
ORIGIN      
        1 ctctgctccc gccgggcgtg cagcgggcgc gcgcgcgtgt gtttatgtgt ctgtgtgcgt
       61 gtgtgtgtgt gtctctctct gtgtgtgtgt gagatgaatt ggagtcatac gactgggtgt
      121 ttccttccga gtggttttca tcagcaatcc attaggaaat catggaaact ttttttttcc
      181 tggctaaaag gatgaaaact gagtcatcca cttttgactg tcatccatgg aagagctctt
      241 attaaaagcc tcagactttc gggacctatg attctttggc acaacctttt ggaaaattct
      301 taagcaggga tgaagcaaac ttgattggag ttggggaaaa agaagacaga ttagtatttt
      361 tcatgctgac aaaaaatagc tgctatgact tttcccgcaa cgtggacagg ggccaagtga
      421 agctgaactg gtcatggtct gtcgcccagt gttcccttgt cgtcggcgat tttgcccccg
      481 acccttcttg gtgggcttag tggtggcaat ctgtctcttc taccagactc tgaccctccg
      541 agggtcgagg aagctcacag ccgctgcccc tggggctgtc ccacacacat ccactgaaac
      601 ccaggcaagc agatgcaaga aaggattctc tcaggacaaa cagtgcttcc ttctctctgg
      661 taatgcccag gaaaccagaa aggtcaaaga atcaatggag acacactttg gcagccatgg
      721 ccgaagggcc atactctaca ggcctccttt ctacagcaaa acagagcttc agctacacca
      781 gcacattctg actcaacatg gctatacggt tgtcatcgct gaagaaaggc tcaatgctgg
      841 cctagggccg gggctactag aacaaggtga tctgggctct tgggatctgc tcatttgcct
      901 gtcttctaag aaagcagaag gaacaccctg tatatccaag gaagtcatgt gccagttagg
      961 tttacatcaa aaggcaaaca gattaccaga aatacagcag ccactttgca gaaaggaagg
     1021 attatgtcaa atagttagaa gattcccaga actgcaactt ccagtgagtc cctctgtgtg
     1081 tctggatcag ggaatgcaat taaagccgag tacttcgagt caccttttaa aaacagtgaa
     1141 gccacgtgtg tggaaaccag gggactggag tcgtgaacag ctgaatgaaa cgacagtcct
     1201 tgctccacat gaaacaatct ttcgagccga agatctatct gtgattctta aagcgtatgt
     1261 gttggtgacg tccttaaccc ctttgcgtgc attcattcat tcgacgggca cagtttggaa
     1321 tccaccaaag aaaaaacgct tcactgtcaa gctgcaaaca ttttttgaga cattcctgag
     1381 agccagttca cctcaacagg cttttgacat tatgaaggaa gcaattggca aactactgct
     1441 agcggctgaa gtattcagtg aaacatctac tctgggacca aagaccttcc atagatgcag
     1501 attctgcttt caacttctaa cttttgatat tggttatggc agtttcatgt accctgtagt
     1561 gctccaggta cacgagcatt taaattttca agattatgat aatatggatt ttgaggacca
     1621 aaatacagaa gaattccttt taaatgacac tttcaatttt ctcttcccta atgaatcatc
     1681 actttccata ttttctgaga tatttcagag actttataga tcagatgttt tcaagggtga
     1741 aaactatcaa aaggaactaa atcagtgtct gtccttagaa gaaattaact caattatgac
     1801 tttcataaag gaacttggaa gtctgggaca attccaactg ctcttcccat ctactactcc
     1861 tgggattcag tcactgatgc atgaatttta tgatgtggca aatcctgtgg gaaatcctgg
     1921 ctcagtcctg acccaatact ggtctctttt aaatgtattt gaacaatttc agttcatgaa
     1981 taaaaagaca cagccacatc cactggaatg gaattctttc acagaagata agaacattga
     2041 aaaaccacaa gtgccatttg atgcaataga aaataaaaaa gctgcagttc cacaaattaa
     2101 aaatgaaaat aaagaaatac attgcagtga tgatgaaaac acaccatgtc atatcaagca
     2161 gatcttcaca catccacatt tggaactaaa tcctgacttt catccaaaga tcaaagatta
     2221 ttactgtgaa gtcccatttg atgtggtaac agtgacaatt ggagtggaaa ctcctaagtg
     2281 tctgtgcaag gtgcacctgt acgagcaggc agggccaagc tttgccagct accctctggg
     2341 cttaggaatg aacaaaatct caatatttgt tgtggatgaa tctccagcac acggtgagac
     2401 tctgatcacg tacaaactca ccatctatag agaagaccgc ccaagtctgc ccttgtttga
     2461 ggccttcaca gcatgtggtt ttgtgcagga ttgtggtttg ctgattcatc cagaggaaac
     2521 ctgtgggtta cagcctattt cttctgacta cattgaagcc attttacagt ctgaactaaa
     2581 aagatgtcca tctggggaca tgaaaggcca gtggattgtg ccttgcctta gttgttcgga
