LOCUS       NM_014912               7781 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens cytoplasmic polyadenylation element binding protein 3
            (CPEB3), transcript variant 1, mRNA.
ACCESSION   NM_014912
VERSION     NM_014912.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7781)
  AUTHORS   Ramirez de Mingo,D., Lopez-Garcia,P., Vaquero,M.E., Hervas,R.,
            Laurents,D.V. and Carrion-Vazquez,M.
  TITLE     Phase separation modulates the functional amyloid assembly of human
            CPEB3
  JOURNAL   Prog Neurobiol 231, 102540 (2023)
   PUBMED   37898314
  REMARK    GeneRIF: Phase separation modulates the functional amyloid assembly
            of human CPEB3.
REFERENCE   2  (bases 1 to 7781)
  AUTHORS   Winkler,I., Engler,J.B., Vieira,V., Bauer,S., Liu,Y.H., Di
            Liberto,G., Grochowska,K.M., Wagner,I., Bier,J., Bal,L.C.,
            Rothammer,N., Meurs,N., Egervari,K., Schattling,B., Salinas,G.,
            Kreutz,M.R., Huang,Y.S., Pless,O., Merkler,D. and Friese,M.A.
  TITLE     MicroRNA-92a-CPEB3 axis protects neurons against inflammatory
            neurodegeneration
  JOURNAL   Sci Adv 9 (47), eadi6855 (2023)
   PUBMED   38000031
  REMARK    GeneRIF: MicroRNA-92a-CPEB3 axis protects neurons against
            inflammatory neurodegeneration.
REFERENCE   3  (bases 1 to 7781)
  AUTHORS   Ramirez de Mingo,D., Pantoja-Uceda,D., Hervas,R.,
            Carrion-Vazquez,M. and Laurents,D.V.
  TITLE     Conformational dynamics in the disordered region of human CPEB3
            linked to memory consolidation
  JOURNAL   BMC Biol 20 (1), 129 (2022)
   PUBMED   35658951
  REMARK    GeneRIF: Conformational dynamics in the disordered region of human
            CPEB3 linked to memory consolidation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7781)
  AUTHORS   Wang,J., Wu,H., Wang,X., Zhao,X., Sun,L., Cheng,Y., Jiang,X., Li,J.
            and Zhang,G.
  TITLE     CPEB3, an RNA-Binding Protein, Modulates the Behavior of
            Endometriosis-Derived Stromal Cells via Regulating CXCL12
  JOURNAL   DNA Cell Biol 41 (6), 606-616 (2022)
   PUBMED   35451884
  REMARK    GeneRIF: CPEB3, an RNA-Binding Protein, Modulates the Behavior of
            Endometriosis-Derived Stromal Cells via Regulating CXCL12.
REFERENCE   5  (bases 1 to 7781)
  AUTHORS   Wang,H., Peng,D., Gan,M., He,Z. and Kuang,Y.
  TITLE     CPEB3 overexpression caused by miR-106b-5p inhibition inhibits
            esophageal carcinoma in-vitro progression and metastasis
  JOURNAL   Anticancer Drugs 33 (4), 335-351 (2022)
   PUBMED   35102025
  REMARK    GeneRIF: CPEB3 overexpression caused by miR-106b-5p inhibition
            inhibits esophageal carcinoma in-vitro progression and metastasis.
REFERENCE   6  (bases 1 to 7781)
  AUTHORS   Vogler,C., Spalek,K., Aerni,A., Demougin,P., Muller,A., Huynh,K.D.,
            Papassotiropoulos,A. and de Quervain,D.J.
  TITLE     CPEB3 is associated with human episodic memory
  JOURNAL   Front Behav Neurosci 3, 4 (2009)
   PUBMED   19503753
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7781)
  AUTHORS   Salehi-Ashtiani,K., Luptak,A., Litovchick,A. and Szostak,J.W.
  TITLE     A genomewide search for ribozymes reveals an HDV-like sequence in
            the human CPEB3 gene
  JOURNAL   Science 313 (5794), 1788-1792 (2006)
   PUBMED   16990549
  REMARK    GeneRIF: isolation of a ribozyme conserved mammalian sequence that
            resides in an intron of the CPEB3 gene
REFERENCE   8  (bases 1 to 7781)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 7781)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 7781)
  AUTHORS   Kurihara,Y., Tokuriki,M., Myojin,R., Hori,T., Kuroiwa,A.,
            Matsuda,Y., Sakurai,T., Kimura,M., Hecht,N.B. and Uesugi,S.
