LOCUS       NM_001365248            3052 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens cytoplasmic polyadenylation element binding protein 1
            (CPEB1), transcript variant 15, mRNA.
ACCESSION   NM_001365248
VERSION     NM_001365248.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Zhang,S., Huang,J., Lan,Z., Xiao,Y., Liao,Y., Basnet,S., Huang,P.,
            Li,Y., Yan,J., Sheng,Y., Zhou,W., Liu,Q., Tan,H., Tan,Y., Yuan,L.,
            Wang,L., Dai,L., Zhang,W. and Du,C.
  TITLE     CPEB1 Controls NRF2 Proteostasis and Ferroptosis Susceptibility in
            Pancreatic Cancer
  JOURNAL   Int J Biol Sci 20 (8), 3156-3172 (2024)
   PUBMED   38904009
  REMARK    GeneRIF: CPEB1 Controls NRF2 Proteostasis and Ferroptosis
            Susceptibility in Pancreatic Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3052)
  AUTHORS   Pico,S., Parras,A., Santos-Galindo,M., Pose-Utrilla,J., Castro,M.,
            Fraga,E., Hernandez,I.H., Elorza,A., Anta,H., Wang,N.,
            Marti-Sanchez,L., Belloc,E., Garcia-Esparcia,P., Garrido,J.J.,
            Ferrer,I., Macias-Garcia,D., Mir,P., Artuch,R., Perez,B.,
            Hernandez,F., Navarro,P., Lopez-Sendon,J.L., Iglesias,T.,
            Yang,X.W., Mendez,R. and Lucas,J.J.
  TITLE     CPEB alteration and aberrant transcriptome-polyadenylation lead to
            a treatable SLC19A3 deficiency in Huntington's disease
  JOURNAL   Sci Transl Med 13 (613), eabe7104 (2021)
   PUBMED   34586830
  REMARK    GeneRIF: CPEB alteration and aberrant transcriptome-polyadenylation
            lead to a treatable SLC19A3 deficiency in Huntington's disease.
REFERENCE   3  (bases 1 to 3052)
  AUTHORS   Shao,K., Pu,W., Zhang,J., Guo,S., Qian,F., Glurich,I., Jin,Q.,
            Ma,Y., Ju,S., Zhang,Z. and Ding,W.
  TITLE     DNA hypermethylation contributes to colorectal cancer metastasis by
            regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter
  JOURNAL   Clin Epigenetics 13 (1), 89 (2021)
   PUBMED   33892791
  REMARK    GeneRIF: DNA hypermethylation contributes to colorectal cancer
            metastasis by regulating the binding of CEBPB and TFCP2 to the
            CPEB1 promoter.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3052)
  AUTHORS   Sovijit,W., Sovijit,W., Ishii,Y., Kambe,J., Fujita,T., Watanabe,G.,
            Yamaguchi,H. and Nagaoka,K.
  TITLE     Estrogen promotes increased breast cancer cell proliferation and
            migration through downregulation of CPEB1 expression
  JOURNAL   Biochem Biophys Res Commun 534, 871-876 (2021)
   PUBMED   33162033
  REMARK    GeneRIF: Estrogen promotes increased breast cancer cell
            proliferation and migration through downregulation of CPEB1
            expression.
REFERENCE   5  (bases 1 to 3052)
  AUTHORS   Jiao,W., Zhao,S., Liu,R., Guo,T. and Qin,Y.
  TITLE     CPEB1 deletion is not a common explanation for premature ovarian
            insufficiency in a Chinese cohort
  JOURNAL   J Ovarian Res 13 (1), 49 (2020)
   PUBMED   32354341
  REMARK    GeneRIF: CPEB1 deletion is not a common explanation for premature
            ovarian insufficiency in a Chinese cohort.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3052)
  AUTHORS   Hagele,S., Kuhn,U., Boning,M. and Katschinski,D.M.
  TITLE     Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2
            bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein
            expression
  JOURNAL   Biochem J 417 (1), 235-246 (2009)
   PUBMED   18752464
REFERENCE   7  (bases 1 to 3052)
  AUTHORS   Sasayama,T., Marumoto,T., Kunitoku,N., Zhang,D., Tamaki,N.,
            Kohmura,E., Saya,H. and Hirota,T.
  TITLE     Over-expression of Aurora-A targets cytoplasmic polyadenylation
            element binding protein and promotes mRNA polyadenylation of Cdk1
            and cyclin B1
  JOURNAL   Genes Cells 10 (7), 627-638 (2005)
   PUBMED   15966895
REFERENCE   8  (bases 1 to 3052)
  AUTHORS   Wilczynska,A., Aigueperse,C., Kress,M., Dautry,F. and Weil,D.
