LOCUS       NM_030627               9418 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens cytoplasmic polyadenylation element binding protein 4
            (CPEB4), transcript variant 1, mRNA.
ACCESSION   NM_030627
VERSION     NM_030627.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9418)
  AUTHORS   Song,J. and Yang,H.
  TITLE     Down-Regulation of CPEB4 Alleviates Preeclampsia through the
            Inhibition of Ferroptosis by PFKFB3
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (3), 73-82 (2024)
   PUBMED   38305290
  REMARK    GeneRIF: Down-Regulation of CPEB4 Alleviates Preeclampsia through
            the Inhibition of Ferroptosis by PFKFB3.
REFERENCE   2  (bases 1 to 9418)
  AUTHORS   Fernandez-Alfara,M., Sibilio,A., Martin,J., Tusquets Uxo,E.,
            Malumbres,M., Alcalde,V., Chanes,V., Canellas-Socias,A.,
            Palomo-Ponce,S., Batlle,E. and Mendez,R.
  TITLE     Antitumor T-cell function requires CPEB4-mediated adaptation to
            chronic endoplasmic reticulum stress
  JOURNAL   EMBO J 42 (9), e111494 (2023)
   PUBMED   36919984
  REMARK    GeneRIF: Antitumor T-cell function requires CPEB4-mediated
            adaptation to chronic endoplasmic reticulum stress.
REFERENCE   3  (bases 1 to 9418)
  AUTHORS   Suner,C., Sibilio,A., Martin,J., Castellazzi,C.L., Reina,O.,
            Dotu,I., Caballe,A., Rivas,E., Calderone,V., Diez,J., Nebreda,A.R.
            and Mendez,R.
  TITLE     Macrophage inflammation resolution requires CPEB4-directed
            offsetting of mRNA degradation
  JOURNAL   Elife 11, e75873 (2022)
   PUBMED   35442882
  REMARK    GeneRIF: Macrophage inflammation resolution requires CPEB4-directed
            offsetting of mRNA degradation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9418)
  AUTHORS   Pell,N., Garcia-Pras,E., Gallego,J., Naranjo-Suarez,S., Balvey,A.,
            Suner,C., Fernandez-Alfara,M., Chanes,V., Carbo,J.,
            Ramirez-Pedraza,M., Reina,O., Thingholm,L., Bang,C., Ruhlemann,M.,
            Franke,A., Schierwagen,R., Rheinwalt,K.P., Trebicka,J., Mendez,R.
            and Fernandez,M.
  TITLE     Targeting the cytoplasmic polyadenylation element-binding protein
            CPEB4 protects against diet-induced obesity and microbiome
            dysbiosis
  JOURNAL   Mol Metab 54, 101388 (2021)
   PUBMED   34774811
  REMARK    GeneRIF: Targeting the cytoplasmic polyadenylation element-binding
            protein CPEB4 protects against diet-induced obesity and microbiome
            dysbiosis.
REFERENCE   5  (bases 1 to 9418)
  AUTHORS   Soylemez,Z., Arikan,E.S., Solak,M., Arikan,Y., Tokyol,C. and
            Seker,H.
  TITLE     Investigation of the expression levels of CPEB4, APC, TRIP13,
            EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different stage
            colorectal tumors
  JOURNAL   Turk J Med Sci 51 (2), 661-674 (2021)
   PUBMED   33237662
  REMARK    GeneRIF: Investigation of the expression levels of CPEB4, APC,
            TRIP13, EIF2S3, EIF4A1, IFNg, PIK3CA and CTNNB1 genes in different
            stage colorectal tumors
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9418)
  AUTHORS   Sawada,S., Takei,M. and Ishiwata,T.
  TITLE     SAP discovery: the sword edges--beneficial and harmful
  JOURNAL   Autoimmun Rev 6 (7), 444-449 (2007)
   PUBMED   17643931
  REMARK    Review article
REFERENCE   7  (bases 1 to 9418)
  AUTHORS   Sawada,S., Takei,M., Inomata,H., Nozaki,T. and Shiraiwa,H.
  TITLE     What is after cytokine-blocking therapy, a novel therapeutic
            target--synovial Epstein-Barr virus for rheumatoid arthritis
  JOURNAL   Autoimmun Rev 6 (3), 126-130 (2007)
   PUBMED   17289546
  REMARK    Review article
REFERENCE   8  (bases 1 to 9418)
  AUTHORS   Sawada,S. and Takei,M.