  TITLE     CPEB2, a novel putative translational regulator in mouse haploid
            germ cells
  JOURNAL   Biol Reprod 69 (1), 261-268 (2003)
   PUBMED   12672660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036444.2, AB023157.1, AK127060.1, BU785463.1 and AL365398.22.
            
            On Nov 23, 2018 this sequence version replaced NM_014912.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036444.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265997.5/ ENSP00000265997.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               BC036444.2         10-430
            422-1169            AB023157.1         347-1094
            1170-1716           BC036444.2         1179-1725
            1717-3250           AK127060.1         705-2238
            3251-4842           BC036444.2         3257-4848
            4843-5245           AB023157.1         4727-5129
            5246-5833           BU785463.1         5-592               c
            5834-7781           AL365398.22        57902-59849         c
FEATURES             Location/Qualifiers
     source          1..7781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.32"
     gene            1..7781
                     /gene="CPEB3"
                     /note="cytoplasmic polyadenylation element binding protein
                     3"
                     /db_xref="GeneID:22849"
                     /db_xref="HGNC:HGNC:21746"
                     /db_xref="MIM:610606"
     exon            1..153
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1169
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2261
                     /gene="CPEB3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CPE-BP3; hCPEB-3; CPE-binding protein 3"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 3 isoform 1"
                     /protein_id="NP_055727.3"
                     /db_xref="CCDS:CCDS31246.1"
                     /db_xref="GeneID:22849"
                     /db_xref="HGNC:HGNC:21746"
                     /db_xref="MIM:610606"
                     /translation="MQDDLLMDKSKTQPQPQQQQRQQQQPQPESSVSEAPSTPLSSET
                     PKPEENSAVPALSPAAAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPAAPGAS
                     LSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQT
                     QHHQQPPPPAPAPQPAQPAQPPQAQPPQQRRSPASPSQAPYAQRSAAAAYGHQPIMTS
                     KPSSSSAVAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGV
                     GVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPF
                     QDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGPPMSFADIMWRNHFAGRMG
                     INFHHPGTDNIMALNNAFLDDSHGDQALSSGLSSPTRCQNGERVERYSRKVFVGGLPP
                     DIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEED
                     GKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELA
                     MIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRV
                     EVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPL
                     VKEGGDRPRHVPFRWS"
     exon            1170..1329
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1386
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1527
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1617
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1736
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1851
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2033
