LOCUS       NM_001177382            7069 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens cytoplasmic polyadenylation element binding protein 2
            (CPEB2), transcript variant D, mRNA.
ACCESSION   NM_001177382
VERSION     NM_001177382.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7069)
  AUTHORS   Zhao,G., Zhao,Z., Xia,M., Xiao,L., Zhu,B., Wang,H., Li,X. and Di,J.
  TITLE     CPEB2 inhibit cell proliferation through upregulating p21 mRNA
            stability in glioma
  JOURNAL   Sci Rep 13 (1), 23103 (2023)
   PUBMED   38158431
  REMARK    GeneRIF: CPEB2 inhibit cell proliferation through upregulating p21
            mRNA stability in glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7069)
  AUTHORS   Zeng,P., Wang,F., Long,X., Cao,Y., Wen,F., Li,J. and Luo,Z.
  TITLE     CPEB2 enhances cell growth and angiogenesis by upregulating ARPC5
            mRNA stability in multiple myeloma
  JOURNAL   J Orthop Surg Res 18 (1), 384 (2023)
   PUBMED   37231521
  REMARK    GeneRIF: CPEB2 enhances cell growth and angiogenesis by
            upregulating ARPC5 mRNA stability in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7069)
  AUTHORS   Zhang,M., Yang,C., Ruan,X., Liu,X., Wang,D., Liu,L., Shao,L.,
            Wang,P., Dong,W. and Xue,Y.
  TITLE     CPEB2 m6A methylation regulates blood-tumor barrier permeability by
            regulating splicing factor SRSF5 stability
  JOURNAL   Commun Biol 5 (1), 908 (2022)
   PUBMED   36064747
  REMARK    GeneRIF: CPEB2 m6A methylation regulates blood-tumor barrier
            permeability by regulating splicing factor SRSF5 stability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7069)
  AUTHORS   Di,J., Zhao,G., Wang,H., Wu,Y., Zhao,Z., Zhu,B., Zhang,Y.,
            Zheng,J., Liu,Y. and Hu,Y.
  TITLE     A p53/CPEB2 negative feedback loop regulates renal cancer cell
            proliferation and migration
  JOURNAL   J Genet Genomics 48 (7), 606-617 (2021)
   PUBMED   34362680
  REMARK    GeneRIF: A p53/CPEB2 negative feedback loop regulates renal cancer
            cell proliferation and migration.
REFERENCE   5  (bases 1 to 7069)
  AUTHORS   Pascual,R., Martin,J., Salvador,F., Reina,O., Chanes,V.,
            Millanes-Romero,A., Suner,C., Fernandez-Miranda,G., Bartomeu,A.,
            Huang,Y.S., Gomis,R.R. and Mendez,R.
  TITLE     The RNA binding protein CPEB2 regulates hormone sensing in mammary
            gland development and luminal breast cancer
  JOURNAL   Sci Adv 6 (20), eaax3868 (2020)
   PUBMED   32440535
  REMARK    GeneRIF: The RNA binding protein CPEB2 regulates hormone sensing in
            mammary gland development and luminal breast cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7069)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 7069)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 7069)
  AUTHORS   Peng,S.C., Lai,Y.T., Huang,H.Y., Huang,H.D. and Huang,Y.S.
  TITLE     A novel role of CPEB3 in regulating EGFR gene transcription via
            association with Stat5b in neurons
  JOURNAL   Nucleic Acids Res 38 (21), 7446-7457 (2010)
   PUBMED   20639532
REFERENCE   9  (bases 1 to 7069)
  AUTHORS   Hagele,S., Kuhn,U., Boning,M. and Katschinski,D.M.
  TITLE     Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2
            bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein
            expression
  JOURNAL   Biochem J 417 (1), 235-246 (2009)
   PUBMED   18752464
REFERENCE   10 (bases 1 to 7069)
  AUTHORS   Kurihara,Y., Tokuriki,M., Myojin,R., Hori,T., Kuroiwa,A.,
            Matsuda,Y., Sakurai,T., Kimura,M., Hecht,N.B. and Uesugi,S.
  TITLE     CPEB2, a novel putative translational regulator in mouse haploid
            germ cells
  JOURNAL   Biol Reprod 69 (1), 261-268 (2003)
   PUBMED   12672660
  REMARK    GeneRIF: Functional studies of the mouse homolog
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105289.4, BC103942.1 and
            AC098829.3.