  TITLE     Epstein-Barr virus etiology in rheumatoid synovitis
  JOURNAL   Autoimmun Rev 4 (2), 106-110 (2005)
   PUBMED   15722257
  REMARK    Review article
REFERENCE   9  (bases 1 to 9418)
  AUTHORS   Kurihara,Y., Tokuriki,M., Myojin,R., Hori,T., Kuroiwa,A.,
            Matsuda,Y., Sakurai,T., Kimura,M., Hecht,N.B. and Uesugi,S.
  TITLE     CPEB2, a novel putative translational regulator in mouse haploid
            germ cells
  JOURNAL   Biol Reprod 69 (1), 261-268 (2003)
   PUBMED   12672660
REFERENCE   10 (bases 1 to 9418)
  AUTHORS   Takei,M., Ishiwata,T., Mitamura,K., Fujiwara,S., Sasaki,K.,
            Nishi,T., Kuga,T., Ookubo,T., Horie,T., Ryu,J., Ohi,H. and
            Sawada,S.
  TITLE     Decreased expression of signaling lymphocytic-activation
            molecule-associated protein (SAP) transcripts in T cells from
            patients with rheumatoid arthritis
  JOURNAL   Int Immunol 13 (4), 559-565 (2001)
   PUBMED   11282995
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA803281.1, BU629646.1, BQ061431.1, BC117150.1, BX538213.1,
            AB051460.1, CR741268.1, AI742270.1, R64139.1 and AC093275.3.
            
            On Nov 23, 2018 this sequence version replaced NM_030627.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX538213.1, SRR1660807.10210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265085.10/ ENSP00000265085.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-535               DA803281.1         23-557
            536-843             BU629646.1         19-326              c
            844-991             BQ061431.1         465-612
            992-3673            BC117150.1         1-2682
            3674-4042           BX538213.1         2837-3205
            4043-6183           BX538213.1         3207-5347
            6184-6637           AB051460.1         4817-5270
            6638-7746           BX538213.1         5802-6910
            7747-8225           CR741268.1         195-673
            8226-8420           AI742270.1         11-205              c
            8421-8424           R64139.1           5-8                 c
            8425-8429           AI742270.1         2-6                 c
            8430-9418           AC093275.3         149461-150449
FEATURES             Location/Qualifiers
     source          1..9418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.2"
     gene            1..9418
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="cytoplasmic polyadenylation element binding protein
                     4"
                     /db_xref="GeneID:80315"
                     /db_xref="HGNC:HGNC:21747"
                     /db_xref="MIM:610607"
     exon            1..2510
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1386..3575
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="isoform a is encoded by transcript variant 1;
                     CPE-binding protein 4"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 4 isoform a"
                     /protein_id="NP_085130.2"
                     /db_xref="CCDS:CCDS4390.1"
                     /db_xref="GeneID:80315"
                     /db_xref="HGNC:HGNC:21747"
                     /db_xref="MIM:610607"
                     /translation="MGDYGFGVLVQSNTGNKSAFPVRFHPHLQPPHHHQNATPSPAAF
                     INNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKAKSQQQEQQDPLEKQQLSPSPGQ
                     EAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEATGLGTSTQPLTS
                     SASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALLFQNFPHHVSPGF