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..7781
                     /gene="CPEB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5810..5815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB3"
                     /note="hexamer: AATAAA"
     polyA_site      5835
                     /gene="CPEB3"
                     /note="major polyA site"
     regulatory      7759..7764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB3"
                     /note="hexamer: ATTAAA"
     polyA_site      7781
                     /gene="CPEB3"
                     /note="major polyA site"
ORIGIN      
        1 agaggctgca cagcccgccc ggaccaacgc ctccgcgcct gccgccgtct ggccggcgcc
       61 ctcccgtttc cttcctccag ggggaaaaaa tgtctttcgg gccgctttcc aggaagcagc
      121 aggatgcgcc gctccactgt cggtagcaac aagctgcgca aaccatgcag gatgatttac
      181 tgatggacaa aagcaaaacc cagccccagc cccagcagca gcagcggcag cagcagcagc
      241 cccaacctga gtccagcgta tccgaagccc cgtccacgcc cctctcctca gagaccccca
      301 agccggagga aaacagcgca gtgccggccc tcagcccagc cgctgccccc ccggccccca
      361 acggcccgga caagatgcag atggaatcac cgctcctgcc aggcttgagt ttccatcagc
      421 ctcctcagca gccgccgccg cctcaggagc ccgcggcacc gggcgcgtcg ctgtcgccgt
      481 ccttcggcag cacctggtcc acgggcacca ccaacgcggt agaggacagc ttcttccagg
      541 ggatcacccc agtcaacggg accatgctct tccagaactt cccgcaccat gtcaacccag
      601 tcttcggagg cactttctcc ccgcagatcg gcctggcgca gacccagcac caccagcagc
      661 cgccgccgcc tgcgcccgcg ccgcagccgg cacagccagc gcagccacca caggcgcagc
      721 ccccgcagca gcgccgctca cccgccagcc ccagccaggc gccctacgcg cagaggagcg
      781 ccgccgcggc gtacggccac cagcccatca tgaccagcaa gccgtcctcg tcttcggcgg
      841 ttgcagccgc tgctgccgca gccgccgcct cgtcggcctc gtccagctgg aacacgcacc
      901 aaagcgtgaa tgcagcctgg agcgcaccgt ccaacccctg gggcggcctg caggcgggcc
      961 gggaccctcg ccgggcggtc ggtgtgggcg tgggtgtggg tgtcggggtg ccttccccgc
     1021 tcaaccccat ctcgccgctc aaaaagccct tctccagcaa cgtgatcgcg ccgcccaagt
     1081 tccctcgcgc ggcccctctc acttccaagt cctggatgga ggataacgct ttccggaccg
     1141 ataatggtaa caatctgttg ccatttcagg accggagtag gccctatgat acttttaact
     1201 tgcactcgtt ggagaactcc ttaatggata tgataaggac tgatcatgaa cctctgaaag
     1261 gtaaacacta ccctcccagt ggcccaccaa tgagtttcgc tgatataatg tggaggaatc
     1321 attttgcagg acgcatgggg ataaatttcc atcatccagg aacagataat attatggcac
     1381 ttaacaatgc cttcctggat gatagccatg gtgatcaagc cttgtcatct ggcttaagtt
     1441 ctcccactcg ctgtcaaaat ggggaacgag tagaacgcta ctctagaaag gtgtttgttg
     1501 gaggacttcc tcctgatatt gatgaagatg agatcactgc cagctttcgc aggtttggac
     1561 ctctcgtagt agactggcct cacaaagctg aaagcaagtc ttattttcct cctaaaggct
     1621 atgcctttct gctgttccaa gaggaaagct cagtacaagc tttgatagat gcctgcctag
     1681 aagaagatgg gaaactctac ctgtgtgtgt caagccccac catcaaggac aagccagtgc
     1741 aaattcgacc atggaaccta agtgacagtg actttgtaat ggatggttct cagcctttgg
     1801 accccagaaa aactatcttt gttgggggag ttccacgacc ccttcgagct gttgaactgg
     1861 caatgatcat ggaccgtttg tacggtggtg tctgctatgc tggcattgat acggacccag
     1921 agctgaagta ccccaaaggt gctggccgcg tggcattctc caatcagcag agttacattg
     1981 cagccatcag cgctcgtttt gtgcagcttc agcacaatga cattgacaaa cgggttgaag
     2041 taaagccata tgtgctggat gatcagatgt gtgatgagtg ccagggcaca cgctgtggtg
     2101 ggaagtttgc cccgttcttc tgtgccaacg tcacctgtct gcagtattac tgtgaatact
     2161 gctgggcgag catacattcc cgagccgggc gggagttcca caaaccgctg gtgaaggagg
     2221 gaggcgaccg ccctcgtcac gtcccgttcc gctggagctg agccacgggc cgacccagcc