  TITLE     The translational regulator CPEB1 provides a link between dcp1
            bodies and stress granules
  JOURNAL   J Cell Sci 118 (Pt 5), 981-992 (2005)
   PUBMED   15731006
  REMARK    GeneRIF: CPEB1 has a role in compartmentalization of mRNA
            metabolism in the cytoplasm, between dcp1 bodies and stress
            granules
REFERENCE   9  (bases 1 to 3052)
  AUTHORS   Mendez,R. and Richter,J.D.
  TITLE     Translational control by CPEB: a means to the end
  JOURNAL   Nat Rev Mol Cell Biol 2 (7), 521-529 (2001)
   PUBMED   11433366
  REMARK    Review article
REFERENCE   10 (bases 1 to 3052)
  AUTHORS   Welk,J.F., Charlesworth,A., Smith,G.D. and MacNicol,A.M.
  TITLE     Identification and characterization of the gene encoding human
            cytoplasmic polyadenylation element binding protein
  JOURNAL   Gene 263 (1-2), 113-120 (2001)
   PUBMED   11223249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245033.2.
            
            Summary: This gene encodes a member of the cytoplasmic
            polyadenylation element binding protein family. This highly
            conserved protein binds to a specific RNA sequence, called the
            cytoplasmic polyadenylation element, found in the 3' untranslated
            region of some mRNAs. The encoded protein functions in both the
            cytoplasm and the nucleus. It is involved in the regulation of mRNA
            translation, as well as processing of the 3' untranslated region,
            and may play a role in cell proliferation and tumorigenesis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.79098.1,
                                           SRR1803616.243843.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC245033.2         176320-176484       c
            166-354             AC245033.2         175762-175950       c
            355-581             AC245033.2         162178-162404       c
            582-834             AC245033.2         160288-160540       c
            835-948             AC245033.2         158296-158409       c
            949-1038            AC245033.2         157885-157974       c
            1039-1175           AC245033.2         156898-157034       c
            1176-1374           AC245033.2         153878-154076       c
            1375-1469           AC245033.2         151561-151655       c
            1470-1550           AC245033.2         150859-150939       c
            1551-3052           AC245033.2         147619-149120       c
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..3052
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:64506"
                     /db_xref="HGNC:HGNC:21744"
                     /db_xref="MIM:607342"
     exon            1..165
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..354
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1661
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="isoform 3 is encoded by transcript variant 15;
                     CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 3"
                     /protein_id="NP_001352177.1"
                     /db_xref="CCDS:CCDS45330.2"
                     /db_xref="GeneID:64506"
                     /db_xref="HGNC:HGNC:21744"
                     /db_xref="MIM:607342"
                     /translation="MLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSS
                     AQSSTHSVLSMLHNPLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILD
                     SRSSSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSLSGGGPRDPLKMGVGSRMDQ
                     EQAALAAVTPSPTSASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATC
                     TWSGQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRC
                     PPKGYVYLVFELEKSVRSLLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLA
                     DSNFVRSPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIG
                     SGRVTFNNQRSYLKAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQ
                     VCFKYFCRSCWHWRHSMEGLRHHSPLMRNQKNRDSS"
     exon            355..581
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..834
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..948
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1038
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1175