                     GGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLAN
                     NLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGLNGGITPLNSISPL
                     KKNFASNHIQLQKYARPSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLID
                     IMRAENDTIKGRLNYSYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQPLH
                     SGLGSPHCFSHQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAES
                     KSYFPPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDS
                     DFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGA
                     GRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCGGKFAPF
                     FCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRWN"
     exon            2511..2592
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2643
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2667
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2841
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2931
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3050
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3165
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3347
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..9418
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7729..7734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="hexamer: AATAAA"
     polyA_site      7748
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="major polyA site"
     regulatory      7757..7762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="hexamer: AATATA"
     polyA_site      7782
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
     regulatory      8412..8417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="hexamer: AATATA"
     polyA_site      8429
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
     regulatory      9039..9044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="hexamer: AATAAA"
     polyA_site      9065
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
     regulatory      9391..9396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
                     /note="hexamer: AATAAA"
     polyA_site      9418
                     /gene="CPEB4"
                     /gene_synonym="CPE-BP4; hCPEB-4"
ORIGIN      
        1 actcggctcg gtcctgagga gaaggactca gccgcggctg cgggacccgg gcaccgggag
       61 gcggtggcgg cggcggcggc ggcagcagcg gcgacagcag aggaggaaga ggaggaagaa
      121 ggaaagaaaa agaagaacca ggaggagtcc tcaacaacga cagcggggac tgcgggacca
      181 gggtaaagcg gcgacggcgg cgacggccca gcaaccgtga ggagaaacaa aagccttcta
      241 aattatagtt taaaaaaaaa ttctggggga aaagagagag aaagccgagg ggggaggccc
      301 ttctccttta aaataactac ggtagtgggt ttttcctttt tttcctcttt tttccctctc
      361 tgcggagaat cgaactgagg gaactgaaca aaccgcccct gggtcccatg agggaaaaaa
      421 accccggagc cgcagagagg ggaagaggca gaaaccgcag gaccttccag gtcgccccct
      481 cggtccccgc acccccaggc cgcccgctca ccctcgtcga gtctcgctaa tccctcctga
      541 tcgcgacccc cgcaagaggg agaaacgggt gtttccaacc cctttcatgg gggagaggaa
      601 gccgcgggga gcccaggaac agcgaccgca gcaagatctg cacccggagc ctcaggaaca
      661 gccccagagg ccaaaactgc accctgcgaa agagcagaaa acaggaccag gaacagcaga
      721 aacctccctg caatcatctt tccattagtc aatgctgatt tcctctcccg aaaccaggaa
      781 ttcacttccc accccagata acctaatata atctatatat ataaatatat aatatataat
      841 gttcttaaat tattcctgat ttttttttaa ccaagctgcc aagaaaagaa cgtattcccc
      901 tcttagtcct attctaattt ttatgtgagt gaatctaaac tgctgaggaa aaccatatgt