     2281 acaagtactg gagtagataa caaggaggga aaagagaggg cactgcctca gggcttacag
     2341 tgttctggaa atctgtgcat tcgttctcga tttttaaaga agaattgggt ctttttatta
     2401 ttattattat tatttacagt catattactg aactcagtgt ccagtataat gcagaattgc
     2461 agagtgtaga atggtactga tttgcacttt gattcacacc tttgtctgct tggtacctta
     2521 attttttata cctgatttgt cactcgtgac agtatgtaga ctgccattct catcagcggc
     2581 cgtcaggcta ctgtctgtga ttcttttgtt tgttgttgtg gtgttgttct gattgttttg
     2641 aactggagca tgcacttatt ttcagaaact tagagagttg cccctaggac aagacttacc
     2701 aaaggtaata ctcgtgagta ggtggcagat gtagcaaaaa cttcacaaca attcagcaat
     2761 cattagctcg ggtcacttag agtaaggata acccttcatg aaaataagcc tttagttgct
     2821 ctctattttg acttgtaagg atacctcata agctggatct tttatttttc cttcatgttt
     2881 gatttttgtt ttgccgagga ttttggttag atcttttagt attatgtaaa tttatgctgc
     2941 aatagctttt gctgctatta aaatggtatt attaatacca taatactcta ttcaggctag
     3001 gatatcaatt aaacacaaaa acccaacaac acacttttgt gattttaggg atagagtcag
     3061 ctgccgaacg gagatcagaa tagacttcag aaagcttcgg tggaaggtca ctatttctga
     3121 ctgcatgttt acttaatcag gttgctgcat gcaataaatt ttatatccaa tgtctagtat
     3181 aaaacgttcc cacaatgcac aaattaagaa tctatataag ctataaaaat actcattttt
     3241 taaaaaaagt ttttttcatt caaagaattg gtaattgacc ggaggaaggc atgcctcaat
     3301 aaatggaatg ctctgaatgg gaagagccca taacagaatg acctatatta caaccgatat
     3361 aaaacctagg tgtaggatat tcttcaagca aatttgtgga tggtagatga agtactttgc
     3421 ggtgctctgt tatatattgt gaaatttatt ttatatagta aagtgattat gtctaactgt
     3481 gatcaaactt aactgtttaa agcctctgtc agacattaat gaacttgaca gttcataact
     3541 gatatattat aaactaacac atgagctctt agttacaatc tcttagtgct tgcaccattt
     3601 tacatagctt cagaccttgt ccagaaaacc aaagagctca tcttagctta caaacactaa
     3661 gaatatatac aggatataga gataagttgt cagattgaca aactaggcac atttttaaga
     3721 aagttgtgta atggtgatgc taaagaaatg tctgtacaaa ataagatggc ctgggcagag
     3781 ttggttgtct gagtgagaaa ctaactactt aattccctgg atttatcctg ttaagcttga
     3841 gtagaatgaa ggcctgctag cactagcgtg gtctagaatg aaggcctgct agcactagcg
     3901 tggacatttt tctagcattc acccttgggc tgcagatagt aatatataaa cacacacaat
     3961 gattgcaaga ctatgtaaat ctttttttaa tcttcttcct atgttttgga attctgggga
     4021 caatctgact ggatatgaca ctgcagaata gatttaagtc gctgtgtttt ctgtgctgtg
     4081 atgtccttgt actgtcttaa gttagtgttg cttgtttttg ttttgttctc ccatgtttag
     4141 ttgcaattac tggctctcaa gctatagttt gttttcaaaa aggaaaaaca aaatagtttt
     4201 ttactggatt aaaaatgctt attttagaat cctccccttt ttgaggcttt ttggtaataa
     4261 ttgctttttt ccagcccagg tgtggttttg tttgtttttt tctatgtttg tgggtttttt
     4321 ttcatctgta caagaaattt tgttatgcac tactactttt tgtattctag acagttttca
     4381 aaagttggca gatttttttt tttgttttta aggaaaaagg catgctttct gactgacatg
     4441 atcttttgca atacctcaat tttgaaatat aggaaagaaa atgatatttt ctaagtaagt
     4501 ttattcagaa aaatatatat taatttaatt ctgcaagaaa atgatttaac agatgggtaa
     4561 ctttattttt ttcatgctta tttgtgtttt ttgaaaatga agaagttaga gctttataac
     4621 tataatatta aagatcatat ctaacctaca gaaatctacc taattatgtg aaagaagcaa
     4681 aactttttga agaagcaccc ctctttcatg tattaaaata acactgagat ttttttaaaa
     4741 gctggaagat tgtacagcat aaagctaaag tgaaggcaaa aaacattgtc ctgaagaata
     4801 ggttacaaaa aataaactcc atttggtgct gaaagttgtg aatagatggt ggaaactact
     4861 ttcccttaat ttgtatattt ctaatcaagt gttgattgtg cgcgactgac caggattgtg
     4921 aaagagttct tctgtttgta tttttttaaa gagaactttt ttagtttatt aaattataac
     4981 atgttccctt ttgttttgta aataaatgtg cccccaagtt gttaatgtta tattaaaaga