            
            On Jan 9, 2019 this sequence version replaced NM_001177382.1.
            
            Summary: The protein encoded by this gene is highly similar to
            cytoplasmic polyadenylation element binding protein (CPEB), an
            mRNA-binding protein that regulates cytoplasmic polyadenylation of
            mRNA as a trans factor in oogenesis and spermatogenesis. Studies of
            the similar gene in mice suggested a possible role of this protein
            in transcriptionally inactive haploid spermatids. Alternatively
            spliced transcript variants encoding distinct isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (D) represents the longest
            transcript and encodes the longest isoform (D).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The genomic coordinates used for
            the transcript record were based on alignments. The 5' CDS is
            inferred based on comparison of the mouse and human orthologs.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.73961.1,
                                           SRR1660805.131197.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538197.7/ ENSP00000443985.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1693              AC105289.4         71032-72724
            1694-4738           BC103942.1         173-3217
            4739-7069           AC098829.3         31475-33805
FEATURES             Location/Qualifiers
     source          1..7069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..7069
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /note="cytoplasmic polyadenylation element binding protein
                     2"
                     /db_xref="GeneID:132864"
                     /db_xref="HGNC:HGNC:21745"
                     /db_xref="MIM:610605"
     exon            1..1855
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..3298
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /note="isoform D is encoded by transcript variant D;
                     CPE-binding protein 2"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 2 isoform D"
                     /protein_id="NP_001170853.1"
                     /db_xref="CCDS:CCDS56325.1"
                     /db_xref="GeneID:132864"
                     /db_xref="HGNC:HGNC:21745"
                     /db_xref="MIM:610605"
                     /translation="MRDFGFGVLQTAPLRSSSPGPLFCGEAYGPYAVGSVNPLPSATP
                     FGPLSPPPLPVTGFLEAASPFSVPLGGGAGSPAAAASSSSPFLAHQQTMQDELLLGLT
                     QQPARPLSGAAATEKLPDHHPGGGTIAGVTHLLPSQDFKPSLHHPSSSSASSCCCCRT
                     SSPQDFSKRQQQQLSSQKRKEFSPPHLPHPPDSKPPPPPPPLHCPGRFSPPPPPAGPL
                     LQPAQLAQRQQQQPPQQFSLLHQQHLSPQDFAPRQRPADLPPLPQLPPSPPAAPRRRH
                     GGAGSPRKTPAAGEGSAAESPNAGLASSTPVNPAPGSMESPNHPLLNSPSNLLPGGAL
                     GAGAFSSLQSPDLPHPGGGGGGGGGGPPGGGGGGGSASPPPLPGFGTPWSVQTASPPP
                     QPQQPPPTQPQQQPPPPQQPPQPQPQPPGSSATTPGGGSGGSLSAMPPPSPDSENGFY
                     PGLPSSMNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMNIP
                     QQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQ
                     SSGWGTGSMSWGAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSL
                     TPKSWIEDNVFRTDNNSNTLLPLQVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSR
                     MYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPGTDNLLMLNARSYGRRRGRSSLFP