      961 gattgttaaa ttatatatat ctatattttt actccgcgca aggcttattc ttctacatcc
     1021 atagatgctt gagaagctct gtttttgtca ttcatgtaca ttttcctttg gaaaaagaaa
     1081 gcgcctattt tactaaccaa agacttgatt tttaccctct tcatttttat tccctcctaa
     1141 aaataagccc aattggatcc aagtcaatgt tttaagagat ttttttaaga gttgtttttt
     1201 ctttcagaga ccagaattcc aaatcagaac aatttaaggt gataagctgc gatctttgag
     1261 ctagctataa ataagacatt tcaagcaagc aagcaaacaa cttaaatttg gggtagagga
     1321 aaaaaaaggc gtgagacatc aggttgtcat tttttattgt gagattctgc tcctaaagat
     1381 aataaatggg ggattacggg tttggagtgc tagtgcaaag caatactggg aataaatctg
     1441 cttttccagt cagattccat ccacatctgc agcctccaca ccatcaccaa aatgccaccc
     1501 ccagccctgc tgcttttata aataataaca cagctgccaa tggcagcagt gctgggtcag
     1561 cttggctttt tcctgctcca gctacccata acattcagga tgagatcttg gggtcagaaa
     1621 aagcaaaaag tcagcaacag gaacagcaag accccttaga aaagcagcag ctttccccaa
     1681 gtccaggtca ggaagctgga atactgcctg aaacagagaa ggcaaaatca gaagaaaatc
     1741 aaggggacaa ttcttcggaa aatggcaatg ggaaggagaa aataaggatc gaatctccag
     1801 tgttgacagg gtttgattat caagaagcca ctgggctagg tacttcaacc caacccttga
     1861 catctagcgc atcgtctctt actggtttca gtaactggtc agcagcgata gcgccttcct
     1921 cctctacaat aatcaatgaa gatgcaagtt tctttcacca gggaggggtc cctgctgctt
     1981 cggctaataa cggtgctctg ttgtttcaaa atttccccca tcatgtcagc cctggctttg
     2041 gaggcagctt ctctcctcag atcgggcctc tctcacagca ccacccacat caccctcatt
     2101 tccagcatca tcacagccag catcagcagc aaaggaggtc tcctgccagt ccccatcccc
     2161 cacccttcac acatagaaat gctgctttta accagctgcc tcatttggcg aataatctta
     2221 acaaaccccc ctctccgtgg agcagctacc agagtccgtc accaacaccc tcctcttcct
     2281 ggagcccggg cggtggtgga tatggtggct ggggaggttc ccaaggccga gatcaccgca
     2341 gagggctgaa tggtggaata acgcccctga actccatctc gcctttgaag aaaaattttg
     2401 caagcaatca tattcagctc cagaagtatg ctcgccccag ctctgccttt gcacctaaat
     2461 cctggatgga agatagcttg aacagggctg acaacatttt tccttttccg gatcgcccca
     2521 ggacattcga catgcactca ctggagagtt cactcattga cataatgaga gctgaaaatg
     2581 ataccattaa aggtcgtcta aactattcat atccaggatc cgatagctct ctgcttatta
     2641 atgcaaggac atatgggcga aggagaggtc agtcttcact gtttccaatg gaagatggat
     2701 tcttggatga tggccgtggg gatcagcctc ttcatagtgg cctgggttca cctcactgct
     2761 tcagtcacca gaatggggaa agagtggaac gatattctcg aaaggtgttt gtaggcggat
     2821 tgcctccaga cattgatgaa gatgagatca cagctagttt tcgtcgcttt ggccctctga
     2881 ttgtggattg gcctcataaa gctgagagca aatcctattt tcctcctaaa ggctatgcat
     2941 tcctgctgtt tcaagatgaa agctctgtgc aggctctcat tgatgcatgc attgaagaag
     3001 atggaaaact ctacctttgt gtatcaagtc ccactatcaa ggataagcca gtccagattc
     3061 ggccttggaa tctcagtgac agtgactttg tgatggatgg ttcacagcca cttgacccac
     3121 gaaaaactat atttgttggt ggtgttcctc gaccattacg agctgtggag cttgcgatga
     3181 taatggatcg gctatatgga ggtgtgtgct acgctgggat tgataccgac cctgagctaa
     3241 aatacccaaa aggagctggg agagttgcgt tctctaatca acagagttac atagctgcta
     3301 tcagtgcccg ctttgttcag ctgcagcatg gagagataga taaacgggtg gaagttaagc
     3361 catatgtctt ggatgatcag ctgtgtgatg aatgtcaggg ggcccgttgt ggggggaaat
     3421 ttgctccatt tttctgtgct aatgttacct gtctgcagta ttactgtgaa tattgctggg
     3481 ctgctatcca ttctcgtgct ggcagggaat tccacaagcc cctggtgaag gaaggcggtg
     3541 accgccctcg gcatatttca ttccgctgga actaaaggat aactgcagtg ctcattttca
     3601 ggcctcagaa taagtgcact cttctgttca ttctgacccc ttcctcaacc tcttcacgct
     3661 ggcatgtcct tttgtagcag tctgtaactt aactatagta taatgaaaag aatgacctat
     3721 aatataggtg ttttgtagat tcttgtgtca ctgcaaacaa tatgaactcc tttttcgtat
