LOCUS       NM_001365242            3482 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens cytoplasmic polyadenylation element binding protein 1
            (CPEB1), transcript variant 9, mRNA.
ACCESSION   NM_001365242
VERSION     NM_001365242.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Zhang,S., Huang,J., Lan,Z., Xiao,Y., Liao,Y., Basnet,S., Huang,P.,
            Li,Y., Yan,J., Sheng,Y., Zhou,W., Liu,Q., Tan,H., Tan,Y., Yuan,L.,
            Wang,L., Dai,L., Zhang,W. and Du,C.
  TITLE     CPEB1 Controls NRF2 Proteostasis and Ferroptosis Susceptibility in
            Pancreatic Cancer
  JOURNAL   Int J Biol Sci 20 (8), 3156-3172 (2024)
   PUBMED   38904009
  REMARK    GeneRIF: CPEB1 Controls NRF2 Proteostasis and Ferroptosis
            Susceptibility in Pancreatic Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Pico,S., Parras,A., Santos-Galindo,M., Pose-Utrilla,J., Castro,M.,
            Fraga,E., Hernandez,I.H., Elorza,A., Anta,H., Wang,N.,
            Marti-Sanchez,L., Belloc,E., Garcia-Esparcia,P., Garrido,J.J.,
            Ferrer,I., Macias-Garcia,D., Mir,P., Artuch,R., Perez,B.,
            Hernandez,F., Navarro,P., Lopez-Sendon,J.L., Iglesias,T.,
            Yang,X.W., Mendez,R. and Lucas,J.J.
  TITLE     CPEB alteration and aberrant transcriptome-polyadenylation lead to
            a treatable SLC19A3 deficiency in Huntington's disease
  JOURNAL   Sci Transl Med 13 (613), eabe7104 (2021)
   PUBMED   34586830
  REMARK    GeneRIF: CPEB alteration and aberrant transcriptome-polyadenylation
            lead to a treatable SLC19A3 deficiency in Huntington's disease.
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Shao,K., Pu,W., Zhang,J., Guo,S., Qian,F., Glurich,I., Jin,Q.,
            Ma,Y., Ju,S., Zhang,Z. and Ding,W.
  TITLE     DNA hypermethylation contributes to colorectal cancer metastasis by
            regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter
  JOURNAL   Clin Epigenetics 13 (1), 89 (2021)
   PUBMED   33892791
  REMARK    GeneRIF: DNA hypermethylation contributes to colorectal cancer
            metastasis by regulating the binding of CEBPB and TFCP2 to the
            CPEB1 promoter.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Sovijit,W., Sovijit,W., Ishii,Y., Kambe,J., Fujita,T., Watanabe,G.,
            Yamaguchi,H. and Nagaoka,K.
  TITLE     Estrogen promotes increased breast cancer cell proliferation and
            migration through downregulation of CPEB1 expression
  JOURNAL   Biochem Biophys Res Commun 534, 871-876 (2021)
   PUBMED   33162033
  REMARK    GeneRIF: Estrogen promotes increased breast cancer cell
            proliferation and migration through downregulation of CPEB1
            expression.
REFERENCE   5  (bases 1 to 3482)
  AUTHORS   Jiao,W., Zhao,S., Liu,R., Guo,T. and Qin,Y.
  TITLE     CPEB1 deletion is not a common explanation for premature ovarian
            insufficiency in a Chinese cohort
  JOURNAL   J Ovarian Res 13 (1), 49 (2020)
   PUBMED   32354341
  REMARK    GeneRIF: CPEB1 deletion is not a common explanation for premature
            ovarian insufficiency in a Chinese cohort.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3482)
  AUTHORS   Hagele,S., Kuhn,U., Boning,M. and Katschinski,D.M.