                     IDDGLLDDGHSDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITASFR
                     RFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTI
                     KDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCY
                     AGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMC
                     DECQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVKEGADRPRQIH
                     FRWN"
     exon            1856..2137
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2227
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2318
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2369
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2393
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2564
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2654
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2773
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2888
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3070
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..7069
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7047..7052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /note="hexamer: AATAAA"
     polyA_site      7069
                     /gene="CPEB2"
                     /gene_synonym="CPE-BP2; CPEB-2; hCPEB-2"
                     /note="major polyA site"
ORIGIN      
        1 gcgacggcgg cggcggcggc gatcgccgcg aggggtggtg gggccgaagt cggtgccccc
       61 tggctcagtc acggtgtccc tctctcactg actccccctc cttccaccac ggccgcgcaa
      121 ccccagcgcc ggcggcttcc taggtggggc aggggacgag gagcgtctcc tcccgctgcc
      181 ggcggcctga taaatgaggg atttcgggtt tggggtgctg cagaccgccc cgctccgaag
      241 tagcagtcct gggcccctgt tctgcggcga ggcgtatggt ccttacgccg tggggtccgt
      301 caacccgctg ccctccgcca cgcccttcgg cccactgtcg ccaccaccgt tgcctgtcac
      361 cggcttctta gaggccgcct cccccttctc cgtccccctc ggcggcggcg cgggcagccc
      421 ggccgccgcc gcttcctctt cctccccgtt cctggcgcat cagcagacca tgcaggatga
      481 gctgcttctg gggctgacac agcagccggc gcggccgctt tcgggggcgg cggccacgga
      541 gaaactcccc gaccaccacc ccggcggcgg cacgatcgcg ggtgtgaccc acctcctccc
      601 ctcccaggac ttcaaaccga gtctgcacca cccctcctcc tcctccgcct cctcctgctg
      661 ctgctgccgc acctcctccc cgcaggactt cagtaagcgg cagcagcagc agctgagcag
      721 ccagaagagg aaagagttca gccctcccca ccttccccac cctccggact cgaagccgcc
      781 gccgccgcct ccgccgctcc actgccccgg tcggttcagc ccgccgccgc cgccagccgg
      841 cccgctcctc cagccggcgc agctcgctca gcgccagcag caacagccgc cgcagcagtt
      901 cagcctcctg catcagcagc acctctcgcc gcaggacttc gccccgcggc agcgtccggc
      961 agacctgccc ccgctcccgc agctccctcc ctcgccgcct gcagccccgc ggcgccgcca
     1021 cggaggcgcg ggcagccctc gcaagacccc agccgcgggc gagggcagcg ccgccgagtc
     1081 ccccaatgcg ggcttggcct cctcgacgcc ggtgaacccc gcgccgggct ccatggagtc
     1141 ccccaaccac cctctgctca acagtcccag taacctcctg cccggaggtg cgcttggcgc
     1201 gggcgccttc agcagcctgc agagcccgga ccttccacac ccgggcggcg gcggcggcgg
     1261 cgggggcggg gggcccccag gaggcggagg gggaggcggc tccgcgtcgc cgccgccgct
     1321 gcccggcttc ggcaccccct ggtcggtgca gaccgcgtcg ccgccacccc agccccagca
     1381 gccgccgccg acccagccgc agcagcagcc gccgccaccc cagcagccgc cccagccgca
     1441 gccgcagccg cccggctcgt ctgccaccac cccgggcggc ggcagcggcg gctcgctcag
     1501 cgccatgccg ccgcccagcc ccgactcaga gaacggcttc taccccgggc tgccgtcgtc
     1561 catgaacccg gccttcttcc ctagcttctc gcccgtgtcg ccgcacggct gcactgggct