     3781 tgccatcggg ttgcatggaa gttttattct cttgttttgc tggaaaccaa gaggatccaa
     3841 acttcctgca acattttctt agaggagaga gagaaatatt aaaagagaaa tgaaacaata
     3901 gagtattttg ggtttttaat taaattattg ttaataatat aacatataag aatactttta
     3961 ttaaaataac catgcaacaa taacactatc ggtctatctg acagtttttc ccccagggaa
     4021 gtgcttttgc cttttccttt cttttttttt tttttttcat cttttttgtc tctctctttt
     4081 ttccatccct ttttaatttt tttaacagca atggaggaag ttaacaattt ttaatggaaa
     4141 gagcatgtta gagcaaacaa atgcataagc aagactgagc agcattataa ttaattttca
     4201 gggttttgag gctgaacata atttcattat ccctcaaaaa gttaccacca catcagaaaa
     4261 aataaaaaaa aaatagtaaa gtaggcagag ctaggtttat tttctcttaa acaattttta
     4321 aaattcagaa tgtaaaaatt gggtaaattt actactgagg ggagtgcact tatttattta
     4381 acttacttat ctggtcaaag ccccaggaaa cctaccaaag ctagaattaa tgacaactgg
     4441 tgggaaacct agcatttcct ctcctgaaga ataaatgtat aaatgttatt tttgatgttt
     4501 atatataaac tctatatcct aatttactaa tactcatcag atgtcagcct ttgctctcca
     4561 ttttgacgtt aaaaaacaac aacagatcta gagatacctc aaggatatca tttttgattt
     4621 tgtgttacag tacacttgta gccaaaactg gaagacaaaa ccaatatata atttggctgc
     4681 tgattggctt acttttagat ttaaagttac tttgggtatc ctgtaattta gttgtaacat
     4741 agaaaatgaa aaaacagtta aaaaaagtga agtagttgca aagtgttttg cactgttgaa
     4801 ctaagtaact gtgtaaatct gtgcaaaggt acgtatgttt atcttactct tcctataaac
     4861 taaaataaca ttacagtttc cgaatttagc atgggacata gtcagtgttt gaagtgccaa
     4921 cttcatcaag taatgcatgc tttattataa ataaaattct agctttgaaa ggcgttatgt
     4981 gttgaacagt atgcttcagg ggtaaattta aaatagtctc ttgaagccct agtcatggaa
     5041 gtaactttta ttttaattga cattctctta ttaaatgccc tatccatcat taaaaggttt
     5101 attatcagtg ggcaaaacat gaaataatat gatcgaatgg caatcttgct agttgcgcta
     5161 cctaacagta ccatcttgga tccttcaaaa ccaaagactt gccccagcac tgctgtggaa
     5221 ccacctggct tatgacccct atggatgatc tttaggaaaa gcagcccttt acttttaata
     5281 caggctttaa tgaactatac ctgttaagtt ccaaaggtca aaatggaggc atttgctgtc
     5341 taatattcaa acatagaaag ggagctgctt ttaaagaatt ccctgcaaat actgaaagca
     5401 gtcatgcgaa tggagggtgc tcttgtgtag ctggtcaggg actttttttt cttttctcct
     5461 gaactacatg attctaattg gaatgttcat ttgcctcttt ttactctttt aaatgcttgt
     5521 aggtggcttg gggtgtgcta tcgtgctgtt cctactcagt aaacaggtgt gatgagttaa
     5581 caagaaataa cactgtttga gaactagctt tgaataataa tttttccctt tgtacatgac
     5641 ctgctgaatt tcggtacagt gtttttgtag ctaacttatt ttgtcatgca cataatgtat
     5701 atttgttatg cactactttt gtatatcttg tttttccaac agtgaacatt tttaggcaca
     5761 cttttcactg acgggatatc tctttatgca atacctcaat ttttcatatt gcaaagagta
     5821 gctttttgta cttttattac tgagagatct tcatatactt cattttttaa tataaataat
     5881 tttaataaat tttattttct tatattctgc tttttataca tttcagtgct ctgcatacat
     5941 tttaaattat gaatgtcgtg cactggcaat gctattttag agtctgcaga gaagagaaag
     6001 catgttgctt aaacatcctt ccccagcacc agctattggt gtacctataa tttaagaaat
     6061 agtctatgta aagtcacaaa ttaatgaaaa aaattcgcat gaaaatgaca gataacactg
     6121 tagttcctaa aaaaaaaatt aaatgcataa gcataaggta gaaattaaaa taacaaaatt
     6181 gtctacagct tcttactaag tttttaaaat tattcataaa atgcagacat ttttggtgaa
     6241 tgtttagcca tttttaatat taataaattg atgttaagtg tttgattcag agatgtctgc
     6301 tcttttaaat tatatataag gaaaaaaaat agcctgcctt gggacaggtg tgtaatgtta
     6361 gtgtgcatga ctaatgtaag aaattgttat tctactaata tttacttgtg attgtgtgac
     6421 aagtgtgttt acagattatt ggttacactt caatttacag ggcataaaca atgattatct
     6481 attactctga actttatgat tacatgttct tcagattaca tgggattgta gttgggagtt
     6541 accatgtaac tcaaacataa ttaacatgta attagtttac agattgtagg gcatcacttc