  TITLE     Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2
            bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein
            expression
  JOURNAL   Biochem J 417 (1), 235-246 (2009)
   PUBMED   18752464
REFERENCE   7  (bases 1 to 3482)
  AUTHORS   Sasayama,T., Marumoto,T., Kunitoku,N., Zhang,D., Tamaki,N.,
            Kohmura,E., Saya,H. and Hirota,T.
  TITLE     Over-expression of Aurora-A targets cytoplasmic polyadenylation
            element binding protein and promotes mRNA polyadenylation of Cdk1
            and cyclin B1
  JOURNAL   Genes Cells 10 (7), 627-638 (2005)
   PUBMED   15966895
REFERENCE   8  (bases 1 to 3482)
  AUTHORS   Wilczynska,A., Aigueperse,C., Kress,M., Dautry,F. and Weil,D.
  TITLE     The translational regulator CPEB1 provides a link between dcp1
            bodies and stress granules
  JOURNAL   J Cell Sci 118 (Pt 5), 981-992 (2005)
   PUBMED   15731006
  REMARK    GeneRIF: CPEB1 has a role in compartmentalization of mRNA
            metabolism in the cytoplasm, between dcp1 bodies and stress
            granules
REFERENCE   9  (bases 1 to 3482)
  AUTHORS   Mendez,R. and Richter,J.D.
  TITLE     Translational control by CPEB: a means to the end
  JOURNAL   Nat Rev Mol Cell Biol 2 (7), 521-529 (2001)
   PUBMED   11433366
  REMARK    Review article
REFERENCE   10 (bases 1 to 3482)
  AUTHORS   Welk,J.F., Charlesworth,A., Smith,G.D. and MacNicol,A.M.
  TITLE     Identification and characterization of the gene encoding human
            cytoplasmic polyadenylation element binding protein
  JOURNAL   Gene 263 (1-2), 113-120 (2001)
   PUBMED   11223249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105339.9, AC110291.7 and
            AC245033.2.
            
            Summary: This gene encodes a member of the cytoplasmic
            polyadenylation element binding protein family. This highly
            conserved protein binds to a specific RNA sequence, called the
            cytoplasmic polyadenylation element, found in the 3' untranslated
            region of some mRNAs. The encoded protein functions in both the
            cytoplasm and the nucleus. It is involved in the regulation of mRNA
            translation, as well as processing of the 3' untranslated region,
            and may play a role in cell proliferation and tumorigenesis.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.227619.1,
                                           SRR1803614.21850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684509.1/ ENSP00000507835.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC105339.9         155624-155850
            228-420             AC110291.7         104071-104263       c
            421-574             AC110291.7         102921-103074       c
            575-595             AC245033.2         231611-231631       c
            596-784             AC245033.2         175762-175950       c
            785-1011            AC245033.2         162178-162404       c
            1012-1264           AC245033.2         160288-160540       c
            1265-1378           AC245033.2         158296-158409       c
            1379-1468           AC245033.2         157885-157974       c
            1469-1605           AC245033.2         156898-157034       c
            1606-1804           AC245033.2         153878-154076       c
            1805-1899           AC245033.2         151561-151655       c
            1900-1980           AC245033.2         150859-150939       c
            1981-3482           AC245033.2         147619-149120       c
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..3482