     1621 cagcgttccg acgagcggcg gcggcggcgg cggcttcggc ggccccttct cggctaccgc
     1681 tgtgccccct ccgccgccgc ccgccatgaa tatacctcaa cagcagcccc cgccgcccgc
     1741 ggcgccgcag cagccgcaga gccggaggtc gcccgtcagc ccgcagctcc agcagcagca
     1801 ccaggcggcg gccgccgcct tcctgcagca gaggaactcc tataaccacc accagcctct
     1861 tctgaaacag tctccctgga gcaaccatca gagcagtggc tggggcactg gaagtatgtc
     1921 ctggggagca atgcatggca gagatcatcg tagaaccgga aacatgggaa tcccaggaac
     1981 tatgaatcag atatctccat tgaagaaacc gttttctggt aatgtcatag caccaccgaa
     2041 atttactcgc tcaactccat cactgactcc aaaatcttgg attgaagata atgtgttcag
     2101 aacagacaac aatagtaata cactcttacc cttacaggtg agatctagtt tgcagttgcc
     2161 agcttggggc tcagattcac tccaagatag ttggtgcact gcagccggaa catccagaat
     2221 agaccaggat cgaagtagaa tgtatgacag tttgaatatg cactctttgg aaaattccct
     2281 tatcgatatt atgagagcag agcatgatcc tcttaagggt cgattgagct atccacatcc
     2341 aggaactgac aatctgttga tgttaaatgc aaggagttat gggcgaagac gaggtcgttc
     2401 ttccctcttt ccaatagatg atggcttgct tgatgatggt cacagtgatc aagttggagt
     2461 tttaaattca cccacctgtt attcagctca ccaaaatgga gagcgaatag aacgcttctc
     2521 tcgaaaagtt tttgttggtg gtcttcctcc agatattgat gaagatgaaa taactgctag
     2581 cttcagaaga tttgggcctt tggtagtaga ttggcctcat aaagcagaaa gcaagtccta
     2641 ttttccacca aaaggctatg catttcttct ctttcaagaa gagagctcag ttcaggcact
     2701 cattgatgct tgtattgaag aagatggaaa actctatctg tgtgtttcta gccctactat
     2761 caaggacaaa ccagttcaaa tacgtccttg gaatttaagt gatagtgatt ttgtaatgga
     2821 tggttctcag cctttggatc cccgaaaaac aatttttgtt ggaggtgttc ctaggccatt
     2881 aagggctgtg gaacttgcta tgatcatgga ccggctgtat ggtggagttt gttatgcagg
     2941 aattgataca gatcctgagc taaaataccc aaaaggtgct gggcgagttg ctttctccaa
     3001 tcagcagagc tatattgctg ccattagtgc tcggtttgtt cagcttcagc atggtgatat
     3061 tgataaacgt gtggaggtaa agccatatgt gctagatgac cagatgtgtg atgaatgcca
     3121 gggcgcacgc tgtggtggaa aatttgctcc ctttttttgt gccaatgtca cttgcctgca
     3181 gtattactgt gagttttgtt gggcaaatat ccactctcgt gctggacgtg agttccataa
     3241 gccattggta aaggaaggtg ctgatcgccc acgtcagatc cacttccgct ggaactaaga
     3301 atagcaaact ggcctctgtt taacaaggaa agaaagggtg catgtggctt actgtgtctg
     3361 aagatactga catgcagaag aaataagtgc attcttctgc ttttcacccc agctatcaat
     3421 acatgcatct ttatcagcag ccaaaacact acaagcctct tgtttttcac caaaacccta
     3481 catctcaggc ttactaattt ttgtgatatt ttcatgttca aataaaatgt ttttttgtat
     3541 tttctccaag ttatttttat atgtaaagtt aaaattagat atgagaatgt tttgcgtagg
     3601 ggcaacacag tctgctgcta tatagtgggg gaagcgtgca cttatttcta aacatgggtt
     3661 tttaacttca agatctgccc cagtaattta ccaaaggtag caaaataata gtgaagatgg
     3721 aatatgtctg ctacaaatgc ttatttttat tgttgctatt ttcagtgtat acataaacta
     3781 aaaattaggg ttgatttttt tgctctccat tttgacttgc aagaaataat acctcaagat
     3841 aatctgattt attagctatt tttaaacatt tttaatcaca agctgtatta gctttgctgc
     3901 tatataggtg ttatgtgtaa atgccaccta ttaatacggg actgaaaacg ttagagacac
     3961 actgcattgc agataaaatg caggcagcac aatatggcct aaactgccat agttttagaa
     4021 tgtgaaaaaa atgcatgttt acttacctgt atacaccata tgcatgcact agaattatta
     4081 actaacgagg tgaggtattg caaatgttca aaaaagctct cttgaatcta ggtagcatga
     4141 acaaattata aaatttgttt aaaaaagcaa acttgcatgc attattgtga cttcaagttt
     4201 aaaaaatcgt cttacatgtg tacaatatgc aaattagttt tagattagag agtgcagcca
     4261 ttttgtgatc tggtcagtag tggaattcga ttttatgcag actggatgta atatttgtaa