     2641 caacaggacg tgtgactgga gagaaataac ctggcagccc cacaactgcc aatatggtgt
     2701 cctaactaag cctcaactcc agcagtgcct gggaggaagg aagattctgt tcattggaga
     2761 ttcaaccaac agagggatca tgtactatct tattgaaagg ctgaatgaaa cgttgcagga
     2821 atggcagaaa gtacatggca ctaaattcta tcacaacgtc aatggtggga agactttgat
     2881 cagttattcc tactatcccc agttctggat aagcccttca ttgagaccaa catttgaaaa
     2941 tgcacttgaa cacctcttgc aaagatcacg tcccctagag aatactggcc agactgtatt
     3001 ggttgttggt ggtgttcagt ggcttaattc caatcacctg caaattattc acaaagtttt
     3061 gaagagggaa aatttactca atatcctagt gatcatcaaa actttgggaa ttggatttca
     3121 tctgccagtg gatggagtac atttcttaac acagagtgaa gtacagaact tatggaaaga
     3181 aaatttgatt attctggata ctgcaaaaaa acatggctat gaagtagttg acacattcac
     3241 tataacaatg gggcgttaca aagagtttct acaggggaag tgtggatgtc atttccatga
     3301 ggtagtgaaa tcaaagttat ccaaagaata taactttatt aaaatgaaaa gatcaagaaa
     3361 tcatatcatg ggaagatatt tcagcaatca aagcaaacta caacaaggca ctgtaacaaa
     3421 ttttcgatcg ccatatcatg tcagaggtcc aataaatcag gtttgttctg aaatccttct
     3481 cagcaggatg tgtgcaaata aaaggactat gtaggctccc tgcaggagag ctgaatctgg
     3541 agctggagac gagctagtca cccggacaat ggtctaggag ccaagcgctg cacatcgcac
     3601 acatttggga tcgaccacac acacttgtgc acaccagcac atgcatgcac accagtacac
     3661 acacagttaa ataatgataa cacttcttac agctttatga attcaagatg tgaccttgaa
     3721 caccagtcca tttcacagtg aaagatatac ctagagaaac gttacttgaa gcataattat
     3781 taaccagaac cactgtgggc caggtatggc attgtgataa taaagagaaa tatagacact
     3841 taaaattatg tgaaaaaaag gataatgctc tttcatgttg tcttaccata tctataggta
     3901 catcaatatt gaaaaggaga aaaaccaatg acattccact ggcaagtaga agttgtcctt
     3961 tcattcttta ccaggagaaa atgtgatgtt tatgatggct taggctttgt gaatctaatg
     4021 cttatgaaaa acatttcttc ctatactttt taaattttat tactgaaagg aaaagaacag
     4081 gaatgttcca caagggaatt tgaagagatt ctgtgagaga gatatgaaat attttatagt
     4141 taaaacacca atatattcaa ctttacactt cttgtgtttt tcataaacat tccctcttgt
     4201 cttatctgtg tacttcgatg ggtaactgca gtctgaatta atgaaatatg taattttaaa
     4261 gtaagtaaca aaatgtagtt cctcatgtat tactgtacta tgtttcattg atgatattac
     4321 ttaaatcttg tgtttgccat tacagcccta tgtaacttaa aattacaatt atattttatg
     4381 taaatatttt gcaaaggact atgcattctg aaatgcatag gtgctttttc ccaccaagca
     4441 tttgcatatg tccacaaata gtattatgtt actagtatct atattttgat tttcctgagc
     4501 aactgtatca aatccaaatt tagattagac aaaaaattat tattttaatt aaactgtggc
     4561 atacatataa tacataccta attatagtag tgagaactat ttcttttatc tctttaggtt
     4621 caaaatggtg aatttcttta ttatatgaat gctttgttgt gagataacat cacactgtta
     4681 caatggattt tagaggtttg tcttttttgg gtggggtggg aagctgagag ggttaattca
     4741 atacatggct gaaattacca aatgtataaa tacctcattt tcactaccat acaagaaaaa
     4801 aacacctatt ttgattgatc agttcttttg tatgaatatc cacctccttt aaatactcta
     4861 tttttatata tatttttata tgaagataaa catgaattta tatttaactg tcttaaatta
     4921 tatttacata aatgcaaata tcacttgata taaacaatac aaatctgcat cttacagatg
     4981 ataatttttt tagaagaatg atacagaatt aactttaaaa ataaaacttt tctaatatac
     5041 acttaaatgc aaacatcatt tttaaatttt cagtgatttt tttaatgaca taaaacgtta
     5101 ccaatgtgtg cagcctctcc atcatgtttt aacatactgt atactctata gcagtattac
     5161 agtcagtatt tcatataatt ttctttagac ctaactgtta ccatctgact gaggttactc
     5221 tggtatttat ctcttcgctg ctgaaataat aatggatttt agaaacaatt gtaataatat
     5281 cattaataaa tgtcttacta gtaa
//