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="cytoplasmic polyadenylation element binding protein
                     1"
                     /db_xref="GeneID:64506"
                     /db_xref="HGNC:HGNC:21744"
                     /db_xref="MIM:607342"
     exon            1..227
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..420
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..2091
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="isoform 5 is encoded by transcript variant 9;
                     CPE-binding protein 1"
                     /codon_start=1
                     /product="cytoplasmic polyadenylation element-binding
                     protein 1 isoform 5"
                     /protein_id="NP_001352171.1"
                     /db_xref="CCDS:CCDS92050.1"
                     /db_xref="GeneID:64506"
                     /db_xref="HGNC:HGNC:21744"
                     /db_xref="MIM:607342"
                     /translation="MFSGIATSTSSSMSGTGLEHSSLSDCLLLIPLEEEAGRIKDCWD
                     NQEAPALSTCSNANIFRRINAILDNSLDFSRVCTTPINRGIHDHLPDFQDSEETVTSR
                     MLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTHSVLSMLHN
                     PLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGF
                     SSGSDHLSDLISSLRISPPLPFLSLSGGGPRDPLKMGVGSRMDQEQAALAAVTPSPTS
                     ASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATCTWSGQLPPRNYKNP
                     IYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGYVYLVFELEK
                     SVRSLLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVRSPSQRLDP
                     SRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYLK
                     AVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSCWHWR
                     HSMEGLRHHSPLMRNQKNRDSS"
     exon            421..595
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..784
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1011
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1264
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1378
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1468
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1605
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1804
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1899
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1980
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..3482
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3463..3468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="hexamer: AATAAA"
     polyA_site      3482
                     /gene="CPEB1"
                     /gene_synonym="CPE-BP1; CPEB; CPEB-1; h-CPEB; hCPEB-1"
                     /note="major polyA site"
ORIGIN      
        1 gtgctctgtg gagagcccca cgacggcggc ggtcgcggca cctttaaggt ggagggctca
       61 agcccctcgt gcggcttccc aatcctgggc aggtcacgtg gcttcacacc ttcgcttggc
      121 gccggagagg gagtctcggg ggcggggctg gccaggtagt gtggcgcgag ggcggaagac
      181 tggcggggct tcgtgcccgg gagacccgcc gggctggcgg cattgagttt cagtgcctgt
      241 gtaatagaag ggtctgtatt gtaaaagaag tcaaaagcag ccttgaataa tcggaaccct
      301 tttgccagat catctaatgt caatatgttt tctggcattg ctacttcaac atcgtcttcc
      361 atgtctggca ctggtttgga gcactcatct ctatcagatt gtcttctgct aattcctctg
      421 gaagaagaag caggaaggat aaaagattgc tgggacaacc aggaagcacc tgctctctcc
      481 acgtgtagta atgccaatat ctttcgaagg ataaatgcca tattggataa ttctctggat
      541 ttcagtagag tctgcactac acctataaac cgaggaattc atgatcattt gccagacttc
      601 caggactctg aagaaacagt tacaagcagg atgcttttcc caacctctgc gcaagaatct