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1374
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1469
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1550
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..3052
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3033..3038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="hexamer: AATAAA"
     polyA_site      3052
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="major polyA site"
ORIGIN      
        1 agtcggctgc tttggctctg ctgtcggcgg agaggacttc agtcgtgcgt gagggctgct
       61 tggccaccat tgctggagac cggagggcgc tgccttgcaa cccagactta acggcactgc
      121 accgggacta ttccaagtag ctgttgtgct gtctttccct gggagacttc caggactctg
      181 aagaaacagt tacaagcagg atgcttttcc caacctctgc gcaagaatct tcccgtggcc
      241 tcccagatgc aaatgacttg tgccttggcc tgcagtccct cagtctgaca ggctgggacc
      301 gaccctggag cacccaggac tcagattcct cagcccagag cagcacacac tcggtactga
      361 gcatgctcca taacccactg ggaaatgtcc taggaaaacc ccccttgagc ttcctgcctc
      421 tggatcccct tgggtctgac ttggtggaca agtttccagc accctcagtt agaggatcac
      481 gcctggacac ccggcccatc ctggactctc gatctagcag cccctctgac tcagacacca
      541 gtggcttcag ctctggatca gatcatctct cagatttgat ttcaagcctt cgcatttctc
      601 cacctctgcc cttcctgtct ctgtcagggg gtggtcccag agacccttta aagatggggg
      661 tagggtctcg gatggaccaa gagcaagctg ctcttgctgc agtcactccc tccccaacca
      721 gtgcttcaaa gagatggcca ggagcttctg tgtggccatc ctgggacctc ctcgaagctc
      781 ccaaagaccc cttcagcata gagagagagg ccaggctgca ccgacaagct gcagctgtga
      841 atgaagccac ctgtacctgg agtggccagc ttcctccccg gaactataag aaccccatct
      901 actcttgcaa ggtgtttcta ggaggtgttc cttgggatat tacagaagct ggattagtta
      961 acaccttccg tgtttttggc tctttgagtg tggagtggcc tggtaaggat ggcaagcatc
     1021 cccggtgtcc tcccaaaggg tatgtgtatc tggtcttcga actagagaag tctgtccgat
     1081 ccttgcttca ggcttgctct catgacccgc tgagcccaga tggcctgagt gaatattatt
     1141 tcaagatgtc cagccgaagg atgcgctgca aggaggtgca ggtgatcccc tgggtattag
     1201 ccgacagtaa ctttgtccgg agcccatctc agaggcttga ccccagcagg acggtgtttg
     1261 tcggtgctct gcatggaatg ctaaatgctg aggccctggc agccatcttg aacgacctat
     1321 ttggtggagt ggtgtatgcc gggattgaca cagataagca caagtatccc attggttctg
     1381 gtcgtgtgac tttcaataac caacggagtt acctgaaagc agtcagcgct gcttttgtgg
     1441 agatcaaaac caccaagttc acaaagaagg ttcagattga cccctaccta gaagattctc
     1501 tgtgtcatat ctgcagttct cagcctggtc ctttcttctg tcgagatcag gtctgcttca
     1561 aatacttctg ccggagctgc tggcactggc ggcacagcat ggagggcctg cgccaccaca
     1621 gccccctgat gcggaaccag aagaaccgag attccagcta gaggagctgg ccttgcccag
     1681 tggcctgtgg cgcccaaagc tggcaggtca ggcaagcagc ctgcaccacc ctgccactgg
     1741 cgaccaggga gctggcttcc caaggacaag ggaaaattgt agtcaccttt gcacttgctg
     1801 aatctgtctt tgtttctgca ctaattaatg cacattgagt tttgtcaggt tttgttttca
     1861 gggggtgtac caagggcaag gaccctctgg cttaccctcc aagcgactct gtagttttcc
     1921 cagattttag ttcctcattt tgcagatgaa aagcggggaa aaaaaaaaaa aaaaaaaaaa
     1981 ctacgtgtcc agaaggtatt gaggtattga cacggatgcc tacacctagg tttatttatt
     2041 aaaagcgctt ttttacattc cttgcaatac tgatggtgat gatgcgcagg tctcattggt
     2101 ttcattcttg cagttgccat acagtgcctt tccatttatt taacccccac ctgaacggca
     2161 taaactgagt gttcagctgg tgttttttac tgtaaacaat aaggagactt tgctcttcat
     2221 ttaaaccaaa atcatatttc atattttacg ctcgagggtt tttaccggtt cctttttaca
     2281 ctccttaaaa cagtttttaa gtcgtttgga acaagatatt ttttctttcc tggcagcttt
     2341 taacattata gcaaatttgt gtctggggga ctgctggtca ctgtttctca cagttgcaaa
     2401 tcaaggcatt tgcaaccaag aaaaaaaaaa ttttttgttt tatttgaaac tggaccggat
     2461 aaacggtgtt tgagcggctg ctgtatatag ttttaaatgg tttattgcac ctccttaagt
     2521 tgcacttatg tgggggggtg gggttgatag aagtttttaa tcacaaagtc acaggacttt
     2581 tttcttttgt aactgagcta aaaagggctg cttttcggtg ggggcagatg aaggctcaca
     2641 ggagcccttt ctcttagagg gggcaagtac ccttccctta tatctttaat ttgaggaatg
     2701 tatgagataa cagttgcagt tgactgaaat gccactggaa tttgaaaact tgactttttt
     2761 ttctttcctt tttttttttt tttttttttt taaaaagaaa caaaaaaccc acaaaaacta
     2821 cttgcccctc ctagggaagc tgtgtgccaa agaaccagtg tcataacccc tccctcctgc
     2881 tgagctgacg ttgcattgtt gcatatccca gctactctgt gggttttgtg aagctgtgtg
     2941 tgaagtctct acctcattgt agtatatgca ggcaagactg cactctccta cagatgtgtg
     3001 gagtaagctg tggtgtagtt tttttggcac ataataaaca cgttgcagca ga
//