     5041 gagggtcctt caaaaaaatt attttttaaa acacagaggt gttctgacct gcaacttgac
     5101 tgggaagccc ctgggtaaca caggtcctgc tgtggccttt ccttggtgtg acacttgaac
     5161 tagtcgattt tttgaaggct ataacctaac ctcgactatt tgttgttatg tgcaatactg
     5221 tttgtactgt ttgtataaaa aatagaaaaa aaaaagaaaa gaaaaaaggc ataaatcttt
     5281 attgcagatt tattttcatt gcaaacttta gacattgtga ttcactgaaa tcatttttct
     5341 actgtcaaat atgtaccttt tcttcatgct ggtatttttt caatagtaat gtagcctttg
     5401 tactgagaca aattttcatt gttattttta gaaagatttt ttgctaagaa aaaaattaaa
     5461 catatttaca tatttttcat tttatttcgt attttcttta aggagtgctt tctcaatcat
     5521 taatagagtt gtttctggga gggactttca tatctggtca atgtcataat attattttgt
     5581 atttttattg gaataaatta attttatgat gctaattctt taaaagttta tttttttcat
     5641 tttcagttat ttttgaagct aaaacctttg taatattgtt actaaagtgt ctagtttttt
     5701 gaaatgcaaa gctttatgta ttaacttgct gatgtggttt acaatagtgt gacaacgatg
     5761 aaaatgcttg gttatgtaaa gtgattggaa atgtaatgga taattgggta ataaaatgac
     5821 agaatgagca gaacatgtga gattttgaga agccttttcc tttatcacag tggtttagtg
     5881 taagactagg gatgtcacag tgcagttctc tagggatgtc acggtggatt tatacaacac
     5941 caggtgcagc caaacctgtg gccctgagaa tgaagtcacc caaccgaagt accactgggt
     6001 ttaaaatctg gctaagtcaa cagaatgttt cattgctttt tcccctctaa ctcgtcatta
     6061 tgtcgtgtgt gtgtgtgtgt gtgtgagaga gagagagaga gagagagaga aaaactgcca
     6121 ccaactgctg tccttgtgtg agacagtgcc tttctcccag gccgaatctt ttatgtgcac
     6181 tgacagtggt gatatcggag tcatacagga agttgctaag aggacacggc tttcgtggtg
     6241 tactgcagac ctcacctgca gggtctcact catgctgcct ccctgtaagg ctcagttggt
     6301 ggcactgagg aagcacactc ggatgtcacc actgtctgtg gaccctgact atgtgtcggg
     6361 ttgcatcttc ctccacaccc atgcctgctt cctgttctgg tgccccttgc ctttcattgt
     6421 ggcaactgcg tgcatgatct gtctgccttt ctgctgctgc ttttccaaca ccctcctcac
     6481 ctggaagctg ggcagttaag gcacagtcat taatgtgtca ttgcaatagc acctacagtc
     6541 aaagcaaaaa ctacaactgc aaaactggtg ttgcgtaaac agaacagcca atgacttgat
     6601 ccagatagat gatatgtttc tactagtggt tgatggcctc tttcagctcc atcgctatgg
     6661 aggcgaggtt catcaataac tcagagaaac ttgtgtccag agttggtctt gggtatgctc
     6721 tatgtattca gttttgtaaa taatatatag attagatcaa gttgtgatgt aaaattttaa
     6781 ctcaaattgg gtactactgg ttggaatttt acattaacta caaataaatg attaggaaca
     6841 gaagaaaagt ggaaaattct tgcttagtgg tataaagatt atgcttagat ttctgcctat
     6901 atcttgtgtt ttatagcttg ttagtgaggc atgggctaat gcagaatgta ctgcatttat
     6961 gcaattagca aataactgct agttttcatt ttatctatta tattagcaac aaaaatggca
     7021 tttaactggg taaagctcct acctaaatat ttgagtattg tgacatctct acttgcaagg
     7081 tttgagtgaa agattagtca cagattagtg aaaaaaatgt atctttttgt taaaactggc
     7141 ttatttgaat ggattgttgc ttttcactag cttgtatggt atgtcagcta acatttgttt
     7201 ttttttttct tttataataa ccaaacttct ctatctcagc tgcaatagtg ttccatctta
     7261 ccacagagtg ttttataatt aatgctgttg actttatacc ccaaaatggg tcaagaagtg
     7321 gctacatgat taggggatgt ttaaatttgt atgacgacaa agttaattgc aacaagtaga
     7381 aaacttgggt gctaacacag gataacttct gctctttttc tttcctggat atagttctgt
     7441 tggggtataa agtattaggt atttgtattt tttgctgtca aaataatgga cttaactttt
     7501 agagtgttca cagctaggat ctctgtattt gtttttcaac taacaactaa ttttaaatgt
     7561 attgtatctt ttattacctg ttctcttaga ttgttttttg ctagtaaccc ttactcagct
     7621 tctgcctttg gggcttggac taatattgct tgtatggaac tacagtactg tgactaaaca
     7681 tggagctcaa tgcagctact gcttacaact gcttaaactt tgtagtttgg acttcatttt
     7741 tttctgtaat aacaacttat taaatctagt tgtatgaagt a
//