      661 tcccgtggcc tcccagatgc aaatgacttg tgccttggcc tgcagtccct cagtctgaca
      721 ggctgggacc gaccctggag cacccaggac tcagattcct cagcccagag cagcacacac
      781 tcggtactga gcatgctcca taacccactg ggaaatgtcc taggaaaacc ccccttgagc
      841 ttcctgcctc tggatcccct tgggtctgac ttggtggaca agtttccagc accctcagtt
      901 agaggatcac gcctggacac ccggcccatc ctggactctc gatctagcag cccctctgac
      961 tcagacacca gtggcttcag ctctggatca gatcatctct cagatttgat ttcaagcctt
     1021 cgcatttctc cacctctgcc cttcctgtct ctgtcagggg gtggtcccag agacccttta
     1081 aagatggggg tagggtctcg gatggaccaa gagcaagctg ctcttgctgc agtcactccc
     1141 tccccaacca gtgcttcaaa gagatggcca ggagcttctg tgtggccatc ctgggacctc
     1201 ctcgaagctc ccaaagaccc cttcagcata gagagagagg ccaggctgca ccgacaagct
     1261 gcagctgtga atgaagccac ctgtacctgg agtggccagc ttcctccccg gaactataag
     1321 aaccccatct actcttgcaa ggtgtttcta ggaggtgttc cttgggatat tacagaagct
     1381 ggattagtta acaccttccg tgtttttggc tctttgagtg tggagtggcc tggtaaggat
     1441 ggcaagcatc cccggtgtcc tcccaaaggg tatgtgtatc tggtcttcga actagagaag
     1501 tctgtccgat ccttgcttca ggcttgctct catgacccgc tgagcccaga tggcctgagt
     1561 gaatattatt tcaagatgtc cagccgaagg atgcgctgca aggaggtgca ggtgatcccc
     1621 tgggtattag ccgacagtaa ctttgtccgg agcccatctc agaggcttga ccccagcagg
     1681 acggtgtttg tcggtgctct gcatggaatg ctaaatgctg aggccctggc agccatcttg
     1741 aacgacctat ttggtggagt ggtgtatgcc gggattgaca cagataagca caagtatccc
     1801 attggttctg gtcgtgtgac tttcaataac caacggagtt acctgaaagc agtcagcgct
     1861 gcttttgtgg agatcaaaac caccaagttc acaaagaagg ttcagattga cccctaccta
     1921 gaagattctc tgtgtcatat ctgcagttct cagcctggtc ctttcttctg tcgagatcag
     1981 gtctgcttca aatacttctg ccggagctgc tggcactggc ggcacagcat ggagggcctg
     2041 cgccaccaca gccccctgat gcggaaccag aagaaccgag attccagcta gaggagctgg
     2101 ccttgcccag tggcctgtgg cgcccaaagc tggcaggtca ggcaagcagc ctgcaccacc
     2161 ctgccactgg cgaccaggga gctggcttcc caaggacaag ggaaaattgt agtcaccttt
     2221 gcacttgctg aatctgtctt tgtttctgca ctaattaatg cacattgagt tttgtcaggt
     2281 tttgttttca gggggtgtac caagggcaag gaccctctgg cttaccctcc aagcgactct
     2341 gtagttttcc cagattttag ttcctcattt tgcagatgaa aagcggggaa aaaaaaaaaa
     2401 aaaaaaaaaa ctacgtgtcc agaaggtatt gaggtattga cacggatgcc tacacctagg
     2461 tttatttatt aaaagcgctt ttttacattc cttgcaatac tgatggtgat gatgcgcagg
     2521 tctcattggt ttcattcttg cagttgccat acagtgcctt tccatttatt taacccccac
     2581 ctgaacggca taaactgagt gttcagctgg tgttttttac tgtaaacaat aaggagactt
     2641 tgctcttcat ttaaaccaaa atcatatttc atattttacg ctcgagggtt tttaccggtt
     2701 cctttttaca ctccttaaaa cagtttttaa gtcgtttgga acaagatatt ttttctttcc
     2761 tggcagcttt taacattata gcaaatttgt gtctggggga ctgctggtca ctgtttctca
     2821 cagttgcaaa tcaaggcatt tgcaaccaag aaaaaaaaaa ttttttgttt tatttgaaac
     2881 tggaccggat aaacggtgtt tgagcggctg ctgtatatag ttttaaatgg tttattgcac
     2941 ctccttaagt tgcacttatg tgggggggtg gggttgatag aagtttttaa tcacaaagtc
     3001 acaggacttt tttcttttgt aactgagcta aaaagggctg cttttcggtg ggggcagatg
     3061 aaggctcaca ggagcccttt ctcttagagg gggcaagtac ccttccctta tatctttaat
     3121 ttgaggaatg tatgagataa cagttgcagt tgactgaaat gccactggaa tttgaaaact
     3181 tgactttttt ttctttcctt tttttttttt tttttttttt taaaaagaaa caaaaaaccc
     3241 acaaaaacta cttgcccctc ctagggaagc tgtgtgccaa agaaccagtg tcataacccc
     3301 tccctcctgc tgagctgacg ttgcattgtt gcatatccca gctactctgt gggttttgtg
     3361 aagctgtgtg tgaagtctct acctcattgt agtatatgca ggcaagactg cactctccta
     3421 cagatgtgtg gagtaagctg tggtgtagtt tttttggcac ataataaaca cgttgcagca
     3481 ga
//