     4321 tccctgtgca attttgtgac gtgcggttct aattcatgtg cagtgatata gtatagataa
     4381 aagaatgagt aaaagaaaat acaagaattc taaagaaagt tggttttagc ccctttgata
     4441 gtccatggtt aagacatcct ttataaacca aagatggcca gcacactgct aaccagtcac
     4501 caaatgtaag acccataaga aacccatatt taaaaatctg aattttttag aagaatgcaa
     4561 aactttagta aaccctaagt aaagtcaaaa tggagaaggg gaaatataca gatggctagt
     4621 tgcataaaat taaattttac ctttataaga caatggtgaa atctggcttg aacttgctta
     4681 tgtgtttaac ctataaatat tggggtcttc tgtctaaact ggggtcactg ttgcatggaa
     4741 cattgttctt aatagttgag aattgctttt ttgaaaattt tcatgaagga attttggtaa
     4801 tgactttgct tgcaggtttt ttggggtgtt ttgagaaagt ggcatggaaa catgcagtag
     4861 ttaatgagtt tctcttggta ctgaacacta ttagaatatc attagtgata ttttttctct
     4921 ttagagcatt tttaatgcaa ctagccccta tattttaatg taagagttac tctgcaatct
     4981 aagcaaagca cccaacaatg gtaaatgttt tttaaaaatg cagaactaag atttttgact
     5041 ctaaagagag aaaattacaa gggtgttgcc ttatagcaaa cccttgggac aatccttcat
     5101 gtgagcaaag tgttgatctt aatattggtt gtctgtggtg tgcttttttg tactgtaaaa
     5161 atatgtggtt catgtctaac tctgctgttt tattgtggtt gtggttcaag tttttaatgt
     5221 ttaaagttga tgctgttttc agaagagctt tttactaatt tatttgtcag tgttccctat
     5281 ttgttactta accatgatcc tccagatttt ttggagtatt cttttctaac cttaaccctg
     5341 ccaaaccttg atccattttg acatttgtta tgcactattt ttatatctct gtgagagatt
     5401 tttccaacag tcagctattt tatggcacac tttttttgac tgatgacatc tcctttgcta
     5461 tacctcaatt tttggaattt agagaagaaa tcagtagttt tgcaatgtta attatttaga
     5521 tatttaattt cgcagatttt taaactttat tttcataatt tctgcttaat gtttaaaatt
     5581 gaagagcctt ttcatgtatt aaataatgaa cacaaattat ataattaaaa taattggaga
     5641 tgttgaaaat cattttccct tcttaaacag aaataaatat ttggaatgaa ggggaatgta
     5701 ctagaacacc ctttttgcca cgggtaaaaa taacagaaat gtatggtttg ttttaccttc
     5761 atttctgtac aagtaaagct tattagtcta atgttttgtt cctttcccac ctcaccccta
     5821 cctcttttgt tttgttttgt ttttgccctt tatgtactac attcttattt tctaactttt
     5881 aaacactgta ttggaggttt ttttttaatt tacagatcat atttatttta ctatttttgt
     5941 agaaaattat taattttgat tgtatttttg tattttaaaa gcttcttcac ttgtgttccc
     6001 taaatattca tattgctgcc caaaagtatg actgtggagg aaaaaaaaat actttaaaaa
     6061 tccacacttt ttgttaagaa ggaaacattt agcatttata tatttgtgta tggaaaacac
     6121 ttgatatttt atccctgttg catctggctg cacagagcct ctcctcaaag atgctacaaa
     6181 acttgaatat aacacatttt ggaaggctga ctaacctcga ttctgtgttg tgatgtgcaa
     6241 tactgtttct aatgtttgta taaaaaaaaa cagtgtaaac ctttttaatg caaatttatt
     6301 tttttcattg catattttgc agattttatc cacagtgtca ttttttactg tcagaaaaga
     6361 tacccctttt gtcattgcaa ctatttttta aatccagaaa tctttgtact gatgtaaatg
     6421 attgtagtta ttttggatag tgttttgcta acaaaaggag agactttttt catgcatatt
     6481 tctattttgt ttttttgggt tttattttat tttaatagta gtaaaatact tggaataatt
     6541 tttcatattc ttgtcattaa tattattttg tatttttatg tggaaatata taattttatg
     6601 acactaattg ctaaagttta ttttatgttg aattattttt ggagctgaaa tctttgtaat
     6661 attaaagcaa ctagtttcta attcccagtt tctgtataga atcgcacaag tggtttatgg
     6721 agtgtttgga ttgtaattat aaatggttct ttgatatgca aattaatatt ttcagttgat
     6781 tttattttat attcctaatg gggtgttaaa gccgtttttt atttttttct aaataaaaag
     6841 agaacccatg cttttatgga cactaggtaa acaccttcag cttaaatttt tcgttaaata
     6901 ttttagttta ttttattgtt atcttccagg tgtctaaatc tccagtctgt ctgttgtact
     6961 ggtaatttaa ctctgtaatg gaatagtttg ctgccaacta tttatattaa gtaattttta
     7021 aatatttgta atattgttga ctgactaata aactattaag ttattggca
//