     6601 aattcaccaa gcatgtagtt ctagcgcact agcatggcgc cagccatgta cttacaatgt
     6661 agttacagag taattacatg gtgatttttg caatgtaaaa taaagtgttt ctgattattt
     6721 tctatgtaaa ggaaccctct cctttcccct tctggtccct gcgctttggt ataatatata
     6781 tacttctcca tacacagacc tctgcagaat gcaaaataaa acttgcagtg aatgaattta
     6841 gcattttatg agagtgctgt tggaaagact tgataattca ccccttttgt tttgaagagt
     6901 tgaatcttct gttaaaaggt gatttaaaac ttgaatgtga tgaattgtgg caagttaact
     6961 tcaagttatg tgcaatactt atttcaaact tttgaaagat ctttgcagtg taattctttg
     7021 tttttaattg cagacattta aaaatgtcat tttctactgt taagagtaat cctctttctt
     7081 gctggtgttt ctaaagaaaa gaatcagaaa tcaatctttc tactaatgta aatttgagat
     7141 tatttttaaa aatggaataa aagaggtttt ggtcatttgc tttattttat tattttaaag
     7201 ctactgtgat tgatagcatt gtaagaatcg ggacaatatt gtattcaact gttttatttt
     7261 ttatattttt aaaatttaaa gtataattag tttttataat tttcatcaga tttttgttat
     7321 attttttgga agtgaaactt ttagcaagtg ggtgtctagt ttttactaat ccctaatttt
     7381 ttttccagtg tattgctcat attatcagaa ggaaaagtta tttaagtatg tcagttaatt
     7441 gtactacttg gctgaatttc catatagttt ttactgtgta tggggaggtt gtagtattta
     7501 ttatagcatt ttaaataagg gtaattcatt ttttattaaa gtcattttca cgttaagttc
     7561 ctatttttgt atgttctact cttaagttat ataacacagt tcctttttta aaagagttca
     7621 tttgttgaag tgctagtgaa aaattaatgt tattaaatag tttgcaaatg actatttata
     7681 ccagtatgca tataattttt aaatatttgt aatgtgagat gttgaatgaa taaaactttt
     7741 aactcagatt tcttttaata tacttatttc tttttaacac aagtagatga tgctttcttg
     7801 actgggaatg taacatttta aaatattagg aatatactgt tcagctaatg cagcacaaac
     7861 caataggaaa aaatcttcag tcatataagt actgtggcca gtgtgcattc ttatgtaagc
     7921 ctataagcgt cggtgggtgg ttgtgtcttt ggcctgtact gttagttcac ctgctgcctg
     7981 ccctgcagag ttctttttat ttgtagcctt caatatgtat acagggagta agcccaggat
     8041 ctaagcattc agttatcagt tgaaggccaa atgcccaaca aaagtgaaaa acccaatgtt
     8101 tagttaataa tgaaagtccg tatctgggag gttcagtttt gagtctttgt caatgaatag
     8161 tcttgatttg tggccacact accaaagggc ttgaaaacaa gtctcttttg acttccaatt
     8221 cccagttcct ccatagacct taatgtcata ggatacggtg tgtgggatta taatctctat
     8281 ggcatgtcaa ttgaaaatat tatctttgat ttgatccatt aatcatgtgg actaccaagt
     8341 gctgtaatgt gttagtattt atattttaaa ctgcattctc aaacttttaa cataaggatt
     8401 tattataaca aaatataaca ctgagaatat cctgttttgt cagatttaat atctgttctt
     8461 tcttgagtat agtattctca agactagaag aggttcttgt cctgagagaa atggactatg
     8521 agatcttttg cgtctaagtt gtctttccca acaggcagct cttctaacta tagagattac
     8581 tgagggtaag ggcaggctgg acagcttccc ctttctctca tctggcaatt cccaaacctt
     8641 acgttgagca ttcaatgaag ggccttgagg aaaccccagg gatgggacac tggagatgtg
     8701 ggtggcattt ggttatcaag tctataatat tcctaggcat tctgggatgg tttcactatt
     8761 ttaagaaaag aaaaaaaaga tagcccaagc atatttagtt tattttagga aatgtttatt
     8821 tcaggtaagt gagatatcaa tgatatgtga tataacaact ctatcttgaa attacatagg
     8881 tgcattgctt tgggtgtttt aaatcacaga atggtgtgtc tggaaagggt gtaagaggct
     8941 tcctgggcta tatttcttca ttcactgatt gcctaaacct acccaacgag gaaaattctt
     9001 tttattttta tcttttgttt ttactgtcta accagatgaa taaacagtgg aaattctcta
     9061 ccacactctt aacaatcaag tcatttcata accccttttg gtaatgggtg tttgtgtcca
     9121 cagctagatc agaaagtaag tactttttct agggattttt tttttttttt aagtttggga
     9181 aatagtttga tcaaaagtca tggggaaagt aatctctgat tttaaaaatt gaagaatact
     9241 gaaggtgtca gtgagttaga aatttttaag gagtaattat tttctgaaat gtgtaataac
     9301 cgaataataa acaagacaaa actctaatat ttcagactgt gatcttcaga ggactaggat
     9361 agtcctttcc acaagaaaaa gacaaaaaaa aataaagttt taccattaaa tacactta
//
